ANN FALSEY

Summary

Publications

  1. pmc Current management of parainfluenza pneumonitis in immunocompromised patients: a review
    Ann R Falsey
    University of Rochester, Rochester General Hospital, Rochester, NY, USA
    Infect Drug Resist 5:121-7. 2012
  2. pmc Bacterial complications of respiratory tract viral illness: a comprehensive evaluation
    Ann R Falsey
    Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 208:432-41. 2013
  3. pmc Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note
    Ann R Falsey
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Int J Chron Obstruct Pulmon Dis 7:127-35. 2012
  4. pmc Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirus
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621 3001, USA
    J Clin Virol 46:314-7. 2009
  5. pmc Humoral immunity to human metapneumovirus infection in adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
    Vaccine 28:1477-80. 2010
  6. doi New emerging technologies and the intradermal route: the novel way to immunize against influenza
    Ann R Falsey
    Rochester General Hospital, NY 14621, USA
    Vaccine 28:D24-32. 2010
  7. pmc Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
    Ann R Falsey
    University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
    J Clin Microbiol 50:21-4. 2012
  8. pmc Long-term care facilities: a cornucopia of viral pathogens
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
    J Am Geriatr Soc 56:1281-5. 2008
  9. ncbi Human metapneumovirus infections in young and elderly adults
    Ann R Falsey
    Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Infect Dis 187:785-90. 2003
  10. ncbi Impact of rapid diagnosis on management of adults hospitalized with influenza
    Ann R Falsey
    Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Arch Intern Med 167:354-60. 2007

Collaborators

Detail Information

Publications29

  1. pmc Current management of parainfluenza pneumonitis in immunocompromised patients: a review
    Ann R Falsey
    University of Rochester, Rochester General Hospital, Rochester, NY, USA
    Infect Drug Resist 5:121-7. 2012
    ..A number of agents show antiviral activity in vitro and in animals, but none are currently approved for human use...
  2. pmc Bacterial complications of respiratory tract viral illness: a comprehensive evaluation
    Ann R Falsey
    Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 208:432-41. 2013
    ..Although bacterial infection is known to complicate viral infections, the frequency and impact of mixed viral-bacterial infections has not been well studied...
  3. pmc Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary note
    Ann R Falsey
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Int J Chron Obstruct Pulmon Dis 7:127-35. 2012
    ..Therefore, we evaluated procalcitonin as a predictor of viral versus bacterial infection in patients hospitalized with AECOPD with and without evidence of pneumonia...
  4. pmc Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirus
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621 3001, USA
    J Clin Virol 46:314-7. 2009
    ..Human metapneumovirus (hMPV) is a newly discovered virus which causes respiratory illness in persons of all ages...
  5. pmc Humoral immunity to human metapneumovirus infection in adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
    Vaccine 28:1477-80. 2010
    ..Serum antibody may play a role in protection from hMPV infection supporting the development of an hMPV vaccine that stimulates humoral immunity...
  6. doi New emerging technologies and the intradermal route: the novel way to immunize against influenza
    Ann R Falsey
    Rochester General Hospital, NY 14621, USA
    Vaccine 28:D24-32. 2010
    ..In addition, these methods of delivery may increase acceptability in children and persons with needle phobias, thus addressing some of the present barriers to influenza immunization...
  7. pmc Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
    Ann R Falsey
    University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
    J Clin Microbiol 50:21-4. 2012
    ..Further studies designed to adapt the use of sputum samples for commercial RT-PCR respiratory virus assays are needed...
  8. pmc Long-term care facilities: a cornucopia of viral pathogens
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
    J Am Geriatr Soc 56:1281-5. 2008
    ..To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period...
  9. ncbi Human metapneumovirus infections in young and elderly adults
    Ann R Falsey
    Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Infect Dis 187:785-90. 2003
    ..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
  10. ncbi Impact of rapid diagnosis on management of adults hospitalized with influenza
    Ann R Falsey
    Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Arch Intern Med 167:354-60. 2007
    ..We compared the clinical management of patients with influenza whose rapid antigen test result was positive (Ag+) with the management of those whose rapid antigen test result was negative or the test was not performed (Ag0)...
  11. ncbi Age related differences in humoral immune response to respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Med Virol 73:295-9. 2004
    ..The relationship of immune response to disease pathogenesis in older persons deserves further study...
  12. ncbi Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 190:373-8. 2004
    ..Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection...
  13. pmc Clinical and immunologic predictors of influenza illness among vaccinated older adults
    Zainab Shahid
    Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Vaccine 28:6145-51. 2010
    ..ILI subjects (p=0.03). The cell-mediated immune response to influenza distinguishes A/H3N2 LCI from other ILI in older adults, and suggests a link between cell-mediated immunity and influenza illness severity in vaccinated older adults...
  14. pmc Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding
    Ann R Falsey
    Department of Medicine Infectious Disease Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Clin Microbiol 41:4160-5. 2003
    ..Quantitative RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a useful tool for future studies addressing viral load and disease pathogenesis...
  15. doi Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 200:172-80. 2009
    ..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed...
  16. ncbi Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness
    Ann R Falsey
    Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Clin Virol 35:46-50. 2006
    ..Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two viruses for which RT-PCR is now frequently used for diagnosis in adult disease...
  17. doi Human metapneumovirus infection in adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Pediatr Infect Dis J 27:S80-3. 2008
    ..Although the true spectrum of adult hMPV remains to be defined, it is clear that hMPV can result in severe illness the frail elderly and adults with underlying diseases...
  18. pmc Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease
    Ann R Falsey
    Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Am J Respir Crit Care Med 173:639-43. 2006
    ..These data raise the possibility of persistent low-grade infection in this population, which could have implications in COPD pathogenesis...
  19. pmc Human metapneumovirus infections in adults: another piece of the puzzle
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arch Intern Med 168:2489-96. 2008
    ..We describe the incidence and clinical impact of human metapneumovirus (HMPV), a newly identified virus, in adults...
  20. pmc The effect of steroid use in hospitalized adults with respiratory syncytial virus-related illness
    F Eun Hyung Lee
    Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Chest 140:1155-61. 2011
    ..The effects of short-term high-dose steroid treatment on viral load and adaptive immunity to RSV have not been examined in adults...
  21. ncbi Risk factors for severe respiratory syncytial virus infection in elderly persons
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Infect Dis 189:233-8. 2004
    ..These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations...
  22. ncbi Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults
    Aida E Casiano-Colón
    ViaHealth Clinical Laboratories and Pathology, Rochester, NY, USA
    J Clin Virol 28:169-74. 2003
    ..DFA detected 14 (23%), VIDAS detected 12 (20%) and BD detected only 6 (10%) of the RSV infected persons. Rapid antigen detection tests for the diagnosis of RSV respiratory illness in adults are of limited value...
  23. pmc Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults
    F Eun Hyung Lee
    Division of Pulmonary and Critical Care Medicine, University of Rochester and Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 202:1659-66. 2010
    ..The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied...
  24. pmc Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Rochester General Hospital, 601 Elmwood Avenue Box 689, Rochester, NY 14642, USA Yoshihiko
    Vaccine 28:6242-6. 2010
    ..Our results have implications for RSV G-based serological diagnostics and vaccine development...
  25. pmc Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization
    Jessica L Halliley
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Vaccine 28:3582-7. 2010
    ..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored...
  26. pmc Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
    Clin Vaccine Immunol 17:695-7. 2010
    ..In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera...
  27. ncbi Experimental infection of humans with A2 respiratory syncytial virus
    F Eun Hyung Lee
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Antiviral Res 63:191-6. 2004
    ..This model provides a safe and efficient mechanism for proof-of-concept studies of anti-viral agents and RSV vaccines, as well as for investigation of immune responses to infection...
  28. ncbi Viral pneumonia in older adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Clin Infect Dis 42:518-24. 2006
    ..Because clinical features and periods of activity for many viruses overlap, laboratory confirmation of influenza is recommended for cases involving seriously ill or institutionalized patients...
  29. ncbi Serum antibody decay in adults following natural respiratory syncytial virus infection
    Ann R Falsey
    Department of Medicine at Rochester General Hospital, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Med Virol 78:1493-7. 2006
    ..In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived...

Research Grants6

  1. Human Metapneumovirus Infection in Adults
    ANN FALSEY; Fiscal Year: 2005
    ..abstract_text> ..
  2. Human Metapneumovirus Infection in Adults
    ANN FALSEY; Fiscal Year: 2006
    ..abstract_text> ..
  3. Human Metapneumovirus Infection in Adults
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  4. Reduction of Uneccessary Antibiotics in Adults by the Use of Viral Diagnostics
    ANN FALSEY; Fiscal Year: 2009
    ....
  5. Reduction of Uneccessary Antibiotics in Adults by the Use of Viral Diagnostics
    Ann R Falsey; Fiscal Year: 2010
    ....
  6. Reduction of Uneccessary Antibiotics in Adults by the Use of Viral Diagnostics
    ANN FALSEY; Fiscal Year: 2009
    ....