Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease: a cautionary noteAnn R Falsey
Department of Medicine, University of Rochester, Rochester, NY, USA
Int J Chron Obstruct Pulmon Dis 7:127-35. 2012
..Therefore, we evaluated procalcitonin as a predictor of viral versus bacterial infection in patients hospitalized with AECOPD with and without evidence of pneumonia...
- Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
Ann R Falsey
University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
J Clin Microbiol 50:21-4. 2012
..Further studies designed to adapt the use of sputum samples for commercial RT-PCR respiratory virus assays are needed...
New emerging technologies and the intradermal route: the novel way to immunize against influenzaAnn R Falsey
Rochester General Hospital, NY 14621, USA
Vaccine 28:D24-32. 2010
..In addition, these methods of delivery may increase acceptability in children and persons with needle phobias, thus addressing some of the present barriers to influenza immunization...
- Humoral immunity to human metapneumovirus infection in adults
Ann R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
Vaccine 28:1477-80. 2010
..Serum antibody may play a role in protection from hMPV infection supporting the development of an hMPV vaccine that stimulates humoral immunity...
- Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirus
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621 3001, USA
J Clin Virol 46:314-7. 2009
..Human metapneumovirus (hMPV) is a newly discovered virus which causes respiratory illness in persons of all ages...
- Long-term care facilities: a cornucopia of viral pathogens
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
J Am Geriatr Soc 56:1281-5. 2008
..To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period...
Human metapneumovirus infections in young and elderly adultsAnn R Falsey
Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
J Infect Dis 187:785-90. 2003
..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
- Impact of rapid diagnosis on management of adults hospitalized with influenza
Ann R Falsey
Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
Arch Intern Med 167:354-60. 2007
..We compared the clinical management of patients with influenza whose rapid antigen test result was positive (Ag+) with the management of those whose rapid antigen test result was negative or the test was not performed (Ag0)...
- Age related differences in humoral immune response to respiratory syncytial virus infection in adults
Edward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Med Virol 73:295-9. 2004
..The relationship of immune response to disease pathogenesis in older persons deserves further study...
- Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults
Edward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
J Infect Dis 190:373-8. 2004
..Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection...
- Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease
Ann R Falsey
Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
Am J Respir Crit Care Med 173:639-43. 2006
..These data raise the possibility of persistent low-grade infection in this population, which could have implications in COPD pathogenesis...
- Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding
Ann R Falsey
Department of Medicine Infectious Disease Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Clin Microbiol 41:4160-5. 2003
..Quantitative RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a useful tool for future studies addressing viral load and disease pathogenesis...
- Clinical and immunologic predictors of influenza illness among vaccinated older adults
Zainab Shahid
Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
Vaccine 28:6145-51. 2010
..ILI subjects (p=0.03). The cell-mediated immune response to influenza distinguishes A/H3N2 LCI from other ILI in older adults, and suggests a link between cell-mediated immunity and influenza illness severity in vaccinated older adults...
- Human metapneumovirus infection in adults
Ann R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
Pediatr Infect Dis J 27:S80-3. 2008
..Although the true spectrum of adult hMPV remains to be defined, it is clear that hMPV can result in severe illness the frail elderly and adults with underlying diseases...
- Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY, USA
J Infect Dis 200:172-80. 2009
..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed...
- Human metapneumovirus infections in adults: another piece of the puzzle
Edward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Arch Intern Med 168:2489-96. 2008
..We describe the incidence and clinical impact of human metapneumovirus (HMPV), a newly identified virus, in adults...
- Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness
Ann R Falsey
Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
J Clin Virol 35:46-50. 2006
..No subject had a positive swab on days 14, 21 or 28. CONCLUSION: Asymptomatic carriage of RSV or hMPV is uncommon. RT-PCR should be a useful method for the diagnosis of these viral illnesses in adults...
- The effect of steroid use in hospitalized adults with respiratory syncytial virus-related illness
F Eun Hyung Lee
Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
Chest 140:1155-61. 2011
..The effects of short-term high-dose steroid treatment on viral load and adaptive immunity to RSV have not been examined in adults...
- Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults
Aida E Casiano-Colón
ViaHealth Clinical Laboratories and Pathology, Rochester, NY, USA
J Clin Virol 28:169-74. 2003
..DFA detected 14 (23%), VIDAS detected 12 (20%) and BD detected only 6 (10%) of the RSV infected persons. Rapid antigen detection tests for the diagnosis of RSV respiratory illness in adults are of limited value...
- Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults
F Eun Hyung Lee
Division of Pulmonary and Critical Care Medicine, University of Rochester and Rochester General Hospital, Rochester, New York, USA
J Infect Dis 202:1659-66. 2010
..The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied...
- Viral pneumonia in older adults
Ann R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
Clin Infect Dis 42:518-24. 2006
..Because clinical features and periods of activity for many viruses overlap, laboratory confirmation of influenza is recommended for cases involving seriously ill or institutionalized patients...
- Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein
Yoshihiko Murata
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Rochester General Hospital, 601 Elmwood Avenue Box 689, Rochester, NY 14642, USA Yoshihiko
Vaccine 28:6242-6. 2010
..Our results have implications for RSV G-based serological diagnostics and vaccine development...
- Serum antibody decay in adults following natural respiratory syncytial virus infection
Ann R Falsey
Department of Medicine at Rochester General Hospital, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Med Virol 78:1493-7. 2006
..In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived...
- Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization
Jessica L Halliley
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 28:3582-7. 2010
..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored...
- Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein
Yoshihiko Murata
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
Clin Vaccine Immunol 17:695-7. 2010
..In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera...
- Experimental infection of humans with A2 respiratory syncytial virus
F Eun-Hyung Lee
Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
Antiviral Res 63:191-6. 2004
..This model provides a safe and efficient mechanism for proof-of-concept studies of anti-viral agents and RSV vaccines, as well as for investigation of immune responses to infection...
- Risk factors for severe respiratory syncytial virus infection in elderly persons
Edward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Infect Dis 189:233-8. 2004
..quot; These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations...
