G P Fadini

Summary

Publications

  1. ncbi request reprint Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Padova, Italy
    J Am Coll Cardiol 45:1449-57. 2005
  2. ncbi request reprint Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Italy
    Arterioscler Thromb Vasc Biol 26:2140-6. 2006
  3. ncbi request reprint Significance of endothelial progenitor cells in subjects with diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 30:1305-13. 2007
  4. ncbi request reprint The good and the bad in the link between insulin resistance and vascular calcification
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 193:241-4. 2007
  5. doi request reprint Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Italy
    Atherosclerosis 197:496-503. 2008
  6. doi request reprint Monocyte-macrophage polarization balance in pre-diabetic individuals
    Gian Paolo Fadini
    Department of Medicine, Policlinico Universitario, Via Giustiniani, 2, 35100, Padua, Italy
    Acta Diabetol 50:977-82. 2013
  7. doi request reprint Diabetes impairs mobilization of stem cells for the treatment of cardiovascular disease: a meta-regression analysis
    Gian Paolo Fadini
    Department of Medicine, University of Padova, 35100 Padova, Italy Venetian Institute of Molecular Medicine, 35100 Padova, Italy Electronic address
    Int J Cardiol 168:892-7. 2013
  8. doi request reprint Independent glucose and weight-reducing effects of Liraglutide in a real-world population of type 2 diabetic outpatients
    Gian Paolo Fadini
    Department of Medicine, University Hospital of Padova, Via Giustiniani, 2, 35100, Padua, Italy
    Acta Diabetol 50:943-9. 2013
  9. doi request reprint Dipeptidyl peptidase-4 inhibition and vascular repair by mobilization of endogenous stem cells in diabetes and beyond
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padova, Italy
    Atherosclerosis 229:23-9. 2013
  10. pmc Diabetes impairs stem cell and proangiogenic cell mobilization in humans
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetes Care 36:943-9. 2013

Detail Information

Publications76

  1. ncbi request reprint Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Padova, Italy
    J Am Coll Cardiol 45:1449-57. 2005
    ..We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients...
  2. ncbi request reprint Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Italy
    Arterioscler Thromb Vasc Biol 26:2140-6. 2006
    ..This study aimed to establish whether number and function of EPCs correlate with PAD severity in type 2 diabetic patients...
  3. ncbi request reprint Significance of endothelial progenitor cells in subjects with diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 30:1305-13. 2007
  4. ncbi request reprint The good and the bad in the link between insulin resistance and vascular calcification
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 193:241-4. 2007
    ..Therefore, we suggest that the functional interactions between ALP and PC-1 may link insulin resistance to vascular calcification...
  5. doi request reprint Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Italy
    Atherosclerosis 197:496-503. 2008
    ..We uncover the many traps hidden in the choice of the right protocol, and suggest the best solutions on the basis of evidence and background theories...
  6. doi request reprint Monocyte-macrophage polarization balance in pre-diabetic individuals
    Gian Paolo Fadini
    Department of Medicine, Policlinico Universitario, Via Giustiniani, 2, 35100, Padua, Italy
    Acta Diabetol 50:977-82. 2013
    ..We show for the first time that otherwise healthy pre-diabetic subjects have excess M1 inflammatory cells in peripheral blood, which may contribute to cardiovascular risk...
  7. doi request reprint Diabetes impairs mobilization of stem cells for the treatment of cardiovascular disease: a meta-regression analysis
    Gian Paolo Fadini
    Department of Medicine, University of Padova, 35100 Padova, Italy Venetian Institute of Molecular Medicine, 35100 Padova, Italy Electronic address
    Int J Cardiol 168:892-7. 2013
    ..We aimed to ascertain whether the presence of diabetes negatively affects the mobilization of stem cells induced by granulocyte-colony stimulation factor (G-CSF) in therapeutic trials for cardiovascular disease (CVD)...
  8. doi request reprint Independent glucose and weight-reducing effects of Liraglutide in a real-world population of type 2 diabetic outpatients
    Gian Paolo Fadini
    Department of Medicine, University Hospital of Padova, Via Giustiniani, 2, 35100, Padua, Italy
    Acta Diabetol 50:943-9. 2013
    ..Glycemic improvement and weight reduction obtained with Liraglutide treatment in T2D patients in a real-world setting are independent and possibly mediated by different mechanisms...
  9. doi request reprint Dipeptidyl peptidase-4 inhibition and vascular repair by mobilization of endogenous stem cells in diabetes and beyond
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padova, Italy
    Atherosclerosis 229:23-9. 2013
    ..As DPP-4 inhibitors show favorable safety profiles and do not cause hypoglycemia, they are attractive drugs also for non-diabetic patients and may become part of a vascular regenerative pharmacotherapy. ..
  10. pmc Diabetes impairs stem cell and proangiogenic cell mobilization in humans
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetes Care 36:943-9. 2013
    ..Herein, we sought to assay mobilization of stem and proangiogenic cells in subjects with and without DM...
  11. doi request reprint A diseased bone marrow fuels atherosclerosis in diabetes
    Gian Paolo Fadini
    Department of Medicine, University of Padova, 35100 Padova
    Atherosclerosis 226:337-8. 2013
    ..Herein, the pathophysiological meaning of a deranged kinetic of smooth muscle progenitor cells in diabetes is discussed...
  12. doi request reprint Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy
    Gian Paolo Fadini
    Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padua, Italy
    Basic Res Cardiol 108:313. 2013
    ..In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation...
  13. doi request reprint Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general population
    Gian Paolo Fadini
    Department of Medicine, University Hospital of Padova, Padua, Italy
    Acta Diabetol 49:445-51. 2012
    ..26; 95 % CI 1.01-1.58). In conclusion, elevated WBC is intimately linked to the prevalence and future development of the MS in a young population of working subjects...
  14. doi request reprint Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemia
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Clin Hemorheol Microcirc 50:293-300. 2012
    ....
  15. pmc Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
    Exp Diabetes Res 2012:274363. 2012
    ..We conclude that glucose control transiently mobilizes PPCs diabetic patients with microangiopathy. Increase in PPCs may represent a vasoregenerative event or may be a consequence of ameliorated glucose control on microvascular lesions...
  16. pmc Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
    Exp Diabetes Res 2012:921685. 2012
    ..In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals...
  17. doi request reprint Characteristics and outcomes of the hyperglycemic hyperosmolar non-ketotic syndrome in a cohort of 51 consecutive cases at a single center
    Gian Paolo Fadini
    Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes Res Clin Pract 94:172-9. 2011
    ..The hyperglycemic hyperosmolar syndrome (HHS) is a life-threatening diabetic complication. We aimed to portrait the short and long term outcome after a HHS episode and to describe features associated with increased early mortality...
  18. doi request reprint Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cells
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cell Biol Int 34:709-15. 2010
    ..In conclusion, we show that rosuvastatin had significant stimulatory effects on EPCs irrespective of the culture protocol. Rosuvastatin also induced anti-inflammatory polarization of monocytic EPCs...
  19. pmc Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Diabetes Care 33:1097-102. 2010
    ..The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes...
  20. doi request reprint Endothelial progenitors in pulmonary hypertension: new pathophysiology and therapeutic implications
    G P Fadini
    Dipartimento di Medicina Clinica e Sperimentale, V Giustiniani 2, 35100 Padova, Italy
    Eur Respir J 35:418-25. 2010
    ..The resulting scenario identifies EPCs as a novel and fascinating tool to study pathophysiology and therapy in the setting of pulmonary hypertension...
  21. doi request reprint Autologous stem cell therapy for peripheral arterial disease meta-analysis and systematic review of the literature
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 209:10-7. 2010
    ..Peripheral arterial disease (PAD) is a common cause of disability and mortality. Up to one third of patients are not susceptible to traditional revascularization and may benefit from stem cell therapies...
  22. doi request reprint Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 207:213-9. 2009
    ..Circulating progenitor cells have been shown to contribute to endothelial homeostasis and repair . We aimed to test whether progenitor cell count is an independent event predictor and modifies cardiovascular risk associated with MetS...
  23. pmc Effects of androgens on endothelial progenitor cells in vitro and in vivo
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Clin Sci (Lond) 117:355-64. 2009
    ..In conclusion, our results collectively demonstrate that androgens exert no direct effects on endothelial progenitor cell biology in vitro and in vivo...
  24. doi request reprint Characteristics and mortality of type 2 diabetic patients hospitalized for severe iatrogenic hypoglycemia
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Diabetes Res Clin Pract 84:267-72. 2009
    ..We aimed to describe clinical characteristics of type 2 diabetic patients hospitalized for iatrogenic hypoglycemia, and find predictors of long-term mortality, with a special regard to anti-hyperglycemic regimens...
  25. doi request reprint Mechanisms and significance of progenitor cell reduction in the metabolic syndrome
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Metab Syndr Relat Disord 7:5-10. 2009
    ..We also highlight how endothelial progenitors may mediate the interactions between cardiometabolic risk factors in a complex interplay and discuss potential implications for prevention and therapy...
  26. pmc The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, School of Medicine, University of Padova, Padova, Italy
    Diabetes Care 33:1607-9. 2010
    ..Because SDF-1alpha is a substrate of dipeptidyl-peptidase-4 (DPP-4), we investigated whether the DPP-4 inhibitor sitagliptin modulates EPC levels in type 2 diabetic patients...
  27. doi request reprint Two cases of statin-induced rhabdomyolysis associated with mononeuropathy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Clin Drug Investig 30:347-50. 2010
    ..Close monitoring for myopathic/neuropathic events is warranted in high-risk patients with pre-existing neuropathies who are taking statins...
  28. ncbi request reprint Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Stroke 37:2277-82. 2006
    ..With this background, we evaluated whether variations in the number of EPCs are associated with subclinical atherosclerosis in healthy subjects...
  29. doi request reprint Optimized glycaemic control achieved with add-on basal insulin therapy improves indexes of endothelial damage and regeneration in type 2 diabetic patients with macroangiopathy: a randomized crossover trial comparing detemir versus glargine
    G P Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Obes Metab 13:718-25. 2011
    ..Given that insulin influences endothelial biology, we compared the effects of add-on basal insulin analogues on endothelial damage and regeneration in type 2 diabetes (T2D)...
  30. doi request reprint Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Circ Res 108:1112-21. 2011
    ..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
  31. doi request reprint At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Aging Cell 10:10-7. 2011
    ..The model described in this viewpoint article is therefore likely to be an oversimplification. Nevertheless, it represents one starting platform for understanding cell biology of lifespan in relation to the metabolic syndrome...
  32. pmc Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    PLoS ONE 5:e11488. 2010
    ..We tested the hypothesis that CPC count improves cardiovascular risk stratification and that this is modulated by low-grade inflammation...
  33. doi request reprint Potential manipulation of endothelial progenitor cells in diabetes and its complications
    G P Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, Medical School, Padova, Italy
    Diabetes Obes Metab 12:570-83. 2010
    ..Herein, we provide a comprehensive overview of EPC pathophysiology and the potential for EPC modulation in diabetes...
  34. pmc The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes 59:2306-14. 2010
    ..Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing...
  35. doi request reprint Cell-based methods for ex vivo evaluation of human endothelial biology
    Gian Paolo Fadini
    Metabolic Division, Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cardiovasc Res 87:12-21. 2010
    ..In this review, we will summarize the current knowledge and the methodological perspective of these cell-based methods...
  36. ncbi request reprint The emerging role of endothelial progenitor cells in pulmonary hypertension and diffuse lung diseases
    Gian Paolo Fadini
    University of Padua, Department of Clinical and Experimental Medicine, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 24:85-93. 2007
    ..In this review, we will focus on the experimental and clinical data suggesting that EPC deregulation may have a role in the pathogenesis of vascular and parenchymal lung diseases...
  37. doi request reprint An underlying principle for the study of circulating progenitor cells in diabetes and its complications
    G P Fadini
    Department of Clinical and Experimental Medicine, University of Padua, Medical School, Via Giustiniani, 2, 35100, Padua, Italy
    Diabetologia 51:1091-4. 2008
  38. doi request reprint A stepwise approach to assess the impact of clustering cardiometabolic risk factors on carotid intima-media thickness: the metabolic syndrome no-more-than-additive
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Eur J Cardiovasc Prev Rehabil 15:190-6. 2008
    ..In this study, we explored the relationship between clustering cardiometabolic risk factors and carotid intima-media thickness (c-IMT)...
  39. ncbi request reprint Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in rats
    G P Fadini
    Department of Clinical and Experimental Medicine, Metabolic Diseases Division, University of Padua Medical School, Via Giustiniani, 2, Padua, Italy
    Diabetologia 49:3075-84. 2006
    ..The aim of this study was to test the hypothesis that weak bone marrow mobilisation is responsible for the decrease in circulating EPCs in diabetes...
  40. ncbi request reprint Endothelial progenitor cells in the natural history of atherosclerosis
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Atherosclerosis 194:46-54. 2007
    ..An attempt to diverge our attention from the vessel wall to the bloodstream reveals a central role of EPCs in atherogenesis...
  41. ncbi request reprint Circulating progenitor cells are reduced in patients with severe lung disease
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova School of Medicine, Italy
    Stem Cells 24:1806-13. 2006
    ..This alteration was more evident in restrictive patients and correlated to disease severity. Depletion of circulating EPCs may be involved in altered endothelial homeostasis of pulmonary circulation in these disorders...
  42. ncbi request reprint Endothelial progenitor cells and the diabetic paradox
    Gian Paolo Fadini
    Dipartimento di Medicina Clinica e Sperimentale, Divisione di Malattie del Metabolismo, Policlinico Universitario, Via Giustiniani 2, 35100 Padua, Italy
    Diabetes Care 29:714-6. 2006
  43. ncbi request reprint Characterization of endothelial progenitor cells
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Italy
    Biochem Biophys Res Commun 336:1-2. 2005
  44. doi request reprint Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens
    Gian Paolo Fadini
    Clinical and Experimental Medicine, University of Padova Medical School, Italy
    Arterioscler Thromb Vasc Biol 28:997-1004. 2008
    ..Endothelial progenitor cells (EPCs) participate in vascular homeostasis and angiogenesis. The aim of the present study was to explore EPC number and function in relation to cardiovascular risk, gender, and reproductive state...
  45. ncbi request reprint Arterio-venous gradient of endothelial progenitor cells across renal artery stenosis
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Atherosclerosis 182:189-91. 2005
    ..Surprisingly, we found that EPCs were more abundant in venous than in arterial blood, suggesting that the kidney subjected to chronic ischemia may become a source rather than a target of EPCs...
  46. ncbi request reprint Low levels of endothelial progenitor cells correlate with disease duration and activity in patients with Behçet's disease
    G P Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Clin Exp Rheumatol 27:814-21. 2009
    ..We tested whether Behçet's disease (BD) is characterized by alterations of circulating endothelial progenitor cells (EPCs),which are involved in vascular homeostasis and repair...
  47. doi request reprint Microangiopathy is independently associated with presence, severity and composition of carotid atherosclerosis in type 2 diabetes
    S Vigili de Kreutzenberg
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 21:286-93. 2011
    ..We aimed to cross-sectionally investigate strength and characteristics of the association between carotid atherosclerosis and microangiopathy in type 2 diabetic patients...
  48. doi request reprint Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice
    M Albiero
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Via Giustiniani, 2 35100 Padova, Italy
    Diabetologia 54:945-53. 2011
    ..We tested the hypothesis that diabetes impairs the contribution of BM-derived cells at sites of wound healing...
  49. doi request reprint The metabolic syndrome, diabetes and lung dysfunction
    A Tiengo
    Division of Metabolic Diseases, Department of Clinical Medicine, University of Padova, Padova, Italy
    Diabetes Metab 34:447-54. 2008
    ..Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction...
  50. ncbi request reprint Glucose tolerance is negatively associated with circulating progenitor cell levels
    G P Fadini
    Department of Clinical and Experimental Medicine, Medical School, University of Padua, Via Giustiniani 2, 35100, Padua, Italy
    Diabetologia 50:2156-63. 2007
    ..This study was designed to evaluate progenitor cell levels in volunteers with different degrees of glucose tolerance...
  51. doi request reprint An unbalanced monocyte polarisation in peripheral blood and bone marrow of patients with type 2 diabetes has an impact on microangiopathy
    G P Fadini
    Department of Medicine, University of Padova, Padova, Italy
    Diabetologia 56:1856-66. 2013
    ..We sought to analyse monocyte polarisation status in type 2 diabetes, which is characterised by chronic inflammation...
  52. doi request reprint The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients
    Gian P Fadini
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Diabetes Obes Metab 14:518-22. 2012
    ..Dipeptidyl peptidase (DPP)-4 in responsible for incretin degradation and some observations suggest that DPP-4 activity is increased in type 2 diabetes (T2D). We aimed to assess the effect of T2D and glucose control on DPP-4 activity...
  53. ncbi request reprint Circulating CD34+ cells, metabolic syndrome, and cardiovascular risk
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padua, Medical School, Padua, Italy
    Eur Heart J 27:2247-55. 2006
    ..As general agreement on their characterization is lacking, this work was carried out to assess the relationships between different antigenic profiles of progenitor cells and CV risk, with special regard to metabolic syndrome (MetSyn)...
  54. pmc Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
    Saula Vigili de Kreutzenberg
    Department of Clinical and Experimental Medicine, Metabolic Diseases, University of Padova, Padova, Italy
    Diabetes 59:1006-15. 2010
    ..We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro...
  55. ncbi request reprint Pharmacologic targeting of endothelial progenitor cells
    Mattia Albiero
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Cardiovasc Hematol Disord Drug Targets 10:16-32. 2010
    ..An alternative strategy to partially overcome these limitations is to target EPCs with available drugs. In this review we will discuss how disparate pharmacological compounds have been used to improve EPCs number and functions...
  56. ncbi request reprint Maternal insulin therapy increases fetal endothelial progenitor cells during diabetic pregnancy
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Diabetes Care 31:808-10. 2008
  57. doi request reprint Clones of interstitial cells from bovine aortic valve exhibit different calcifying potential when exposed to endotoxin and phosphate
    Marcello Rattazzi
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Padova, Treviso, Italy
    Arterioscler Thromb Vasc Biol 28:2165-72. 2008
    ..Our purpose was to study in vitro whether phenotypically-distinct interstitial cell clones from bovine aortic valve (BVIC) possess different calcifying potential in response to endotoxin (lipopolysaccharide [LPS]) and phosphate (Pi)...
  58. doi request reprint Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
    Acta Ophthalmol 88:135-41. 2010
    ....
  59. doi request reprint Selective estrogen receptor-alpha agonist provides widespread heart and vascular protection with enhanced endothelial progenitor cell mobilization in the absence of uterotrophic action
    Chiara Bolego
    Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti 2, 35131 Padua, Italy
    FASEB J 24:2262-72. 2010
    ..By conferring cardiovascular protection dissected from unwanted uterotrophic effects, ER alpha-selective agonists may represent a potential safer alternative to natural hormones...
  60. doi request reprint Insulin signaling and life span
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Pflugers Arch 459:301-14. 2010
    ....
  61. ncbi request reprint Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
    Giulio Ceolotto
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
    Arterioscler Thromb Vasc Biol 27:2627-33. 2007
    ..In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation...
  62. doi request reprint Development of metabolic syndrome and electrocardiographic features of left ventricular hypertrophy in middle-aged working subjects
    M Rigato
    Department of Medicine, University Hospital of Padova, 35100 Padova, Italy
    J Endocrinol Invest 36:1027-31. 2013
    ..Herein, we tested the association between development of MS and of electrocardiographic LVH in a cohort of middle-aged individuals...
  63. doi request reprint Why to screen heart disease in diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division and Diabetology, University of Padova Medical School, Padova, Italy
    Atherosclerosis 204:11-5. 2009
    ..In this article, we underline the importance of an early diagnosis of coronary artery disease and heart failure in diabetic patients, suggesting that positive screening tests have significant implications in clinical management...
  64. doi request reprint Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid?
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
    Free Radic Biol Med 44:1209-15. 2008
    ....
  65. ncbi request reprint Endothelial dysfunction in type 2 diabetes mellitus
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Nutr Metab Cardiovasc Dis 16:S39-45. 2006
    ..The aim of the present study is to illustrate possible mechanisms responsible for endothelial dysfunction in DM...
  66. doi request reprint Heme oxygenase-1 is an important modulator in limiting glucose-induced apoptosis in human umbilical vein endothelial cells
    Elisabetta Iori
    Department of Clinical and Experimental Medicine, University of Padua, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Life Sci 82:383-92. 2008
    ..Lack of homeostatic HO-1 upregulation fails to protect from oxidative damage and results in a higher rate of apoptotic cell death...
  67. ncbi request reprint Autologous transplantation of granulocyte colony-stimulating factor- mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes
    Gian Paolo Fadini
    Diabetes Care 29:478-9; author reply 479-80. 2006
  68. ncbi request reprint Endothelial progenitor cells in cerebrovascular disease
    Gian Paolo Fadini
    Stroke 36:1112-3; author reply 1113. 2005
  69. ncbi request reprint Pathophysiology of circulating progenitor cells in pulmonary disease and parallels with cardiovascular disease
    Gian Paolo Fadini
    Am J Respir Cell Mol Biol 35:403-4. 2006
  70. ncbi request reprint The Janus face of nicotinic angiogenesis
    Angelo Avogaro
    J Am Coll Cardiol 48:2561-3. 2006
  71. ncbi request reprint Critical assessment of putative endothelial progenitor phenotypes
    Gian Paolo Fadini
    Exp Hematol 35:1479-80; author reply 1481-2. 2007
  72. ncbi request reprint Depletion of endothelial progenitor cells may link pulmonary fibrosis and pulmonary hypertension
    Gian Paolo Fadini
    Am J Respir Crit Care Med 176:724-5; author reply 725. 2007
  73. ncbi request reprint Circulating CD34+ cells, pulmonary hypertension, and myelofibrosis
    Gian Paolo Fadini
    Blood 108:1776-7; author reply 1777. 2006
  74. ncbi request reprint Endothelial progenitor cells and erectile dysfunction
    Gian Paolo Fadini
    Eur Heart J 28:639-40; author reply 640. 2007
  75. ncbi request reprint Endothelial progenitor cells in coronary artery disease
    Gian Paolo Fadini
    J Am Coll Cardiol 49:1585; author reply 1585-6. 2007
  76. ncbi request reprint Is the metabolic syndrome a cardiovascular risk factor beyond its specific components?
    Sandro Inchiostro
    J Am Coll Cardiol 49:2465; author reply 2465-6. 2007