Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitusGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Padova, Italy
J Am Coll Cardiol 45:1449-57. 2005
..Depletion of circulating EPCs in diabetic patients may be involved in the pathogenesis of peripheral vascular complications...
Number and function of endothelial progenitor cells as a marker of severity for diabetic vasculopathyGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Italy
Arterioscler Thromb Vasc Biol 26:2140-6. 2006
..EPC count may be considered a novel biological marker of peripheral atherosclerosis in diabetes...
Significance of endothelial progenitor cells in subjects with diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Diabetes Care 30:1305-13. 2007
The good and the bad in the link between insulin resistance and vascular calcificationGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Atherosclerosis 193:241-4. 2007
..Therefore, we suggest that the functional interactions between ALP and PC-1 may link insulin resistance to vascular calcification...
Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateauGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Italy
Atherosclerosis 197:496-503. 2008
..We uncover the many traps hidden in the choice of the right protocol, and suggest the best solutions on the basis of evidence and background theories...
Diabetes impairs stem cell and proangiogenic cell mobilization in humansGian Paolo Fadini
Corresponding author Gian Paolo Fadini
Diabetes Care 36:943-9. 2013
..These alterations may hamper tissue repair and favor the development of cardiovascular complications...
A diseased bone marrow fuels atherosclerosis in diabetesGian Paolo Fadini
Department of Medicine, University of Padova, 35100 Padova, Italy Venetian Institute of Molecular Medicine VIMM, Laboratory of Experimental Diabetology, 35100 Padova, Italy 1 Electronic address
Atherosclerosis 226:337-8. 2013
..Herein, the pathophysiological meaning of a deranged kinetic of smooth muscle progenitor cells in diabetes is discussed...
Elevated white blood cell count is associated with prevalence and development of the metabolic syndrome and its components in the general populationGian Paolo Fadini
Department of Medicine, University Hospital of Padova, Padua, Italy
Acta Diabetol 49:445-51. 2012
..26; 95 % CI 1.01-1.58). In conclusion, elevated WBC is intimately linked to the prevalence and future development of the MS in a young population of working subjects...
Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathyGian Paolo Fadini
Department of Medicine, University of Padova, Via Giustiniani, 2, 35100 Padua, Italy
Basic Res Cardiol 108:313. 2013
..In conclusion, the analysis of stem cell compartmentalization in humans led us to discover mechanisms of BM unresponsiveness in diabetes determined by tissue-specific DPP-4 dysregulation...
Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemiaGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Clin Hemorheol Microcirc 50:293-300. 2012
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Amelioration of glucose control mobilizes circulating pericyte progenitor cells in type 2 diabetic patients with microangiopathyGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
Exp Diabetes Res 2012:274363. 2012
..We conclude that glucose control transiently mobilizes PPCs diabetic patients with microangiopathy. Increase in PPCs may represent a vasoregenerative event or may be a consequence of ameliorated glucose control on microvascular lesions...
Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery diseaseGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, 35128 Padova, Italy
Exp Diabetes Res 2012:921685. 2012
..In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals...
Characteristics and outcomes of the hyperglycemic hyperosmolar non-ketotic syndrome in a cohort of 51 consecutive cases at a single centerGian Paolo Fadini
Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Diabetes Res Clin Pract 94:172-9. 2011
..The hyperglycemic hyperosmolar syndrome (HHS) is a life-threatening diabetic complication. We aimed to portrait the short and long term outcome after a HHS episode and to describe features associated with increased early mortality...
Characteristics and mortality of type 2 diabetic patients hospitalized for severe iatrogenic hypoglycemiaGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
Diabetes Res Clin Pract 84:267-72. 2009
..We aimed to describe clinical characteristics of type 2 diabetic patients hospitalized for iatrogenic hypoglycemia, and find predictors of long-term mortality, with a special regard to anti-hyperglycemic regimens...
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healingGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Diabetes 59:2306-14. 2010
..Genetic deletion of p66Shc prolongs life span and protects against oxidative stress. In the present study, we evaluated the role of p66Shc in an animal model of diabetic wound healing...
Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Diabetes Care 33:1097-102. 2010
..The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes...
Two cases of statin-induced rhabdomyolysis associated with mononeuropathyGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Clin Drug Investig 30:347-50. 2010
..Close monitoring for myopathic/neuropathic events is warranted in high-risk patients with pre-existing neuropathies who are taking statins...
Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogensGian Paolo Fadini
Clinical and Experimental Medicine, University of Padova Medical School, Italy
Arterioscler Thromb Vasc Biol 28:997-1004. 2008
..Endothelial progenitor cells (EPCs) participate in vascular homeostasis and angiogenesis. The aim of the present study was to explore EPC number and function in relation to cardiovascular risk, gender, and reproductive state...
A stepwise approach to assess the impact of clustering cardiometabolic risk factors on carotid intima-media thickness: the metabolic syndrome no-more-than-additiveGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Eur J Cardiovasc Prev Rehabil 15:190-6. 2008
..In this study, we explored the relationship between clustering cardiometabolic risk factors and carotid intima-media thickness (c-IMT)...
An underlying principle for the study of circulating progenitor cells in diabetes and its complicationsG P Fadini
Department of Clinical and Experimental Medicine, University of Padua, Medical School, Via Giustiniani, 2, 35100, Padua, Italy
Diabetologia 51:1091-4. 2008
The emerging role of endothelial progenitor cells in pulmonary hypertension and diffuse lung diseasesGian Paolo Fadini
University of Padua, Department of Clinical and Experimental Medicine, Italy
Sarcoidosis Vasc Diffuse Lung Dis 24:85-93. 2007
..In this review, we will focus on the experimental and clinical data suggesting that EPC deregulation may have a role in the pathogenesis of vascular and parenchymal lung diseases...
Endothelial progenitors in pulmonary hypertension: new pathophysiology and therapeutic implicationsG P Fadini
Dipartimento di Medicina Clinica e Sperimentale, V Giustiniani 2, 35100 Padova, Italy
Eur Respir J 35:418-25. 2010
..The resulting scenario identifies EPCs as a novel and fascinating tool to study pathophysiology and therapy in the setting of pulmonary hypertension...
Autologous stem cell therapy for peripheral arterial disease meta-analysis and systematic review of the literatureGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Atherosclerosis 209:10-7. 2010
..Peripheral arterial disease (PAD) is a common cause of disability and mortality. Up to one third of patients are not susceptible to traditional revascularization and may benefit from stem cell therapies...
The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alphaGian Paolo Fadini
Department of Clinical and Experimental Medicine, School of Medicine, University of Padova, Padova, Italy
Diabetes Care 33:1607-9. 2010
..Because SDF-1alpha is a substrate of dipeptidyl-peptidase-4 (DPP-4), we investigated whether the DPP-4 inhibitor sitagliptin modulates EPC levels in type 2 diabetic patients...
Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomesGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Atherosclerosis 207:213-9. 2009
..Circulating progenitor cells have been shown to contribute to endothelial homeostasis and repair . We aimed to test whether progenitor cell count is an independent event predictor and modifies cardiovascular risk associated with MetS...
Effects of androgens on endothelial progenitor cells in vitro and in vivoGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Clin Sci (Lond) 117:355-64. 2009
..In conclusion, our results collectively demonstrate that androgens exert no direct effects on endothelial progenitor cell biology in vitro and in vivo...
Rosuvastatin stimulates clonogenic potential and anti-inflammatory properties of endothelial progenitor cellsGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Cell Biol Int 34:709-15. 2010
..In conclusion, we show that rosuvastatin had significant stimulatory effects on EPCs irrespective of the culture protocol. Rosuvastatin also induced anti-inflammatory polarization of monocytic EPCs...
Mechanisms and significance of progenitor cell reduction in the metabolic syndromeGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Metab Syndr Relat Disord 7:5-10. 2009
..We also highlight how endothelial progenitors may mediate the interactions between cardiometabolic risk factors in a complex interplay and discuss potential implications for prevention and therapy...
Potential manipulation of endothelial progenitor cells in diabetes and its complicationsG P Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, Medical School, Padova, Italy
Diabetes Obes Metab 12:570-83. 2010
..Herein, we provide a comprehensive overview of EPC pathophysiology and the potential for EPC modulation in diabetes...
Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysisGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
PLoS ONE 5:e11488. 2010
..We tested the hypothesis that CPC count improves cardiovascular risk stratification and that this is modulated by low-grade inflammation...
Cell-based methods for ex vivo evaluation of human endothelial biologyGian Paolo Fadini
Metabolic Division, Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Cardiovasc Res 87:12-21. 2010
..In this review, we will summarize the current knowledge and the methodological perspective of these cell-based methods...
Arterio-venous gradient of endothelial progenitor cells across renal artery stenosisGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
Atherosclerosis 182:189-91. 2005
..Surprisingly, we found that EPCs were more abundant in venous than in arterial blood, suggesting that the kidney subjected to chronic ischemia may become a source rather than a target of EPCs...
Characterization of endothelial progenitor cellsGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Italy
Biochem Biophys Res Commun 336:1-2. 2005
Endothelial progenitor cells and the diabetic paradoxGian Paolo Fadini
Dipartimento di Medicina Clinica e Sperimentale, Divisione di Malattie del Metabolismo, Policlinico Universitario, Via Giustiniani 2, 35100 Padua, Italy
Diabetes Care 29:714-6. 2006
Circulating progenitor cells are reduced in patients with severe lung diseaseGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova School of Medicine, Italy
Stem Cells 24:1806-13. 2006
..This alteration was more evident in restrictive patients and correlated to disease severity. Depletion of circulating EPCs may be involved in altered endothelial homeostasis of pulmonary circulation in these disorders...
Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general populationGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Stroke 37:2277-82. 2006
..With this background, we evaluated whether variations in the number of EPCs are associated with subclinical atherosclerosis in healthy subjects...
Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia-reperfusion injury in ratsG P Fadini
Department of Clinical and Experimental Medicine, Metabolic Diseases Division, University of Padua Medical School, Via Giustiniani, 2, Padua, Italy
Diabetologia 49:3075-84. 2006
..The aim of this study was to test the hypothesis that weak bone marrow mobilisation is responsible for the decrease in circulating EPCs in diabetes...
Optimized glycaemic control achieved with add-on basal insulin therapy improves indexes of endothelial damage and regeneration in type 2 diabetic patients with macroangiopathy: a randomized crossover trial comparing detemir versus glargineG P Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Diabetes Obes Metab 13:718-25. 2011
..Given that insulin influences endothelial biology, we compared the effects of add-on basal insulin analogues on endothelial damage and regeneration in type 2 diabetes (T2D)...
Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
Circ Res 108:1112-21. 2011
..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathwaysGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Aging Cell 10:10-7. 2011
..The model described in this viewpoint article is therefore likely to be an oversimplification. Nevertheless, it represents one starting platform for understanding cell biology of lifespan in relation to the metabolic syndrome...
Endothelial progenitor cells in the natural history of atherosclerosisGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Atherosclerosis 194:46-54. 2007
..An attempt to diverge our attention from the vessel wall to the bloodstream reveals a central role of EPCs in atherogenesis...
Low levels of endothelial progenitor cells correlate with disease duration and activity in patients with Behçet's diseaseG P Fadini
Department of Clinical and Experimental Medicine, University of Padova, Italy
Clin Exp Rheumatol 27:814-21. 2009
..We tested whether Behçet's disease (BD) is characterized by alterations of circulating endothelial progenitor cells (EPCs),which are involved in vascular homeostasis and repair...
Microangiopathy is independently associated with presence, severity and composition of carotid atherosclerosis in type 2 diabetesS Vigili de Kreutzenberg
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
Nutr Metab Cardiovasc Dis 21:286-93. 2011
..We aimed to cross-sectionally investigate strength and characteristics of the association between carotid atherosclerosis and microangiopathy in type 2 diabetic patients...
Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in miceM Albiero
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Via Giustiniani, 2 35100 Padova, Italy
Diabetologia 54:945-53. 2011
..We tested the hypothesis that diabetes impairs the contribution of BM-derived cells at sites of wound healing...
The metabolic syndrome, diabetes and lung dysfunctionA Tiengo
Division of Metabolic Diseases, Department of Clinical Medicine, University of Padova, Padova, Italy
Diabetes Metab 34:447-54. 2008
..Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction...
Glucose tolerance is negatively associated with circulating progenitor cell levelsG P Fadini
Department of Clinical and Experimental Medicine, Medical School, University of Padua, Via Giustiniani 2, 35100, Padua, Italy
Diabetologia 50:2156-63. 2007
..This study was designed to evaluate progenitor cell levels in volunteers with different degrees of glucose tolerance...
The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patientsGian P Fadini
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Diabetes Obes Metab 14:518-22. 2012
..Dipeptidyl peptidase (DPP)-4 in responsible for incretin degradation and some observations suggest that DPP-4 activity is increased in type 2 diabetes (T2D). We aimed to assess the effect of T2D and glucose control on DPP-4 activity...
Circulating CD34+ cells, metabolic syndrome, and cardiovascular riskGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padua, Medical School, Padua, Italy
Eur Heart J 27:2247-55. 2006
..Progenitor cell count may be used as a surrogate marker of CV risk, whereas extensive antigenic characterization may not be useful for this purpose...
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanismsSaula Vigili de Kreutzenberg
Department of Clinical and Experimental Medicine, Metabolic Diseases, University of Padova, Padova, Italy
Diabetes 59:1006-15. 2010
..We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro...
Maternal insulin therapy increases fetal endothelial progenitor cells during diabetic pregnancyGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Diabetes Care 31:808-10. 2008
Pharmacologic targeting of endothelial progenitor cellsMattia Albiero
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Cardiovasc Hematol Disord Drug Targets 10:16-32. 2010
..An alternative strategy to partially overcome these limitations is to target EPCs with available drugs. In this review we will discuss how disparate pharmacological compounds have been used to improve EPCs number and functions...
Selective estrogen receptor-alpha agonist provides widespread heart and vascular protection with enhanced endothelial progenitor cell mobilization in the absence of uterotrophic actionChiara Bolego
Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti 2, 35131 Padua, Italy
FASEB J 24:2262-72. 2010
..By conferring cardiovascular protection dissected from unwanted uterotrophic effects, ER alpha-selective agonists may represent a potential safer alternative to natural hormones...
Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucomaGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova Medical School, Padova, Italy
Acta Ophthalmol 88:135-41. 2010
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Clones of interstitial cells from bovine aortic valve exhibit different calcifying potential when exposed to endotoxin and phosphateMarcello Rattazzi
Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Padova, Treviso, Italy
Arterioscler Thromb Vasc Biol 28:2165-72. 2008
..Our purpose was to study in vitro whether phenotypically-distinct interstitial cell clones from bovine aortic valve (BVIC) possess different calcifying potential in response to endotoxin (lipopolysaccharide [LPS]) and phosphate (Pi)...
Insulin signaling and life spanAngelo Avogaro
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
Pflugers Arch 459:301-14. 2010
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Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanismGiulio Ceolotto
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2 35128 Padova, Italy
Arterioscler Thromb Vasc Biol 27:2627-33. 2007
..In this study, we tested the hypothesis that rosiglitazone (RSG) is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation...
Why to screen heart disease in diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division and Diabetology, University of Padova Medical School, Padova, Italy
Atherosclerosis 204:11-5. 2009
..In this article, we underline the importance of an early diagnosis of coronary artery disease and heart failure in diabetic patients, suggesting that positive screening tests have significant implications in clinical management...
Endothelial dysfunction in type 2 diabetes mellitusAngelo Avogaro
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
Nutr Metab Cardiovasc Dis 16:S39-45. 2006
..The aim of the present study is to illustrate possible mechanisms responsible for endothelial dysfunction in DM...
Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid?Angelo Avogaro
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Free Radic Biol Med 44:1209-15. 2008
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Heme oxygenase-1 is an important modulator in limiting glucose-induced apoptosis in human umbilical vein endothelial cellsElisabetta Iori
Department of Clinical and Experimental Medicine, University of Padua, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
Life Sci 82:383-92. 2008
..Lack of homeostatic HO-1 upregulation fails to protect from oxidative damage and results in a higher rate of apoptotic cell death...
Pathophysiology of circulating progenitor cells in pulmonary disease and parallels with cardiovascular diseaseGian Paolo Fadini
Am J Respir Cell Mol Biol 35:403-4. 2006
The Janus face of nicotinic angiogenesisAngelo Avogaro
J Am Coll Cardiol 48:2561-3. 2006
Autologous transplantation of granulocyte colony-stimulating factor- mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetesGian Paolo Fadini
Diabetes Care 29:478-9; author reply 479-80. 2006
Depletion of endothelial progenitor cells may link pulmonary fibrosis and pulmonary hypertensionGian Paolo Fadini
Am J Respir Crit Care Med 176:724-5; author reply 725. 2007
Critical assessment of putative endothelial progenitor phenotypesGian Paolo Fadini
Exp Hematol 35:1479-80; author reply 1481-2. 2007
Endothelial progenitor cells in cerebrovascular diseaseGian Paolo Fadini
Stroke 36:1112-3; author reply 1113. 2005
Endothelial progenitor cells and erectile dysfunctionGian Paolo Fadini
Eur Heart J 28:639-40; author reply 640. 2007
Circulating CD34+ cells, pulmonary hypertension, and myelofibrosisGian Paolo Fadini
Blood 108:1776-7; author reply 1777. 2006
Endothelial progenitor cells in coronary artery diseaseGian Paolo Fadini
J Am Coll Cardiol 49:1585; author reply 1585-6. 2007
Is the metabolic syndrome a cardiovascular risk factor beyond its specific components?Sandro Inchiostro
J Am Coll Cardiol 49:2465; author reply 2465-6. 2007