Oluwole Fadare

..The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied...

..Further studies are required to address the significance of marked atypia in grade 1 cervical intraepithelial neoplasia and whether patients with this finding should be managed differently...

..48% in the >66% group). If confirmed, our findings suggest that in an LEEP specimen with CIN 2 to 3 that was excised with negative margins, the extent of disease lacks prognostic significance and need not be reported...

..However, the findings in this study do not provide direct evidentiary support for routine complete processing...

..The greatest diagnostic utility of HNF1β expression may be in a supportive evidentiary role favoring clear cell carcinoma when the principal differential diagnostic consideration is endometrioid carcinoma...

..In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications...

..Finally, the most common tumor metastatic to the male breast in this series was cutaneous melanoma...

..However, because classic LIN with necrosis is apparently rare in its pure form, reexcision is recommended when this lesion is detected in isolation in a core biopsy...

..It is concluded that this is an example of a purely signet ring variant of pleomorphic LCIS...

..We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants...

..The historical and evidentiary basis for the Bethesda 2001 recommendations, which calls for the reporting of cytologically benign endometrial cells only in patients 40 years and older, is reviewed in detail...

..03), consistent with smaller extent of disease. These findings further illustrate that lesional factors are important potential contributors to the false-negative rate of the Papanicolaou test...

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..These cases further expand the morphologic spectrum of epithelioid sarcoma...

..A mitotic count of >1/10 HPF and/or coagulative necrosis are features that, if present, raise the definite potential for aggressive behavior...

..It is critical to promote lucid morphologic definitions of the molecular subtypes, if this information is intended for use in targeted therapies and patient management...

..Using our clinical efficacy standard, when no pathologic findings are initially identified in a colposcopic-directed biopsy, at least 5 levels (a priori or in recuts) are required to ensure a 100% diagnostic accuracy for CIN 2-3...

..The clinicopathologic features of cases reported as epithelioid smooth muscle tumors and cases reported as uterine PEComas are compared and contrasted, and a practical approach to their reporting is proposed...

..Future studies are required to define the prognostic significance of CK5/6 expression in ILCs...

..Similarly to tumors of luminal epithelial differentiation, carcinomas of the 'basal' type have a spectrum of morphologic and clinical characteristics...

..In general, strikingly divergent morphologic features in an otherwise typical thyroid neoplasm should elicit a differential diagnosis that takes into consideration the possibility of metastasis...

..However, if the latter staining pattern is confirmed, our findings herein suggest that CD1a may be a useful immunohistochemical adjunct in distinguishing uterine epithelioid smooth muscle tumors from uterine PEComas...

..This may have adjuvant management implications for patients with these rare tumors...

..Potential differential diagnostic considerations are discussed. It is postulated that this lesion is an unusual reparative stromal change that may be related to atrophy-related vaginal irritation or injury...

..The term "localized vulvar lymphedema" is an appropriate generic descriptor for the spectrum of lesions whose fundamental and underlying etiology is thought to be chronic lymphedema...

..BMP2 is rarely expressed in the other nonendothelial tissues of the human uterine corpus that were evaluated. The significance of frequent BMP2 expression in small vessels of the uterus requires further investigation...

..The differential diagnosis for these sarcomas is often extensive and varies by histotype, but their accurate diagnosis fundamentally requires the careful exclusion of biphasic malignancies...

..If corroborated in other laboratories, the expression patterns of proteins in this pathway, especially pan-Akt, may be of diagnostic use...

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..This increased risk may be related, at least partially, to an increased rate of tissue factor expression in endometrial CCC...

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..These data indicate that pleomorphic rhabdomyosarcoma of the uterine corpus is a highly aggressive, rapidly progressive tumor with a high case-fatality rate...

..Core biopsy features are of limited value in predicting a close or positive margin in these lesions...

..Historical, prognostic, and diagnostic aspects of margins in EST, especially in those borderline cases such as ours, are also discussed...

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..Although the significance of the latter finding remains unclear, the differential diagnosis between decidual changes and endometrial serous carcinoma is rarely problematic...

..5%), but does not appear to affect their overall outcome. Although this is a small single site study, it raises questions about the value of this procedure in patients with endometrial cancer...

..However, LVSI does not denote an increased likelihood of vaginal recurrences in S1EE. The presence of LVSI should not, in of itself, alter clinical staging, or trigger unnecessary therapeutic intervention...

..The histologic subtype of the underlying ovarian tumor was found to have an effect on the likelihood of detection of peritoneal involvement using this diagnostic assay...

..The full composite of histopathologic features should form the basis for this determination...

..Further studies are needed to clarify the relationship between these two cancers in this age group and whether this increased risk is reflective of a genetic predisposition...

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..Further studies are required to conclusively define the nature of these lesions. However, such studies can only be performed if diagnostic surgical pathologists recognize, highlight, and segregate these lesions for further analysis...

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..This is, to the authors' knowledge, the first detailed clinicopathologic description of such a case as an ovarian lesion...

..We conclude that in erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups...

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..A variety of clinicopathologic arguments are presented that support the notion that the current neoplasm is an embryonal rhabdomyosarcoma with divergent neuroectodermal and cartilaginous differentiation...

..However, the extraordinary rarity of the most clinically significant interpretations of HGSIL and carcinoma in this setting can be confirmed because no such cases were identified during the follow-up of either group...

..5) When 1 or more psammoma bodies are identified on a cervicovaginal smear, this finding should not be ignored and should generate some clinical investigation to identify its source...

..This amelogenin marker results in a product of low molecular weight, enabling unequivocal resolution of identity despite a poor DNA yield. The prevalence of errors in pathology due to specimen misidentifications is reviewed...

..This orthotopic model of platinum sensitive high grade serous FTCA is a viable platform to study the biology and treatment of FTCA and other STIC-related pelvic serous carcinomas...

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..High index of suspicion and an awareness of elevation of serum chorionic gonadotropin are crucial in reaching a correct diagnosis...

..However, our preliminary analysis suggests that the isolated presence of CIN 1 at the margin of a LEEP specimen, whose margins are otherwise negative, lacks adverse prognostic significance...

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..This affirms the benign nature of this tumor, its alarming gross appearance and growth patterns notwithstanding...

..Cases that display broad and significant qualitative deviations from the aforementioned profile should prompt the consideration of a diagnosis other than CCC...

..However, there was no concentration of the mucin pools near the areas with the most viable tumor cells, which would have provided evidence for a temporal sequence that eventuates in lack of mucin in the most sclerotic regions...

..This case supports the theory that the various primary carcinomas of the thyroid may represent points along a spectrum rather than distinct entities...

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..These preliminary findings suggest the need for larger analyses to evaluate the prognostic significance, if any, of the loss of BAF250a expression in this rare histotype of endometrial cancer...

..Detection of aneuploid neoplastic T cells in peripheral blood samples of patients with CTCL is associated with LCT in skin, lymph node, or other tissues...

..01). In conclusion, our study demonstrated that hypocellular MDS has characteristic clinicopathologic features, and bone marrow hypocellularity in MDS is an independent factor which predicts a favorable outcome...

..These may represent metaplastic lesions of the secondary mullerian system, or a unique peritoneal response to previous surgical manipulation. Alternatively, these may represent benign neoplastic lesions (chondroma) of the submesothelium...

..Our case series shows that extramedullary relapse of MM is characterized by high-grade histology, loss of CD56 expression, frequent resistance to current therapeutic regimens, aggressive biological behavior, and very short survival...