Visith Thongboonkerd

Summary

Affiliation: Faculty of Medicine

Publications

  1. doi request reprint Extensive characterizations of bacteria isolated from catheterized urine and stone matrices in patients with nephrolithiasis
    Ratree Tavichakorntrakool
    Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen, Thailand
    Nephrol Dial Transplant 27:4125-30. 2012
  2. doi request reprint The promise and challenge of systems biology in translational medicine
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, Bangkok 10700, Thailand
    Clin Sci (Lond) 124:389-90. 2013
  3. doi request reprint The variability in tissue proteomics
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, Bangkok, Thailand
    Proteomics Clin Appl 6:340-2. 2012
  4. ncbi request reprint Proteomics in leptospirosis research: towards molecular diagnostics and vaccine development
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, 12th Floor, Adulyadej Vikrom Building, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Expert Rev Mol Diagn 8:53-61. 2008
  5. doi request reprint Should urine pH be adjusted prior to gel-based proteome analysis?
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:3206-11. 2009
  6. ncbi request reprint Proteomic identification of altered proteins in skeletal muscle during chronic potassium depletion: Implications for hypokalemic myopathy
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 5:3326-35. 2006
  7. doi request reprint Proteomics in extracorporeal blood purification and peritoneal dialysis
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteomics 73:521-6. 2010
  8. ncbi request reprint Proteomic identification of alterations in metabolic enzymes and signaling proteins in hypokalemic nephropathy
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics 6:2273-85. 2006
  9. ncbi request reprint Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, pH, stirring and temperature
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 12th Floor Adulyadej Vikrom Building, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Clin Chim Acta 367:120-31. 2006
  10. ncbi request reprint Quantitative analysis and evaluation of the solubility of hydrophobic proteins recovered from brain, heart and urine using UV-visible spectrophotometry
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
    Anal Bioanal Chem 384:964-71. 2006

Detail Information

Publications103 found, 100 shown here

  1. doi request reprint Extensive characterizations of bacteria isolated from catheterized urine and stone matrices in patients with nephrolithiasis
    Ratree Tavichakorntrakool
    Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen, Thailand
    Nephrol Dial Transplant 27:4125-30. 2012
    ..e. Proteus mirabilis. However, our observation indicated that it might not be the case of stone formers in Thailand. We therefore extensively characterized microorganisms associated with all types of kidney stones...
  2. doi request reprint The promise and challenge of systems biology in translational medicine
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, Bangkok 10700, Thailand
    Clin Sci (Lond) 124:389-90. 2013
    ..These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical practice...
  3. doi request reprint The variability in tissue proteomics
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, Bangkok, Thailand
    Proteomics Clin Appl 6:340-2. 2012
    ..This urges caution to all proteomists to carefully consider sample preservation and preparation for tissue proteome analysis...
  4. ncbi request reprint Proteomics in leptospirosis research: towards molecular diagnostics and vaccine development
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, 12th Floor, Adulyadej Vikrom Building, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Expert Rev Mol Diagn 8:53-61. 2008
    ..The results obtained from these studies may lead to the development of earlier and more accurate diagnostic test(s) and vaccine discovery...
  5. doi request reprint Should urine pH be adjusted prior to gel-based proteome analysis?
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:3206-11. 2009
    ..Our data suggest that the urine pH has no significant effects on urinary proteome profile and thus needs no adjustment prior to gel-based proteome analysis...
  6. ncbi request reprint Proteomic identification of altered proteins in skeletal muscle during chronic potassium depletion: Implications for hypokalemic myopathy
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 5:3326-35. 2006
    ..These findings may lead to a new roadmap for research on hypokalemic myopathy, to better understanding of the pathophysiology of this medical disease, and to biomarker discovery...
  7. doi request reprint Proteomics in extracorporeal blood purification and peritoneal dialysis
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteomics 73:521-6. 2010
    ..This review summarizes important findings obtained from recent proteomic studies applied to extracorporeal blood purification and peritoneal dialysis in settings of ESRD, AKI and hepatic failure...
  8. ncbi request reprint Proteomic identification of alterations in metabolic enzymes and signaling proteins in hypokalemic nephropathy
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics 6:2273-85. 2006
    ....
  9. ncbi request reprint Factors determining types and morphologies of calcium oxalate crystals: molar concentrations, buffering, pH, stirring and temperature
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 12th Floor Adulyadej Vikrom Building, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Clin Chim Acta 367:120-31. 2006
    ..Calcium oxalate (CaOx) can be crystallized in several forms and morphologies. We evaluated factors that determine differential types and shapes of CaOx crystals generated in vitro...
  10. ncbi request reprint Quantitative analysis and evaluation of the solubility of hydrophobic proteins recovered from brain, heart and urine using UV-visible spectrophotometry
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
    Anal Bioanal Chem 384:964-71. 2006
    ..12 appears to denote highly hydrophobic samples. Our data suggest that direct UV-visible spectrophotometry can be used as a simple method to quantify and evaluate the solubilities of hydrophobic proteins...
  11. ncbi request reprint Systematic evaluation of sample preparation methods for gel-based human urinary proteomics: quantity, quality, and variability
    Visith Thongboonkerd
    Siriraj Proteomics Facility, Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand
    J Proteome Res 5:183-91. 2006
    ..Male urine had greater amount of total protein but provided smaller number of protein spots compared to female urine. These data offer a wealth of useful information for designing a high-quality, large-scale human urine proteome project...
  12. doi request reprint Analysis of differential proteomes in pathogenic and non-pathogenic Leptospira: potential pathogenic and virulence factors
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics 9:3522-34. 2009
    ..Some of these identified proteins may serve as the pathogenic and/or virulence factors of leptospirosis...
  13. ncbi request reprint Altered proteome in Burkholderia pseudomallei rpoE operon knockout mutant: insights into mechanisms of rpoE operon in stress tolerance, survival, and virulence
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 6:1334-41. 2007
    ..pseudomallei. Our findings underscore the usefulness of proteomics for unraveling pathogenic mechanisms of diseases at the molecular level...
  14. ncbi request reprint Urinary proteome profiling using microfluidic technology on a chip
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Division of Nephrology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Proteome Res 6:2011-8. 2007
    ..These data indicate that the microfluidic chip technology is applicable for urinary proteome profiling with potential uses in clinical diagnostics and biomarker discovery...
  15. doi request reprint Urinary trefoil factor 1 is a novel potent inhibitor of calcium oxalate crystal growth and aggregation
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Urol 179:1615-9. 2008
    ..Moreover, we also evaluated whether urinary trefoil factor 1 has any effects on calcium oxalate crystal aggregation and transformation...
  16. doi request reprint Searching for novel biomarkers and new therapeutic targets of diabetic nephropathy using proteomics approaches
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Contrib Nephrol 160:37-52. 2008
    ..This chapter summarizes recent studies that applied proteomics for the investigation of diabetic nephropathy with major aims to search for novel biomarkers and new therapeutic targets...
  17. doi request reprint Proteomics and kidney stone disease
    Visith Thongboonkerd
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Contrib Nephrol 160:142-58. 2008
    ..This chapter provides a brief overview of proteomic methodologies recently used for the investigation of nephrolithiasis and recent proteomic studies of nephrolithiasis are summarized...
  18. doi request reprint Urinary proteomics: towards biomarker discovery, diagnostics and prognostics
    Visith Thongboonkerd
    Faculty of Medicine Siriraj Hospital, Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Mahidol University, Bangkok, Thailand
    Mol Biosyst 4:810-5. 2008
    ..Urinary proteomics thus becomes one of the most interesting subdisciplines in the clinical proteomics area. This article highlights and updates recent progress in the urinary proteomics field for clinical applications...
  19. ncbi request reprint Bacterial overgrowth affects urinary proteome analysis: recommendation for centrifugation, temperature, duration, and the use of preservatives during sample collection
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Proteome Res 6:4173-81. 2007
    ..Moreover, the addition of 200 mM boric acid or 10 mM NaN3 is highly recommended for the prevention of bacterial overgrowth in the urine...
  20. ncbi request reprint Practical points in urinary proteomics
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 6:3881-90. 2007
    ..The discussion herein should stimulate further discussion and refinement to develop guidelines and standardizations for urinary proteome study...
  21. doi request reprint Proteomic analysis of calcium oxalate monohydrate crystal-induced cytotoxicity in distal renal tubular cells
    Visith Thongboonkerd
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 7:4689-700. 2008
    ..These data provide some novel mechanistic insights into the molecular mechanisms of COM crystal-induced tubular toxicity...
  22. ncbi request reprint Proteomics
    Visith Thongboonkerd
    Siriraj Proteomics Facility, Medical Molecular Biolo gy Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol Uni versity, Bangkok, Thailand
    Forum Nutr 60:80-90. 2007
    ..Due to the extent of information that can be obtained from systems biology, this ideal approach holds great promise for future nutrition research...
  23. doi request reprint Altered plasma proteome during an early phase of peritonitis-induced sepsis
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Clin Sci (Lond) 116:721-30. 2009
    ..In conclusion, these findings may lead to a better understanding of the pathophysiology and molecular mechanisms underlying the sepsis syndrome...
  24. ncbi request reprint Proteomic analysis of renal diseases: unraveling the pathophysiology and biomarker discovery
    Visith Thongboonkerd
    Siriraj Proteomics Center, Medical Molecular Biology Unit, Office for Research and Development, 12th Floor Adulyadej Vikrom Bldg, Siriraj Hospital, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Expert Rev Proteomics 2:349-66. 2005
    ..Personal opinion, future perspectives and information resources for the field of renal and urinary proteomics are provided...
  25. ncbi request reprint Practical bioinformatics for proteomics
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:79-92. 2004
    ..Publicly accessible bioinformatic tools can provide a wealth of information to guide subsequent approaches that use traditional molecular biology tools...
  26. ncbi request reprint Proteomic identification of a large complement of rat urinary proteins
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Nephron Exp Nephrol 95:e69-78. 2003
    ..This approach may lead to better understanding of renal physiology and pathophysiology, and to biomarker discovery...
  27. ncbi request reprint Proteomics and diabetic nephropathy
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, USA
    Contrib Nephrol 141:142-54. 2004
  28. ncbi request reprint Proteomics and hypertension
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:245-56. 2004
  29. ncbi request reprint Urinary proteomics and biomarker discovery for glomerular diseases
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:292-307. 2004
  30. ncbi request reprint Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis
    Visith Thongboonkerd
    Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    J Am Soc Nephrol 15:650-62. 2004
    ..The identification of these coordinated changes in protein expression in diabetic nephropathy indicates the potential value of proteomic analysis in defining pathophysiology...
  31. doi request reprint Biomarker discovery in glomerular diseases using urinary proteomics
    Visith Thongboonkerd
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics Clin Appl 2:1413-21. 2008
    ..Recent findings from these studies are summarized and discussed. These data clearly underline the great promise of urinary proteomics in biomarker discovery for glomerular diseases...
  32. ncbi request reprint Proteomics in nephrology: current status and future directions
    Visith Thongboonkerd
    Siriraj Proteomics Center, Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Am J Nephrol 24:360-78. 2004
    ..e., glomerular, vascular, tubular, brush border membrane, mesangial, and podocyte proteomes), urinary proteome, and protein profiles in dialysate or ultrafiltrate removed by renal replacement therapy are summarized...
  33. doi request reprint Recent progress in urinary proteomics
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics Clin Appl 1:780-91. 2007
    ..Proteomic analyses of dialysate and ultrafiltrate fluids derived from renal replacement therapy (or artificial kidney) are also discussed...
  34. ncbi request reprint Sample preparation for 2-D proteomic analysis
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:11-24. 2004
  35. ncbi request reprint Renal and urinary proteomics: current applications and challenges
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Proteomics 5:1033-42. 2005
    ..Optimization of analytical protocols is required to overcome current limitations. Applications of proteomics to nephrology will then be more fruitful and successful...
  36. ncbi request reprint Genomics, proteomics and integrative "omics" in hypertension research
    Visith Thongboonkerd
    Siriraj Proteomics Center, Medical Molecular Biology Unit, Office for Research and Development, Mahidol University, Faculty of Medicine at Siriraj Hospital, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Curr Opin Nephrol Hypertens 14:133-9. 2005
    ..This review provides an overview and summarizes the current status of applications of these omics fields to essential and secondary hypertension. Some perspectives of these fields for future hypertension research are discussed...
  37. doi request reprint Study of diabetic nephropathy in the proteomic era
    Visith Thongboonkerd
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, Bangkok, Thailand
    Contrib Nephrol 170:172-83. 2011
    ..This chapter summarizes recent progress of proteomics applied to DN with ultimate goals to better understand its pathogenic mechanisms and to search for novel bio-markers for earlier diagnosis...
  38. ncbi request reprint Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia
    Jon B Klein
    Department of Medicine, Core Proteomics Laboratory, Kidney Disease Program, University of Louisville, 570 South Preston Street, Suite 102, Louisville, KY 40202, USA
    Respir Physiol Neurobiol 136:91-103. 2003
    ....
  39. doi request reprint Alterations in macrophage cellular proteome induced by calcium oxalate crystals: the association of HSP90 and F-actin is important for phagosome formation
    Nilubon Singhto
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 12:3561-72. 2013
    ..Our findings enlightened the significant role of these altered proteins, especially HSP90, in enhanced phagocytic activity of the COM-exposed macrophages. ..
  40. doi request reprint High calcium enhances calcium oxalate crystal binding capacity of renal tubular cells via increased surface annexin A1 but impairs their proliferation and healing
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, 10700 Bangkok, Thailand
    J Proteome Res 11:3650-63. 2012
    ..Our in vitro study offers several candidates for further targeted functional studies to confirm their relevance in hypercalciuria and kidney stone disease in vivo...
  41. doi request reprint Large-scale identification of calcium oxalate monohydrate crystal-binding proteins on apical membrane of distal renal tubular epithelial cells
    Kedsarin Fong-ngern
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 10:4463-77. 2011
    ..This large data set offers many opportunities for further investigations of kidney stone disease and may lead to the development of new therapeutic targets...
  42. doi request reprint Metabolic enzymes, antioxidants, and cytoskeletal proteins are significantly altered in vastus lateralis muscle of K-depleted cadaveric subjects
    Ratree Tavichakorntrakool
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    J Proteome Res 8:2586-93. 2009
    ..001), as well as a significant positive correlation between troponin-I level and muscle K content (r=0.618; p<0.05). Our results implicate the important roles these altered proteins play in the development of KD-associated myopathy...
  43. doi request reprint C-terminal hemocyanin from hemocytes of Penaeus vannamei interacts with ERK1/2 and undergoes serine phosphorylation
    Phattara Orn Havanapan
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:2476-83. 2009
    ..Our findings demonstrate for the first time that ERK1/2 signaling pathway may play an important role in molecular immune response of P. vannamei upon TSV infection through its interaction with the C-terminal hemocyanin...
  44. doi request reprint Proteome changes in human monocytes upon interaction with calcium oxalate monohydrate crystals
    Nilubon Singhto
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 9:3980-8. 2010
    ..Our data may help to understand how monocytes interact with COM crystals. These processes are proposed to cause subsequent inflammatory response in kidney stone disease through oxidative stress pathway(s)...
  45. pmc Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor
    Somchai Chutipongtanate
    Medical Molecular Biology Unit, Office for Research and Development, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Clin Invest 115:3613-22. 2005
    ..These data indicate that TFF1 is a novel potent CaOx crystal growth inhibitor with a potential pathophysiological role in nephrolithiasis...
  46. doi request reprint Alterations in actin cytoskeletal assembly and junctional protein complexes in human endothelial cells induced by dengue virus infection and mimicry of leukocyte transendothelial migration
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Department of Immunology and Immunology Graduate Program, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:2551-62. 2009
    ..These alterations may potentially be a molecular basis explaining increased endothelial permeability or vascular leakage in DSS...
  47. doi request reprint Calcium oxalate dihydrate crystal induced changes in glycoproteome of distal renal tubular epithelial cells
    Wararat Chiangjong
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 12th Fl Adulyadej Vikrom Bldg, 2 Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand
    Mol Biosyst 7:1917-25. 2011
    ..Our findings provide some novel insights into the pathogenic mechanisms of kidney stone disease at the molecular level, particularly cell-crystal interactions...
  48. doi request reprint Altered proteins in MDCK renal tubular cells in response to calcium oxalate dihydrate crystal adhesion: a proteomics approach
    Theptida Semangoen
    Medical Proteomics Unit and Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 7:2889-96. 2008
    ..An increase in annexin II was confirmed by 2-D Western blot analysis. These data may lead to better understanding of the cellular responses in distal renal tubular cells during COD crystal adhesion...
  49. doi request reprint Differential plasma proteome profiles of mild versus severe β-thalassemia/Hb E
    Suneerat Hatairaktham
    Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Ann Hematol 92:365-77. 2013
    ....
  50. doi request reprint Association of Alix with late endosomal lysobisphosphatidic acid is important for dengue virus infection in human endothelial cells
    Sa nga Pattanakitsakul
    Medical Molecular Biology Unit, Office for Research and Development, Department of Immunology and Immunology Graduate Program, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 9:4640-8. 2010
    ..Blocking this step may lead to a novel therapeutic approach to reducing the level of DENV replication in vivo...
  51. doi request reprint Peeling as a novel, simple, and effective method for isolation of apical membrane from intact polarized epithelial cells
    Kedsarin Fong-ngern
    Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Anal Biochem 395:25-32. 2009
    ....
  52. ncbi request reprint Proteomic analysis of peritoneal dialysate fluid in patients with different types of peritoneal membranes
    Suchai Sritippayawan
    Division of Nephrology, Department of Internal Medicine, Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 6:4356-62. 2007
    ....
  53. ncbi request reprint Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia
    Evelyne Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40204, USA
    J Neurochem 83:331-45. 2002
    ..These findings provide initial insights into mechanisms underlying differences in susceptibility to hypoxia in neural tissue, and may allow for future delineation of interventional strategies aiming to enhance neuronal adaptation to IH...
  54. doi request reprint Citrate, not phosphate, can dissolve calcium oxalate monohydrate crystals and detach these crystals from renal tubular cells
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Eur J Pharmacol 689:219-25. 2012
    ..Moreover, citrate could detach up to 85% of the adherent COM crystals from renal tubular cell surface. These data indicate that citrate is better than phosphate for dissolution and detachment of COM crystals...
  55. ncbi request reprint K+, Na+, Mg2+, Ca2+, and water contents in human skeletal muscle: correlations among these monovalent and divalent cations and their alterations in K+ -depleted subjects
    Ratree Tavichakorntrakool
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Transl Res 150:357-66. 2007
    ..Our study not only provided the descriptive data but also implied the balance or homeostasis of these monovalent and divalent cations in their muscle pools...
  56. doi request reprint Comprehensive proteome analysis of hippocampus, brainstem, and spinal cord from paralytic and furious dogs naturally infected with rabies
    Natthapaninee Thanomsridetchai
    Inter Department Program of BioMedical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Proteome Res 10:4911-24. 2011
    ..These data will be useful for better understanding of molecular mechanisms of rabies and for differentiation of its paralytic and furious forms...
  57. doi request reprint Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells
    Primchanien Moongkarndi
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    J Proteome Res 9:2076-86. 2010
    ..Further characterizations of these proteins may lead to identification of novel therapeutic targets for successful prevention and/or decreasing the severity of AD...
  58. doi request reprint Subcellular localizations and time-course expression of dengue envelope and non-structural 1 proteins in human endothelial cells
    Jesdaporn Poungsawai
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Microb Pathog 51:225-9. 2011
    ..Our data may provide a new roadmap for studying mechanisms of replication of dengue virus and its interactions with host cells...
  59. ncbi request reprint Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
    Visith Thongboonkerd
    Core Proteomics Laboratory and Molecular Signaling Group, Kidney Disease Program, Department of Medicine, University of Louisville, 570 South Preston Street, Louisville, KY 40202, USA
    Kidney Int 62:1461-9. 2002
    ..We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques to isolate the proteins...
  60. doi request reprint The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 9:4960-71. 2010
    ..Our findings suggest that various biological processes were triggered in response to dengue infection, particularly antiviral IFN and ubiquitin-proteasome pathways...
  61. doi request reprint Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cells
    Paleerath Peerapen
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Lab Invest 91:97-105. 2011
    ....
  62. doi request reprint Characterizations of urinary sediments precipitated after freezing and their effects on urinary protein and chemical analyses
    Putita Saetun
    Medical Proteomics Unit, 12th Floor, Adulyadej Vikrom Bldg, 2 Prannok Rd, Siriraj Hospital, Bangkoknoi, Bangkok 10700, Thailand
    Am J Physiol Renal Physiol 296:F1346-54. 2009
    ..However, vigorous shaking of the sample at room temperature could redissolve these precipitates. Our data strongly indicate that these freezer-induced precipitates must be taken into account when the frozen urine samples are analyzed...
  63. doi request reprint Altered secretome of Burkholderia pseudomallei induced by salt stress
    Pornpan Pumirat
    Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Biochim Biophys Acta 1794:898-904. 2009
    ..Our study provided the first dataset of the secretome of B. pseudomallei and its alterations, which may lead to novel insights into adaptive response of B. pseudomallei during the salt stress...
  64. ncbi request reprint Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 277:34708-16. 2002
    ..Transgenic hKLK1 animals were protected from EH-induced hypertension. We conclude that EH-induced hypertension may result, at least in part, from altered regulation of the renal kallikrein system...
  65. ncbi request reprint Sodium loading changes urinary protein excretion: a proteomic analysis
    Visith Thongboonkerd
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 284:F1155-63. 2003
    ..Some of these proteins have previously been shown to be associated with tubular transport. These data indicate that alterations in the excretion of several urinary proteins occur during acute sodium loading...
  66. doi request reprint Are protease inhibitors required for gel-based proteomics of kidney and urine?
    Phattara Orn Havanapan
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:3109-17. 2009
    ..From these data, the addition of protease inhibitors is highly recommended for gel-based renal proteomics, but no longer recommended for gel-based urinary proteomics...
  67. ncbi request reprint Enrichment of the basic/cationic urinary proteome using ion exchange chromatography and batch adsorption
    Visith Thongboonkerd
    Medical Molecular Biology Unit, Office for Research and Development, and Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Proteome Res 6:1209-14. 2007
    ..Moreover, the techniques described herein may be applicable for enrichment of cationic proteomes in other body fluids, cells, and tissues...
  68. ncbi request reprint Two-dimensional gel electrophoresis: a fundamental tool for expression proteomics studies
    Elias Klein
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:25-39. 2004
  69. doi request reprint Renal tubular cell membranes inhibit growth but promote aggregation of calcium oxalate monohydrate crystals
    Somchai Chutipongtanate
    Mahidol University, Bangkok, Thailand
    Chem Biol Interact 188:421-6. 2010
    ..Although growth of individual COM crystals was inhibited, their aggregation was promoted. These findings provide additional insights into the mechanisms of COM kidney stone formation...
  70. doi request reprint Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 12th Floor Adulyadejvikrom Building, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Mol Biosyst 6:795-806. 2010
    ..Our data report for the first time that vimentin interacts with hnRNPs and dengue NS1, and plays a crucial role in replication and release of dengue virus...
  71. ncbi request reprint Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion
    Madhavi J Rane
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 174:7242-9. 2005
    ..The GABA(B)R potentially plays a significant role in the inflammatory response and neutrophil-dependent ischemia-reperfusion injury such as stroke...
  72. ncbi request reprint Proteomic analysis of host responses in HepG2 cells during dengue virus infection
    Sa nga Pattanakitsakul
    Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 6:4592-600. 2007
    ....
  73. doi request reprint Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles
    Veerachat Muangsombut
    Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Arch Microbiol 190:623-31. 2008
    ..pseudomallei mutant to escape from the vacuoles of macrophages...
  74. doi request reprint The rpoE operon regulates heat stress response in Burkholderia pseudomallei
    Muthita Vanaporn
    Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    FEMS Microbiol Lett 284:191-6. 2008
    ..e. GroEL and HtpG) were also absent in the rpoE operon mutant. Altogether, our data suggest that the rpoE operon regulates B. pseudomallei heat stress response through the function of rpoH...
  75. doi request reprint Serial analyses of postmortem changes in human skeletal muscle: A case study of alterations in proteome profile, histology, electrolyte contents, water composition, and enzyme activity
    Ratree Tavichakorntrakool
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Proteomics Clin Appl 2:1255-64. 2008
    ....
  76. ncbi request reprint Overview of proteomics
    Jon B Klein
    Core Proteomics Laboratory, Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, KY, USA
    Contrib Nephrol 141:1-10. 2004
  77. doi request reprint Identification and characterization of RpoS regulon and RpoS-dependent promoters in Burkholderia pseudomallei
    Yupaporn Osiriphun
    Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Proteome Res 8:3118-31. 2009
    ..We finally confirmed the co-expression of these RpoS-dependent genes in operons using RT-PCR. Our data lead to better understanding of RpoS regulation in B. pseudomallei, whose RpoS regulon differs from other Gram-negative bacteria...
  78. doi request reprint Comparative analyses of cell disruption methods for mitochondrial isolation in high-throughput proteomics study
    Sakdithep Chaiyarit
    Medical Proteomics Unit, Office for Research and Development, Department of Immunology and Immunology Graduate Program, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Anal Biochem 394:249-58. 2009
    ..Our data demonstrated that sonication is the method of choice for disruption of cells prior to mitochondrial isolation for proteome analysis...
  79. ncbi request reprint IgA nephropathy associated with Hodgkin's disease in children: a case report, literature review and urinary proteome analysis
    Sookkasem Khositseth
    Department of Pediatrics, Faculty of Medicine, Thammasat University, Bangkok, Thailand
    Pediatr Nephrol 22:541-6. 2007
    ..Their potential roles in the pathogenesis and pathophysiology of IgAN are discussed...
  80. doi request reprint Systematic comparisons of artificial urine formulas for in vitro cellular study
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, and Center for Research in Complex Systems Sciences, Mahidol University, Bangkok 10700, Thailand
    Anal Biochem 402:110-2. 2010
    ..The data indicate that AU-Siriraj is the best, and AU-3 is the second best, AU formula for in vitro cellular study...
  81. doi request reprint Establishment of a novel colorimetric assay for high-throughput analysis of calcium oxalate crystal growth modulation
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Center for Research in Complex Systems Sciences, Mahidol University, Bangkok, Thailand
    Analyst 135:1309-14. 2010
    ..In summary, we have successfully established a novel assay for high-throughput analysis of CaOx crystal growth modulatory activities of compounds that will be very useful for a large-scale analysis of CaOx crystal growth modulators...
  82. doi request reprint Red blood cell membrane fragments but not intact red blood cells promote calcium oxalate monohydrate crystal growth and aggregation
    Somchai Chutipongtanate
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital and Center for Research in Complex Systems Sciences, Mahidol University, Bangkok, Thailand
    J Urol 184:743-9. 2010
    ..Thus, we examined the effects of red blood cell membrane fragments on calcium oxalate monohydrate and calcium oxalate dihydrate crystal growth and aggregation...
  83. doi request reprint Proteomic analysis of altered proteins in lymphoid organ of yellow head virus infected Penaeus monodon
    Apichai Bourchookarn
    Institute of Molecular Biology and Genetics IMBG, Mahidol University, Salaya Campus, Nakhonpathom, Thailand
    Biochim Biophys Acta 1784:504-11. 2008
    ..Identification of these altered proteins in the YHV-infected shrimps may provide novel insights into the molecular responses of P. monodon to YHV infection...
  84. ncbi request reprint Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
    Alessandra Castegna
    Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurochem 88:1540-6. 2004
    ..These findings are discussed with reference to the effect of specific protein oxidation on potential mechanisms of neurodegeneration that pertain to the gad mouse...
  85. ncbi request reprint Proteomic identification of nitrated proteins in Alzheimer's disease brain
    Alessandra Castegna
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    J Neurochem 85:1394-401. 2003
    ....
  86. ncbi request reprint Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future
    David M Good
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Proteome Res 6:4549-55. 2007
    ....
  87. doi request reprint Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA
    Tadashi Yamamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan
    Proteomics 8:2156-9. 2008
    ..An initial draft of standard protocols and guidelines for proteome analysis of non-proteinuric urine (urine protein excretion < or =150 mg/day) will soon be released as the first HKUPP product...
  88. ncbi request reprint Advances in urinary proteome analysis and biomarker discovery
    Danilo Fliser
    Mosaiques Diagnostics and Therapeutics AG, Mellendorfer Strasse 7 9, D 30625 Hannover, Germany
    J Am Soc Nephrol 18:1057-71. 2007
    ..It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists...
  89. ncbi request reprint Serial changes in urinary proteome profile of membranous nephropathy: implications for pathophysiology and biomarker discovery
    Heidi Hoi Yee Ngai
    Department of Zoology, The University of Hong Kong, HKSAR, P R China
    J Proteome Res 5:3038-47. 2006
    ..These data underscore the significant impact of urinary proteomics in unraveling disease pathophysiology and biomarker discovery...
  90. ncbi request reprint Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington KY 40506, USA
    Free Radic Biol Med 39:453-62. 2005
    ....
  91. doi request reprint Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  92. ncbi request reprint Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1
    Alessandra Castegna
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington 40506 0055, USA
    Free Radic Biol Med 33:562-71. 2002
    ..Proteomics offers a rapid means of identifying oxidatively modified proteins in aging and age-related neurodegenerative disorders without the limitations of the immunochemical detection method...
  93. ncbi request reprint Differential expression of proteins in renal cortex and medulla: a proteomic approach
    John M Arthur
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Kidney Int 62:1314-21. 2002
    ..However, only a few proteins can be studied in each experiment by Western blot. We have used proteomic tools to construct protein maps of rat kidney cortex and medulla...
  94. doi request reprint Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein
    Sansanee Noisakran
    Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand
    Biochem Biophys Res Commun 372:67-72. 2008
    ..Their interaction may have implications in virus replication and/or cellular responses favorable to survival of the virus in host cells...
  95. ncbi request reprint Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
    Alessandra Castegna
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurochem 82:1524-32. 2002
    ..These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain...
  96. ncbi request reprint Proteomics analysis of human astrocytes expressing the HIV protein Tat
    Chava B Pocernich
    Department of Chemistry and Center of Membrane Sciences, 125 Chemistry Physics Building, University of Kentucky, Lexington, KY 40506, USA
    Brain Res Mol Brain Res 133:307-16. 2005
    ..These findings are discussed with reference to astrocytes serving as a reservoir for the HIV virus and how Tat promotes survival of the astrocytic host...
  97. ncbi request reprint Renal magnesium wasting and tubular dysfunction in leptospirosis
    Sookkasem Khositseth
    Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
    Nephrol Dial Transplant 23:952-8. 2008
    ..The aim of this study was to evaluate renal tubular function and excretion of solutes in leptospirosis patients during a recent outbreak of leptospirosis in Nan province, Thailand...
  98. ncbi request reprint Proteomic analysis of differentially expressed proteins in Penaeus vannamei hemocytes upon Taura syndrome virus infection
    Phattara Orn Chongsatja
    Institute of Molecular Biology and Genetics, Mahidol University, Salaya Campus, Nakhonpathom, Thailand
    Proteomics 7:3592-601. 2007
    ..Further investigation of these data may lead to better understanding of the molecular responses of crustacean hemocytes to TSV infection...
  99. ncbi request reprint Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach
    Heidi Hoi Yee Ngai
    Department of Zoology, The University of Hong Kong, HKSAR, People s Republic of China
    J Proteome Res 6:3313-20. 2007
    ..Our findings may lead to a significant advance in the attempt to define a new therapeutic target and/or novel biomarker for human MN...
  100. ncbi request reprint Use of immunoblotting as an alternative method for serogrouping Leptospira
    Galayanee Doungchawee
    Department of Pathobiology, Mahidol University, Bangkok 10400, Thailand
    J Med Microbiol 56:587-92. 2007
    ..With its simplicity and safety of experimental procedures, it is proposed that immunoblotting may potentially be useful as an alternative method for differentiating between serogroups of leptospires...
  101. ncbi request reprint Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
    Xia Shen
    Dept of Pharmacology and Toxicology, University of Louisville, 570 S Preston St, Suite 304, Louisville, KY 40202, USA
    Am J Physiol Endocrinol Metab 287:E896-905. 2004
    ..Taken together, these results show that mitochondria are a primary target in the diabetic heart, probably due to oxidative stress, and that this damage coincides with and may stimulate mitochondrial biogenesis...