Gehan A Mostafa

Summary

Affiliation: Faculty of Medicine

Publications

  1. doi The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children
    Gehan Ahmed Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 261:77-81. 2013
  2. pmc Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 10:72. 2013
  3. doi The link between some alleles on human leukocyte antigen system and autism in children
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroimmunol 255:70-4. 2013
  4. ncbi The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children
    Gehan Ahmed Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia
    Eur J Paediatr Neurol 16:464-8. 2012
  5. pmc Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity
    Gehan A Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:201. 2012
  6. pmc Elevated serum levels of interleukin-17A in children with autism
    Laila Yousef Al-Ayadhi
    Department of Physiology, Autism Research and Treatment Center, AL Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:158. 2012
  7. pmc A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:54. 2012
  8. doi The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 227:195-201. 2010
  9. ncbi The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 223:115-9. 2010
  10. ncbi Oxidative stress in Egyptian children with autism: relation to autoimmunity
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 219:114-8. 2010

Collaborators

  • Laila Yousef Al-Ayadhi
  • Laila Y Al-Ayadhi
  • Zeinab A El-Sayed
  • Hoda Y Tomoum
  • Safaa M El-Emam
  • Gamal S Aly
  • Manal M Abd El-Aziz
  • Esraa M F El-Shahat
  • Ghada S El-Shahed

Detail Information

Publications23

  1. doi The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children
    Gehan Ahmed Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 261:77-81. 2013
    ..Indeed, we need to know more about the links between allergy, immune system and brain in autism for finding new therapeutic modalities in autism. ..
  2. pmc Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 10:72. 2013
    ..They direct trafficking and recruitment of Th2 cells. We are the first to measure serum levels of CCR4 ligands in relation to the degree of the severity of autism...
  3. doi The link between some alleles on human leukocyte antigen system and autism in children
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroimmunol 255:70-4. 2013
    ..This is important to determine whether therapeutic modulations of the immune function are legitimate avenues for novel therapy in selected cases of autism...
  4. ncbi The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children
    Gehan Ahmed Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia
    Eur J Paediatr Neurol 16:464-8. 2012
    ..Autism may involve an autoimmune pathogenesis. Immunotherapy may have a role in autistic children who have brain auto-antibodies...
  5. pmc Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity
    Gehan A Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:201. 2012
    ..We are the first to investigate the relationship between serum levels of 25-hydroxy vitamin D and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children...
  6. pmc Elevated serum levels of interleukin-17A in children with autism
    Laila Yousef Al-Ayadhi
    Department of Physiology, Autism Research and Treatment Center, AL Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:158. 2012
    ..The aim of this study was to measure serum levels of IL-17A in relation to the degree of the severity of autism...
  7. pmc A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:54. 2012
    ..We are the first to investigate the relationship between serum levels of S100B protein, a marker of neuronal damage, and antiribosomal P protein antibodies in autistic children...
  8. doi The role of measurement of serum autoantibodies in prediction of pediatric neuropsychiatric systemic lupus erythematosus
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 227:195-201. 2010
    ..001). In addition, anti-ganglioside seropositivity had a significant risk for association with cognitive dysfunction (odds ratio: 36; 95% CI: 4.3-302.8)...
  9. ncbi The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 223:115-9. 2010
    ..5-14.1). C4B null allele had a significant risk for association with autism (odds ratio=6.26, 95% CI=2.55-15.36) and with a family history of autoimmunity (odds ratio=21, 95% CI=6.5-67.8)...
  10. ncbi Oxidative stress in Egyptian children with autism: relation to autoimmunity
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 219:114-8. 2010
    ..5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37-112.10 and 1.21-34.19, respectively)...
  11. doi Frequency of CD4+CD25high regulatory T cells in the peripheral blood of Egyptian children with autism
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Nasr City, Cairo, Egypt
    J Child Neurol 25:328-35. 2010
    ..Deficiency of these cells may contribute to autoimmunity in a subgroup of children with autism. Consequently, CD4(+)CD25(high) regulatory T cells could be new potential therapeutic targets in these patients...
  12. doi Blood lead levels in Egyptian children from high and low lead-polluted areas: impact on cognitive function
    G A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Acta Neurol Scand 120:30-7. 2009
    ..Many children are harmed by low-level lead exposure which impairs cognitive development with subsequent poor scholastic achievement. We investigated blood lead levels in children in relation to cognitive function...
  13. doi Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Pediatr Neurol 40:107-12. 2009
    ..Further studies are warranted to assess anti-nuclear antibody seropositivity, other markers of autoimmunity (e.g., brain-specific autoantibodies), and the role of immunotherapy in children with autism...
  14. ncbi Serum anti-myelin-associated glycoprotein antibodies in Egyptian autistic children
    Gehan Ahmed Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Child Neurol 23:1413-8. 2008
    ..Further studies are warranted to shed light on the etiopathogenic role of anti-myelin-associated glycoprotein antibodies and the role of immunotherapy in autism...
  15. pmc The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism
    Gehan A Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:180. 2011
    ..We are the first to measure serum neurokinin A levels in autistic children. The relationship between serum levels of neurokinin A and anti-ribosomal P protein antibodies was also studied...
  16. pmc A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children
    Gehan Ahmed Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:71. 2011
    ..We are the first to investigate the possible role of hyperserotonemia in the induction of autoimmunity, as indicated by serum anti-myelin-basic protein (anti-MBP) auto-antibodies, in autism...
  17. pmc Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity
    Gehan A Mostafa
    Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:39. 2011
    ..We are the first to measure the relationship between these antibodies and the degree of the severity of autism...
  18. doi Antineuronal antibodies and electroneurophysiological studies in pediatric patients with neuropsychiatric systemic lupus erythematosus
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Pediatr Allergy Immunol 20:192-9. 2009
    ..Further studies on a large scale are warranted to evaluate the predictive value of these parameters in NPSLE...
  19. ncbi Systemic auto-antibodies in children with autism
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia Electronic address
    J Neuroimmunol 272:94-8. 2014
    ..However, replication studies of larger samples are warranted to validate whether these antibodies are a mere association or have a pathogenic role in some autistic children...
  20. doi Increased serum osteopontin levels in autistic children: relation to the disease severity
    Laila Y Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    Brain Behav Immun 25:1393-8. 2011
    ..The therapeutic role of anti-osteopontin antibodies in amelioration of autistic manifestations should also be studied...
  21. pmc Low plasma progranulin levels in children with autism
    Laila Y Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:111. 2011
    ..We are the first to measure plasma progranulin levels in autism...
  22. doi Cardiovascular autonomic function assessed by autonomic function tests and serum autonomic neuropeptides in Egyptian children and adolescents with rheumatic diseases
    Zeinab A El-Sayed
    Department of Paediatrics, Faculty of Medicine, Institute of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt
    Rheumatology (Oxford) 48:843-8. 2009
    ..Autonomic dysfunction may contribute to initiation and perpetuation of rheumatic diseases. Thus, we aimed to assess cardiovascular autonomic function in lupus and juvenile idiopathic arthritis (JIA) patients...
  23. doi Autoantibody to heterogeneous nuclear ribonucleoprotein-A2 (RA33) in juvenile idiopathic arthritis: clinical significance
    Hoda Y Tomoum
    Department of Pediatrics, Faculty of Medicaine, Ain Shams University, Cairo, Egypt
    Pediatr Int 51:188-92. 2009
    ..The aim of the present study was therefore to investigate the value of anti-RA33 for diagnosis of JIA (both early and established disease), and its relation to markers of disease activity, and bone resorption...