Affiliation: Faculty of Medicine
- Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue SyndromeGeorge Anderson
CRC, Rm 30, 57 Laurel St, Glasgow, G11 7QT Scotland, United Kingdom
Med Hypotheses 78:752-6. 2012..Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...
- Neurodegeneration in Parkinson's disease: interactions of oxidative stress, tryptophan catabolites and depression with mitochondria and sirtuinsGeorge Anderson
CRC, Rm 30, 57 Laurel St, Glasgow, G11 7QT, Scotland, UK
Mol Neurobiol 49:771-83. 2014..We review this data here in the context of neurodegeneration in Parkinson's disease and to the future directions indicated for slowing disease progression. ..
- Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactionsGeorge Anderson
CRC, Rm 30, 57 Laurel St Glasgow G11 7QT, Scotland
CNS Neurol Disord Drug Targets 13:126-36. 2014....
- TRYCAT Pathways Link Peripheral Inflammation, Nicotine, Somatization and Depression in the Etiology and Course of Parkinson's DiseaseGeorge Anderson
George Anderson, CRC, Rm 30, 57 Laurel St Glasgow G11 7QT, Scotland
CNS Neurol Disord Drug Targets 13:137-49. 2014..As a consequence, the data reviewed here has treatment implications; relevant to both the course of PD and in the management of L-DOPA induced dyskinesias. ..
- Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cellsElina M Sutinen
University of Eastern Finland, Institute of Clinical Medicine Neurology, Canthia, FI 70211, Kuopio, Finland
J Neuroinflammation 9:199. 2012..Elevated IL-18 has been detected in several risk conditions for AD, including obesity, type-II diabetes, and cardiovascular diseases as well as in stress...
- A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behaviorGerwyn Morris
Tir Na Nog, Bryn Road Seaside 87, Llanelli SA152LW, UK
BMC Med 11:64. 2013..It is concluded that sickness behavior and ME/CFS are two different conditions. ..
- Depression and sickness behavior are Janus-faced responses to shared inflammatory pathwaysMichael Maes
Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
BMC Med 10:66. 2012....
- Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effectsGeorge Anderson
CRC, Glasgow, Scotland, UK
Metab Brain Dis 27:113-9. 2012..Melatonin is likely to have impacts on the metabolic side effects of anti-psychotics that contribute to subsequent decreases in life-expectancy...
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorderGeorge Anderson
Clinical Research Centre Communications, Glasgow, UK
J Perinat Med 38:585-7. 2010..It is proposed that the optimization of melatonin levels, perhaps in conjunction with optimized vitamin D3 level, would decrease post-partum psychosis and depression associated with BD...
- Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatoninG Anderson
CRC, Glasgow, Scotland
Eur J Neurol 18:680-5. 2011..Antiepileptic drugs modulate wider MS symptomatology, interacting with melatonin and vitamin D3. This manuscript provides a framework for the wider understanding and treatment of seizures in MS and wider MS symptomatology...
- Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: role of the amygdala in developmental co-ordinationGeorge Anderson
CRC, 1229 Dumbarton Road, Glasgow, Scotland, UK
Med Hypotheses 76:54-60. 2011..The likely involvement of glia in mediating increases in the KP products suggests that adaptation to stress is driven by neuronal activity as a form of glia to glia communication...
- Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathwaysGeorge Anderson
CRC, Rm 30, Glasgow, Scotland, United Kingdom
Prog Neuropsychopharmacol Biol Psychiatry 42:101-14. 2013....
- Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogressionGeorge Anderson
CRC, Rm 30, Glasgow, Scotland, United Kingdom
Prog Neuropsychopharmacol Biol Psychiatry 42:5-19. 2013....
- Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatizationGeorge Anderson
CRC, Glasgow, UK
Adv Protein Chem Struct Biol 88:27-48. 2012..We lastly review new pathophysiologically driven drug candidates for somatization, including St. John's wort, resveratrol, melatonin, agomelatine, Garcinia mangostana (γ-mangostin), N-acetyl cysteine, and pamoic acid...
- Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogressionGeorge Anderson
CRC Clinical Research Centre Communications, Rm 30, 57 Laurel Street, Glasgow, G11 7QT, Scotland
Pharmacol Rep 65:1647-54. 2013....
- Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implicationsGeorge Anderson
CRC, Rm 30, 57 Laurel Street, Glasgow, G11 7QT, Scotland
CNS Drugs 28:1-10. 2014..The use of such a frame of reference and the treatment benefits attained are likely to have wider implications and utility for depression-associated conditions, including the neuroinflammatory and (neuro)degenerative disorders. ..
- Postpartum depression: psychoneuroimmunological underpinnings and treatmentGeorge Anderson
CRC Clincial Research Centre Communications, Glasgow, Scotland
Neuropsychiatr Dis Treat 9:277-87. 2013....