Rebecca Taub

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. ncbi request reprint Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
  2. ncbi request reprint A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha
    Robert A DeAngelis
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hepatology 42:1148-57. 2005
  3. ncbi request reprint STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    Wei Li
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28411-7. 2002
  4. pmc Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation
    Julia I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:1251-9. 2003
  5. pmc Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations
    Samir Sayed
    Clinical Translational Research Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:1419-27. 2009
  6. pmc Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice
    Julia I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 111:129-39. 2003
  7. ncbi request reprint Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
    Bogumil Zelent
    Department of Biochemistry and Biophysics and Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem J 413:269-80. 2008
  8. ncbi request reprint Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration
    Xavier Aldeguer
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hepatology 35:40-8. 2002
  9. ncbi request reprint Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration
    Marina Macias-Silva
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28483-90. 2002
  10. ncbi request reprint A glucose sensor role for glucokinase in anterior pituitary cells
    Dorothy Zelent
    University of Pennsylvania School of Medicine, BiochemistryBiophysics, 501 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Diabetes 55:1923-9. 2006

Collaborators

  • Wei Li
  • John D Lambris
  • Christoph Kellendonk
  • Mariko Suchi
  • Maciej M Markiewski
  • Hong Fu
  • Julia I Leu
  • Carol Buettger
  • Joseph Grimsby
  • Franz M Matschinsky
  • Mary Ann S Crissey
  • Samir Sayed
  • Stella Odili
  • Lin Lin
  • Bogumil Zelent
  • Dorothy Zelent
  • Robert A DeAngelis
  • Marina Macias-Silva
  • Xavier Aldeguer
  • David R Langdon
  • Charles A Stanley
  • Pan Chen
  • Alisa B Schiffman
  • Brad Spellberg
  • Chiyo Shiota
  • Beverlie Baquir
  • Yue Fu
  • Jane M Vanderkooi
  • John E Edwards
  • Ashraf S Ibrahim
  • Mark A Magnuson
  • Valentina Avanesian
  • Frans Schuit
  • Maria L Golson
  • Heather Weik-Collins
  • Brigitte Koeberlein
  • Klaus H Kaestner
  • Roel Quintens
  • Leentje Van Lommel
  • Linden E Craig
  • Gideon A Zamir
  • Kim M Olthoff
  • Shungo Hiroyasu
  • Xingyi Que
  • Abraham Shaked
  • Fotini Debonera
  • Kellen K Kovalovich
  • Alyssa M Krasinkas
  • Andrew E Gelman

Detail Information

Publications13

  1. ncbi request reprint Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
    ..So what is known about this process at present and which questions remain?..
  2. ncbi request reprint A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha
    Robert A DeAngelis
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hepatology 42:1148-57. 2005
    ..In conclusion, high fat in the diet impairs liver regeneration and predisposes steatotic livers to increased injury through IkappaBalpha overexpression and subsequent NF-kappaB inhibition...
  3. ncbi request reprint STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
    Wei Li
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28411-7. 2002
    ..This study provides the first in vivo evidence that STAT3 promotes cell cycle progression and cell proliferation under physiological growth conditions...
  4. pmc Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation
    Julia I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:1251-9. 2003
    ..These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways...
  5. pmc Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations
    Samir Sayed
    Clinical Translational Research Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:1419-27. 2009
    ..We report three children with de novo glucokinase hyperinsulinism mutations who displayed a spectrum of clinical phenotypes corresponding to marked differences in enzyme kinetics...
  6. pmc Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice
    Julia I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 111:129-39. 2003
    ..These findings indicate that IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals...
  7. ncbi request reprint Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
    Bogumil Zelent
    Department of Biochemistry and Biophysics and Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem J 413:269-80. 2008
    ....
  8. ncbi request reprint Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration
    Xavier Aldeguer
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hepatology 35:40-8. 2002
    ..This investigation demonstrates a paracrine mechanism by which cells of bone marrow origin, most likely Kupffer cells, regulate the regenerative capacity of the hepatocyte through IL-6 expression...
  9. ncbi request reprint Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration
    Marina Macias-Silva
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28483-90. 2002
    ..Our data show that active TGF-beta/Smad signals are present during regeneration and suggest that SnoN/Ski induction might explain hepatocyte resistance to TGF-beta during the proliferative phase...
  10. ncbi request reprint A glucose sensor role for glucokinase in anterior pituitary cells
    Dorothy Zelent
    University of Pennsylvania School of Medicine, BiochemistryBiophysics, 501 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Diabetes 55:1923-9. 2006
    ....
  11. pmc Hepatoprotection via the IL-6/Stat3 pathway
    Rebecca Taub
    Bristol Myers Squibb Co, PO Box 5100, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    J Clin Invest 112:978-80. 2003
    ..A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species...
  12. ncbi request reprint Adenovirus-mediated overexpression of activin beta(C) subunit accelerates liver regeneration in partially hepatectomized rats
    Rebecca Taub
    J Hepatol 43:751-3. 2005
  13. pmc Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant
    Lin Lin
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Clin Vaccine Immunol 15:582-4. 2008
    ..Thus, protein binding, by itself, may not predict the efficacy of some vaccines with aluminum adjuvants...

Research Grants17

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2002
    ....
  2. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Rebecca Taub; Fiscal Year: 2001
    ..The applicant will assess basic parameters of glucose metabolism in IGFBP-1 null mice and determine the basis for any abnormalities. ..
  3. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2001
    ....
  4. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Rebecca Taub; Fiscal Year: 2000
    ..The applicant will assess basic parameters of glucose metabolism in IGFBP-1 null mice and determine the basis for any abnormalities. ..
  5. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ....
  6. EXPRESSION OF IGFBP-1 IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 1993
    ..4. Genetic assessment of the role of IGFBP-1 in hepatic regeneration and development following underexpression of IGFBP-1 by gene "knock out", and overexpression of IGFBP-1 in transgenic mice...
  7. EXPRESSION OF IGFBP-1 IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 1992
    ..4. Genetic assessment of the role of IGFBP-1 in hepatic regeneration and development following underexpression of IGFBP-1 by gene "knock out", and overexpression of IGFBP-1 in transgenic mice...
  8. EXPRESSION OF IGFBP-1 IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 1991
    ..4. Genetic assessment of the role of IGFBP-1 in hepatic regeneration and development following underexpression of IGFBP-1 by gene "knock out", and overexpression of IGFBP-1 in transgenic mice...
  9. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 1999
    ..We will determine the importance of PRL- I in development and liver regeneration will also be determined by using a conditional knockout approach (specific aim 3). ..
  10. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Rebecca Taub; Fiscal Year: 2002
    ..The applicant will assess basic parameters of glucose metabolism in IGFBP-1 null mice and determine the basis for any abnormalities. ..