S L Peng

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. ncbi Interactions of Fox proteins with inflammatory transcription-factor pathways
    Stanford L Peng
    Director, Arthritis Research Inflammation, Autoimmunity and Transplantation Research Roche Palo Alto, LLC3431 Hillview Ave, Mailstop R7 101 Palo Alto, CA 94304, USA
    Expert Rev Clin Immunol 2:869-76. 2006
  2. ncbi The T-box transcription factor T-bet in immunity and autoimmunity
    Stanford L Peng
    Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, Palo Alto, CA 94304, USA
    Cell Mol Immunol 3:87-95. 2006
  3. doi Foxo in the immune system
    S L Peng
    Clinical Research and Exploratory Development, Roche Palo Alto, Palo Alto, CA 94304, USA
    Oncogene 27:2337-44. 2008
  4. ncbi Transcription factors in autoimmune diseases
    Stanford L Peng
    Clinical Research and Exploratory Development, Roche Palo Alto, 3431 Hillview Ave, M S A2 259, Palo Alto, CA 94304, USA
    Front Biosci 13:4218-40. 2008
  5. doi Altered T and B lymphocyte signaling pathways in lupus
    Stanford L Peng
    Clinical Research and Exploratory Development, 3431 Hillview Ave, M S A2 259, Palo Alto, CA 94304, USA
    Autoimmun Rev 8:179-83. 2009
  6. ncbi Neutrophil apoptosis in autoimmunity
    Stanford L Peng
    Inflammation, Autoimmunity, and Transplantation Research, Roche Palo Alto, 3431 Hillview Avenue, M S R7 101, Palo Alto, CA, 94304, USA
    J Mol Med (Berl) 84:122-5. 2006
  7. ncbi Fas (CD95)-related apoptosis and rheumatoid arthritis
    S L Peng
    Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, CA 94025, USA
    Rheumatology (Oxford) 45:26-30. 2006
  8. ncbi Immune regulation by Foxo transcription factors
    Stanford L Peng
    Inflammation, Autoimmunity, Transplantation Research, Palo Alto, CA 94304, USA
    Autoimmunity 40:462-9. 2007
  9. doi Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity
    Ronald J Hill
    Department of Cellular and Molecular Pharmacology, Roche Pharmaceuticals, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 327:610-9. 2008
  10. ncbi Mechanisms of disease: Transcription factors in inflammatory arthritis
    Dee Aud
    Roche Palo Alto, Palo Alto, CA 94304, USA
    Nat Clin Pract Rheumatol 2:434-42. 2006

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi Interactions of Fox proteins with inflammatory transcription-factor pathways
    Stanford L Peng
    Director, Arthritis Research Inflammation, Autoimmunity and Transplantation Research Roche Palo Alto, LLC3431 Hillview Ave, Mailstop R7 101 Palo Alto, CA 94304, USA
    Expert Rev Clin Immunol 2:869-76. 2006
    ..This review summarizes a present understanding of these factors in this context...
  2. ncbi The T-box transcription factor T-bet in immunity and autoimmunity
    Stanford L Peng
    Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, Palo Alto, CA 94304, USA
    Cell Mol Immunol 3:87-95. 2006
    ..This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention...
  3. doi Foxo in the immune system
    S L Peng
    Clinical Research and Exploratory Development, Roche Palo Alto, Palo Alto, CA 94304, USA
    Oncogene 27:2337-44. 2008
    ..This review summarizes such current and expanding knowledge of the Foxo family members in immunity, and their potential as therapeutic targets in inflammatory disease...
  4. ncbi Transcription factors in autoimmune diseases
    Stanford L Peng
    Clinical Research and Exploratory Development, Roche Palo Alto, 3431 Hillview Ave, M S A2 259, Palo Alto, CA 94304, USA
    Front Biosci 13:4218-40. 2008
    ....
  5. doi Altered T and B lymphocyte signaling pathways in lupus
    Stanford L Peng
    Clinical Research and Exploratory Development, 3431 Hillview Ave, M S A2 259, Palo Alto, CA 94304, USA
    Autoimmun Rev 8:179-83. 2009
    ..This review focuses on recently elucidated signaling abnormalities currently thought to be intrinsic to T and/or B cells in human SLE...
  6. ncbi Neutrophil apoptosis in autoimmunity
    Stanford L Peng
    Inflammation, Autoimmunity, and Transplantation Research, Roche Palo Alto, 3431 Hillview Avenue, M S R7 101, Palo Alto, CA, 94304, USA
    J Mol Med (Berl) 84:122-5. 2006
    ....
  7. ncbi Fas (CD95)-related apoptosis and rheumatoid arthritis
    S L Peng
    Inflammation, Autoimmunity and Transplantation Research, Roche Palo Alto, CA 94025, USA
    Rheumatology (Oxford) 45:26-30. 2006
    ..Therefore, modulation of the Fas pathway will hopefully be of both pathogenic and therapeutic interest in the study of inflammatory arthritis conditions in general...
  8. ncbi Immune regulation by Foxo transcription factors
    Stanford L Peng
    Inflammation, Autoimmunity, Transplantation Research, Palo Alto, CA 94304, USA
    Autoimmunity 40:462-9. 2007
    ..This review summarizes current knowledge of the Foxo family members in general and in immunity, including their potential use as therapeutic targets...
  9. doi Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity
    Ronald J Hill
    Department of Cellular and Molecular Pharmacology, Roche Pharmaceuticals, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 327:610-9. 2008
    ..Our study demonstrates that pamapimod is a potent, selective inhibitor of p38alpha with the ability to inhibit the signs and symptoms of RA and other autoimmune diseases...
  10. ncbi Mechanisms of disease: Transcription factors in inflammatory arthritis
    Dee Aud
    Roche Palo Alto, Palo Alto, CA 94304, USA
    Nat Clin Pract Rheumatol 2:434-42. 2006
    ....
  11. ncbi Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate
    Eileen T Samy
    Inflammation, Autoimmunity, and Transplantation Research, Roche Palo Alto, Palo Alto, CA 94304, USA
    J Immunol 179:5644-8. 2007
    ..Thus, Sphk2 regulates IL-2 pathways in T cells, and the modulation of Sphk2 activity may be of therapeutic utility in inflammatory and/or infectious diseases...
  12. ncbi Failed efficacy of soluble human CD83-Ig in allogeneic mixed lymphocyte reactions and experimental autoimmune encephalomyelitis: implications for a lack of therapeutic potential
    Achal Pashine
    Roche Palo Alto, LLC, Palo Alto, CA 94304, USA
    Immunol Lett 115:9-15. 2008
    ..These results raise concern as to the viability of a eukaryotically expressed soluble CD83 strategy for clinical therapeutic use...
  13. pmc T cells require Foxo1 to populate the peripheral lymphoid organs
    Melanie R Gubbels Bupp
    Inflammation Discovery, Roche Palo Alto, Palo Alto, CA, USA
    Eur J Immunol 39:2991-9. 2009
    ..Thus, Foxo1 is critical for naïve T cells to populate the peripheral lymphoid organs by coordinating a molecular program that maintains homeostasis and regulates trafficking...
  14. pmc Foxo1 regulates marginal zone B-cell development
    Jing Chen
    Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California Irvine, Irvine, CA, USA
    Eur J Immunol 40:1890-6. 2010
    ..These findings show that Foxo1 regulates the balance of mature B-cell subsets and is required for the marginal zone B-cell deficiency phenotype of mice lacking CD19...
  15. ncbi Target identification and validation in systemic autoimmunity
    Stanford L Peng
    Department of Internal Medicine Rheumatology, Washington University School of Medicine St Louis, MO 63110, USA
    Immunol Res 32:201-9. 2005
    ..It is hoped that continued investigation of such pathogenic targets will yield novel and specific therapeutic agents for the treatment of human autoimmune conditions...
  16. ncbi Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1
    Ling Lin
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 303:1017-20. 2004
    ..These results suggest a potentially general role for forkhead genes in the enforcement of lymphocyte quiescence...
  17. ncbi Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis
    Helena Jonsson
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Nat Med 11:666-71. 2005
    ..Thus, Foxo3a ensures neutrophil survival during inflammation, identifying Foxo3a as therapeutic target in inflammation...
  18. pmc T-bet regulates IgG class switching and pathogenic autoantibody production
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Proc Natl Acad Sci U S A 99:5545-50. 2002
    ..These results identify T-bet as a selective transducer of IFN-gamma-mediated IgG2a class switching in B cells and emphasize the importance of this regulation in the pathogenesis of humorally mediated autoimmunity...
  19. ncbi Type I IFN protects against murine lupus
    Jonathan D Hron
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:2134-42. 2004
    ....
  20. ncbi An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells
    Andrea J Gerth
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gastroenterology 126:1115-21. 2004
    ..We describe here a specific role for nuclear factor of activated T cells c2 in the pathogenesis of murine inflammatory bowel disease...
  21. ncbi Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    Ling Lin
    Division of Rheumatology, Department of Internal Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
    Immunity 21:203-13. 2004
    ....
  22. ncbi Transcription factors in the pathogenesis of autoimmunity
    Stanford L Peng
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Immunol 110:112-23. 2004
  23. ncbi T-bet regulates metastasis rate in a murine model of primary prostate cancer
    Stanford L Peng
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 64:452-5. 2004
    ....
  24. ncbi The role of T-bet in B cells
    Stanford L Peng
    Nat Immunol 4:1041; author reply 1041. 2003
  25. ncbi Molecular mechanisms regulating Th1 immune responses
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, Massachusetts 02115, USA
    Annu Rev Immunol 21:713-58. 2003
    ..Although the picture is still incomplete, the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models...
  26. ncbi Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2
    Carme Roura-Mir
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:1758-66. 2005
    ..These dual activation signals may represent a system for selectively promoting the presentation of exogenous foreign lipids by those myeloid APCs, which come into direct contact with pathogens...
  27. doi Toll-like receptor 9 in murine lupus: more friend than foe!
    Philipp Yu
    Institute of Immunology, Philipps University Marburg, Hans Meerwein Street 2, 35043 Marburg, Germany
    Immunobiology 213:151-7. 2008
    ..Most surprisingly, TLR9 deletion does not ameliorate but rather exacerbates pathology in murine models. Such observations warrant caution with therapeutic efforts to treat autoimmune diseases, especially SLE, via TLR modulation...
  28. ncbi T-bet regulates T-independent IgG2a class switching
    Andrea J Gerth
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Int Immunol 15:937-44. 2003
    ..T-bet-deficient B cells therefore represent a novel paradigm by which to investigate the regulation of humoral immune responses...
  29. pmc Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor
    Ling Lin
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:115-22. 2004
    ..Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate...
  30. pmc SH2D1A regulates T-dependent humoral autoimmunity
    Jonathan D Hron
    Washington University School of Medicine, Campus Box 8045, CSRB 6617, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:261-6. 2004
    ....
  31. ncbi Translating regulatory t cells in rheumatoid arthritis: revisiting the past?
    Stanford L Peng
    Arthritis Rheum 56:395-8. 2007
  32. ncbi Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:6781-90. 2005
    ....
  33. ncbi Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6
    Ling Lin
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:951-8. 2005
    ..Thus, Foxj1 restrains B cell activation and the maturation of humoral responses, demonstrating a critical role for at least this forkhead transcription factor in the regulation of B lymphocyte homeostasis...
  34. ncbi Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus
    Ling Lin
    Washington University School of Medicine, St Louis, MO, USA
    Arthritis Rheum 52:984-6. 2005
  35. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...
  36. ncbi Regulation of the symmetry and intensity of immune complex-mediated synovitis by nuclear factor of activated T cells
    Andrea J Gerth
    Washington University School of Medicine, St Louis, MO, USA
    Arthritis Rheum 50:3392-5. 2004
  37. ncbi Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress
    Subhashini Srivatsan
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:7805-9. 2005
    ..These findings confirm the importance of Foxj1 in the regulation of T cell tolerance but furthermore suggest a novel and specific role for Foxj1 in regulating thymic egress...
  38. ncbi Toll-like receptor 9 signaling protects against murine lupus
    Xiaobo Wu
    Washington University School of Medicine, St Louis, Missouri, USA
    Arthritis Rheum 54:336-42. 2006
    ..This study was undertaken to determine the role of TLR-9 in the MRL/+ and MRL/lpr models of murine lupus...
  39. ncbi Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1
    Ling Lin
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 176:4793-803. 2006
    ..These findings indicate the presence of a general network of forkhead proteins that enforce T cell quiescence...
  40. ncbi Experimental use of murine lupus models
    Stanford L Peng
    Department of Internal Medicine Rheumatology, Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Med 102:227-72. 2004
    ..This chapter contrasts the clinical characteristics of these various models, providing an outline for the use and analysis of these in vivo autoimmune systems...
  41. ncbi Signaling in B cells via Toll-like receptors
    Stanford L Peng
    Departments of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Immunol 17:230-6. 2005
    ....

Research Grants1

  1. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    ..abstract_text> ..