Matthew C Lucas

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. ncbi Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors
    Matthew C Lucas
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 19:4630-3. 2009
  2. ncbi Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain
    Matthew C Lucas
    Roche Palo Alto LLC, Department of Medicinal Chemistry, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 20:5559-66. 2010
  3. ncbi 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression
    David S Carter
    Department of Medicinal Chemistry, Roche Palo Alto LLC, CA 94304, USA
    Bioorg Med Chem Lett 20:3941-5. 2010
  4. ncbi Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
    Linda M Bannwart
    Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:6062-6. 2008
  5. ncbi Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
    Hanbiao Yang
    Medicinal Chemistry Department, Roche Palo Alto, LLC, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 20:4614-9. 2010

Collaborators

  • David S Carter
  • Robert T Hendricks
  • Hanbiao Yang
  • Linda M Bannwart
  • Kerem Ozboya
  • Clara J Lin
  • Marzia Villa
  • Robert J Weikert
  • Karin Ann Stein
  • Hai Ying Cai
  • Eun Kyung Lee
  • Ann Marie Madera
  • Sandra Steiner
  • Stephen M Lynch
  • Amy Moore
  • Robert Greenhouse
  • Saul Jaime-Figueroa
  • Ryan C Schoenfeld
  • Pravin S Iyer
  • Lubica Raptova
  • Yansheng Zhai
  • Ralf Roetz
  • Jason C Choy

Detail Information

Publications5

  1. ncbi Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors
    Matthew C Lucas
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 19:4630-3. 2009
    ..A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified...
  2. ncbi Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain
    Matthew C Lucas
    Roche Palo Alto LLC, Department of Medicinal Chemistry, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 20:5559-66. 2010
    ..Representative compounds from these series displayed good in vivo pharmacokinetics and high monoamine receptor occupancies which are indicators of good brain penetration...
  3. ncbi 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression
    David S Carter
    Department of Medicinal Chemistry, Roche Palo Alto LLC, CA 94304, USA
    Bioorg Med Chem Lett 20:3941-5. 2010
    ..In this Letter we describe the optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors...
  4. ncbi Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
    Linda M Bannwart
    Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:6062-6. 2008
    ..One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg i.p...
  5. ncbi Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
    Hanbiao Yang
    Medicinal Chemistry Department, Roche Palo Alto, LLC, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 20:4614-9. 2010
    ..Inhibitor binding at the Thumb-II site was ultimately confirmed by solving a crystal structure of 8b complexed with NS5B...