Nicole A Kratochwil


Affiliation: F. Hoffmann-La Roche Ltd


  1. request reprint
    Kratochwil N, Gatti McArthur S, Hoener M, Lindemann L, Christ A, Green L, et al. G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey. Curr Top Med Chem. 2011;11:1902-24 pubmed
    ..Illustrative examples are taken from the GPCR family class C, metabotropic glutamate receptors 1 and 5 and sweet taste receptors, and from the GPCR class A, e.g. nicotinic acid and 5-hydroxytryptamine 5A receptor. ..
  2. Kratochwil N, Triyatni M, Mueller M, Klammers F, Leonard B, Turley D, et al. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018;365:237-248 pubmed publisher
    ..Thus, long-term liver models have great potential as translational research tools exploring pharmacokinetics of novel drugs in vitro in health and disease. ..
  3. Heckel T, Schmucki R, Berrera M, Ringshandl S, Badi L, Steiner G, et al. Functional analysis and transcriptional output of the Göttingen minipig genome. BMC Genomics. 2015;16:932 pubmed publisher
    ..Potential impact of our data for comparative genomics, translational research, and experimental medicine are discussed. ..
  4. Kratochwil N, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, et al. Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling. AAPS J. 2017;19:534-550 pubmed publisher
    ..Further research is needed to understand whether transporter activity and drug metabolism by non-CYP enzymes, such as UGTs, SULTs, AO, and FMO, is comparable to the in vivo situation in these long-term culture models. ..