Anthony M Giannetti

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. pmc Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus
    Sophie Le Pogam
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    J Virol 80:6146-54. 2006
  2. doi Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors
    Anthony M Giannetti
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    J Med Chem 51:574-80. 2008
  3. doi Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase
    Zachary K Sweeney
    Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:4348-51. 2008
  4. ncbi Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology
    Giuseppe A Papalia
    Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Anal Biochem 359:94-105. 2006
  5. pmc Mechanism for multiple ligand recognition by the human transferrin receptor
    Anthony M Giannetti
    Graduate Option in Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 1:E51. 2003
  6. ncbi Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor
    Shaina L Byrne
    Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Biochemistry 45:6663-73. 2006
  7. pmc The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
    Paul J Schmidt
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell Metab 7:205-14. 2008
  8. doi Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
    Stephen S Antonysamy
    Medicinal Chemistry, SGX Pharmaceuticals, Inc, 10505 Roselle Street, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:2990-5. 2008

Collaborators

  • K Klumpp
  • Connie Oshiro
  • Todd R Elworthy
  • Zachary K Sweeney
  • David Myszka
  • IGOR KALTASHOV
  • Andres S Hernandez
  • Paul J Schmidt
  • Stephen S Antonysamy
  • Michelle F Browner
  • Seth F Harris
  • Vincent Leveque
  • Isabel Najera
  • Sophie Le Pogam
  • Giuseppe A Papalia
  • Shaina L Byrne
  • Eduardo Torres
  • Paul T Toran
  • Nancy C Andrews
  • Stephanie Hopkins
  • Masaki Tomimoto
  • David Marciano
  • Elizabeth Jefferson
  • Tobi Wright
  • Charles Kissinger
  • Ethel McGee
  • Brandon Aubol
  • Brian Nolan
  • Pamela J Bjorkman
  • Jeff Blaney
  • Jorg Hendle
  • Normand H├ębert
  • Lakshman Bindu
  • Yun Hee Cho
  • Samir Ali
  • Nick Cammack
  • Maggie A Bynum
  • Julian Symons
  • Barry D Bruce
  • Hyunsoon Kang
  • Sanjay Phogat
  • Michael Vaughn
  • Thomas E Ryan
  • Mieke Steukers
  • Phinikoula S Katsamba
  • Wen Rong Jiang
  • Bryan C Tieman
  • Anh Pham-Baginski
  • Huawei Qiu
  • Valerie C Smith
  • Michael Baksh
  • Alexandra Smets
  • Jonathan Brooks
  • Joshua S Klein
  • Anne B Mason
  • Johan Vandersmissen
  • Agnes Nowakowski
  • Stephanie Leavitt
  • Ross T A MacGillivray
  • Mieke De Wit
  • Rachael Leverence
  • Than Hendricks
  • Sonal Rajyaguru
  • Siming Wang
  • Klaus M Michelson
  • Gisele Tavares
  • Lieve Michiels
  • Rosemarie Wilton
  • Victoria A Pudlak
  • Katarzyna Matusiewicz

Detail Information

Publications8

  1. pmc Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus
    Sophie Le Pogam
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    J Virol 80:6146-54. 2006
    ..Additionally, these findings provide initial insights into the in vitro mutational threshold of the HCV NS5B polymerase and the potential impact of viral fitness on the selection of multiple-resistant mutants...
  2. doi Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors
    Anthony M Giannetti
    Roche Palo Alto LLC, Palo Alto, CA 94304, USA
    J Med Chem 51:574-80. 2008
    ..A classification scheme for these compounds is presented that can be used to rapidly characterize the hits from high-throughput screens and eliminate compounds with a nonspecific mechanism of inhibition...
  3. doi Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase
    Zachary K Sweeney
    Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 18:4348-51. 2008
    ..Pharmacokinetic studies indicated that inhibitor 7e has good bioavailability in rats. Several fragments of inhibitor 7c were prepared, and the binding of these compounds to HIV-RT was analyzed by surface plasmon resonance spectroscopy...
  4. ncbi Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology
    Giuseppe A Papalia
    Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Anal Biochem 359:94-105. 2006
    ..The results of this study provide insight into the challenges, as well as the level of experimental variation, that one would expect to observe when using Biacore technology for small molecule analyses...
  5. pmc Mechanism for multiple ligand recognition by the human transferrin receptor
    Anthony M Giannetti
    Graduate Option in Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 1:E51. 2003
    ..From these data, we propose a structure-based model for the mechanism of TfR-assisted iron release from Fe-Tf...
  6. ncbi Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor
    Shaina L Byrne
    Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
    Biochemistry 45:6663-73. 2006
    ..6 reveals that only the N317D mutant has a significant effect. The carbohydrate at position 317 lies close to a region of the TFR previously shown to interact with hTF...
  7. pmc The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
    Paul J Schmidt
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell Metab 7:205-14. 2008
    ..Together, these models suggest that Hfe induces hepcidin expression when it is not in complex with Tfr1...
  8. doi Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
    Stephen S Antonysamy
    Medicinal Chemistry, SGX Pharmaceuticals, Inc, 10505 Roselle Street, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 18:2990-5. 2008
    ..Crystallographic fragment screening hits with approximately 1-10mM binding affinity (K(D)) were iteratively optimized to give leads with approximately 200nM biochemical activity and low microM cellular activity in a Replicon assay...