B Bohrmann

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. doi request reprint Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β
    Bernd Bohrmann
    F Hoffmann La Roche Ltd, pRED, Basel, Switzerland
    J Alzheimers Dis 28:49-69. 2012
  2. ncbi request reprint Cryosubstitution of frozen biological specimens in electron microscopy: use and application as an alternative to chemical fixation
    B Bohrmann
    Preclinical Research, F Hoffmann La Roche Ltd, CH 4070, Basel, Switzerland
    Micron 32:11-9. 2001
  3. ncbi request reprint Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates
    B Bohrmann
    Pharma Division, F Hoffmann La Roche AG, Basel, CH 4070, Switzerland
    J Struct Biol 130:232-46. 2000
  4. ncbi request reprint High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain
    A Güntert
    Pharma Research Basel, F Hoffmann La Roche Ltd, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
    Neuroscience 143:461-75. 2006
  5. pmc Large and small splice variants of collagen XII: differential expression and ligand binding
    M Koch
    Department of Biophysical Chemistry, Biocenter of the University, Basel, Switzerland
    J Cell Biol 130:1005-14. 1995
  6. pmc Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
    C Ullmer
    DTA CV and Metabolism, Discovery Research CV and Metabolic Diseases, F Hoffmann La Roche AG, pRED, Pharma Research and Early Development, Basel, Switzerland
    Br J Pharmacol 167:1448-66. 2012
  7. ncbi request reprint Antiproliferative activity of the human IFN-alpha-inducible protein IFI44
    L C Hallen
    Roche Center for Medical Genomics, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    J Interferon Cytokine Res 27:675-80. 2007

Collaborators

Detail Information

Publications7

  1. doi request reprint Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β
    Bernd Bohrmann
    F Hoffmann La Roche Ltd, pRED, Basel, Switzerland
    J Alzheimers Dis 28:49-69. 2012
    ..These studies demonstrated that gantenerumab preferentially interacts with aggregated Aβ in the brain and lowers amyloid-β by eliciting effector cell-mediated clearance...
  2. ncbi request reprint Cryosubstitution of frozen biological specimens in electron microscopy: use and application as an alternative to chemical fixation
    B Bohrmann
    Preclinical Research, F Hoffmann La Roche Ltd, CH 4070, Basel, Switzerland
    Micron 32:11-9. 2001
    ..We conclude that low-temperature dehydration by cryosubstitution in organic solvents is able to form stable cross-links between macromolecules by hydrophobic interactions...
  3. ncbi request reprint Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates
    B Bohrmann
    Pharma Division, F Hoffmann La Roche AG, Basel, CH 4070, Switzerland
    J Struct Biol 130:232-46. 2000
    ..Ro 90-7501 may serve as a prototypic inhibitor for Abeta42 fibril formation and as a tool for studying the molecular mechanism of fibril assembly...
  4. ncbi request reprint High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain
    A Güntert
    Pharma Research Basel, F Hoffmann La Roche Ltd, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
    Neuroscience 143:461-75. 2006
    ..Our data support the concept that diffuse plaques represent initial Abeta deposits but indicate a structural difference for Abeta depositions in human AD compared with PS2APP mice already at the stage of diffuse plaque formation...
  5. pmc Large and small splice variants of collagen XII: differential expression and ligand binding
    M Koch
    Department of Biophysical Chemistry, Biocenter of the University, Basel, Switzerland
    J Cell Biol 130:1005-14. 1995
    ..Our results indicate that collagen XII is specifically associated with fibrillar collagen, and that the large variant has binding sites for extracellular ligands not present in the small variant...
  6. pmc Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
    C Ullmer
    DTA CV and Metabolism, Discovery Research CV and Metabolic Diseases, F Hoffmann La Roche AG, pRED, Pharma Research and Early Development, Basel, Switzerland
    Br J Pharmacol 167:1448-66. 2012
    ..Here, we characterized a selective, potent and functional anti-mGlu(7) monoclonal antibody, MAB1/28, that triggers receptor internalization...
  7. ncbi request reprint Antiproliferative activity of the human IFN-alpha-inducible protein IFI44
    L C Hallen
    Roche Center for Medical Genomics, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    J Interferon Cytokine Res 27:675-80. 2007
    ..Based on these results, we propose a model in which IFI44 binds intracellular GTP, and this depletion abolishes extracellular signal-regulated kinase (ERK) signaling and results finally in cell cycle arrest...