H J Böhm

Summary

Affiliation: F. Hoffmann-La Roche Ltd

Publications

  1. ncbi Current computational tools for de novo ligand design
    H J Böhm
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Basel, Switzerland
    Curr Opin Biotechnol 7:433-6. 1996
  2. ncbi Structure-based library design: molecular modelling merges with combinatorial chemistry
    H J Böhm
    Pharmaceuticals Division, Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
    Curr Opin Chem Biol 4:283-6. 2000
  3. ncbi Fluorine in medicinal chemistry
    Hans Joachim Böhm
    Discovery Research, Pharmaceuticals Division, Roche, CH 4070 Basel, Switzerland
    Chembiochem 5:637-43. 2004
  4. ncbi Development of filter functions for protein-ligand docking
    M Stahl
    Hoffmann La Roche, Ltd, Pharmaceuticals Division, Basel, Switzerland
    J Mol Graph Model 16:121-32. 1998

Detail Information

Publications4

  1. ncbi Current computational tools for de novo ligand design
    H J Böhm
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Basel, Switzerland
    Curr Opin Biotechnol 7:433-6. 1996
    ..Several new algorithms have been proposed recently for computational de novo ligand design. Empirical scoring functions are now available to prioritize the suggested structures. The first successful applications have been reported...
  2. ncbi Structure-based library design: molecular modelling merges with combinatorial chemistry
    H J Böhm
    Pharmaceuticals Division, Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
    Curr Opin Chem Biol 4:283-6. 2000
    ..Recent advances in both computational and experimental techniques now allow a very fruitful interplay of computational and combinatorial chemistry in the structure-based design of combinatorial libraries...
  3. ncbi Fluorine in medicinal chemistry
    Hans Joachim Böhm
    Discovery Research, Pharmaceuticals Division, Roche, CH 4070 Basel, Switzerland
    Chembiochem 5:637-43. 2004
    ..Recent 3D-structure determinations of protein complexes with bound fluorinated ligands have led to an improved understanding of the nonbonding protein-ligand interactions that involve fluorine...
  4. ncbi Development of filter functions for protein-ligand docking
    M Stahl
    Hoffmann La Roche, Ltd, Pharmaceuticals Division, Basel, Switzerland
    J Mol Graph Model 16:121-32. 1998
    ..On a test set of 32 protein-ligand complexes, this protocol significantly improves the accuracy of the structure predictions...