Ilker Y Eyupoglu

Summary

Publications

  1. ncbi request reprint Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen, Germany
    J Neurochem 93:992-9. 2005
  2. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
  3. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
  4. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
  5. doi request reprint Dynamic contrast enhancement of experimental glioma an intra-individual comparative study to assess the optimal time delay
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Acad Radiol 17:188-93. 2010
  6. ncbi request reprint Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 111:264-71. 2006
  7. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
  8. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
  9. doi request reprint Cellular characterization of the peritumoral edema zone in malignant brain tumors
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    Cancer Sci 100:1856-62. 2009
  10. pmc Improving the extent of malignant glioma resection by dual intraoperative visualization approach
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Germany
    PLoS ONE 7:e44885. 2012

Detail Information

Publications18

  1. ncbi request reprint Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen, Germany
    J Neurochem 93:992-9. 2005
    ..These observations identify chromatin-modifying enzymes as possible and promising targets for the pharmacotherapy of malignant gliomas...
  2. ncbi request reprint Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg Department of Neuropathology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 102:738-44. 2005
    ..This new model allows researchers to address in a systematic manner the molecular pathways of brain invasion as well as specific tumor-host interactions such as necrosis...
  3. ncbi request reprint Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Mol Cancer Ther 5:1248-55. 2006
    ..Furthermore, its propensity to pass the blood-brain barrier and to increase the protein level of acetylated histone H3 in brain tissue identifies MS-275 as a promising candidate drug in the treatment of malignant gliomas...
  4. ncbi request reprint Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    Annett Hölsken
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 112:205-15. 2006
    ....
  5. doi request reprint Dynamic contrast enhancement of experimental glioma an intra-individual comparative study to assess the optimal time delay
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Acad Radiol 17:188-93. 2010
    ....
  6. ncbi request reprint Abundant hypermethylation of SOCS-1 in clinically silent pituitary adenomas
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 111:264-71. 2006
    ..The data is compatible with epigenetic silencing of the SOCS-1 gene and constitutive activation of the JAK-STAT pathway in PA. This appears to contribute particularly to those tumours characterized by a hormone-inactive status...
  7. ncbi request reprint The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion
    Roland Coras
    Department of NeuropathologyI, University of Erlangen, Erlangen, Germany, Germany
    Mol Cancer Ther 6:1745-54. 2007
    ....
  8. ncbi request reprint Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells
    Florian A Siebzehnrubl
    Department of Neuropathology, University of Erlangen Nuremberg, Krankenhausstr 8 10, 91054, Erlangen, Germany
    Exp Brain Res 176:672-8. 2007
    ..Increased expression levels of NeuroD, Cyclin D2 and B-lymphocyte translocation gene 3 (Btg3) point to a shift towards neuronal fate determination targeted by HDAC inhibitors...
  9. doi request reprint Cellular characterization of the peritumoral edema zone in malignant brain tumors
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    Cancer Sci 100:1856-62. 2009
    ..These data corroborate that perifocal edema identified in T2-weighted MR scans are characterized with alterations in glial cell distribution and marker expression forming an inflammatory tumor microenvironment...
  10. pmc Improving the extent of malignant glioma resection by dual intraoperative visualization approach
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Germany
    PLoS ONE 7:e44885. 2012
    ..The extent of resection could be increased from 57.1% to 71.2% without incurring postoperative neurological deficits...
  11. doi request reprint Clinical evaluation of flat-panel detector compared with multislice computed tomography in 65 patients with acute intracranial hemorrhage: initial results. Clinical article
    Tobias Struffert
    Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurosurg 113:901-7. 2010
    ....
  12. doi request reprint Surgical resection of malignant gliomas-role in optimizing patient outcome
    Ilker Y Eyupoglu
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Nat Rev Neurol 9:141-51. 2013
    ..We highlight key surgical factors that enable optimization of adjuvant treatment to enhance patient quality of life and improve life expectancy...
  13. doi request reprint xCT modulation in gliomas: relevance to energy metabolism and tumor microenvironment normalization
    Nic E Savaskan
    Institute of Cell Biology and Neurobiology, Center for Anatomy, CCM2, Charite Medical School Berlin, D 10117 Berlin, Germany
    Ann Anat 192:309-13. 2010
    ....
  14. ncbi request reprint High resolution neurochemical gold staining method for myelin in peripheral and central nervous system at the light- and electron-microscopic level
    Nic E Savaskan
    Brain Research Institute, Swiss Federal Institute of Technology and University Zurich, Switzerland
    Cell Tissue Res 337:213-21. 2009
    ....
  15. doi request reprint In vivo micro-CT imaging of rat brain glioma: a comparison with 3T MRI and histology
    Tobias Engelhorn
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurosci Lett 458:28-31. 2009
    ..14). In conclusion, micro-CT allows in vivo imaging of the contrast-enhancing part of experimental gliomas with an accuracy comparable to high-field MRI...
  16. pmc Dexamethasone alleviates tumor-associated brain damage and angiogenesis
    Zheng Fan
    Department of Neurosurgery, University Hospital of Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Bavaria, Germany
    PLoS ONE 9:e93264. 2014
    ..Thus, our investigations reveal that DEXA acts pleiotropically and impacts tumor growth, tumor vasculature and tumor-associated brain damage. ..
  17. pmc Brain miffed by macrophage migration inhibitory factor
    Nic E Savaskan
    Department of Neurosurgery, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Int J Cell Biol 2012:139573. 2012
    ..We consider the possibility of MIF targeting in neurodegenerative processes and brain tumors by novel MIF-neutralizing approaches...
  18. ncbi request reprint Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region
    Rolf Buslei
    Department of Neuropathology, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054, Erlangen, Germany
    Acta Neuropathol 109:589-97. 2005
    ..We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma...