Douglas W Ethell

Summary

Publications

  1. pmc Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis
    D Joshua Cameron
    Molecular Neurobiology, Western University of Health Sciences, Pomona, California, United States of America
    PLoS ONE 7:e39598. 2012
  2. doi request reprint An amyloid-notch hypothesis for Alzheimer's disease
    Douglas W Ethell
    Division of Biomedical Sciences Neuroscience, University of California Riverside, Riverside, CA, USA
    Neuroscientist 16:614-7. 2010
  3. doi request reprint Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    Antioxid Redox Signal 11:529-40. 2009
  4. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
  5. pmc Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    Kai Ti Lin
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    J Biol Chem 283:28969-79. 2008
  6. pmc Amyloid-β and APP deficiencies cause severe cerebrovascular defects: important work for an old villain
    Salvadore Luna
    Molecular Neurobiology, Western University of Health Sciences, Pomona, California, United States of America Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, California, United States of America
    PLoS ONE 8:e75052. 2013
  7. ncbi request reprint Paraquat neurotoxicity is mediated by a Bak-dependent mechanism
    Qingyan Fei
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 283:3357-64. 2008
  8. doi request reprint Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members
    Qingyan Fei
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurochem 105:2091-7. 2008
  9. ncbi request reprint Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
    Douglas W Ethell
    Biomedical Sciences, University of California Riverside, 92521 0121, USA
    Neurobiol Dis 23:351-61. 2006
  10. ncbi request reprint Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    Iryna M Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurosci Res 85:2813-23. 2007

Collaborators

Detail Information

Publications14

  1. pmc Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis
    D Joshua Cameron
    Molecular Neurobiology, Western University of Health Sciences, Pomona, California, United States of America
    PLoS ONE 7:e39598. 2012
    ....
  2. doi request reprint An amyloid-notch hypothesis for Alzheimer's disease
    Douglas W Ethell
    Division of Biomedical Sciences Neuroscience, University of California Riverside, Riverside, CA, USA
    Neuroscientist 16:614-7. 2010
    ..This revised amyloid-Notch hypothesis may also explain the disappointing results of recent clinical trials with γ-secretase inhibitors...
  3. doi request reprint Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    Antioxid Redox Signal 11:529-40. 2009
    ..Here we describe how related cell death mechanisms are involved in the pathophysiology of Parkinson's disease...
  4. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
    ....
  5. pmc Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    Kai Ti Lin
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    J Biol Chem 283:28969-79. 2008
    ..This study provides the first evidence that MMP-mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses...
  6. pmc Amyloid-β and APP deficiencies cause severe cerebrovascular defects: important work for an old villain
    Salvadore Luna
    Molecular Neurobiology, Western University of Health Sciences, Pomona, California, United States of America Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, California, United States of America
    PLoS ONE 8:e75052. 2013
    ..The ability of Aβ to modify blood vessels may coordinate capillary density with local metabolic activity, which could explain the evolutionary conservation of this peptide from lobe-finned fish to man. ..
  7. ncbi request reprint Paraquat neurotoxicity is mediated by a Bak-dependent mechanism
    Qingyan Fei
    Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 283:3357-64. 2008
    ..Finally, we tested the sensitivity of Bak-deficient mice and found them to be resistant to PQ treatments that depleted tyrosine hydroxylase immuno-positive neurons in the substantia nigra pars compacta of wild-type mice...
  8. doi request reprint Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members
    Qingyan Fei
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurochem 105:2091-7. 2008
    ..Those responses favor Bax-dependent MOMP and apoptosis. SiRNA knockdown of Bax and Bak confirmed that individually PQ and maneb induce Bak-dependent cell death, but together they block the Bak pathway and activate apoptosis through Bax...
  9. ncbi request reprint Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
    Douglas W Ethell
    Biomedical Sciences, University of California Riverside, 92521 0121, USA
    Neurobiol Dis 23:351-61. 2006
    ....
  10. ncbi request reprint Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    Iryna M Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
    J Neurosci Res 85:2813-23. 2007
    ..Finally, we discuss how the development of therapeutics to attenuate MMP activity in neurodegenerative disorders may become powerful tools for future studies of synaptic formation and function within the developing and mature brain...
  11. ncbi request reprint Amyloid-β increases capillary bed density in the adult zebrafish retina
    Khomthorn Cunvong
    Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, California, USA
    Invest Ophthalmol Vis Sci 54:1516-21. 2013
    ....
  12. pmc Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation
    Tina V Bilousova
    Division of Biomedical Sciences, University of California Riverside, California 92521 0121, USA
    J Neurochem 97:44-56. 2006
    ..These findings are the first direct evidence that MMPs can influence the morphology of mature dendritic spines, and hence synaptic stability...
  13. ncbi request reprint Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, Riverside, California, USA
    J Clin Immunol 23:439-46. 2003
    ..Here we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...
  14. ncbi request reprint Fas ligand-mediated apoptosis in degenerative disorders of the brain
    Douglas W Ethell
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, California 92521 0121, USA
    J Clin Immunol 23:363-70. 2003
    ..Here, we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...