An amyloid-notch hypothesis for Alzheimer's diseaseDouglas W Ethell
Division of Biomedical Sciences Neuroscience, University of California Riverside, Riverside, CA, USA
Neuroscientist 16:614-7. 2010
..This revised amyloid-Notch hypothesis may also explain the disappointing results of recent clinical trials with γ-secretase inhibitors...
- Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family
Douglas W Ethell
Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
Antioxid Redox Signal 11:529-40. 2009
..Here we describe how related cell death mechanisms are involved in the pathophysiology of Parkinson's disease...
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitisLillian A Buhler
Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
BMC Neurosci 10:17. 2009
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- Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
Kai Ti Lin
Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
J Biol Chem 283:28969-79. 2008
..This study provides the first evidence that MMP-mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses...
Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's miceDouglas W Ethell
Biomedical Sciences, University of California Riverside, 92521 0121, USA
Neurobiol Dis 23:351-61. 2006
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- Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members
Qingyan Fei
Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
J Neurochem 105:2091-7. 2008
..Those responses favor Bax-dependent MOMP and apoptosis. SiRNA knockdown of Bax and Bak confirmed that individually PQ and maneb induce Bak-dependent cell death, but together they block the Bak pathway and activate apoptosis through Bax...
- Paraquat neurotoxicity is mediated by a Bak-dependent mechanism
Qingyan Fei
Division of Biomedical Sciences, University of California, Riverside, California 92521, USA
J Biol Chem 283:3357-64. 2008
..Finally, we tested the sensitivity of Bak-deficient mice and found them to be resistant to PQ treatments that depleted tyrosine hydroxylase immuno-positive neurons in the substantia nigra pars compacta of wild-type mice...
- Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
Iryna M Ethell
Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521 0121, USA
J Neurosci Res 85:2813-23. 2007
..Finally, we discuss how the development of therapeutics to attenuate MMP activity in neurodegenerative disorders may become powerful tools for future studies of synaptic formation and function within the developing and mature brain...
- Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation
Tina V Bilousova
Division of Biomedical Sciences, University of California Riverside, California 92521 0121, USA
J Neurochem 97:44-56. 2006
..These findings are the first direct evidence that MMPs can influence the morphology of mature dendritic spines, and hence synaptic stability...
- Fas ligand-mediated apoptosis in degenerative disorders of the brain
Douglas W Ethell
Division of Biomedical Sciences, University of California Riverside, Riverside, California, USA
J Clin Immunol 23:439-46. 2003
..Here we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...
- Fas ligand-mediated apoptosis in degenerative disorders of the brain
Douglas W Ethell
Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, California 92521 0121, USA
J Clin Immunol 23:363-70. 2003
..Here, we discuss how FasL-mediated apoptosis may balance immune cell access to the brain with Alzheimer's disease and MS representing extremes of too little and too much immune access, respectively...
