Affiliation: University of Tartu
- Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian populationRiin Tamm
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Clin Chem Lab Med 46:974-9. 2008..To date, at least 25 single nucleotide polymorphisms have been reported in the TPMT gene, 23 of these are associated with reduced enzyme activity...
- Determination of thiopurine S-methyltransferase (TPMT) activity by comparing various normalization factors: reference values for Estonian population using HPLC-UV assayKersti Oselin
Department of Pharmacology, Tartu University, 51014 Tartu, Estonia
J Chromatogr B Analyt Technol Biomed Life Sci 834:77-83. 2006..001). This sensitive HPLC assay for quantitative determination of TPMT activity could easily be used in clinical settings. Under constant experimental conditions for haemolysate preparation no normalization is required...
- Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangementsMark Braschinsky
Department of Neurology, University of Tartu, Estonia
BMC Neurol 10:17. 2010..The most common autosomal-dominant form of the disease derives from mutations in the SPAST gene...