Affiliation: University of Tartu
Lulla V, Karo Astover L, Rausalu K, Saul S, Merits A, Lulla A. Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase. J Virol. 2018;92: pubmed publisher
Das P, Puusepp L, Varghese F, Utt A, Ahola T, Kananovich D, et al
. Design and Validation of Novel Chikungunya Virus Protease Inhibitors. Antimicrob Agents Chemother. 2016;60:7382-7395 pubmed
..Combining the data obtained from different assays also indicates that some of the analyzed compounds may suppress CHIKV replication using more than one mechanism. ..
Ianevski A, Zusinaite E, Shtaida N, Kallio Kokko H, Valkonen M, Kantele A, et al
. Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses. 2019;11: pubmed publisher
..Associations between these meteorological factors and IV activity could improve surveillance and promote development of accurate predictive models for future influenza outbreaks in the region. ..
Wichit S, Hamel R, Zanzoni A, Diop F, Cribier A, Talignani L, et al
. SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts. Int J Mol Sci. 2019;20: pubmed publisher
..Together, these results suggest that IFITs are involved in the restriction of replication of CHIKV and ZIKV and provide, as yet unreported, evidence for a proviral role of SAMHD1 in arbovirus infection of human skin cells. ..
Zusinaite E, Ianevski A, Niukkanen D, Poranen M, Bjørås M, Afset J, et al
. A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents. Viruses. 2018;10: pubmed publisher
..It can also include other omics techniques, such as genomics and epigenomics, to allow identification of individual markers associated with adverse reactions to antivirals with immuno- and neuro-modulatory properties. ..
Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, et al
. Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Res. 2018;154:174-182 pubmed publisher
..Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases. ..
Mutso M, Morro A, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, et al
. Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses. 2018;10: pubmed publisher
..Similar to CD2AP, its homolog SH3KBP1 also bound the identified motif in CHIKV and SFV nsP3. ..
Varjak M, Dietrich I, Sreenu V, Till B, Merits A, Kohl A, et al
. Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells. Viruses. 2018;10: pubmed publisher
..Surprisingly, this effect was found to be independent of the siRNA and piRNA pathways in Ae. aegypti cells and specific for alphaviruses. This suggests a small RNA-independent antiviral function for this protein in mosquitoes. ..
Utt A, Das P, Varjak M, Lulla V, Lulla A, Merits A. Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. J Virol. 2015;89:3145-62 pubmed publisher