J Harro

Summary

Affiliation: University of Tartu
Country: Estonia

Publications

  1. doi request reprint Animal models of depression vulnerability
    Jaanus Harro
    Unit of Psychophysiology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Estonia
    Curr Top Behav Neurosci 14:29-54. 2013
  2. pmc Stability of the factorial structure of metabolic syndrome from childhood to adolescence: a 6-year follow-up study
    Vicente Martínez-Vizcaíno
    Social and Health Care Research Center, University of Castilla La Mancha, Cuenca, Spain
    Cardiovasc Diabetol 10:81. 2011
  3. pmc Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity
    Tanel Mällo
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Brain Res 1194:110-7. 2008
  4. ncbi request reprint Personality and the serotonin transporter gene: Associations in a longitudinal population-based study
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi, Estonia
    Biol Psychol 81:9-13. 2009
  5. doi request reprint Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology
    Jaanus Harro
    Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Tiigi 78, 50410 Tartu, Estonia
    Pharmacol Ther 125:402-22. 2010
  6. doi request reprint Droplets of black bile? Development of vulnerability and resilience to depression in young age
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia
    Psychoneuroendocrinology 36:380-92. 2011
  7. ncbi request reprint CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies
    J Harro
    Department of Psychology and Psychopharmacological Drug Development Group, Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia
    Amino Acids 31:215-30. 2006
  8. doi request reprint Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: relevance of animal affective systems to human disorders, with a focus on resilience to adverse events
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Neurosci Biobehav Rev 35:1876-89. 2011
  9. ncbi request reprint Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment
    J Harro
    Department of Psychology, University of Tartu, Estonia
    Eur Neuropsychopharmacol 10:5-16. 1999
  10. doi request reprint Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect
    T Mällo
    Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia
    Neuroscience 164:963-74. 2009

Collaborators

  • J E Wikberg
  • L Oreland
  • A Kask
  • Evelyn Kiive
  • Erika Comasco
  • K Pruus
  • Jaak Panksepp
  • K Kõiv
  • A Rinken
  • Vicente Martínez-Vizcaíno
  • T Mällo
  • M Tõnissaar
  • Tanel Mällo
  • M Eller
  • A Alttoa
  • M Harro
  • Michael Sjostrom
  • Toomas Veidebaum
  • Idoia Labayen
  • Montserrat Solera-Martínez
  • Helle Mai Loit
  • Jonatan R Ruiz
  • Francisco B Ortega
  • Diva Eensoo
  • D Matrov
  • Tõnis Timmusk
  • Kadri Kõiv
  • L Herm
  • Ain Uustare
  • Ago Rinken
  • Indrek Koppel
  • Karita Raudkivi
  • A Uustare
  • V Matto
  • D Eensoo
  • L Merenäkk
  • J Alep
  • L Engstrom
  • L Allikmets

Detail Information

Publications28

  1. doi request reprint Animal models of depression vulnerability
    Jaanus Harro
    Unit of Psychophysiology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Estonia
    Curr Top Behav Neurosci 14:29-54. 2013
    ..Studies comparing effects of stress on males and females should reveal to which extent the pathogenetic processes leading to depression can be specific to sex/gender...
  2. pmc Stability of the factorial structure of metabolic syndrome from childhood to adolescence: a 6-year follow-up study
    Vicente Martínez-Vizcaíno
    Social and Health Care Research Center, University of Castilla La Mancha, Cuenca, Spain
    Cardiovasc Diabetol 10:81. 2011
    ..There is no consistent evidence on whether the MS construct works in the same way in different populations and at different stages in life...
  3. pmc Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity
    Tanel Mällo
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Brain Res 1194:110-7. 2008
    ..The differential regulation of 5-HT-ergic system in LE- and HE-rats in PFC and hippocampus may form the basis for their distinct anxiety-related behaviours...
  4. ncbi request reprint Personality and the serotonin transporter gene: Associations in a longitudinal population-based study
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi, Estonia
    Biol Psychol 81:9-13. 2009
    ..Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence...
  5. doi request reprint Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology
    Jaanus Harro
    Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences, Tiigi 78, 50410 Tartu, Estonia
    Pharmacol Ther 125:402-22. 2010
    ..It is argued that further studies on inter-individual differences in affect and underlying neurobiology should include formal modeling of their epistatic, hierarchical and dynamic nature...
  6. doi request reprint Droplets of black bile? Development of vulnerability and resilience to depression in young age
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia
    Psychoneuroendocrinology 36:380-92. 2011
    ..It is proposed that subjects with genetically determined neurotic tendencies are likely to attempt to select coping strategies that reduce events perceived as harmful and can by this means develop resilience towards affective disorders...
  7. ncbi request reprint CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies
    J Harro
    Department of Psychology and Psychopharmacological Drug Development Group, Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia
    Amino Acids 31:215-30. 2006
    ..At least Y1, Y2 and Y5 receptors in various brain regions are involved, with the strongest evidence for contribution of Y1...
  8. doi request reprint Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: relevance of animal affective systems to human disorders, with a focus on resilience to adverse events
    Jaanus Harro
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia
    Neurosci Biobehav Rev 35:1876-89. 2011
    ..These brain regions appear as primary targets for further identification of endophenotypes specific to affective disorders...
  9. ncbi request reprint Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment
    J Harro
    Department of Psychology, University of Tartu, Estonia
    Eur Neuropsychopharmacol 10:5-16. 1999
    ..These results show that chronic mild stress applied to group-housed rats can prevent the development of certain behavioural and biochemical changes caused by the denervation of the locus coeruleus projection areas...
  10. doi request reprint Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect
    T Mällo
    Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia
    Neuroscience 164:963-74. 2009
    ....
  11. ncbi request reprint Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats
    A Kask
    Department of Pharmacology, University of Tartu, Estonia
    Regul Pept 75:255-62. 1998
    ..5 microg) were ineffective in modifying the plus-maze exploration. These data suggest that endogenous NPY may regulate anxiety-related behaviour in rats by acting via the NPY Y1 receptors in DPAG...
  12. ncbi request reprint Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and beta-adrenoceptor binding in the rat
    J Harro
    Department of Psychology, University of Tartu, Estonia
    J Neural Transm 106:619-29. 1999
    ....
  13. ncbi request reprint Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats
    A Kask
    Department of Pharmacology, University of Tartu, Ulikooli 18, Tartu EE 2400, Estonia
    Brain Res 788:345-8. 1998
    ..These data suggest that NPY applied close to LC has anxiolytic-like effects by acting on NPY Y2, not on Y1 receptors. Thus, NPY Y2 receptors in the vicinity of LC may be involved in the regulation of anxiety in rats...
  14. ncbi request reprint Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry
    J Harro
    Department of Psychology, University of Tartu, Tiigi 78, E 50410, Tartu, Estonia
    Brain Res 899:227-39. 2001
    ....
  15. ncbi request reprint Effects of low dose N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine administration on exploratory and amphetamine-induced behavior and dopamine D2 receptor function in rats with high or low exploratory activity
    A Alttoa
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Estonia
    Neuroscience 132:979-90. 2005
    ..Together these findings suggest that LC noradrenergic neurotransmission is differently involved in dopaminergic mechanisms which mediate novelty-related vs amphetamine-induced behavior...
  16. doi request reprint The effect of the NMDA receptor antagonist dizocilpine on behavioral manifestations of serotonin and adrenergic antidepressants in rats
    K Pruus
    Department of Pharmacology, University of Tartu, Tartu, Estonia
    Methods Find Exp Clin Pharmacol 32:123-8. 2010
    ..In contrast, the NMDA antagonists did not potentiate the antidepressant-like effects of noradrenergic antidepressants...
  17. ncbi request reprint Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats
    A Kask
    Department of Pharmacology, University of Tartu, Estonia
    Prog Neuropsychopharmacol Biol Psychiatry 23:705-11. 1999
    ..4. These data suggest that the blockade of central NPY Y1 receptors is aversive and provide additional evidence to the hypothesis that the NPY Y1 receptors are involved in the regulation of affective states...
  18. ncbi request reprint The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat
    V Matto
    Department of Pharmacology, University of Tartu, Estonia
    Neuropharmacology 36:389-96. 1997
    ..These data support the hypothesis of the involvement of the CCK(B) receptor subtype in the neurobiological mechanisms of anxiety...
  19. ncbi request reprint Lesioning of locus coeruleus projections by DSP-4 neurotoxin treatment: effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in rats
    J Harro
    Department of Psychology, University of Tartu, Estonia
    Pharmacol Toxicol 86:197-202. 2000
    ..These data suggest that supersensitivity of D2 receptors develops after locus coeruleus denervation, but that the enhanced efficacy of amphetamine in DSP-4-treated rats is masked by neophobia...
  20. ncbi request reprint Inhibition of amphetamine- and apomorphine-induced behavioural effects by neuropeptide Y Y(1) receptor antagonist BIBO 3304
    A Kask
    Department of Pharmacology, Faculty of Medicine, University of Tartu, Ravila 19, 50411, Tartu, Estonia
    Neuropharmacology 39:1292-302. 2000
    ....
  21. doi request reprint Rats with high or low sociability are differently affected by chronic variable stress
    M Tõnissaar
    Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, EE 50410 Tartu, Estonia
    Neuroscience 152:867-76. 2008
    ..This study thus revealed that animals with high sociability trait are more vulnerable to anhedonia elicited by chronic stress in conditions of single housing...
  22. ncbi request reprint Orexigenic effect of the melanocortin MC4 receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists
    A Kask
    Department of Pharmacology, Faculty of Medicine, University of Tartu, Estonia
    Can J Physiol Pharmacol 78:143-9. 2000
    ..These results suggest that stimulation of food intake caused by weakening of melanocortinergic tone at the MC4 receptor is partially but not exclusively related to NPY Y1 receptor activation...
  23. ncbi request reprint Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8S to rat brain cortical membranes
    A Rinken
    Institute of Chemical Physics, University of Tartu, Estonia
    Biochem Pharmacol 55:423-31. 1998
    ....
  24. ncbi request reprint Association of depressiveness with blunted growth hormone response to maximal physical exercise in young healthy men
    J Harro
    Department of Psychology, University of Tartu, Estonia
    Psychoneuroendocrinology 24:505-17. 1999
    ..Hence, this study demonstrates that growth hormone response to physiological stimuli is reduced in psychometrically measured depressiveness...
  25. ncbi request reprint The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat
    J Harro
    Department of Psychology, University of Tartu, Estonia
    Neuropeptides 35:100-9. 2001
    ..However, large doses of CRF1 receptor antagonists may reduce motivation of exploratory behaviour in familiar environments...
  26. ncbi request reprint Platelet monoamine oxidase in healthy 9- and 15-years old children: the effect of gender, smoking and puberty
    M Harro
    Department of Public Health, University of Tartu, Estonia
    Prog Neuropsychopharmacol Biol Psychiatry 25:1497-511. 2001
    ..4. Differences in gender, age, pubertal status and smoking habits must be taken into account if the relationship between platelet MAO activity, personality and psychiatric disorders is studied in children...
  27. doi request reprint The effect of serotonin transporter gene promoter polymorphism on adolescent and adult ADHD symptoms and educational attainment: A longitudinal study
    E Kiive
    Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, Tartu, 50410, Estonia Electronic address
    Eur Psychiatry 28:372-8. 2013
    ..Neuroticism, depressive symptoms and general mental abilities were controlled for as possible confounding factors...
  28. ncbi request reprint Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus
    J Harro
    Department of Psychology, University of Tartu, Tiigi 78, EE 50410 Tartu, Estonia
    Brain Res Brain Res Rev 38:79-128. 2001
    ..Dysregulation of CRF and other neuropeptides such as neuropeptide Y, galanin and substance P may reinforce the LC dysfunction and thus further weaken the adaptivity to stressful stimuli...