Research Topics
| Marko VendelinSummaryAffiliation: Institute of Cybernetics Country: Estonia Publications
| Collaborators
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Detail Information
Publications
The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approachesValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
Subcell Biochem 46:27-65. 2007....- Cardiac mechanoenergetics replicated by cross-bridge modelM Vendelin
Institute of Cybernetics at Tallinn Technical University, Estonia
Ann Biomed Eng 28:629-40. 2000..e., cross bridges that detach without hydrolyzing ATP molecule, is relatively small and (2) ATP consumption rate profile within a beat and the amount of the passenger cross bridges depend on the contraction protocol... 
Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopyMarko Vendelin
Laboratory of Systems Biology, Institute of Cybernetics at Tallinn Univ of Technology Akadeemia 21, 12618 Tallinn, Estonia
Am J Physiol Cell Physiol 295:C1302-15. 2008..Although the source for such anisotropy is uncertain, we speculate that it may be induced by the ordered pattern of intracellular structures in rat cardiomyocytes...- Mitochondrial regular arrangement in muscle cells: a "crystal-like" patternMarko Vendelin
Group of Quantitative and Structural Bioenergetics, Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
Am J Physiol Cell Physiol 288:C757-67. 2005..This is consistent with the concept of the unitary nature of the organization of the muscle energy metabolism... - Analysis of functional coupling: mitochondrial creatine kinase and adenine nucleotide translocaseMarko Vendelin
Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
Biophys J 87:696-713. 2004..The analysis revealed the minimal changes in the free energy profile of the MiCK-ANT interaction required to reproduce the experimental data. A possible free energy profile of the coupled MiCK-ANT system is presented... - Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscleMarko Vendelin
Institute of Cybernetics, Tallinn Technical University, Akadeemia, Tallinn, Estonia
Mol Cell Biochem 256:229-41. 2004..It was concluded that intracellular diffusion restrictions for adenosine phosphates are not distributed uniformly, but rather are localized in certain compartments of the cardiac cells... - Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heartMarko Vendelin
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
J Biol Chem 285:37240-50. 2010..Our results provide experimental evidence for the existence of two pathways of energy transfer, direct ATP transfer, and PCr transfer through the CK shuttle, whose contribution may vary depending on the metabolic status of the heart... - Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiencyMarko Vendelin
Institute of Cybernetics, Tallinn Technical University, 12618 Tallinn, Estonia
Am J Physiol Heart Circ Physiol 283:H1072-81. 2002..If ATP(var) was minimized, then the transverse fiber angle was considerably underestimated. The results suggest that ATP consumption distribution is not regulating the fiber orientation in the heart... - Cardiac mechanoenergetics in silicoMarko Vendelin
Institute of Cybernetics, Akadeemia 21, 12618 Tallinn, Estonia
Neuro Endocrinol Lett 23:13-20. 2002..Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole... 
Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinaseClaire Monge
Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
Mol Cell Biochem 318:147-65. 2008..These results emphasize important role and various pathophysiological implications of the phosphocreatine-creatine kinase system in energy transfer in brain cells, including synaptosomes...- Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cellsTiia Anmann
Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
FEBS J 272:3145-61. 2005.... - ADP compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscleMervi Sepp
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
Biophys J 98:2785-93. 2010..To our knowledge, this is the first time such a strong coupling of PK to ATPases has been demonstrated in permeabilized cardiomyocytes... - Heterogeneity of ADP diffusion and regulation of respiration in cardiac cellsValdur Saks
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
Biophys J 84:3436-56. 2003.... - Cardiac system bioenergetics: metabolic basis of the Frank-Starling lawValdur Saks
Structural and Quantitative Bioenergetics Research Group, Laboratory of Bioenergetics, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
J Physiol 571:253-73. 2006..Such integration of energetics with calcium signalling systems provides the basis for 'metabolic pacing', synchronizing the cellular electrical and mechanical activities with energy supply processes... - Permeabilized rat cardiomyocyte response demonstrates intracellular origin of diffusion obstaclesNatalja Jepihhina
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
Biophys J 101:2112-21. 2011..By calculating the flow profile around the cell in the microscope chamber and comparing model solutions to measured data, we demonstrate that intracellular structures impose significant diffusion obstacles in rat cardiomyocytes... - Diffusion restrictions surrounding mitochondria: a mathematical model of heart muscle fibersHena R Ramay
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
Biophys J 97:443-52. 2009..Such a low level of permeability indicates that the proteins should play a dominant part in formation of the diffusion restrictions... - Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscleKaren Guerrero
Laboratoire de Bioénergétique Fondamentale et Appliquée, Institut National de la Santé et de la Recherche Médicale E221, Universite Joseph Fourier, Grenoble, France
Am J Physiol Regul Integr Comp Physiol 289:R1144-54. 2005.... - Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow troutNiina Sokolova
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
BMC Cell Biol 10:90. 2009..Experiments were performed at 10, 15 and 20 degrees C in the absence and presence of creatine... - Sensitivity Analysis of Flux Determination in Heart by H(2) (18)O -provided Labeling Using a Dynamic Isotopologue Model of Energy Transfer PathwaysDavid W Schryer
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
PLoS Comput Biol 8:e1002795. 2012..Our analysis suggests that the flux distributions obtained using dynamic [Formula: see text] labeling, after removing the net flux assumption, are comparable with those from [Formula: see text] inversion and saturation transfer... - Analysis of molecular movement reveals latticelike obstructions to diffusion in heart muscle cellsArdo Illaste
Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
Biophys J 102:739-48. 2012.... - Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patchJaanus Karo
Laboratory of Systems Biology, Institute of Cybernetics at Tallinn University of Technology, Akadeemia tee 21, 12618 Tallinn, Estonia
J Biol Chem 287:7467-76. 2012..In addition, our simulations predict which part of the MtCK protein sequence interacts with the membrane. Taken together, the model has been verified by dynamical and structural data and can be used as the basis for further studies... - Symbolic flux analysis for genome-scale metabolic networksDavid W Schryer
Laboratory of Systems Biology, Institute of Cybernetics at Tallinn University of Technology, Akadeemia tee 21, 12618 Tallinn, Estonia
BMC Syst Biol 5:81. 2011..One way to resolve those technical issues is to analyze the network using symbolic methods. The aim of this paper is to develop a routine that symbolically finds the steady state solutions of large metabolic networks... - Systems biology of the mitochondrionDaniel A Beard
Am J Physiol Cell Physiol 291:C1101-3. 2006 - Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to orderRikke Birkedal
Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
Am J Physiol Cell Physiol 291:C1148-58. 2006..The obtained quantitative description of mitochondrial organization is a requisite for accurate mathematical analysis of mitochondrial systems biology...