Marko Vendelin

Summary

Affiliation: Institute of Cybernetics
Country: Estonia

Publications

  1. ncbi request reprint The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Subcell Biochem 46:27-65. 2007
  2. ncbi request reprint Cardiac mechanoenergetics replicated by cross-bridge model
    M Vendelin
    Institute of Cybernetics at Tallinn Technical University, Estonia
    Ann Biomed Eng 28:629-40. 2000
  3. pmc Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    J Biol Chem 285:37240-50. 2010
  4. pmc Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics at Tallinn Univ of Technology Akadeemia 21, 12618 Tallinn, Estonia
    Am J Physiol Cell Physiol 295:C1302-15. 2008
  5. ncbi request reprint Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern
    Marko Vendelin
    Group of Quantitative and Structural Bioenergetics, Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
    Am J Physiol Cell Physiol 288:C757-67. 2005
  6. pmc Analysis of functional coupling: mitochondrial creatine kinase and adenine nucleotide translocase
    Marko Vendelin
    Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
    Biophys J 87:696-713. 2004
  7. ncbi request reprint Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle
    Marko Vendelin
    Institute of Cybernetics, Tallinn Technical University, Akadeemia, Tallinn, Estonia
    Mol Cell Biochem 256:229-41. 2004
  8. ncbi request reprint Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency
    Marko Vendelin
    Institute of Cybernetics, Tallinn Technical University, 12618 Tallinn, Estonia
    Am J Physiol Heart Circ Physiol 283:H1072-81. 2002
  9. ncbi request reprint Cardiac mechanoenergetics in silico
    Marko Vendelin
    Institute of Cybernetics, Akadeemia 21, 12618 Tallinn, Estonia
    Neuro Endocrinol Lett 23:13-20. 2002
  10. doi request reprint Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase
    Claire Monge
    Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 318:147-65. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Subcell Biochem 46:27-65. 2007
    ....
  2. ncbi request reprint Cardiac mechanoenergetics replicated by cross-bridge model
    M Vendelin
    Institute of Cybernetics at Tallinn Technical University, Estonia
    Ann Biomed Eng 28:629-40. 2000
    ..e., cross bridges that detach without hydrolyzing ATP molecule, is relatively small and (2) ATP consumption rate profile within a beat and the amount of the passenger cross bridges depend on the contraction protocol...
  3. pmc Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    J Biol Chem 285:37240-50. 2010
    ..Our results provide experimental evidence for the existence of two pathways of energy transfer, direct ATP transfer, and PCr transfer through the CK shuttle, whose contribution may vary depending on the metabolic status of the heart...
  4. pmc Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics at Tallinn Univ of Technology Akadeemia 21, 12618 Tallinn, Estonia
    Am J Physiol Cell Physiol 295:C1302-15. 2008
    ..Although the source for such anisotropy is uncertain, we speculate that it may be induced by the ordered pattern of intracellular structures in rat cardiomyocytes...
  5. ncbi request reprint Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern
    Marko Vendelin
    Group of Quantitative and Structural Bioenergetics, Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
    Am J Physiol Cell Physiol 288:C757-67. 2005
    ..This is consistent with the concept of the unitary nature of the organization of the muscle energy metabolism...
  6. pmc Analysis of functional coupling: mitochondrial creatine kinase and adenine nucleotide translocase
    Marko Vendelin
    Laboratory of Fundamental and Applied Bioenergetics, Institut National de la Santé et de la Recherche Médicale E0221, Joseph Fourier University, Grenoble, France
    Biophys J 87:696-713. 2004
    ..The analysis revealed the minimal changes in the free energy profile of the MiCK-ANT interaction required to reproduce the experimental data. A possible free energy profile of the coupled MiCK-ANT system is presented...
  7. ncbi request reprint Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle
    Marko Vendelin
    Institute of Cybernetics, Tallinn Technical University, Akadeemia, Tallinn, Estonia
    Mol Cell Biochem 256:229-41. 2004
    ..It was concluded that intracellular diffusion restrictions for adenosine phosphates are not distributed uniformly, but rather are localized in certain compartments of the cardiac cells...
  8. ncbi request reprint Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency
    Marko Vendelin
    Institute of Cybernetics, Tallinn Technical University, 12618 Tallinn, Estonia
    Am J Physiol Heart Circ Physiol 283:H1072-81. 2002
    ..If ATP(var) was minimized, then the transverse fiber angle was considerably underestimated. The results suggest that ATP consumption distribution is not regulating the fiber orientation in the heart...
  9. ncbi request reprint Cardiac mechanoenergetics in silico
    Marko Vendelin
    Institute of Cybernetics, Akadeemia 21, 12618 Tallinn, Estonia
    Neuro Endocrinol Lett 23:13-20. 2002
    ..Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole...
  10. doi request reprint Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase
    Claire Monge
    Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    Mol Cell Biochem 318:147-65. 2008
    ..These results emphasize important role and various pathophysiological implications of the phosphocreatine-creatine kinase system in energy transfer in brain cells, including synaptosomes...
  11. ncbi request reprint Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells
    Tiia Anmann
    Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    FEBS J 272:3145-61. 2005
    ....
  12. doi request reprint Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts
    Jelena Branovets
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia and
    Am J Physiol Heart Circ Physiol 305:H506-20. 2013
    ..This raises questions on the importance of the CK system as a spatial energy buffer in unstressed cardiomyocytes. ..
  13. pmc ADP compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle
    Mervi Sepp
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
    Biophys J 98:2785-93. 2010
    ..To our knowledge, this is the first time such a strong coupling of PK to ATPases has been demonstrated in permeabilized cardiomyocytes...
  14. pmc Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, 2280 Rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    Biophys J 84:3436-56. 2003
    ....
  15. pmc Cardiac system bioenergetics: metabolic basis of the Frank-Starling law
    Valdur Saks
    Structural and Quantitative Bioenergetics Research Group, Laboratory of Bioenergetics, Joseph Fourier University, 2280, rue de la Piscine, BP53X 38041, Grenoble Cedex 9, France
    J Physiol 571:253-73. 2006
    ..Such integration of energetics with calcium signalling systems provides the basis for 'metabolic pacing', synchronizing the cellular electrical and mechanical activities with energy supply processes...
  16. pmc Diffusion restrictions surrounding mitochondria: a mathematical model of heart muscle fibers
    Hena R Ramay
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
    Biophys J 97:443-52. 2009
    ..Such a low level of permeability indicates that the proteins should play a dominant part in formation of the diffusion restrictions...
  17. pmc Permeabilized rat cardiomyocyte response demonstrates intracellular origin of diffusion obstacles
    Natalja Jepihhina
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
    Biophys J 101:2112-21. 2011
    ..By calculating the flow profile around the cell in the microscope chamber and comparing model solutions to measured data, we demonstrate that intracellular structures impose significant diffusion obstacles in rat cardiomyocytes...
  18. ncbi request reprint Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle
    Karen Guerrero
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Institut National de la Santé et de la Recherche Médicale E221, Universite Joseph Fourier, Grenoble, France
    Am J Physiol Regul Integr Comp Physiol 289:R1144-54. 2005
    ....
  19. pmc Real-time determination of sarcomere length of a single cardiomyocyte during contraction
    Pearu Peterson
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    Am J Physiol Cell Physiol 304:C519-31. 2013
    ..The developed method is implemented in open-source software...
  20. pmc Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow trout
    Niina Sokolova
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    BMC Cell Biol 10:90. 2009
    ..Experiments were performed at 10, 15 and 20 degrees C in the absence and presence of creatine...
  21. pmc Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways
    David W Schryer
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Estonia
    PLoS Comput Biol 8:e1002795. 2012
    ..Our analysis suggests that the flux distributions obtained using dynamic ¹⁸O labeling, after removing the net flux assumption, are comparable with those from ³¹P − NMR inversion and saturation transfer...
  22. pmc Bidirectionality and compartmentation of metabolic fluxes are revealed in the dynamics of isotopomer networks
    David W Schryer
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    Int J Mol Sci 10:1697-718. 2009
    ..The flux parameters of an example metabolic network were optimized to examine the compartmentalization of metabolites and and the bidirectionality of fluxes in the TCA cycle of Saccharomyces uvarum for steady-state respiratory growth...
  23. pmc Symbolic flux analysis for genome-scale metabolic networks
    David W Schryer
    Laboratory of Systems Biology, Institute of Cybernetics at Tallinn University of Technology, Akadeemia tee 21, 12618 Tallinn, Estonia
    BMC Syst Biol 5:81. 2011
    ..One way to resolve those technical issues is to analyze the network using symbolic methods. The aim of this paper is to develop a routine that symbolically finds the steady state solutions of large metabolic networks...
  24. pmc Analysis of molecular movement reveals latticelike obstructions to diffusion in heart muscle cells
    Ardo Illaste
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
    Biophys J 102:739-48. 2012
    ....
  25. pmc ADP Protects Cardiac Mitochondria under Severe Oxidative Stress
    Niina Sokolova
    Institute of Cybernetics, Tallinn University of Technology, Tallinn, Estonia
    PLoS ONE 8:e83214. 2013
    ..This effect is most likely not related to a reduction in ROS production. As the effect of ADP relates to its concentration, increased ADP as occurs in the pathophysiological situation may protect mitochondrial integrity and function. ..
  26. pmc Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch
    Jaanus Karo
    Laboratory of Systems Biology, Institute of Cybernetics at Tallinn University of Technology, Akadeemia tee 21, 12618 Tallinn, Estonia
    J Biol Chem 287:7467-76. 2012
    ..In addition, our simulations predict which part of the MtCK protein sequence interacts with the membrane. Taken together, the model has been verified by dynamical and structural data and can be used as the basis for further studies...
  27. ncbi request reprint Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to order
    Rikke Birkedal
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Am J Physiol Cell Physiol 291:C1148-58. 2006
    ..The obtained quantitative description of mitochondrial organization is a requisite for accurate mathematical analysis of mitochondrial systems biology...
  28. ncbi request reprint Systems biology of the mitochondrion
    Daniel A Beard
    Am J Physiol Cell Physiol 291:C1101-3. 2006