Research Topics
| T KivisildSummaryAffiliation: Institute of Molecular and Cell Biology Country: Estonia Publications
| Collaborators
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Detail Information
Publications
A prehistory of Indian Y chromosomes: evaluating demic diffusion scenariosSanghamitra Sahoo
National DNA Analysis Centre, Central Forensic Science Laboratory, Kolkata 700014, India
Proc Natl Acad Sci U S A 103:843-8. 2006..The dyadic Y-chromosome composition of Tibeto-Burman speakers of India, however, can be attributed to a recent demographic process, which appears to have absorbed and overlain populations who previously spoke Austro-Asiatic languages...
Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humansMait Metspalu
Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
BMC Genet 5:26. 2004..The results were integrated and analyzed together with published data from South, Southeast Asia and West Eurasia...- Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tearsToomas Kivisild
Estonian Biocentre and Tartu University, Tartu, Estonia
Am J Hum Genet 75:752-70. 2004.... 
The emerging limbs and twigs of the East Asian mtDNA treeToomas Kivisild
Department of Evolutionary Biology, Tartu University and Estonian Biocentre, Estonia
Mol Biol Evol 19:1737-51. 2002....- The genetic heritage of the earliest settlers persists both in Indian tribal and caste populationsT Kivisild
Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
Am J Hum Genet 72:313-32. 2003.... - The role of selection in the evolution of human mitochondrial genomesToomas Kivisild
Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
Genetics 172:373-87. 2006..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups... - The evidence of mtDNA haplogroup F in a European population and its ethnohistoric implicationsH V Tolk
Department of Evolutionary Biology, Institute for Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
Eur J Hum Genet 9:717-23. 2001..The first published phylogenetic analysis of haplogroup F worldwide is presented, applying the median network method, suggesting several scenarios how this maternal lineage may have been added to the Croatian mtDNA pool... - Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in EurasiaEva Liis Loogväli
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Mol Biol Evol 21:2012-21. 2004.... - MtDNA profile of West Africa Guineans: towards a better understanding of the Senegambia regionAlexandra Rosa
Department of Evolutionary Biology, Estonian Biocenter, Tartu University, Riia 23, 51010 Tartu, Estonia
Ann Hum Genet 68:340-52. 2004..Particular haplotypes, found almost exclusively in East-African populations, were found in some ethnic groups with an oral tradition claiming Sudanese origin... - Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspectiveU Roostalu
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Mol Biol Evol 24:436-48. 2007..In a contrast, the North Caucasus mitochondrial gene pool has received an influx of hg H variants, arriving from the Ponto-Caspian/East European area... - Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unitMari Järve
Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
PLoS ONE 4:e7276. 2009..Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used... - Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europeSiiri Rootsi
Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Riia, Tartu, Estonia
Am J Hum Genet 75:128-37. 2004..In contrast, I1b2 most likely arose in southern France/Iberia. Similarly to the other subclades, it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago... - Phylogeography of mtDNA haplogroup R7 in the Indian peninsulaGyaneshwer Chaubey
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
BMC Evol Biol 8:227. 2008.... - A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards EuropeSiiri Rootsi
Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Eur J Hum Genet 15:204-11. 2007..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage... - Beringian standstill and spread of Native American foundersErika Tamm
Department of Evolutionary Biology, University of Tartu, Estonian Biocentre, Tartu, Estonia
PLoS ONE 2:e829. 2007..This pause in movement was followed by a swift migration southward that distributed the founder types all the way to South America. The data also suggest more recent bi-directional gene flow between Siberia and the North American Arctic... - Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysisGeorgi Hudjashov
Estonian Biocentre and Tartu University, Department of Evolutionary Biology, Riia 23, 51010 Tartu, Estonia
Proc Natl Acad Sci U S A 104:8726-30. 2007.... - Peopling of South Asia: investigating the caste-tribe continuum in IndiaGyaneshwer Chaubey
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Bioessays 29:91-100. 2007..This review attempts to summarize recent genetic studies on Indian caste and tribal populations with the focus on the information embedded in the socially defined structure of Indian populations... - The western and eastern roots of the Saami--the story of genetic "outliers" told by mitochondrial DNA and Y chromosomesKristiina Tambets
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
Am J Hum Genet 74:661-82. 2004..In particular, no evidence of a significant directional gene flow from extant aboriginal Siberian populations into the haploid gene pools of the Saami was found... - Origin and diffusion of mtDNA haplogroup XMaere Reidla
Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
Am J Hum Genet 73:1178-90. 2003..The position of X2a in the phylogenetic tree suggests an early split from the other X2 clades, likely at the very beginning of their expansion and spread from the Near East... - Explaining the imperfection of the molecular clock of hominid mitochondriaEva Liis Loogväli
Estonian Biocentre, Tartu, Estonia
PLoS ONE 4:e8260. 2009..However, for humans, the weakness of purifying selection has been further exacerbated by the population expansions associated with the out-of Africa migration and the end of the Last Ice Age... - Predominance of a rare type of HIV-1 in EstoniaMaarja Adojaan
FIT Biotech Oyj Plc Eesti, Tartu, Estonia
J Acquir Immune Defic Syndr 39:598-605. 2005..At least 9 mosaic forms were identified, each with distinct patterns of multiple crossover. To characterize Estonian CRF06_cpx as well as recombinant isolates in more detail, 4 near-full-length HIV-1 genomes were sequenced... - The unresolved location of Otzi's mtDNA within haplogroup KPhillip Endicott
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
Am J Phys Anthropol 132:590-1; discussion 591-3. 2007 - Mitochondrial portraits of the Madeira and Açores archipelagos witness different genetic pools of its settlersAntonio Brehm
Human Genetics Laboratory, Centre of Macaronesian Studies, University of Madeira, Campus of Penteada, 9000 Funchal, Portugal
Hum Genet 114:77-86. 2003..Nevertheless the recorded introduction of Canary native Guanches, who are characterized by the presence of particular sub-clade U6b1, has left no detectable imprints in the present day population of Madeira... - An mtDNA perspective of French genetic variationChrystelle Richard
Laboratoire d Etude du Polymorphisme de l ADN, Faculte de Medecine, Nantes, France
Ann Hum Biol 34:68-79. 2007..The French has been insufficiently characterized so far for mitochondrial DNA (mtDNA) diversity... - Reconstruction of patrilineages and matrilineages of Samaritans and other Israeli populations from Y-chromosome and mitochondrial DNA sequence variationPeidong Shen
Stanford Genome Technology Center, Palo Alto, California 94305-5020, USA
Hum Mutat 24:248-60. 2004..Most of the former may be traced back to a common ancestor in the paternally-inherited Jewish high priesthood (Cohanim) at the time of the Assyrian conquest of the kingdom of Israel... - Y chromosomal heritage of Croatian population and its island isolatesLovorka Barac
Institute for Anthropological Research, Zagreb, Croatia
Eur J Hum Genet 11:535-42. 2003..Interestingly, the same population also harbored mitochondrial haplogroup F that is virtually absent in European populations--indicating a connection with Central Asian populations, possibly the Avars... - Maternal footprints of Southeast Asians in North IndiaKumarasamy Thangaraj
Centre for Cellular and Molecular Biology, Hyderabad, India
Hum Hered 66:1-9. 2008..The presence of R6 in the Nepalese, on the other hand, suggests that the gene flow between India and Nepal has been reciprocal... - Counting the founders: the matrilineal genetic ancestry of the Jewish DiasporaDoron M Behar
Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa, Israel
PLoS ONE 3:e2062. 2008..These findings highlight striking differences in the demographic history of the widespread Jewish Diaspora... - Evidence of authentic DNA from Danish Viking Age skeletons untouched by humans for 1,000 yearsLinea Melchior
Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 3:e2214. 2008.... 
Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in GreenlandM Thomas P Gilbert
Center for Ancient Genetics, Department of Biology, Universitetsparken 15, DK 2100 Copenhagen, Denmark
Science 320:1787-9. 2008..This result suggests that the earliest migrants into the New World's northern extremes derived from populations in the Bering Sea area and were not directly related to Native Americans or the later Neo-Eskimos that replaced them...- To trust or not to trust an idiosyncratic mitochondrial data setYong-Gang Yao
Am J Hum Genet 72:1341-6; author reply 1346-9. 2003 - Phylogeographic differentiation of mitochondrial DNA in Han ChineseYong-Gang Yao
Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
Am J Hum Genet 70:635-51. 2002.... - Excavating Y-chromosome haplotype strata in AnatoliaCengiz Cinnioglu
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5120, USA
Hum Genet 114:127-48. 2004..The variety of Turkish haplotypes is witness to Turkey being both an important source and recipient of gene flow... - Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populationsKumarasamy Thangaraj
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
Hum Genet 116:507-17. 2005..More than 18 independent origins of the deletion or insertion mutation could be inferred in the phylogenetic analysis of the D-loop sequences... - The population history of the Croatian linguistic minority of Molise (southern Italy): a maternal viewCarla Babalini
Department of Biology, University of Rome Tor Vergata, Italy
Eur J Hum Genet 13:902-12. 2005.... - Reconstructing the origin of Andaman IslandersKumarasamy Thangaraj
Centre for Cellular and Molecular Biology, Hyderabad-500 007, India
Science 308:996. 2005..In contrast, Nicobarese sequences illustrate a close genetic relationship with populations from Southeast Asia... - Y-chromosome lineages from Portugal, Madeira and Açores record elements of Sephardim and Berber ancestryRita Goncalves
Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
Ann Hum Genet 69:443-54. 2005.... - Y-chromosome lineages in Cabo Verde Islands witness the diverse geographic origin of its first male settlersRita Goncalves
Human Genetics Laboratory, Center of Macaronesian Studies, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
Hum Genet 113:467-72. 2003..9%. Overall, these results indicate that gene flow from multiple sources and various sex-specific patterns have been important in the formation of the genomic diversity in the Cabo Verde islands... - The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene poolAlessandro Achilli
Dipartimento di Genetica e Microbiologia, , Pavia, Italy
Am J Hum Genet 75:910-8. 2004..The survey revealed that the previously reported excess of H among these families is caused entirely by H3 and is due to a major, probably nonrecent, founder event... - Traces of archaic mitochondrial lineages persist in Austronesian-speaking Formosan populationsJean A Trejaut
Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
PLoS Biol 3:e247. 2005.... - Mitochondrial genes and schizophreniaHans Jurgen Bandelt
Schizophr Res 72:267-9. 2005 - What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?Armand M Leroi
Department of Biological Sciences, Imperial College London, Silwood Park Campus, Ascot, Berks, SL5 7PY, UK
Mech Ageing Dev 126:421-9. 2005..This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study... - High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patientsHans Jurgen Bandelt
Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
Biochem Biophys Res Commun 352:283-91. 2007..Here, we re-analyse four problematic LHON studies and propose guidelines by which some of the pitfalls could be avoided... - Two sources of the Russian patrilineal heritage in their Eurasian contextOleg Balanovsky
Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, Russia
Am J Hum Genet 82:236-50. 2008.... - Use of y chromosome and mitochondrial DNA population structure in tracing human migrationsPeter A Underhill
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Annu Rev Genet 41:539-64. 2007..We introduce new results concerning Y chromosome founder haplogroups C, DE, and F that resolve their previous trifurcation and improve the harmony with the mtDNA recapitulation of the out-of-Africa migration... - The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence timeLev A Zhivotovsky
N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Am J Hum Genet 74:50-61. 2004..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria... - The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder eventDoron M Behar
Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
Am J Hum Genet 78:487-97. 2006..We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium... - High prevalence of the CCR5Delta32 HIV-resistance mutation among Estonian HIV type 1-infected individualsMaarja Adojaan
FIT Biotech Oyj Plc Eesti Filiaal, Institute of Molecular and Cell Biology, University of Tartu, Nooruse 9, Tartu 50411, Estonia
AIDS Res Hum Retroviruses 23:193-7. 2007....