T Kivisild

Summary

Affiliation: Institute of Molecular and Cell Biology
Country: Estonia

Publications

  1. pmc A prehistory of Indian Y chromosomes: evaluating demic diffusion scenarios
    Sanghamitra Sahoo
    National DNA Analysis Centre, Central Forensic Science Laboratory, Kolkata 700014, India
    Proc Natl Acad Sci U S A 103:843-8. 2006
  2. pmc Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
    Mait Metspalu
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    BMC Genet 5:26. 2004
  3. pmc Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears
    Toomas Kivisild
    Estonian Biocentre and Tartu University, Tartu, Estonia
    Am J Hum Genet 75:752-70. 2004
  4. ncbi request reprint The emerging limbs and twigs of the East Asian mtDNA tree
    Toomas Kivisild
    Department of Evolutionary Biology, Tartu University and Estonian Biocentre, Estonia
    Mol Biol Evol 19:1737-51. 2002
  5. pmc The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations
    T Kivisild
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    Am J Hum Genet 72:313-32. 2003
  6. pmc The role of selection in the evolution of human mitochondrial genomes
    Toomas Kivisild
    Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Genetics 172:373-87. 2006
  7. ncbi request reprint The evidence of mtDNA haplogroup F in a European population and its ethnohistoric implications
    H V Tolk
    Department of Evolutionary Biology, Institute for Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    Eur J Hum Genet 9:717-23. 2001
  8. ncbi request reprint Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia
    Eva Liis Loogväli
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Mol Biol Evol 21:2012-21. 2004
  9. ncbi request reprint MtDNA profile of West Africa Guineans: towards a better understanding of the Senegambia region
    Alexandra Rosa
    Department of Evolutionary Biology, Estonian Biocenter, Tartu University, Riia 23, 51010 Tartu, Estonia
    Ann Hum Genet 68:340-52. 2004
  10. ncbi request reprint Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspective
    U Roostalu
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Mol Biol Evol 24:436-48. 2007

Detail Information

Publications48

  1. pmc A prehistory of Indian Y chromosomes: evaluating demic diffusion scenarios
    Sanghamitra Sahoo
    National DNA Analysis Centre, Central Forensic Science Laboratory, Kolkata 700014, India
    Proc Natl Acad Sci U S A 103:843-8. 2006
    ..The dyadic Y-chromosome composition of Tibeto-Burman speakers of India, however, can be attributed to a recent demographic process, which appears to have absorbed and overlain populations who previously spoke Austro-Asiatic languages...
  2. pmc Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
    Mait Metspalu
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    BMC Genet 5:26. 2004
    ..The results were integrated and analyzed together with published data from South, Southeast Asia and West Eurasia...
  3. pmc Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears
    Toomas Kivisild
    Estonian Biocentre and Tartu University, Tartu, Estonia
    Am J Hum Genet 75:752-70. 2004
    ....
  4. ncbi request reprint The emerging limbs and twigs of the East Asian mtDNA tree
    Toomas Kivisild
    Department of Evolutionary Biology, Tartu University and Estonian Biocentre, Estonia
    Mol Biol Evol 19:1737-51. 2002
    ....
  5. pmc The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations
    T Kivisild
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    Am J Hum Genet 72:313-32. 2003
    ....
  6. pmc The role of selection in the evolution of human mitochondrial genomes
    Toomas Kivisild
    Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Genetics 172:373-87. 2006
    ..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups...
  7. ncbi request reprint The evidence of mtDNA haplogroup F in a European population and its ethnohistoric implications
    H V Tolk
    Department of Evolutionary Biology, Institute for Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    Eur J Hum Genet 9:717-23. 2001
    ..The first published phylogenetic analysis of haplogroup F worldwide is presented, applying the median network method, suggesting several scenarios how this maternal lineage may have been added to the Croatian mtDNA pool...
  8. ncbi request reprint Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia
    Eva Liis Loogväli
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Mol Biol Evol 21:2012-21. 2004
    ....
  9. ncbi request reprint MtDNA profile of West Africa Guineans: towards a better understanding of the Senegambia region
    Alexandra Rosa
    Department of Evolutionary Biology, Estonian Biocenter, Tartu University, Riia 23, 51010 Tartu, Estonia
    Ann Hum Genet 68:340-52. 2004
    ..Particular haplotypes, found almost exclusively in East-African populations, were found in some ethnic groups with an oral tradition claiming Sudanese origin...
  10. ncbi request reprint Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspective
    U Roostalu
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Mol Biol Evol 24:436-48. 2007
    ..In a contrast, the North Caucasus mitochondrial gene pool has received an influx of hg H variants, arriving from the Ponto-Caspian/East European area...
  11. pmc Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit
    Mari Järve
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    PLoS ONE 4:e7276. 2009
    ..Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used...
  12. pmc Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Riia, Tartu, Estonia
    Am J Hum Genet 75:128-37. 2004
    ..In contrast, I1b2 most likely arose in southern France/Iberia. Similarly to the other subclades, it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago...
  13. pmc Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
    Gyaneshwer Chaubey
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    BMC Evol Biol 8:227. 2008
    ....
  14. ncbi request reprint A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Eur J Hum Genet 15:204-11. 2007
    ..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage...
  15. pmc Beringian standstill and spread of Native American founders
    Erika Tamm
    Department of Evolutionary Biology, University of Tartu, Estonian Biocentre, Tartu, Estonia
    PLoS ONE 2:e829. 2007
    ..This pause in movement was followed by a swift migration southward that distributed the founder types all the way to South America. The data also suggest more recent bi-directional gene flow between Siberia and the North American Arctic...
  16. pmc Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis
    Georgi Hudjashov
    Estonian Biocentre and Tartu University, Department of Evolutionary Biology, Riia 23, 51010 Tartu, Estonia
    Proc Natl Acad Sci U S A 104:8726-30. 2007
    ....
  17. ncbi request reprint Peopling of South Asia: investigating the caste-tribe continuum in India
    Gyaneshwer Chaubey
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Bioessays 29:91-100. 2007
    ..This review attempts to summarize recent genetic studies on Indian caste and tribal populations with the focus on the information embedded in the socially defined structure of Indian populations...
  18. pmc The western and eastern roots of the Saami--the story of genetic "outliers" told by mitochondrial DNA and Y chromosomes
    Kristiina Tambets
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 74:661-82. 2004
    ..In particular, no evidence of a significant directional gene flow from extant aboriginal Siberian populations into the haploid gene pools of the Saami was found...
  19. pmc Origin and diffusion of mtDNA haplogroup X
    Maere Reidla
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 73:1178-90. 2003
    ..The position of X2a in the phylogenetic tree suggests an early split from the other X2 clades, likely at the very beginning of their expansion and spread from the Near East...
  20. pmc Explaining the imperfection of the molecular clock of hominid mitochondria
    Eva Liis Loogväli
    Estonian Biocentre, Tartu, Estonia
    PLoS ONE 4:e8260. 2009
    ..However, for humans, the weakness of purifying selection has been further exacerbated by the population expansions associated with the out-of Africa migration and the end of the Last Ice Age...
  21. ncbi request reprint Predominance of a rare type of HIV-1 in Estonia
    Maarja Adojaan
    FIT Biotech Oyj Plc Eesti, Tartu, Estonia
    J Acquir Immune Defic Syndr 39:598-605. 2005
    ..At least 9 mosaic forms were identified, each with distinct patterns of multiple crossover. To characterize Estonian CRF06_cpx as well as recombinant isolates in more detail, 4 near-full-length HIV-1 genomes were sequenced...
  22. ncbi request reprint The unresolved location of Otzi's mtDNA within haplogroup K
    Phillip Endicott
    Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Am J Phys Anthropol 132:590-1; discussion 591-3. 2007
  23. ncbi request reprint Mitochondrial portraits of the Madeira and Açores archipelagos witness different genetic pools of its settlers
    Antonio Brehm
    Human Genetics Laboratory, Centre of Macaronesian Studies, University of Madeira, Campus of Penteada, 9000 Funchal, Portugal
    Hum Genet 114:77-86. 2003
    ..Nevertheless the recorded introduction of Canary native Guanches, who are characterized by the presence of particular sub-clade U6b1, has left no detectable imprints in the present day population of Madeira...
  24. ncbi request reprint An mtDNA perspective of French genetic variation
    Chrystelle Richard
    Laboratoire d Etude du Polymorphisme de l ADN, Faculte de Medecine, Nantes, France
    Ann Hum Biol 34:68-79. 2007
    ..The French has been insufficiently characterized so far for mitochondrial DNA (mtDNA) diversity...
  25. ncbi request reprint Reconstruction of patrilineages and matrilineages of Samaritans and other Israeli populations from Y-chromosome and mitochondrial DNA sequence variation
    Peidong Shen
    Stanford Genome Technology Center, Palo Alto, California 94305 5020, USA
    Hum Mutat 24:248-60. 2004
    ..Most of the former may be traced back to a common ancestor in the paternally-inherited Jewish high priesthood (Cohanim) at the time of the Assyrian conquest of the kingdom of Israel...
  26. ncbi request reprint Y chromosomal heritage of Croatian population and its island isolates
    Lovorka Barac
    Institute for Anthropological Research, Zagreb, Croatia
    Eur J Hum Genet 11:535-42. 2003
    ..Interestingly, the same population also harbored mitochondrial haplogroup F that is virtually absent in European populations--indicating a connection with Central Asian populations, possibly the Avars...
  27. pmc Maternal footprints of Southeast Asians in North India
    Kumarasamy Thangaraj
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Hum Hered 66:1-9. 2008
    ..The presence of R6 in the Nepalese, on the other hand, suggests that the gene flow between India and Nepal has been reciprocal...
  28. pmc Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora
    Doron M Behar
    Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa, Israel
    PLoS ONE 3:e2062. 2008
    ..These findings highlight striking differences in the demographic history of the widespread Jewish Diaspora...
  29. pmc Evidence of authentic DNA from Danish Viking Age skeletons untouched by humans for 1,000 years
    Linea Melchior
    Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 3:e2214. 2008
    ....
  30. doi request reprint Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in Greenland
    M Thomas P Gilbert
    Center for Ancient Genetics, Department of Biology, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 320:1787-9. 2008
    ..This result suggests that the earliest migrants into the New World's northern extremes derived from populations in the Bering Sea area and were not directly related to Native Americans or the later Neo-Eskimos that replaced them...
  31. pmc To trust or not to trust an idiosyncratic mitochondrial data set
    Yong Gang Yao
    Am J Hum Genet 72:1341-6; author reply 1346-9. 2003
  32. pmc Phylogeographic differentiation of mitochondrial DNA in Han Chinese
    Yong Gang Yao
    Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    Am J Hum Genet 70:635-51. 2002
    ....
  33. ncbi request reprint Excavating Y-chromosome haplotype strata in Anatolia
    Cengiz Cinnioglu
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5120, USA
    Hum Genet 114:127-48. 2004
    ..The variety of Turkish haplotypes is witness to Turkey being both an important source and recipient of gene flow...
  34. ncbi request reprint Different population histories of the Mundari- and Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp deletion/insertion polymorphism in Indian populations
    Kumarasamy Thangaraj
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
    Hum Genet 116:507-17. 2005
    ..More than 18 independent origins of the deletion or insertion mutation could be inferred in the phylogenetic analysis of the D-loop sequences...
  35. ncbi request reprint The population history of the Croatian linguistic minority of Molise (southern Italy): a maternal view
    Carla Babalini
    Department of Biology, University of Rome Tor Vergata, Italy
    Eur J Hum Genet 13:902-12. 2005
    ....
  36. ncbi request reprint Reconstructing the origin of Andaman Islanders
    Kumarasamy Thangaraj
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    Science 308:996. 2005
    ..In contrast, Nicobarese sequences illustrate a close genetic relationship with populations from Southeast Asia...
  37. ncbi request reprint Y-chromosome lineages from Portugal, Madeira and Açores record elements of Sephardim and Berber ancestry
    Rita Goncalves
    Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
    Ann Hum Genet 69:443-54. 2005
    ....
  38. ncbi request reprint Y-chromosome lineages in Cabo Verde Islands witness the diverse geographic origin of its first male settlers
    Rita Goncalves
    Human Genetics Laboratory, Center of Macaronesian Studies, University of Madeira, Campus of Penteada, 9000 390 Funchal, Portugal
    Hum Genet 113:467-72. 2003
    ..9%. Overall, these results indicate that gene flow from multiple sources and various sex-specific patterns have been important in the formation of the genomic diversity in the Cabo Verde islands...
  39. pmc The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 75:910-8. 2004
    ..The survey revealed that the previously reported excess of H among these families is caused entirely by H3 and is due to a major, probably nonrecent, founder event...
  40. pmc Traces of archaic mitochondrial lineages persist in Austronesian-speaking Formosan populations
    Jean A Trejaut
    Transfusion Medicine Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
    PLoS Biol 3:e247. 2005
    ....
  41. ncbi request reprint Mitochondrial genes and schizophrenia
    Hans Jurgen Bandelt
    Schizophr Res 72:267-9. 2005
  42. ncbi request reprint What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
    Armand M Leroi
    Department of Biological Sciences, Imperial College London, Silwood Park Campus, Ascot, Berks, SL5 7PY, UK
    Mech Ageing Dev 126:421-9. 2005
    ..This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study...
  43. ncbi request reprint High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, 20146 Hamburg, Germany
    Biochem Biophys Res Commun 352:283-91. 2007
    ..Here, we re-analyse four problematic LHON studies and propose guidelines by which some of the pitfalls could be avoided...
  44. pmc Two sources of the Russian patrilineal heritage in their Eurasian context
    Oleg Balanovsky
    Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, Russia
    Am J Hum Genet 82:236-50. 2008
    ....
  45. ncbi request reprint Use of y chromosome and mitochondrial DNA population structure in tracing human migrations
    Peter A Underhill
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Annu Rev Genet 41:539-64. 2007
    ..We introduce new results concerning Y chromosome founder haplogroups C, DE, and F that resolve their previous trifurcation and improve the harmony with the mtDNA recapitulation of the out-of-Africa migration...
  46. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  47. pmc The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event
    Doron M Behar
    Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 78:487-97. 2006
    ..We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium...
  48. ncbi request reprint High prevalence of the CCR5Delta32 HIV-resistance mutation among Estonian HIV type 1-infected individuals
    Maarja Adojaan
    FIT Biotech Oyj Plc Eesti Filiaal, Institute of Molecular and Cell Biology, University of Tartu, Nooruse 9, Tartu 50411, Estonia
    AIDS Res Hum Retroviruses 23:193-7. 2007
    ....