Affiliation: Institute of Molecular and Cell Biology
Kadaja L, Laos S, Maimets T. Overexpression of leukocyte marker CD43 causes activation of the tumor suppressor proteins p53 and ARF. Oncogene. 2004;23:2523-30 pubmed
..These data provide the first evidence of the connection between p53- and CD43-dependent pathways. ..
Kadaja Saarepuu L, Laos S, Jääger K, Viil J, Balikova A, Lõoke M, et al. CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. Oncogene. 2008;27:1705-15 pubmed
..These observations suggest CD43 as a potential contributor to tumor development and the functional ARF-p53 pathway is required for the elimination of cells with aberrant CD43 expression. ..