Magnus Essand

Summary

Publications

  1. doi request reprint Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
    Victoria Hillerdal
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University SE 75185 Uppsala, Sweden
    BMC Cancer 14:30. 2014
  2. doi request reprint Virotherapy of neuroendocrine tumors
    Magnus Essand
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Neuroendocrinology 97:26-34. 2013
  3. pmc Genetically engineered T cells for the treatment of cancer
    M Essand
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Intern Med 273:166-81. 2013
  4. doi request reprint Oncolytic viruses for the treatment of neuroendocrine tumors
    M Essand
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden
    Horm Metab Res 43:877-83. 2011
  5. pmc Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
    Di Yu
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e54952. 2013
  6. pmc Tat-PTD-modified oncolytic adenovirus driven by the SCG3 promoter and ASH1 enhancer for neuroblastoma therapy
    Chuan Jin
    Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala SE 75185, Sweden
    Hum Gene Ther 24:766-75. 2013
  7. pmc Adenovirus with hexon Tat-protein transduction domain modification exhibits increased therapeutic effect in experimental neuroblastoma and neuroendocrine tumors
    Di Yu
    Department of Immunology, Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden
    J Virol 85:13114-23. 2011
  8. pmc The HDAC inhibitor FK228 enhances adenoviral transgene expression by a transduction-independent mechanism but does not increase adenovirus replication
    Angelika Danielsson
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e14700. 2011
  9. pmc T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells
    Victoria Hillerdal
    Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    Proc Natl Acad Sci U S A 109:15877-81. 2012
  10. pmc An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
    Mohanraj Ramachandran
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Mol Ther 21:2008-18. 2013

Collaborators

  • Fredrik Eriksson
  • Binfeng Lu
  • Katarina Le Blanc
  • Angelica S I Loskog
  • Goran Akerstrom
  • Kjell Oberg
  • Di Yu
  • Berith Nilsson
  • Justyna Leja
  • Mohanraj Ramachandran
  • Victoria Hillerdal
  • Chuan Jin
  • Christian Molnar
  • Olle Korsgren
  • Moa Fransson
  • Angelika Danielsson
  • Rachel Adamson
  • Lene Uhrbom
  • Jing Xu
  • Bengt Westermark
  • Karin Forsberg-Nilsson
  • Erik Larsson
  • Christian Berne
  • Lars Wennberg
  • Xiaolong Fan
  • Alkwin Wanders
  • Norman Maitland
  • Matko Cančer
  • Gunnar Tufveson
  • Eva Brittebo
  • Peetra U Magnusson
  • Elena Piras
  • Joachim Burman
  • Bjorn Carlsson
  • Robert A Harris
  • Victoria Rashkova
  • Nadim Majdalani
  • Wing Shing Cheng
  • Helena Dzojic
  • Elisabet Gustafson
  • Valeria Giandomenico

Detail Information

Publications13

  1. doi request reprint Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
    Victoria Hillerdal
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University SE 75185 Uppsala, Sweden
    BMC Cancer 14:30. 2014
    ..The prostate stem cell antigen (PSCA) is a protein expressed on the surface of prostate epithelial cells as well as in primary and metastatic prostate cancer cells and therefore a promising target for immunotherapy of prostate cancer...
  2. doi request reprint Virotherapy of neuroendocrine tumors
    Magnus Essand
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Neuroendocrinology 97:26-34. 2013
    ..In addition, it points out the advantages and shortcomings of using replicating viruses in the treatment of cancer and addresses research fields that can increase the efficacy of virus-based therapy...
  3. pmc Genetically engineered T cells for the treatment of cancer
    M Essand
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Intern Med 273:166-81. 2013
    ..Here we review the recent progress in the field, and summarize the challenges that lie ahead and the strategies being used to overcome them...
  4. doi request reprint Oncolytic viruses for the treatment of neuroendocrine tumors
    M Essand
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden
    Horm Metab Res 43:877-83. 2011
    ..This article reviews the recent literature on oncolytic viruses used so far for neuroendocrine tumors and indicates important issues to focus on in the future...
  5. pmc Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
    Di Yu
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e54952. 2013
    ....
  6. pmc Tat-PTD-modified oncolytic adenovirus driven by the SCG3 promoter and ASH1 enhancer for neuroblastoma therapy
    Chuan Jin
    Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala SE 75185, Sweden
    Hum Gene Ther 24:766-75. 2013
    ..Furthermore, it delays tumor growth and thereby prolonged survival for nude mice harboring subcutaneous human neuroblastoma xenograft. In conclusion, we report a novel oncolytic adenovirus with potential use for neuroblastoma therapy...
  7. pmc Adenovirus with hexon Tat-protein transduction domain modification exhibits increased therapeutic effect in experimental neuroblastoma and neuroendocrine tumors
    Di Yu
    Department of Immunology, Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden
    J Virol 85:13114-23. 2011
    ..Our data suggest that modification of Ad5 with Tat-PTD in HVR5 expands its utility as an oncolytic agent...
  8. pmc The HDAC inhibitor FK228 enhances adenoviral transgene expression by a transduction-independent mechanism but does not increase adenovirus replication
    Angelika Danielsson
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e14700. 2011
    ..Furthermore, since histone deacetylase inhibitors may affect the differentiation of cells, it is important to keep in mind that the activity and specificity of tissue- and tumor-specific promoters may also be affected...
  9. pmc T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells
    Victoria Hillerdal
    Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    Proc Natl Acad Sci U S A 109:15877-81. 2012
    ..To our knowledge this report on engineering of T cells with a TCR directed against an antigen specifically expressed by prostate cells is unique...
  10. pmc An infection-enhanced oncolytic adenovirus secreting H. pylori neutrophil-activating protein with therapeutic effects on neuroendocrine tumors
    Mohanraj Ramachandran
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Mol Ther 21:2008-18. 2013
    ..Our observations suggest that HP-NAP can serve as a potent immunomodulator in promoting antitumor immune response in the tumor microenvironment and enhance the therapeutic effect of oncolytic adenovirus...
  11. pmc Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability
    Justyna Leja
    Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 5:e8916. 2010
    ..Herein, we explore miRNA-based regulation of E1A expression as a complementary mechanism to promoter-based transcriptional control...
  12. pmc CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
    Moa Fransson
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Neuroinflammation 9:112. 2012
    ..Here, we propose gene engineering to achieve CNS-targeting Tregs from naïve CD4 cells and demonstrate their efficacy in the EAE model...
  13. doi request reprint Islet engraftment and revascularization in clinical and experimental transplantation
    Christian Molnar
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Cell Transplant 22:243-51. 2013
    ..Also, formation of an extensive intraislet capillary network, similar to that seen in native islets in the pancreas, was seen after clinical islet transplantation...