Virotherapy of neuroendocrine tumorsMagnus Essand
Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Neuroendocrinology 97:26-34. 2013
..In addition, it points out the advantages and shortcomings of using replicating viruses in the treatment of cancer and addresses research fields that can increase the efficacy of virus-based therapy...
Genetically engineered T cells for the treatment of cancerM Essand
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
J Intern Med 273:166-81. 2013
..Here we review the recent progress in the field, and summarize the challenges that lie ahead and the strategies being used to overcome them...
- Oncolytic viruses for the treatment of neuroendocrine tumors
M Essand
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden
Horm Metab Res 43:877-83. 2011
..This article reviews the recent literature on oncolytic viruses used so far for neuroendocrine tumors and indicates important issues to focus on in the future...
- Adenovirus with hexon Tat-protein transduction domain modification exhibits increased therapeutic effect in experimental neuroblastoma and neuroendocrine tumors
Di Yu
Department of Immunology, Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden
J Virol 85:13114-23. 2011
..Our data suggest that modification of Ad5 with Tat-PTD in HVR5 expands its utility as an oncolytic agent...
- The HDAC inhibitor FK228 enhances adenoviral transgene expression by a transduction-independent mechanism but does not increase adenovirus replication
Angelika Danielsson
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
PLoS ONE 6:e14700. 2011
..Furthermore, since histone deacetylase inhibitors may affect the differentiation of cells, it is important to keep in mind that the activity and specificity of tissue- and tumor-specific promoters may also be affected...
- Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
Di Yu
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
PLoS ONE 8:e54952. 2013
....
- T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells
Victoria Hillerdal
Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Proc Natl Acad Sci U S A 109:15877-81. 2012
..To our knowledge this report on engineering of T cells with a TCR directed against an antigen specifically expressed by prostate cells is unique...
- CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Moa Fransson
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
J Neuroinflammation 9:112. 2012
..Here, we propose gene engineering to achieve CNS-targeting Tregs from naïve CD4 cells and demonstrate their efficacy in the EAE model...
- Islet engraftment and revascularization in clinical and experimental transplantation
Christian Molnar
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Cell Transplant 22:243-51. 2013
..Also, formation of an extensive intraislet capillary network, similar to that seen in native islets in the pancreas, was seen after clinical islet transplantation...
- Double-detargeted oncolytic adenovirus shows replication arrest in liver cells and retains neuroendocrine cell killing ability
Justyna Leja
Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
PLoS ONE 5:e8916. 2010
..Herein, we explore miRNA-based regulation of E1A expression as a complementary mechanism to promoter-based transcriptional control...
