Christian Ertmer

Summary

Publications

  1. pmc Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome I 00161, Italy
    Crit Care 15:R217. 2011
  2. ncbi request reprint Efficacy and safety of 10% HES 130/0.4 versus 10% HES 200/0.5 for plasma volume expansion in cardiac surgery patients
    C Ertmer
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Muenster Muenster, Germany
    Minerva Med 103:111-22. 2012
  3. pmc Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 14:R232. 2010
  4. pmc Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 13:R130. 2009
  5. pmc Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 12:R143. 2008
  6. pmc Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
    Crit Care 10:R144. 2006
  7. doi request reprint Effects of balanced crystalloid vs. 0.9% saline-based vs. balanced 6% tetrastarch infusion on renal function and tubular integrity in ovine endotoxemic shock
    Christian Ertmer
    Departments of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 39:783-92. 2011
  8. ncbi request reprint Vasopressin analogues in the treatment of shock states: potential pitfalls
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 22:393-406. 2008
  9. ncbi request reprint Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia
    C Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
    Br J Anaesth 99:830-6. 2007
  10. ncbi request reprint Relevance of non-albumin colloids in intensive care medicine
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Street 33, 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 23:193-212. 2009

Detail Information

Publications49

  1. pmc Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome I 00161, Italy
    Crit Care 15:R217. 2011
    ..The primary study end point was a difference of ≥ 20% in the microvascular flow index of small vessels among groups...
  2. ncbi request reprint Efficacy and safety of 10% HES 130/0.4 versus 10% HES 200/0.5 for plasma volume expansion in cardiac surgery patients
    C Ertmer
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Muenster Muenster, Germany
    Minerva Med 103:111-22. 2012
    ..g., HES 130/0.4, are characterised by improved pharmacological properties. The present study was designed to compare the efficacy and safety of 10% HES 130/0.4 and 10% HES 200/0.5...
  3. pmc Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 14:R232. 2010
    ..e. dobutamine). The primary end point was a difference of ≥ 20% in the microvascular flow index of small vessels (MFIs) among groups...
  4. pmc Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 13:R130. 2009
    ....
  5. pmc Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
    Crit Care 12:R143. 2008
    ..The aim of the present study was, therefore, to investigate the effects of a first-line therapy with either phenylephrine or norepinephrine on systemic and regional hemodynamics in patients with septic shock...
  6. pmc Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
    Crit Care 10:R144. 2006
    ..The purpose of the present study was to evaluate whether dobutamine may be titrated to reverse the AVP-related decrease in cardiac index (CI) and systemic oxygen delivery index (DO2I) in an established model of ovine endotoxemia...
  7. doi request reprint Effects of balanced crystalloid vs. 0.9% saline-based vs. balanced 6% tetrastarch infusion on renal function and tubular integrity in ovine endotoxemic shock
    Christian Ertmer
    Departments of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 39:783-92. 2011
    ..9% saline-based and balanced 6% tetrastarch solutions, on renal function and ultrastructural morphologic correlates of acute kidney injury in an established model of ovine endotoxemic shock...
  8. ncbi request reprint Vasopressin analogues in the treatment of shock states: potential pitfalls
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 22:393-406. 2008
    ..Finally, platelet count, surrogate variables of hepatic dysfunction, electrolytes and osmolality should be strictly monitored in patients treated with vasopressin analogues...
  9. ncbi request reprint Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia
    C Ertmer
    Department of Anaesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
    Br J Anaesth 99:830-6. 2007
    ....
  10. ncbi request reprint Relevance of non-albumin colloids in intensive care medicine
    Christian Ertmer
    Department of Anaesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Street 33, 48149 Muenster, Germany
    Best Pract Res Clin Anaesthesiol 23:193-212. 2009
    ..Such studies are currently ongoing and their results should be awaited before drawing final conclusions on the HES preparations...
  11. doi request reprint Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shock
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Anesthesiology 112:936-47. 2010
    ..The current study evaluates the effects of saline-based 6% HES 130/0.4, 10% HES 200/0.5, and a balanced isotonic crystalloid on renal function and microscopic changes in ovine endotoxemic shock...
  12. ncbi request reprint Continuous versus bolus infusion of terlipressin in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Shock 28:623-9. 2007
    ..Continuous low-dose terlipressin infusion may represent a useful alternative treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome...
  13. doi request reprint Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 38:2016-23. 2010
    ..To compare the effects of a first-line therapy of combined arginine vasopressin, levosimendan, and norepinephrine with arginine vasopressin + norepinephrine or norepinephrine alone in ovine septic shock...
  14. ncbi request reprint Hemodynamic effects of titrated norepinephrine in healthy versus endotoxemic sheep
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    J Endotoxin Res 13:53-7. 2007
    ....
  15. doi request reprint Somatostatin infusion increases intestinal ischemia and does not improve vasoconstrictor response to norepinephrine in ovine endotoxemia
    Stefan Lauer
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Shock 30:603-9. 2008
    ..In addition, combined SOMA and NE therapy resulted in intestinal injury. Therefore, SOMA does not seem to represent a therapeutic option to treat arterial hypotension resulting from sepsis and systemic inflammatory response syndrome...
  16. doi request reprint Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
    Inflamm Res 60:429-37. 2011
    ..To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model...
  17. ncbi request reprint Employing dobutamine as a useful agent to reverse the terlipressin-linked impairments in cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep
    Katrin Bröking
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 29:71-7. 2008
    ..This study provides evidence that dobutamine in a dosage of 2 microg x kg(1) x min(1) is useful to reverse the terlipressin-linked depressions in CI, DO(2)I and SvO(2) in ovine endotoxemia without obvious side effects...
  18. ncbi request reprint Methylprednisolone reverses vasopressin hyporesponsiveness in ovine endotoxemia
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 27:281-8. 2007
    ....
  19. ncbi request reprint Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implications
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Germany
    Shock 28:394-400. 2007
    ....
  20. doi request reprint Role of selective V1a receptor agonism in ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care Med 39:119-25. 2011
    ..arginine vasopressin or norepinephrine on cardiopulmonary hemodynamics and organ function in ovine septic shock...
  21. ncbi request reprint Continuously infused glipizide reverses the hyperdynamic circulation in ovine endotoxemia
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Shock 27:701-6. 2007
    ..From these results, we conclude that continuous glipizide infusion may represent a useful therapeutic option in the treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome...
  22. doi request reprint Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, 48149, Muenster, Germany
    Intensive Care Med 35:1286-96. 2009
    ..To compare the effects of first-line therapy with low-dose arginine vasopressin (AVP) or terlipressin (TP) on mesenteric blood flow, plasma AVP levels, organ function and mortality in ovine septic shock...
  23. doi request reprint Fluid resuscitation in patients with traumatic brain injury: what is a SAFE approach?
    Hugo K Van Aken
    Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 25:563-5. 2012
    ..The purpose of the present article is to review the underlying physiology of osmolality and fluid therapy in TBI...
  24. pmc Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str, 33, Muenster 48149, Germany
    Crit Care 14:R200. 2010
    ..the mixed V(1a)R/V(2)R-agonist arginine vasopressin (AVP) or placebo in an established ovine model of septic shock...
  25. doi request reprint Fluid resuscitation in multiple trauma patients
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 24:202-8. 2011
    ..The coincidence of brain injury complicates management of these patients. This article summarizes the current knowledge on nonblood component fluid resuscitation and choice of fluids in patients with multiple trauma...
  26. doi request reprint Role of levosimendan in sepsis and septic shock
    Bernardo Bollen Pinto
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Curr Opin Anaesthesiol 21:168-77. 2008
    ..To present the pharmacologic and biologic profile of levosimendan and discuss potential indications in the treatment of sepsis and septic shock, with a special focus on myocardial and pulmonary dysfunction...
  27. ncbi request reprint Vasopressin vs. terlipressin in the treatment of cardiovascular failure in sepsis
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Intensive Care Med 34:821-32. 2008
    ..We briefly describe the pathophysiology and pharmacology of septic shock relevant to the treatment with vasopressin analogues. In addition, differences in pharmacokinetics and pharmacodynamics between AVP and TP are discussed...
  28. ncbi request reprint Arteriovenous carboxyhemoglobin difference in critical illness: fiction or fact?
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Munster, Munster, Germany
    Biochem Biophys Res Commun 299:479-82. 2002
    ..001 each). We conclude that (a) arteriovenous COHb difference per se does not reflect critical illness and (b) measurements with an ABL 625 underestimate COHb concentrations...
  29. ncbi request reprint Processing of stored packed red blood cells using autotransfusion devices decreases potassium and microaggregates: a prospective, randomized, single-blinded in vitro study
    B Westphal-Varghese
    Department of Transfusion Medicine, University of Muenster, Muenster, Germany
    Transfus Med 17:89-95. 2007
    ..e. hyperkalaemia and microvascular obstruction secondary to free cell fragments. This approach could be especially useful in patients undergoing massive transfusion and/or suffering from renal failure...
  30. ncbi request reprint [Role of adrenomedullin in the pathogenesis and treatment of cardiovascular dysfunctions and sepsis]
    M Westphal
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum, Munster
    Anaesthesist 55:171-8. 2006
    ..The objectives of this review article are to characterize the regulative properties of AM and to discuss clinical and experimental studies which allow to judge the role of AM in the setting of cardiovascular dysfunction and sepsis...
  31. doi request reprint Sleep disturbances after posterior scoliosis surgery with an intraoperative wake-up test using remifentanil
    Sebastian Rehberg
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Anesthesiology 109:629-41. 2008
    ..In this prospective, single-blinded cohort study, the impact of the wake-up test and the opioid used for anesthesia on the quality of the patients' sleep after scoliosis surgery was investigated up to 12 months postoperatively...
  32. pmc Arginine vasopressin versus norepinephrine: will the stronger one win the race?
    Christian Ertmer
    Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
    Crit Care 10:144. 2006
    ..This in turn raises the question whether the quality of vasopressors should be judged by their potency...
  33. doi request reprint Fluid therapy in critical illness: a special focus on indication, the use of hydroxyethyl starch and its different raw materials
    Christian Ertmer
    Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Munster, Germany
    Curr Opin Anaesthesiol 26:253-60. 2013
    ....
  34. pmc Translational research in sepsis - an ultimate challenge?
    Tim G Kampmeier
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Exp Transl Stroke Med 3:14. 2011
    ..The present article elucidates some of the difficulties in translating research from bench to bedside...
  35. ncbi request reprint Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transport
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Shock 28:530-5. 2007
    ..These data suggest that oral glibenclamide in doses from 10 to 30 mg fails to counteract arterial hypotension and thus to reduce norepinephrine requirements in catecholamine-dependent human septic shock...
  36. ncbi request reprint Hemodynamic effects of thoracic epidural analgesia in ovine hyperdynamic endotoxemia
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital of Bern, Bern, Switzerland
    Reg Anesth Pain Med 32:311-6. 2007
    ..The objective of the present study was to assess the effects of TEA on systemic and pulmonary hemodynamics in a sepsis model of hyperdynamic endotoxemia...
  37. ncbi request reprint "Terlipressin in the treatment of septic shock: the earlier the better"?
    Andrea Morelli
    Department of Anaesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Best Pract Res Clin Anaesthesiol 22:317-21. 2008
    ..Randomised, clinical multicenter trials are now needed to investigate whether or not early institution of low-dose continuous terlipressin infusion improves overall outcome of patients suffering from vasodilatory shock states...
  38. ncbi request reprint Is vasopressin increasing or decreasing mortality in patients with septic shock?
    Sebastian Rehberg
    Surg Infect (Larchmt) 9:215 author reply 216. 2008
  39. ncbi request reprint Short-term effects of phenylephrine on systemic and regional hemodynamics in patients with septic shock: a crossover pilot study
    Andrea Morelli
    Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
    Shock 29:446-51. 2008
    ..Our results suggest that for the same MAP, phenylephrine causes a more pronounced hepatosplanchnic vasoconstriction as compared with NE...
  40. ncbi request reprint Vasopressin in critical illness: sometimes even old players leave a lot to discover. Preface
    Martin Westphal
    Best Pract Res Clin Anaesthesiol 22:vii-ix. 2008
  41. ncbi request reprint Calcium sensitizing in sepsis: is levosimendan on the right path?
    Andrea Morelli
    Crit Care Med 36:1981-2. 2008
  42. ncbi request reprint Combining arginine-vasopressin with catecholamines during cardiopulmonary resuscitation: mirror, mirror, on the wall, is there a best mixture at all?
    Martin Westphal
    Crit Care Med 33:2705-6. 2005
  43. doi request reprint Effects of inhaled aerosolized iloprost and inhaled NO on pulmonary circulation and edema formation in ovine lung injury
    Christoph Hucklenbruch
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Munster, Germany
    Shock 30:75-80. 2008
    ..In contrast to iNO, the investigated dose of iloprost was ineffective to attenuate acute lung injury-induced changes in pulmonary hemodynamics and lung edema in this experimental model...
  44. ncbi request reprint Terlipressin for haemodynamic support in septic shock: less may be more
    Christian Ertmer
    Resuscitation 70:292-3. 2006
  45. ncbi request reprint Ten years of vasopressin research in septic shock: constant dripping wears the stone
    Andrea Morelli
    Crit Care Med 35:2447-8. 2007
  46. ncbi request reprint Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?
    Andrea Morelli
    Intensive Care Med 33:1669-70. 2007
  47. ncbi request reprint Norepinephrine in septic shock--does the early bird catch the worm?
    Christian Ertmer
    Crit Care Med 35:1794-5. 2007
  48. ncbi request reprint Cyclooxygenase-2 inhibition and increased arterial vasoconstriction to vasopressin: what is the link?
    Christian Ertmer
    Crit Care Med 36:353-4. 2008
  49. doi request reprint Levo is in the air: take a deep breath!
    Christian Ertmer
    Crit Care Med 36:1979-81. 2008