W B Ershler

Summary

Publications

  1. ncbi request reprint Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    W B Ershler
    Institute for the Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20006, USA
    Annu Rev Med 51:245-70. 2000
  2. ncbi request reprint Capecitabine use in geriatric oncology: an analysis of current safety, efficacy, and quality of life data
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    Crit Rev Oncol Hematol 58:68-78. 2006
  3. ncbi request reprint Capecitabine monotherapy: safe and effective treatment for metastatic breast cancer
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    Oncologist 11:325-35. 2006
  4. ncbi request reprint Cancer: a disease of the elderly
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    J Support Oncol 1:5-10. 2003
  5. ncbi request reprint Issues of aging and geriatric medicine: relevance to cancer treatment and hematopoietic reconstitution
    William B Ershler
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 12:100-6. 2006
  6. ncbi request reprint Cancer and ageing: a nexus at several levels
    Lodovico Balducci
    Senior Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Rev Cancer 5:655-62. 2005
  7. ncbi request reprint Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature
    Claudia Beghe
    Division of Geriatrics, University of South Florida, Tampa, Florida 33612, USA
    Am J Med 116:3S-10S. 2004
  8. doi request reprint Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim
    Lodovico Balducci
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Oncologist 12:1416-24. 2007
  9. ncbi request reprint Meeting report: Translational Research at the Aging and Cancer Interface
    Christopher C Benz
    Buck Institute for Age Research, Novato, California, USA
    Cancer Res 67:4560-3. 2007
  10. ncbi request reprint Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006

Research Grants

  1. 2004 Conference on Advancing Cancer Care in Elderly
    WILLIAM ERSHLER; Fiscal Year: 2005

Detail Information

Publications27

  1. ncbi request reprint Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    W B Ershler
    Institute for the Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20006, USA
    Annu Rev Med 51:245-70. 2000
    ..Like the syndrome of inappropriate antidiuretic hormone, it is possible that certain clinically important late-life changes are due to an inappropriate presence of IL-6...
  2. ncbi request reprint Capecitabine use in geriatric oncology: an analysis of current safety, efficacy, and quality of life data
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    Crit Rev Oncol Hematol 58:68-78. 2006
    ..For both breast and colon cancer, capecitabine alone or in combination with other cytotoxics is safe and effective...
  3. ncbi request reprint Capecitabine monotherapy: safe and effective treatment for metastatic breast cancer
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    Oncologist 11:325-35. 2006
    ..Nonetheless, the drug administered alone is a reasonable choice when single-agent chemotherapy is entertained as a treatment option for metastatic breast cancer, including in the first-line setting...
  4. ncbi request reprint Cancer: a disease of the elderly
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20007, USA
    J Support Oncol 1:5-10. 2003
    ..The goals of managing cancer in older patients may differ from those in younger patients, as the potential benefits of treatment decrease and the risks of treatment and the need for supportive care increase...
  5. ncbi request reprint Issues of aging and geriatric medicine: relevance to cancer treatment and hematopoietic reconstitution
    William B Ershler
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 12:100-6. 2006
    ..Such assessment would also identify those who are likely to benefit from more aggressive treatments, including bone marrow or stem cell transplantation...
  6. ncbi request reprint Cancer and ageing: a nexus at several levels
    Lodovico Balducci
    Senior Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Rev Cancer 5:655-62. 2005
    ....
  7. ncbi request reprint Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature
    Claudia Beghe
    Division of Geriatrics, University of South Florida, Tampa, Florida 33612, USA
    Am J Med 116:3S-10S. 2004
    ....
  8. doi request reprint Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim
    Lodovico Balducci
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Oncologist 12:1416-24. 2007
    ....
  9. ncbi request reprint Meeting report: Translational Research at the Aging and Cancer Interface
    Christopher C Benz
    Buck Institute for Age Research, Novato, California, USA
    Cancer Res 67:4560-3. 2007
  10. ncbi request reprint Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006
    ..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process...
  11. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
    ..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts...
  12. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  13. ncbi request reprint A gripping reality: oxidative stress, inflammation, and the pathway to frailty
    William B Ershler
    J Appl Physiol 103:3-5. 2007
  14. ncbi request reprint Framework for evaluating disease severity measures in older adults with comorbidity
    Cynthia M Boyd
    Johns Hopkins University School of Medicine, Division of Geriatric Medicine and Gerontology, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 62:286-95. 2007
    ..Although approaches to classifying severity of individual diseases and conditions have been developed, the utility of these classification systems has not been evaluated in the presence of multiple conditions...
  15. ncbi request reprint A report card for geriatric oncology: borderline pass, improvement needed
    William B Ershler
    J Gerontol A Biol Sci Med Sci 61:688. 2006
  16. ncbi request reprint Economic burden of patients with anemia in selected diseases
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC, USA
    Value Health 8:629-38. 2005
    ..To examine the economic impact of patients with anemia in selected diseases...
  17. ncbi request reprint Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database
    William F Anderson
    NCI Division of Cancer Prevention, EPN, Bethesda, MD 20892 7317, USA
    Breast Cancer Res Treat 76:27-36. 2002
    ..Researchers question whether estrogen receptor alpha-negative (ERN) and -positive (ERP) represent different stages of one disease or different breast cancer types...
  18. ncbi request reprint Biological interactions of aging and anemia: a focus on cytokines
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC 20006, USA
    J Am Geriatr Soc 51:S18-21. 2003
    ....
  19. ncbi request reprint Future challenges in analysis and treatment of human immune senescence
    Juan Salvador
    Institute for Advanced Studies in Aging and Geriatric Medicine, 1700 Wisconsin Ave, NW, Washington, DC 20007, USA
    Immunol Allergy Clin North Am 23:133-48. 2003
    ..More selective approaches, such as with specific cytokines or organ transplantation are of experimental interest but are quite distant from achieving clinical applicability as interventions to restore immunity in the frail elderly...
  20. ncbi request reprint In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging
    Jian Zhang
    Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA
    Exp Gerontol 39:239-47. 2004
    ..We conclude that ability of ROS to act as secondary messengers and induce gene expression may contribute to the aging process...
  21. ncbi request reprint Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta)
    Sam Gandy
    Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mech Ageing Dev 125:149-51. 2004
    ..These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta...
  22. ncbi request reprint Aging biology and cancer
    Neelima Denduluri
    Institute for Advanced Studies in Aging and Geriatric Medicine, 1700 Wisconsin Avenue NW, Washington, DC 20007, USA
    Semin Oncol 31:137-48. 2004
    ..In this review we attempt to frame specific aspects of cancer biology in the context of normal aging...
  23. ncbi request reprint The influence of advanced age on cancer occurrence and growth
    William B Ershler
    Institute for Advanced Studies in Aging and Geriatric Medicine, Washington, DC, USA
    Cancer Treat Res 124:75-87. 2005
  24. ncbi request reprint Serum erythropoietin and aging: a longitudinal analysis
    William B Ershler
    Institute for Advanced Studies in Aging, Washington, DC, USA
    J Am Geriatr Soc 53:1360-5. 2005
    ..To determine the changes in serum erythropoietin with age in patients with and without anemia and to assess the importance of certain comorbidities on changes in erythropoietin level and the development of anemia...
  25. ncbi request reprint From bedside to bench: research agenda for frailty
    Linda P Fried
    Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
    Sci Aging Knowledge Environ 2005:pe24. 2005
    ..This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty...
  26. ncbi request reprint Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
    ..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin...
  27. doi request reprint Hutchinson-Gilford progeria syndrome
    William B Ershler
    N Engl J Med 358:2409-10; author reply 2410-1. 2008

Research Grants1

  1. 2004 Conference on Advancing Cancer Care in Elderly
    WILLIAM ERSHLER; Fiscal Year: 2005
    ..ACCE will also feature the first annual "Giving Our Commitment to Survivorship Gala" in which the GOC will celebrate two cancer survivors who demonstrate unfailing optimism and advocacy while surviving cancer. ..