Mert Erkan

Summary

Publications

  1. pmc How fibrosis influences imaging and surgical decisions in pancreatic cancer
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universität München Munich, Germany
    Front Physiol 3:389. 2012
  2. doi Understanding the stroma of pancreatic cancer: co-evolution of the microenvironment with epithelial carcinogenesis
    Mert Erkan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Pathol 231:4-7. 2013
  3. doi The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 12, 81675 Munich, Germany
    Nat Rev Gastroenterol Hepatol 9:454-67. 2012
  4. ncbi The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Curr Mol Med 12:288-303. 2012
  5. doi The role of pancreatic stellate cells in pancreatic cancer
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Klinikum rechts der Isar, 81675 Munich, Germany
    Pancreatology 13:106-9. 2013
  6. pmc Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 11:497-508. 2009
  7. ncbi Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1447-64. 2007
  8. doi Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer
    Tamar Samkharadze
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Gastroenterol 106:968-80. 2011
  9. pmc Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype
    Tiago De Oliveira
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Mol Cancer 11:19. 2012
  10. doi Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 251:923-31. 2010

Collaborators

Detail Information

Publications40

  1. pmc How fibrosis influences imaging and surgical decisions in pancreatic cancer
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universität München Munich, Germany
    Front Physiol 3:389. 2012
    ..In this review the impact of pancreatic fibrosis on diagnosis of pancreatic cancer and surgical decisions are discussed from a clinical point of view...
  2. doi Understanding the stroma of pancreatic cancer: co-evolution of the microenvironment with epithelial carcinogenesis
    Mert Erkan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Pathol 231:4-7. 2013
    ..This work may be instrumental for better understanding the types of stoma in PDAC before eliminating it non-selectively...
  3. doi The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 12, 81675 Munich, Germany
    Nat Rev Gastroenterol Hepatol 9:454-67. 2012
    ..Third, what are the (experimental) antifibrotic therapy options in PDAC? Fourth, what lessons can be learned from Langton's Ant (a simple mathematical model) regarding the unpredictability of genetically engineered mouse models?..
  4. ncbi The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance
    Mert Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Curr Mol Med 12:288-303. 2012
    ..In this review, the interaction of the epithelial tumor cells with the stroma in humans and in various animal models is scrutinized, and novel therapeutic options for uncoupling cancer-stroma interactions are discussed...
  5. doi The role of pancreatic stellate cells in pancreatic cancer
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Klinikum rechts der Isar, 81675 Munich, Germany
    Pancreatology 13:106-9. 2013
    ..Therefore, applying antifibrotic therapy at a late stage can be counterproductive. It may increase delivery of chemotherapy, but also lead to the escape of cancer cells...
  6. pmc Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Neoplasia 11:497-508. 2009
    ..Although both cancer and stellate cells (PSCs) secrete proangiogenic factors, pancreatic cancer is a scirrhous and hypoxic tumor. The impact of cancer-PSCs interactions on angiogenesis was analyzed...
  7. ncbi Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gastroenterology 132:1447-64. 2007
    ..The aim of this study was to analyze the impact of the PSC-specific matrix protein periostin on tumor responses to radiochemotherapy...
  8. doi Pigment epithelium-derived factor associates with neuropathy and fibrosis in pancreatic cancer
    Tamar Samkharadze
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Gastroenterol 106:968-80. 2011
    ..Its role in pancreatic fibrosis and neuropathy is unknown...
  9. pmc Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype
    Tiago De Oliveira
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Mol Cancer 11:19. 2012
    ..We have identified syndecan-2 as a protein potentially involved in perineural invasion of pancreatic adenocarcinoma (PDAC) cells...
  10. doi Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Ann Surg 251:923-31. 2010
    ..To further characterize the neurotrophic attributes of pancreatic cancer (PCa)...
  11. doi Comparative analysis of the revenues of pylorus-preserving pancreatic head resections and laparoscopic cholecystectomies as prototypic surgical procedures in the German health-care system
    Tina Stellwag
    Department of Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, Munich 81675, Germany
    Langenbecks Arch Surg 398:825-31. 2013
    ....
  12. pmc Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    J Transl Med 5:63. 2007
    ..Interactions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP)...
  13. pmc Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    PLoS ONE 3:e1701. 2008
    ..While cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown...
  14. doi Hypoxia inducible BHLHB2 is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    Weibin Wang
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Biochem Biophys Res Commun 401:422-8. 2010
    ..In the present study, the expression, regulation, functions and prognostic impact of BHLHB2 in pancreatic cancer were investigated...
  15. ncbi Neural fractalkine expression is closely linked to pain and pancreatic neuritis in human chronic pancreatitis
    Güralp O Ceyhan
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Lab Invest 89:347-61. 2009
    ..However, pancreatic fibrogenesis is probably indirectly influenced by fractalkine. Taken together, these novel findings suggest that CX3CR1 represents a potential novel therapeutic target to reduce inflammation and modulate pain in CP...
  16. pmc Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Mol Cancer 9:88. 2010
    ..To identify organ- and disease-specific stellate cell transcriptional fingerprints, we employed genome-wide transcriptional analysis of primary human PSC and HSC isolated from patients with chronic inflammation or cancer...
  17. pmc Cannabinoids in pancreatic cancer: correlation with survival and pain
    Christoph W Michalski
    Department of General Surgery, Technische Universität Munich, Munich, Germany
    Int J Cancer 122:742-50. 2008
    ..Therefore, changes in the levels of endocannabinoid metabolizing enzymes and cannabinoid receptors on pancreatic cancer cells may affect prognosis and pain status of PDAC patients...
  18. ncbi Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma
    Carolin Reiser-Erkan
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Cancer Biol Ther 7:1352-9. 2008
    ..Clinically, absence of Pim-1 expression correlates with poor prognosis in prostate cancer. In the present study, the expression of Pim-1 is analyzed in pancreatic cancer and correlated to clinicopathological parameters...
  19. doi Confirmation of DNA microarray-derived differentially expressed genes in pancreatic cancer using quantitative RT-PCR
    Sylvia Streit
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Pancreatology 9:577-82. 2009
    ....
  20. doi Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling
    Alexander Herner
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Int J Cancer 129:2349-59. 2011
    ..Glutamate might serve as a molecular switch that decreases the threshold of K-ras-induced oncogenic signalling and increases the chance of malignant transformation of pancreatic cancer precursor lesions...
  21. pmc Second-look operation for unresectable pancreatic ductal adenocarcinoma at a high-volume center
    Christoph W Michalski
    Department of General Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    Ann Surg Oncol 15:186-92. 2008
    ..The value of re-exploration for pancreatic ductal adenocarcinoma after the initial diagnosis of unresectability is unclear...
  22. ncbi Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells
    Zheng Pan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Int J Oncol 35:823-8. 2009
    ..18 months, respectively, p=0.006). Down-regulation of GRP94 decreases apoptosis resistance in pancreatic cancer cells. Clinically, patients with high GRP94 expression show a tendency for a worsened survival...
  23. doi The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Clin Gastroenterol Hepatol 6:1155-61. 2008
    ..Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed...
  24. doi Resection of primary pancreatic cancer and liver metastasis: a systematic review
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Dig Surg 25:473-80. 2008
    ....
  25. ncbi Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells
    Grace Kusumawidjaja
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 6:367-76. 2007
    ..In conclusion, BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis...
  26. doi Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer
    Xiaohua Jiang
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Pancreatology 9:165-72. 2009
    ..This study investigates the expression and localization of EG-VEGF and its receptors in pancreatic tissues and pancreatic stellate cells (PSCs)...
  27. pmc The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis
    Güralp O Ceyhan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Gut 56:534-44. 2007
    ..Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFRalpha3 was investigated in patients with chronic pancreatitis...
  28. ncbi Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells
    Weiwei Zhang
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Cancer Biol Ther 6:218-27. 2007
    ....
  29. pmc The neurotrophic factor artemin promotes pancreatic cancer invasion
    Güralp O Ceyhan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 244:274-81. 2006
    ..To analyze the role of Artemin in pancreatic ductal adenocarcinoma (PDAC) in terms of expression, influence on cancer cell behavior, and pain correlation...
  30. doi Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues
    Sylvia Streit
    Department of Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Nat Protoc 4:37-43. 2009
    ..This entire northern blotting protocol takes approximately 4 d to complete...
  31. ncbi From tissue turnover to the cell of origin for pancreatic cancer
    Bo Kong
    Department of Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Nat Rev Gastroenterol Hepatol 8:467-72. 2011
    ..An integrated approach combining techniques from stem cell and cancer biology will be necessary to define and map these cells...
  32. doi Energy metabolism and proliferation in pancreatic carcinogenesis
    Ivonne Regel
    Department of Surgery, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Langenbecks Arch Surg 397:507-12. 2012
    ..Uncontrolled cell proliferation is mediated by a number of core signaling pathways. Recently, novel data of PDAC biology suggest that these core signal pathways affect cell proliferation and metabolism simultaneously...
  33. ncbi Preoperative acute pancreatitis in periampullary tumors: implications for surgical management
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Digestion 75:165-71. 2007
    ..Currently there is no information about the impact of preoperative pancreatitis on the surgical management of periampullary tumors...
  34. pmc Standard abdominal wound edge protection with surgical dressings vs coverage with a sterile circular polyethylene drape for prevention of surgical site infections (BaFO): study protocol for a randomized controlled trial
    Andre L Mihaljevic
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Trials 13:57. 2012
    ..Approximately 14% to 30% of all patients undergoing elective open abdominal surgery are affected and methods to reduce surgical site infection rates warrant further investigation and evaluation in randomized controlled trials...
  35. doi Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery
    Norbert Hüser
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Ann Surg 248:52-60. 2008
    ..The role of a defunctioning stoma in patients undergoing low anterior resection for rectal cancer is still the subject of controversy. Recent studies suggest reduced morbidity after low anterior rectal resection with a defunctioning stoma...
  36. ncbi The role of inflammation in pancreatic cancer
    Simone Hausmann
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    Adv Exp Med Biol 816:129-51. 2014
    ..In this chapter, we discuss the role of inflammatory pathways in the initiation and progression of pancreatic cancer as well as the role of inhibitors used in treatment and prevention of pancreatic cancer. ..
  37. ncbi Tumor metabolism to blood flow ratio in pancreatic cancer: helpful in patient stratification?
    Christoph W Michalski
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Future Oncol 6:13-5. 2010
    ....
  38. ncbi Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    Mert Erkan
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
    Oncogene 24:4421-32. 2005
    ..In conclusion, loss of BNIP3 expression occurs late in pancreatic cancer, contributes to resistance to chemotherapy, and correlates with a worsened prognosis...
  39. pmc Cystic colon duplication causing intussusception in a 25-year-old man: report of a case and review of the literature
    Carolin Reiser-Erkan
    Department of General Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    BMC Surg 10:19. 2010
    ..In adults it may occur idiopathically or due to an intraluminal tumor mass...