- Schistosomiasis and HIV-1 infection in rural Zimbabwe: implications of coinfection for excretion of eggs
Center of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
J Infect Dis 191:1311-20. 2005
..This study explores the effect that HIV-1-associated immunodeficiency has on the excretion of schistosome eggs in a large cohort of coinfected individuals...
- T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication
Department of Clinical Immunology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
J Acquir Immune Defic Syndr 53:303-10. 2010
..CD4 T-cell recovery is impeded in some HIVinfected patients despite successful combination antiretroviral therapy (cART) with suppressed HIV RNA. We hypothesized that T-cell dysfunction would be increased in these patients...
- Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis
Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark
Am J Trop Med Hyg 79:331-7. 2008
..Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation...
- HLA-G 3' untranslated region 14-base pair deletion: association with poor survival in an HIV-1-infected Zimbabwean population
Margit Hørup Larsen
Department of Clinical Immunology, Copenhagen University Hospital Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
J Infect Dis 207:903-6. 2013
..004), lower CD4 cell count (P = .01), and increased mortality (hazard ratio, 1.9; 95% confidence interval, 1.033-3.522; P = .04) compared with HLA-G +14-bp carriers...
- CCL3L gene copy number and survival in an HIV-1 infected Zimbabwean population
Margit Hørup Larsen
Department of Clinical Immunology, Copenhagen University Hospital, Denmark
Infect Genet Evol 12:1087-93. 2012
..9), viral load (P=0.9), or CCL3 protein levels (P=1.0). Survival among the HIV infected individuals did not differ according to CCL3L copy number. In this cohort, CCL3L CNV did not affect HIV status, pathogenesis, or survival...
- Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment
Judith M Haissman
Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark
J Acquir Immune Defic Syndr 52:493-7. 2009
..To evaluate the role immune activation leading to the production and circulation of cytokines has in the pathogenesis of HIV infection in sub-Saharan Africa and the effect of antiretroviral treatment (ART) on these parameters...
- The impact of B-cell perturbations on pneumococcal conjugate vaccine response in HIV-infected adults
Thomas G Johannesson
Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
PLoS ONE 7:e42307. 2012
- No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
Department of Clinical Immunology, Blood Bank, National University Hospital, Copenhagen, Denmark
J Neuroimmunol 243:69-72. 2012
..Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects...
- A genetic risk factor for low serum ferritin levels in Danish blood donors
Department of Clinical Immunology, Capital Region, Copenhagen University Hospital, Denmark
Transfusion 52:2585-9. 2012
..Knowledge of genetic variants that predispose donors to iron deficiency would allow bleeding frequency and iron supplementation to be tailored to the individual donor...
- p24 as a predictor of mortality in a cohort of HIV-1-infected adults in rural Africa
The Centre of Inflammation and Metabolism, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
J Acquir Immune Defic Syndr 48:345-9. 2008
..p24 measurements have been proposed as an alternative to HIV-RNA because of the low cost of reagents and equipment needed. Here, we evaluate p24 as a prognostic marker in a cohort of HIV-1-infected individuals in Zimbabwe...
- Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults
Centre for Inflammation and Metabolism, Denmark
AIDS 21:2283-91. 2007
..To evaluate the effect on HIV progression of single nucleotide polymorphisms in promoters of the genes for tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 and known to influence cytokine production...
- Predictors of mortality in a cohort of HIV-1-infected adults in rural Africa
Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
J Acquir Immune Defic Syndr 44:478-83. 2007
..We explored the prognostic strengths of classic and alternative progression markers in this study set in rural Zimbabwe...
- Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection
Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Clin Infect Dis 42:1781-9. 2006
..Consequently, human immunodeficiency virus (HIV)-related immunodeficiency may impair the effect of praziquantel treatment...
- Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load
Center for Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
J Infect Dis 192:1956-61. 2005
..17). The present study suggests that treatment of schistosomiasis can reduce the rate of viral replication and increase CD4 cell count in the coinfected host...