Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Ann Endocrinol (Paris). 2010;71:291-6 pubmed publisher
..05) reduced elevated MDA levels. Honey treatment also restored SOD and CAT activities. These results suggest that hypoglycemic effect of tualang honey might be attributed to its antioxidative effect on the pancreas. ..
Erejuwa O, Omotayo E, Gurtu S, Sulaiman S, Ab Wahab M, Sirajudeen K, et al
. Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res. 2010;80:74-82 pubmed publisher
..Honey exerts a hypoglycemic effect and ameliorates oxidative stress in kidneys of streptozotocin-induced diabetic rats. ..
Erejuwa O, Sulaiman S, Wahab M, Salam S, Salleh M, Gurtu S. Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. Int J Mol Sci. 2010;11:2056-66 pubmed publisher
..These findings suggest that tualang honey potentiates the effect of glibenclamide and metformin to protect diabetic rat pancreas against oxidative stress and damage. ..
Erejuwa O, Sulaiman S, Wahab M, Salam S, Salleh M, Gurtu S. Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats. Int J Mol Sci. 2011;12:829-43 pubmed publisher
..These results suggest that combination of honey with metformin or glibenclamide might offer additional antioxidant effect to these drugs. This might reduce oxidative stress-mediated damage in diabetic kidneys. ..
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: effects of antioxidant (honey) treatment. Int J Mol Sci. 2011;12:1888-907 pubmed publisher
..These data suggest that differences in types, severity, and complications of diseases as well as strains may influence responses to blood pressure and oxidative stress. ..
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. Int J Biol Sci. 2011;7:244-52 pubmed
..These results indicate that combination of glibenclamide or metformin with honey improves glycemic control, and provides additional metabolic benefits, not achieved with either glibenclamide or metformin alone. ..
Erejuwa O, Nwobodo N, Akpan J, Okorie U, Ezeonu C, Ezeokpo B, et al
. Nigerian Honey Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Rats. Nutrients. 2016;8:95 pubmed publisher
..05) reduced TGs and VLDL cholesterol. This study confirms the reproducibility of glucose lowering and hypolipidemic effects of honey using Nigerian honey. However, none of the doses deteriorated hyperglycemia and dyslipidemia. ..
Erejuwa O, Sulaiman S, Ab Wahab M, Sirajudeen K, Salleh S, Gurtu S. Honey supplementation in spontaneously hypertensive rats elicits antihypertensive effect via amelioration of renal oxidative stress. Oxid Med Cell Longev. 2012;2012:374037 pubmed publisher
..These results indicate that Nrf2 expression is impaired in the kidney of SHR. Honey supplementation considerably reduces elevated SBP via amelioration of oxidative stress in the kidney of SHR. ..
Erejuwa O, Sulaiman S, Wahab M. Honey--a novel antidiabetic agent. Int J Biol Sci. 2012;8:913-34 pubmed publisher
..Hence, it is very important to have well-designed, randomized controlled clinical trials that investigate the reproducibility (or otherwise) of these experimental data in diabetic human subjects. ..