Jeanette Erdmann

Summary

Publications

  1. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
  2. doi request reprint Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Eur Heart J 32:158-68. 2011
  3. ncbi request reprint Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
    Björn Mayer
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 24:1965-70. 2006
  4. doi request reprint Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Clin Sci (Lond) 115:309-15. 2008
  5. ncbi request reprint Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification
    Zouhair Aherrahrou
    Medizinische Klinik II, University of Luebeck, Luebeck, Germany
    Physiol Genomics 28:203-12. 2007
  6. ncbi request reprint Association of low-grade urinary albumin excretion with left ventricular hypertrophy in the general population: the MONICA/KORA Augsburg Echocardiographic Substudy
    Wolfgang Lieb
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nephrol Dial Transplant 21:2780-7. 2006
  7. ncbi request reprint Lack of association between the MEF2A gene and myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:185-91. 2008
  8. ncbi request reprint No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Clin Sci (Lond) 111:365-72. 2006
  9. doi request reprint Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 86:1163-70. 2008
  10. pmc Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 3:e2986. 2008

Detail Information

Publications31

  1. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
    ..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)...
  2. doi request reprint Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Eur Heart J 32:158-68. 2011
    ..However, these loci explain only a small proportion of the genetic variability of these pertinent diseases. We sought to identify additional CAD/MI loci by applying a three-stage approach...
  3. ncbi request reprint Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
    Björn Mayer
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 24:1965-70. 2006
    ..The present study aimed to investigate the impact of the functionally relevant T8590C polymorphism of this gene on blood pressure and the prevalence of hypertension in MI patients...
  4. doi request reprint Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Clin Sci (Lond) 115:309-15. 2008
    ....
  5. ncbi request reprint Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification
    Zouhair Aherrahrou
    Medizinische Klinik II, University of Luebeck, Luebeck, Germany
    Physiol Genomics 28:203-12. 2007
    ..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC...
  6. ncbi request reprint Association of low-grade urinary albumin excretion with left ventricular hypertrophy in the general population: the MONICA/KORA Augsburg Echocardiographic Substudy
    Wolfgang Lieb
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nephrol Dial Transplant 21:2780-7. 2006
    ..We investigated whether sub-threshold microalbuminuria or mildly decreased estimated glomerular filtration rate (eGFR) are related to left ventricular hypertrophy (LVH) in the general population...
  7. ncbi request reprint Lack of association between the MEF2A gene and myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:185-91. 2008
    ..In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results...
  8. ncbi request reprint No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Clin Sci (Lond) 111:365-72. 2006
    ..We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy...
  9. doi request reprint Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 86:1163-70. 2008
    ..In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either...
  10. pmc Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 3:e2986. 2008
    ..Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD...
  11. ncbi request reprint Association between arterial pressure and coronary artery calcification
    Björn Mayer
    Medizinische Klinik II, Universitatsklinik Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 25:1731-8. 2007
    ..This study investigates conditions affecting CAC severity in patients with coronary artery disease (CAD) undergoing coronary angiography...
  12. ncbi request reprint Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 84:88-96. 2006
    ..This study provides evidence that genetic variants in the ACE2 gene may be associated with left ventricular mass, SWT and left ventricular hypertrophy in hemizygous men...
  13. ncbi request reprint Impact of diabetes on QT dynamicity in patients with and without myocardial infarction: The KORA Family Heart Study
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S183-7. 2007
    ..QT dynamicity is an independent predictor of SCD in post-MI patients. However, the effects of diabetes on QT dynamicity in patients with MI have not been described...
  14. ncbi request reprint Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy
    Bjoern Mayer
    Medizinische Klinik II, Universitatsklinik Schleswig Holstein, Campus Lubeck, D 23538 Lubeck, Germany
    Hypertension 46:766-71. 2005
    ..In contrast, we found no blood pressure-independent modulatory effect of CYP4A11 T8590C on cardiac size, structure, and function...
  15. pmc Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    Heribert Schunkert
    Universitat zu Lubeck, Medizinische Klinik II, Lubeck, Germany
    Nat Genet 43:333-8. 2011
    ..Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits...
  16. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  17. ncbi request reprint Molecular signatures of cardiovascular disease risk: potential for test development and clinical application
    Heribert Schunkert
    Medicine Clinic II, University of Lubeck, Lubeck, Germany
    Mol Diagn Ther 12:281-7. 2008
    ..However, the strategy for individualized risk prediction by incorporation of new biomarkers in established scores has so far proven to be more difficult than at first hoped...
  18. pmc Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls
    Michael Preuss
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Germany
    Circ Cardiovasc Genet 3:475-83. 2010
    ..Therefore, to maximize the chance of finding novel susceptibility loci for CAD and MI, the Coronary ARtery DIsease Genome-wide Replication And Meta-analysis (CARDIoGRAM) consortium was formed...
  19. pmc Myeloid CD34+CD13+ precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification
    Lars Christian Doehring
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Am J Pathol 177:473-80. 2010
    ....
  20. pmc Genetic causes of myocardial infarction: new insights from genome-wide association studies
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Dtsch Arztebl Int 107:694-9. 2010
    ....
  21. doi request reprint Genetics of myocardial infarction: a progress report
    Heribert Schunkert
    Universitat zu Lubeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Eur Heart J 31:918-25. 2010
    ..In summary, modern MI genetics carries the promise to identify individuals at high risk and to improve prevention and therapy of this important disease...
  22. ncbi request reprint How to include chromosome X in your genome-wide association study
    Inke R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany DZHK German Centre for Cardiovascular Research, Lubeck, Germany
    Genet Epidemiol 38:97-103. 2014
    ..Closing this gap is expected to further elucidate the genetic background of complex diseases, especially of those with sex-specific features. ..
  23. doi request reprint Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification
    Ann Kathrin Sowa
    Institute for Integrative and Experimental Genomics and DZHK German Centre for Cardiovascular Research, partner site Lübeck Hamburg Kiel, University of Lubeck, Lubeck, Germany
    Am J Pathol 183:60-8. 2013
    ..Our data suggest a key role of Runx2 in the regulation of Opn in a model of cardiovascular calcification and demonstrate a synergistic cooperation of Runx2 and Vdr...
  24. pmc Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography
    Patrick Linsel-Nitschke
    Department of Medicine, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Lipids Health Dis 8:14. 2009
    ..We have therefore measured macrophage cholesterol efflux in 142 normolipidemic subjects undergoing coronary angiography...
  25. doi request reprint Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
    Patrick Linsel-Nitschke
    Medizinische Klinik 2, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Atherosclerosis 208:183-9. 2010
    ..A functional link explaining the association of SNP rs599839 with LDL-C levels and CAD risk has not yet been elucidated...
  26. ncbi request reprint No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors
    Wolfgang Lieb
    Clinic and Policlinic for Internal Medicine II, University of Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Int J Cardiol 97:205-12. 2004
    ..The aim of the present study was to further investigate the association of the IL-6 -174 G/C allele status with specific end organ damage, i.e. myocardial infarction in large population-based samples...
  27. ncbi request reprint Genetics and heritability of coronary artery disease and myocardial infarction
    Björn Mayer
    Universitätsklinikum Schleswig Holstein UKSH, Ratzeburger Allee 160, Campus Lubeck, Medizinische Klinik II, 23538 Lubeck, Germany
    Clin Res Cardiol 96:1-7. 2007
    ..Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction...
  28. ncbi request reprint Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014
    ..Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases...
  29. ncbi request reprint SNPtoGO: characterizing SNPs by enriched GO terms
    Daniel F Schwarz
    Institut fur Medizinische Biometrie und Statistik, Lubeck, Germany
    Bioinformatics 24:146-8. 2008
    ..The tool presented here hence adds external information, i.e. GeneOntology (GO) terms (Gene Ontology Consortium), to the analysis of SNP data...
  30. doi request reprint Forty-five years to diagnosis
    Jeanette Erdmann
    Institut für Integrative und Experimentelle Genomik, Universitat zu Lubeck, Ratzeburger Allee 160, D 23562 Lubeck, Germany
    Neuromuscul Disord 23:503-5. 2013
    ..A long lasting journey of almost 45 years led in the end to a diagnosis of a Collagen 6A myopathy. Modern information technology and next generation sequencing made the difference - a very personal report...
  31. ncbi request reprint Arterial calcification in mice after freeze-thaw injury
    Lars C Doehring
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Ann Anat 188:235-42. 2006
    ..We present evidence that the occurrence of arterial calcification in C3H/He mice seems to be actively regulated by certain bone-matrix associated proteins...