Hakan Erdem



  1. Erdem H, Ozturk Engin D, Tireli H, Kilicoglu G, Defres S, Gulsun S, et al. Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study. J Neurol. 2015;262:890-8 pubmed publisher
    ..Altered consciousness, diabetes mellitus, immunosuppression, neurological deficits, hydrocephalus, and vasculitis predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis. ..
  2. Erdem H, Cağ Y, Ozturk Engin D, Defres S, Kaya S, Larsen L, et al. Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrob Agents Chemother. 2015;59:3084-9 pubmed publisher
    ..The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome. ..
  3. Erdem H, Senbayrak S, Gencer S, Hasbun R, Karahocagil M, Sengoz G, et al. Tuberculous and brucellosis meningitis differential diagnosis. Travel Med Infect Dis. 2015;13:185-91 pubmed publisher
    ..When the Thwaites or Lancet scoring systems indicate TBM, brucellar etiology should also be taken into consideration particularly in endemic countries. ..
  4. Batirel A, Erdem H, Sengoz G, Pehlivanoglu F, Ramosaco E, Gülsün S, et al. The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study. Clin Microbiol Infect. 2015;21:1008.e9-1008.e18 pubmed publisher
    ..Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae. ..
  5. Erdem H, Elaldi N, Batirel A, Aliyu S, Sengoz G, Pehlivanoglu F, et al. Comparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter "Backbone-1 Study". Spine J. 2015;15:2509-17 pubmed publisher
  6. Senbayrak S, Ozkutuk N, Erdem H, Johansen I, Civljak R, Inal A, et al. Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study. Ann Clin Microbiol Antimicrob. 2015;14:47 pubmed publisher
    ..Still, empiric TBM treatment should be started immediately without waiting the drug susceptibility testing. ..
  7. Erdem H, Ak O, Elaldi N, Demirdal T, Hargreaves S, Nemli S, et al. Infections in travellers returning to Turkey from the Arabian peninsula: a retrospective cross-sectional multicenter study. Eur J Clin Microbiol Infect Dis. 2016;35:903-10 pubmed publisher
    ..1 %. Returning travellers from the Arabian Peninsula present as inpatients with a broad range of infectious diseases similar to common community acquired infections frequently seen in daily medical practices in Turkey. ..
  8. Cag Y, Erdem H, Leib S, Defres S, Kaya S, Larsen L, et al. Managing atypical and typical herpetic central nervous system infections: results of a multinational study. Clin Microbiol Infect. 2016;22:568.e9-568.e17 pubmed publisher
    ..5% of the cases with and without encephalitic clinical presentation, respectively. Considering the subtle nature of HME, CSF HSV PCR, EEG and MRI data should be collected for all patients with a central nervous system infection. ..
  9. Erdem H, Senbayrak S, Meriç K, Batirel A, Karahocagil M, Hasbun R, et al. Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study. Infection. 2016;44:623-31 pubmed publisher
    ..The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses. ..

More Information


  1. Tosun S, Batirel A, Oluk A, Aksoy F, Puca E, Bénézit F, et al. Tetanus in adults: results of the multicenter ID-IRI study. Eur J Clin Microbiol Infect Dis. 2017;36:1455-1462 pubmed publisher
    ..A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival. ..
  2. Turktan M, Ak O, Erdem H, Ozcengiz D, Hargreaves S, Kaya S, et al. Community acquired infections among refugees leading to Intensive Care Unit admissions in Turkey. Int J Infect Dis. 2017;58:111-114 pubmed publisher
    ..More research needs to be done to better understand how to deliver preventative and timely health care services to this group of patients. ..
  3. Erdem H, Kilic S, Coskun O, Ersoy Y, Cagatay A, Onguru P, et al. Community-acquired acute bacterial meningitis in the elderly in Turkey. Clin Microbiol Infect. 2010;16:1223-9 pubmed publisher
    ..Fever did not differ between survivors and fatal cases. The mean duration of antibiotic therapy in survivors was 16.3 +/- 6.4 days. One-fifth of the patients had complications, and in 5.7% of the patients sequelae persisted at follow-up...
  4. Erdem H, Inan A, Guven E, Hargreaves S, Larsen L, Shehata G, et al. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. Eur J Clin Microbiol Infect Dis. 2017;36:1595-1611 pubmed publisher
    ..05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity. ..
  5. Hakyemez I, Erdem H, Beraud G, Lurdes M, Silva Pinto A, Alexandru C, et al. Prediction of unfavorable outcomes in cryptococcal meningitis: results of the multicenter Infectious Diseases International Research Initiative (ID-IRI) cryptococcal meningitis study. Eur J Clin Microbiol Infect Dis. 2018;37:1231-1240 pubmed publisher
    ..On the other hand, malignancy (p?=?0.026) was associated with poor outcomes. Although all CM patients require prompt and rational fungal management, those with significant risks for poor outcomes need to be closely monitored. ..