Ayse Basak Engin



  1. Engin A, Engin A. Nanoparticles and neurotoxicity: Dual response of glutamatergic receptors. Prog Brain Res. 2019;245:281-303 pubmed publisher
    ..Therefore, investigation of the interaction of NPs with the neuronal signaling molecules and neuronal receptors is necessary for the better understanding of the neurotoxicity or neurosafety of nanomaterials. ..
  2. Engin A, Engin A. DNA damage checkpoint response to aflatoxin B1. Environ Toxicol Pharmacol. 2019;65:90-96 pubmed publisher
    ..Majority of AFB1 associated hepatocellular cancer cases carry TP53 mutant DNA, which is an indicator of AFB1 exposure, as well as hepatocellular cancer risk. ..
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    Engin A. Dual function of nitric oxide in carcinogenesis, reappraisal. Curr Drug Metab. 2011;12:891-9 pubmed
    ..In this review critical links between the nitric oxide and chronic inflammation associated carcinogenesis are summarized. ..
  4. Engin A, Karahalil B, Engin A, Karakaya A. DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma. Mol Biol Rep. 2011;38:5379-86 pubmed publisher
    ..05). None of the evaluated polymorphisms or Helicobacter pylori IgG seropositivity associated with increased risk of gastric cancer, despite of the increased oxidative stress in cancer patients. ..
  5. Engin A, Tsatsakis A, Tsoukalas D, Engin A. Do flavanols-rich natural products relieve obesity-related insulin resistance?. Food Chem Toxicol. 2018;112:157-167 pubmed publisher
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    Engin A, Engin A, Sepici Dincel A. Influence of surgical trauma on neopterin concentrations in gastric carcinoma patients. Tumori. 2010;96:589-93 pubmed
    ..The present study was undertaken to evaluate the impact of major surgical trauma on host cellular immunity of gastric carcinoma cases...
  7. Engin A. What Is Lipotoxicity?. Adv Exp Med Biol. 2017;960:197-220 pubmed publisher
    ..In this context, chronic adipose tissue inflammation, mitochondrial dysfunction and IR have been discussed within the scope of lipotoxicity. ..
  8. Engin A. MicroRNA and Adipogenesis. Adv Exp Med Biol. 2017;960:489-509 pubmed publisher
  9. Engin A, Engin A. The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. Adv Exp Med Biol. 2017;960:511-527 pubmed publisher
    ..Additionally, in obese patients, folate-deficiency leads to hyperhomocysteinemia. Folic acid confers protection against hyperhomocysteinemia-induced oxidative stress. ..

More Information


  1. Engin A, Karahalil B, Engin A, Karakaya A. Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma. Genet Test Mol Biomarkers. 2010;14:559-64 pubmed publisher
    ..094) did not associate with the increased risk of cancer progression, despite the increased oxidative stress in cancer patients. Seropositivity of H. pylori IgG has been found to increase the risk of colorectal carcinoma by 2.2-fold. ..
  2. Engin A, Karahalil B, Karakaya A, Engin A. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol. 2011;62:207-14 pubmed publisher
    ..However, XRCC1 homozygous Gln allele at codon 399 was associated with 2.54 times higher risk of gastric cancer. ..
  3. Engin A. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017;960:327-343 pubmed publisher
    ..Macrophage/adipocyte fatty-acid-binding proteins act at the interface of metabolic and inflammatory pathways. Both macrophages and adipocytes are the sites for active lipid metabolism and signaling. ..
  4. Engin A, Engin E, Karakus R, Aral A, Gulbahar O, Engin A. N-Methyl-D aspartate receptor-mediated effect on glucose transporter-3 levels of high glucose exposed-SH-SY5Y dopaminergic neurons. Food Chem Toxicol. 2017;109:465-471 pubmed publisher
    ..KynA is a noteworthy compound, as an endogenous, specific NMDA receptor antagonist; it significantly reduces oxidative stress, while increasing cell viability at high glucose and insulin concentrations. ..