Wael El-Sayed


Affiliation: King Faisal University - Ain Shams University


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    El Sayed W, Aboul Fadl T, Lamb J, Roberts J, Franklin M. Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. Toxicology. 2006;220:179-88 pubmed
  2. El Sayed W, Aboul Fadl T, Roberts J, Lamb J, Franklin M. Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol In Vitro. 2007;21:157-64 pubmed
    ..Thus, Hepa1c1c7 cells appear to provide a viable platform for the study of protective enzyme regulation by selenocompounds, and with the exception of Ugt1a6, the mRNA elevations from selenazolidines are transcriptionally dependent. ..
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    Li L, Xie Y, El Sayed W, Szakacs J, Roberts J. Characteristics of selenazolidine prodrugs of selenocysteine: toxicity, selenium levels, and glutathione peroxidase induction in A/J mice. Life Sci. 2004;75:447-59 pubmed
    ..Increased activity of selenium-dependent glutathione peroxidase (GPx) in blood and liver illustrated that the selenazolidines provided a source of biologically-available selenium. ..
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    Li L, Xie Y, El Sayed W, Szakacs J, Franklin M, Roberts J. Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. J Biochem Mol Toxicol. 2005;19:396-405 pubmed
    ..The two compounds showing significant tumor reduction (OSCA and selenocystine) were the only two compounds that showed ubiquity of changes, elevating both selenium levels and GPx activity in both liver and RBC. ..
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    El Sayed W, Franklin M. Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. J Biochem Mol Toxicol. 2006;20:292-301 pubmed
    ..Thus, although constituting a closely related series of compounds, each 2-substituted SCA produced its own unique pattern of changes, and for most members, changes were predominant following i.p. administration. ..
  6. El Sayed W, Hussin W, Franklin M. The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids. Mutat Res. 2007;627:136-45 pubmed
  7. Franklin M, Moos P, El Sayed W, Aboul Fadl T, Roberts J. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. Chem Biol Interact. 2007;168:211-20 pubmed
    ..Thus, several 2-aryl/alkyl selenazolidines possess chemopreventive activity against NNK-induced lung tumors, and variously demonstrate pre-initiation and post-initiation efficacy. ..
  8. Ramadan G, Al Kahtani M, El Sayed W. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation. 2011;34:291-301 pubmed publisher
    ..05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model...
  9. El Sayed W. Effect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice. Eur J Pharmacol. 2011;660:291-7 pubmed publisher
    ..This study not only filled the void about the murine PXR-induction profile but also will help in the course of drug development research with respect to extrapolation to human risk assessment. ..

More Information


  1. El Sayed W, Al Kahtani M, Abdel Moneim A. Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice. J Hazard Mater. 2011;192:880-6 pubmed publisher
    ..The rate of recovery was better when taurine was administered prior to Al. Taurine had anaphylactic and therapeutic activity against hepatotoxicity induced by aluminum in mice. ..
  2. El Sayed W, Al Kahtani M. Potential adverse effects of oseltamivir in rats: males are more vulnerable than females. Can J Physiol Pharmacol. 2011;89:623-30 pubmed publisher
    ..There was a sexual differentiation in these adverse effects, with adverse effects being more evident in male rats. ..
  3. El Sayed W. Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats. Int J Toxicol. 2011;30:707-14 pubmed publisher
    ..This protection could be attributed to the induction of chemoprotective enzymes probably through increasing transcription. ..
  4. Shaaban R, El Sayed W, Samir S, El Dabaa E. Molecular and Biological Characterization of a Prepared Recombinant Human Interferon Alpha 2b Isoform. Appl Biochem Biotechnol. 2018;: pubmed publisher
  5. Ismail M, Youssef M, Arafa R, Al Shihry S, El Sayed W. Synthesis and antiproliferative activity of monocationic arylthiophene derivatives. Eur J Med Chem. 2017;126:789-798 pubmed publisher
    ..The tested monocations have selective anticancer activity without insulting normal cells most probably due to inhibition of the key enzyme TK at nanomolar concentrations. ..
  6. Nour Eldein N, Hassanin E, El Sayed W. Mitigation of Acute Aluminum Toxicity by Sodium Selenite and N-Acetylcysteine in Adult Male Rats. Biol Trace Elem Res. 2018;183:128-137 pubmed publisher