Hepatocellular carcinoma: an epidemiologic viewHashem B El-Serag
Section of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Gastroenterol 35:S72-8. 2002
..The future incidence trends of HCC will be determined to a large extent by the clinical course of HCV-infected people...
- Survival in hepatitis C and HIV co-infection: a cohort study of hospitalized veterans
Hashem B El-Serag
Houston Center for Quality of Care and Utilization Studies, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
Clin Gastroenterol Hepatol 3:175-83. 2005
..However, the long-term effect of hepatitis C virus (HCV) co-infection on the mortality of HIV-infected patients remains unclear...
Importance of patient, provider, and facility predictors of hepatitis C virus treatment in veterans: a national studyJennifer R Kramer
Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
Am J Gastroenterol 106:483-91. 2011
..Several patient characteristics are known to impact hepatitis C virus (HCV) antiviral treatment rates. However, it is unclear whether, and to what extent, health-care providers or facility characteristics impact HCV treatment rates...
- Is the length of newly diagnosed Barrett's esophagus decreasing? The experience of a VA Health Care System
Hashem B El-Serag
Section of Gastroenterology, Houston VA Medical Center, and Baylor College of Medicine, Texas 77030, USA
Clin Gastroenterol Hepatol 2:296-300. 2004
..Secular trends in the length of newly diagnosed Barrett's esophagus (BE) are unknown. We have anecdotally noticed less frequent new diagnoses of long segments of BE...
- The prevalence of suspected Barrett's esophagus in children and adolescents: a multicenter endoscopic study
Hashem B El-Serag
The Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Gastrointest Endosc 64:671-5. 2006
..The prevalence of Barrett's esophagus (BE) in young individuals is unclear...
- The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update
Hashem B El-Serag
The Houston Center for Quality of Care and Utilization Studies, Sections of Gastroenterology and Health Services Research at The Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA
Ann Intern Med 139:817-23. 2003
..The incidence of hepatocellular carcinoma was reported to be increasing in the United States. However, alternate explanations were diagnostic or reclassification bias and changes in the demographic features of the general population...
Patient-centered, comparative effectiveness of esophageal cancer screening: protocol for a comparative effectiveness research study to inform guidelines for evidence-based approach to screening and surveillance endoscopyJennifer R Kramer
Houston VA HSR and D Center of Excellence, Michael E, DeBakey Veterans Affairs Medical Center, Houston, TX, USA
BMC Health Serv Res 12:288. 2012
..Therefore, it is imperative to establish the CE and acceptability about the risks and outcomes related to these practices to better inform expert recommendations and provider-patient decisions...
- Gastroesophageal reflux among different racial groups in the United States
Hashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Gastroenterology 126:1692-9. 2004
..It remains unknown whether this racial discrepancy reflects a higher prevalence of gastroesophageal reflux disease (GERD) symptoms or a higher degree of esophageal damage...
- Prevalence and determinants of histological abnormalities of the gastric cardia in volunteers
Hashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Scand J Gastroenterol 42:1158-66. 2007
..There have been no studies on non-patient populations. The aim of this study was to mitigate the potential effects of selection bias...
- Utilization and outcomes of palliative therapy for hepatocellular carcinoma: a population-based study in the United States
Jessica A Davila
Section of Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
J Clin Gastroenterol 46:71-7. 2012
..To evaluate the utilization and determinants of receiving palliative treatment for hepatocellular carcinoma (HCC), and its effect on survival...
- Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the united states: a population-based study
Yasser H Shaib
Sections of Health Services, Houston, TX, USA
J Clin Gastroenterol 41:911-7. 2007
..Intrahepatic cholangiocarcinoma (ICC) is a highly fatal disease with limited therapeutic options. The determinants, trends, and outcomes of different therapies for ICC are largely unknown in the United States...
- Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001
Thomas P Giordano
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, Houston, Tex 77030, USA
Arch Intern Med 164:2349-54. 2004
....
- Racial differences in the association between adiposity measures and the risk of hepatitis C-related liver disease
Donna L White
Clinical Epidemiology and Outcomes Program, Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
J Clin Gastroenterol 46:779-88. 2012
..It is unknown whether relative differences in the distribution of adipose tissue, lean mass, and other anthropometric measurements may explain these observed interethnic differences in disease risk...
- Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
Hashem B El-Serag
Section of Gastroenterology, Houston Departmentof Veterans Affais Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Gastroenterology 126:460-8. 2004
..An association between diabetes and chronic liver disease has been reported. However, the temporal relationship between these conditions remains unknown...
- Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus-infected veterans in the United States
Jessica A Davila
the Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
Ann Intern Med 154:85-93. 2011
..Surveillance for hepatocellular carcinoma (HCC) is recommended for patients with hepatitis C virus (HCV) infection and cirrhosis. However, whether surveillance is being done as recommended is unknown...
- Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study
Yasser H Shaib
The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 102:1016-21. 2007
..We evaluated hepatitis C virus (HCV), hepatitis B virus (HBV), and liver cirrhosis as risk factors for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC)...
- Helicobacter pylori-negative gastritis: prevalence and risk factors
Helena Nordenstedt
Houston VA HSR and D Center of Excellence, Houston, TX, USA
Am J Gastroenterol 108:65-71. 2013
..The objective of this study was to investigate the prevalence of H. pylori among individuals with histologic gastritis...
- Surveillance for hepatocellular carcinoma: development and validation of an algorithm to classify tests in administrative and laboratory data
Peter Richardson
Section of Health Services Research, Houston Center for Quality of Care and Utilization Studies, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 55:3241-51. 2010
..The purpose of alpha-fetoprotein (AFP) and abdominal ultrasound (US) cannot be discerned in administrative data...
- Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study
Hashem B El-Serag
Section of Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard 152, Houston, TX 77030, USA
J Hepatol 44:158-66. 2006
..Yet, neither the extent to which potentially curative or palliative therapy is used to treat HCC, nor the determinants of using such therapies are known. Further, it is unclear how effective different modalities are for treating HCC...
- National adherence to evidence-based guidelines for the prescription of nonsteroidal anti-inflammatory drugs
Neena S Abraham
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Texas 77030, USA
Gastroenterology 129:1171-8. 2005
..Our objective was to assess adherence to evidence-based guidelines by providers of the Department of Veterans Affairs nationwide...
- Obesity and disease of the esophagus and colon
Hashem B El-Serag
Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center at Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Gastroenterol Clin North Am 34:63-82. 2005
..This article discusses the evidence linking obesity to the different manifestations of gastroesophageal reflux disease and colorectal cancer...
- Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
Hashem B El-Serag
Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
Gastroenterology 132:2557-76. 2007
..A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve our current concepts for screening and treatment of this disease...
- Determinants of gastroesophageal reflux disease in adults with a history of childhood gastroesophageal reflux disease
Hashem B El-Serag
Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:696-701. 2007
..We conducted a nested case-control study to examine the prevalence and risk factors for current gastroesophageal reflux disease (GERD) symptoms in young adults with a history of childhood GERD...
- The epidemic of esophageal adenocarcinoma
Hashem B El-Serag
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
Gastroenterol Clin North Am 31:421-40, viii. 2002
....
- Secular trends in the use, quality, and outcomes of gastrectomy for noncardia gastric cancer in the United States
Anne Le
Department of Surgery, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, Texas, USA
Ann Surg Oncol 14:2519-27. 2007
..We examined the trends, extent, and determinants of surgical treatment and the influence of gastrectomy and adequacy of lymphadenectomy (defined as collection of 15 or more lymph nodes) on non-cardia gastric cancer survival...
- The effect of HIV coinfection on the risk of cirrhosis and hepatocellular carcinoma in U.S. veterans with hepatitis C
Jennifer R Kramer
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Am J Gastroenterol 100:56-63. 2005
..84, p= 0.40). CONCLUSIONS: Coinfection was a significant risk factor for cirrhosis only during the pre-HAART era and was not associated with hepatocellular carcinoma, irrespective of time period...
- Hepatitis C coinfection increases the risk of fulminant hepatic failure in patients with HIV in the HAART era
Jennifer R Kramer
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Michael E DeBakey Veterans Affairs Medical Center 152, Houston, TX 77030, USA
J Hepatol 42:309-14. 2005
..It is uncertain if patients coinfected with hepatitis C and HIV are more likely to suffer fulminant hepatic failure (FHF) when compared to patients with HIV-only...
- Is there a race-based disparity in the survival of veterans with HIV?
Thomas P Giordano
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Gen Intern Med 21:613-7. 2006
..Disparities in survival for black patients with HIV in the United States have been reported. The VA is an equal access health care system...
- Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans
Hashem B El-Serag
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Hepatology 49:116-23. 2009
..Absence of an association with ECC was consistent in adjusted and unadjusted models. A significant association with pancreatic cancer was erased by alcohol use and other variables...
- Finasteride and methadone use and risk of advanced hepatitis C related liver disease
Donna L White
Clinical Epidemiology and Outcomes Program, Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veteran Affairs Medical Center, Houston, TX, USA
Dig Dis Sci 57:3004-10. 2012
..We evaluated the association between two medications that alter bioavailable androgen levels, finasteride and methadone, and risk of advanced HCV-related liver disease...
- Determinants of serum alpha-fetoprotein levels in hepatitis C-infected patients
Peter Richardson
Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
Clin Gastroenterol Hepatol 10:428-33. 2012
..This information might improve AFP-based algorithms for HCC detection...
- Complications of pediatric colonoscopy: a five-year multicenter experience
Kalpesh Thakkar
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA
Clin Gastroenterol Hepatol 6:515-20. 2008
- Obesity is an independent risk factor for GERD symptoms and erosive esophagitis
Hashem B El-Serag
Section of Gastroenterology at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 100:1243-50. 2005
..CONCLUSIONS: Overweight and obesity are strong independent risk factor of GERD symptoms and esophageal erosions. The amount or composition of dietary intake does not appear to be a likely explanation for these findings...
- Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study
Thomas Tran
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 100:1002-8. 2005
..The adjusted hazard ratio of esophageal cancer with fundoplication was 1.88 (95% CI: 0.70-5.03). CONCLUSIONS: GERD is a risk factor for esophageal cancer, but there is insufficient evidence that fundoplication reduces that risk...
- Physical and psychosocial contributors to quality of life in veterans with hepatitis C not on antiviral therapy
Paul J Rowan
Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
J Clin Gastroenterol 39:731-6. 2005
..CONCLUSIONS: Psychosocial factors, especially depression, are strong indicators of impaired HRQOL for HCV-infected veterans not receiving antiviral therapy. Screening and treatment of psychosocial factors is recommended...
- Prevention of complicated ulcer disease among chronic users of nonsteroidal anti-inflammatory drugs: the use of a nomogram in cost-effectiveness analysis
Hashem B El-Serag
Health Services Research Sections, Houston Center for Quality of Care and Utilization Studies, Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Arch Intern Med 162:2105-10. 2002
..Our objective in this study was to compare the cost-effectiveness of several strategies aimed at reducing the risk of clinical UGI events in NSAID users...
- Management of the single liver nodule in a cirrhotic patient: a decision analysis model
Hashem B El-Serag
Sections of Gastroenterology, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Gastroenterol 39:152-9. 2005
..The long waiting time prior to OLT limits its advantage over surgical resection in the treatment of patients with early HCC...
- The use of screening colonoscopy for patients cared for by the Department of Veterans Affairs
Hashem B El-Serag
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
Arch Intern Med 166:2202-8. 2006
..Because of differences in the delivery of health care, this trend in use of colonoscopy in fee-for-service settings might not be paralleled in the Department of Veterans Affairs (VA)...
- Barrett's esophagus in children and adolescents without neurodevelopmental or tracheoesophageal abnormalities: a prospective study
Dang M Nguyen
Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
Gastrointest Endosc 73:875-80. 2011
..Barrett's esophagus (BE) in children has been examined in retrospective studies, consisting of case series and cross-sectional studies...
- Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United States
Jessica A Davila
Section of Health Services Research, Houston Center for Quality of Care and Utilization Studies, Houston VA Medical Center and Baylor College of Medicine, Houston, TX, USA
Hepatology 52:132-41. 2010
..CONCLUSION: Less than 20% of patients with cirrhosis who developed HCC received regular surveillance. Gastroenterologists/hepatologists or physicians with an academic affiliation are more likely to perform surveillance...
- Obesity increases oesophageal acid exposure
Hashem B El-Serag
Section of Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Gut 56:749-55. 2007
..Obesity has been associated with gastro-oesophageal reflux disease (GERD); however, the mechanism by which obesity may cause GERD is unclear...
- Process of care for hepatitis C infection is linked to treatment outcome and virologic response
Fasiha Kanwal
Houston VA Health Services Research and Development Center of Excellence, Health Services Research and Development Service, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 10:1270-1277.e3. 2012
..Process of care-based measures are used commonly to assess the quality of medical care provided to patients with chronic hepatitis C virus (HCV) infection. However, the links between these processes and patient outcomes are not clear...
- Practice patterns of surveillance endoscopy in a Veterans Affairs database of 29,504 patients with Barrett's esophagus
Hashem B El-Serag
the Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd 152, Houston, TX 77030, USA
Gastrointest Endosc 76:743-55. 2012
..Although surveys report that >95% of gastroenterologists recommend or practice BE surveillance, the extent and patterns of surveillance in clinical practice are unknown...
- Epidemiology of viral hepatitis and hepatocellular carcinoma
Hashem B El-Serag
Section of Gastroenterology and Hepatology, Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Gastroenterology 142:1264-1273.e1. 2012
....
- Risk of colorectal cancer among Caucasian and African American veterans with ulcerative colitis
Jason K Hou
Houston VA HSR and D Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
Inflamm Bowel Dis 18:1011-7. 2012
..Ulcerative colitis (UC) is a risk factor for developing CRC; however, risk differences for CRC between African Americans and Caucasians with UC are unknown...
- Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
Yasser H Shaib
Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 128:620-6. 2005
..In this case-control study, we used the Surveillance, Epidemiology, and End Results-Medicare database to evaluate the prevalence of known risk factors for intrahepatic cholangiocarcinoma and explore other potential risk factors...
- Diabetes increases the risk of acute hepatic failure
Hashem B El-Serag
Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center, Texas 77030, USA
Gastroenterology 122:1822-8. 2002
..It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs...
- Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis
Donna L White
The Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Am J Epidemiol 167:377-89. 2008
..However, given the relatively limited total number of subjects examined and observed between-study heterogeneity, chance could not be excluded...
- Prevalence of endoscopic findings of erosive esophagitis in children: a population-based study
Mark A Gilger
Department of Pediatrics, Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Veterans Administration Hospital, Houston, TX, USA
J Pediatr Gastroenterol Nutr 47:141-6. 2008
..The prevalence of such GERD complications in children is unknown. The purpose of this study was to determine the prevalence of endoscopic findings of erosive esophagitis in children...
- Gene expression in Barrett's esophagus: laser capture versus whole tissue
Hashem B El-Serag
Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas, USA
Scand J Gastroenterol 44:787-95. 2009
..The purpose of this study was to determine the degree of overlap of the two sample types and to define a set of genes that might serve as biochemical markers for BE...
- Is fibrolamellar carcinoma different from hepatocellular carcinoma? A US population-based study
Hashem B El-Serag
Section of Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard 152, Houston, TX 77030, USA
Hepatology 39:798-803. 2004
..In conclusion, in a population-based study, we observed remarkable differences in the epidemiology and prognosis of FLC compared to HCC...
- The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000
Thomas Tran
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Am J Gastroenterol 100:162-8. 2005
..CONCLUSIONS: Malignant gastrointestinal stromal tumors rare, but are more common in the older population, men, and Blacks. Risk factors for mortality include older age, Black race, advanced stage, and no surgical intervention...
- Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study
Jessica A Davila
Section of Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Gastroenterology 127:1372-80. 2004
..CONCLUSIONS: There has been a significant recent increase in HCV- and HBV-related HCC. Increasing rates of HCV-related HCC can explain a substantial proportion of the reported increase in HCC incidence during recent years...
- Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett's esophagus
Dang M Nguyen
Section of Gastroenterology and Section of Health Services Research, Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Gastroenterology 138:2260-6. 2010
..However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients with existing Barrett's esophagus (BE) is unclear...
- Higher serum testosterone is associated with increased risk of advanced hepatitis C-related liver disease in males
Donna L White
Clinical Epidemiology and Outcomes Program, Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Hepatology 55:759-68. 2012
..Testosterone may be important in the pathogenesis of HCV-related advanced liver disease in males...
- Level of α-fetoprotein predicts mortality among patients with hepatitis C-related hepatocellular carcinoma
Gia L Tyson
Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
Clin Gastroenterol Hepatol 9:989-94. 2011
..We investigated whether higher levels of AFP at the time of diagnosis are associated with increased mortality of patients with HCV-related HCC...
- Utilization of screening for hepatocellular carcinoma in the United States
Jessica A Davila
Section of Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
J Clin Gastroenterol 41:777-82. 2007
..Screening for hepatocellular carcinoma (HCC) has been recommended for patients at high-risk of developing HCC. Yet, the utilization and determinants of screening remain unclear...
- The extent and determinants of prescribing and adherence with acid-reducing medications: a national claims database study
Hashem B El-Serag
Section of Gastroenterology and Hepatology, Houston Center for Quality of Care and Utilization Studies, The Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 104:2161-7. 2009
..No community-based, large-scale studies have examined the extent of prescribing acid-reducing medications or adherence and persistence to these medication regimens...
- Medication usage and the risk of neoplasia in patients with Barrett's esophagus
Dang M Nguyen
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
Clin Gastroenterol Hepatol 7:1299-304. 2009
..However, only limited data are available on chemoprevention in patients with BE...
- Reducing referral delays in colorectal cancer diagnosis: is it about how you ask?
Hardeep Singh
VA Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Qual Saf Health Care 19:e27. 2010
..The authors tested whether certain details of information transmitted through computerised provider order entry (CPOE)-based referrals affected timeliness of diagnostic colonoscopy for patients with newly diagnosed CRC...
- Anthropometric correlates of intragastric pressure
Hashem B El-Serag
Sections of Health Services Research and Gastroenterology, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Scand J Gastroenterol 41:887-91. 2006
..However, the association between anthropometric measures of total body as well as abdominal obesity and intragastric pressure has not been examined...
- Is there a true "shift" to the right colon in the incidence of colorectal cancer?
Linda Rabeneck
Department of Veterans Affairs Health Services Research, the Gastroenterology and Health Services Research Sections, Houston, Texas, USA
Am J Gastroenterol 98:1400-9. 2003
..Previous studies have reported a migration in the occurrence of colorectal cancer (CRC) toward a proximal colonic location. To assess the potential impact of this, we evaluated recent temporal trends in the United States...
- Effectiveness of AFP and ultrasound tests on hepatocellular carcinoma mortality in HCV-infected patients in the USA
Hashem B El-Serag
The Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
Gut 60:992-7. 2011
..The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Case Registry...
- Hepatocellular carcinoma: recent trends in the United States
Hashem B El-Serag
The Houston Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, Texas 77030, USA
Gastroenterology 127:S27-34. 2004
..The insulin resistance syndrome, manifesting as obesity and diabetes, is emerging as a risk factor for HCC in the United States; however, its impact on the current trend in HCC remains unclear...
- The risk of end stage liver disease and hepatocellular carcinoma among persons infected with hepatitis C virus: publication bias?
Boone Goodgame
Section of Gastroenterology, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 98:2535-42. 2003
..We performed a systematic review of the literature to identify and to analyze studies that examine such cohorts...
- Psychiatric disorders among veterans with hepatitis C infection
Hashem B El-Serag
Section of Gastroenterology, The Houston Center for Quality Care and Utilization Studies, The Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 123:476-82. 2002
..The presence of psychiatric, drug-, and alcohol-use disorders in hepatitis C virus (HCV)-infected patients may influence their management and prognosis. The frequency and the risk for these disorders among HCV-infected patients are unknown...
- Prevalence and histological features of the gastric cardia-type mucosa in children
Hashem B El-Serag
Section of Gastroenterology, Houston Center for Quality of Care and Utilization Studies, The Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
Dig Dis Sci 53:1792-6. 2008
..We examined the presence and determinants of gastric cardia-type mucosa at a normally located z-line in children without underlying gastroesophageal reflux disease (GERD)-predisposing disorders...
- Adapting the Rx-Risk-V for mortality prediction in outpatient populations
Michael L Johnson
Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Med Care 44:793-7. 2006
..We sought to operationalize, test, and validate an outpatient pharmacy-based case-mix adjuster...
- Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis
Donna L White
Section of Gastroenterology and Hepatology, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
J Hepatol 49:831-44. 2008
..We performed meta-analyses to examine whether HCV infection does increase DM risk in comparison to the general population and in other sub-groups with increased liver disease rates including with hepatitis B (HBV)...
- Statin therapy and serum transaminases among a cohort of HCV-infected veterans
Louise M Henderson
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 55:190-5. 2010
..We sought to determine the effect of statin therapy on serum AST and ALT levels in a cohort of HCV-infected veterans with well-characterized liver disease...
- Oral bisphosphonate prescriptions and the risk of esophageal adenocarcinoma in patients with Barrett's esophagus
Dang M Nguyen
Gastroenterology, Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 55:3404-7. 2010
..We therefore examined the association between these medications and the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE)...
- Abdominal obesity and the risk of Barrett's esophagus
Hashem B El-Serag
The Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA
Am J Gastroenterol 100:2151-6. 2005
..CONCLUSIONS: Obesity seems to be associated with an increased risk of BE. Abdominal visceral adiposity might mediate most of this risk...
- Extrahepatic manifestations of hepatitis C among United States male veterans
Hashem B El-Serag
Section of Gastroenterology and Section of Health Services Research at The Houston Veterans Affairs Medical Center, Houston, TX, USA
Hepatology 36:1439-45. 2002
..In conclusion, we found a significant association between HCV infection and PCT, lichen planus, vitiligo, cryoglobulinemia, membranoproliferative GN, and NHL. Patients presenting with these disorders should be tested for HCV infection...
- The use of cytokeratin stain to distinguish Barrett's esophagus from contiguous tissues: a systematic review
Zhannat Nurgalieva
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Dig Dis Sci 52:1345-54. 2007
..CK immunostaining distinguished well between BE and IM in noncardiac segments of the stomach; however, these comparisons are not clinically relevant...
- Hepatocellular carcinoma and hepatitis C in the United States
Hashem B El-Serag
Sections of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, 77030, USA
Hepatology 36:S74-83. 2002
..Future research should focus on improving understanding of the incidence and risk factors for HCC, causes of HCV-related carcinogenesis, means of early detection, and better treatment for HCC...
- Epidemiology of hepatocellular carcinoma in Hispanics in the United States
Hashem B El-Serag
Section of Gastroenterology, The Houston Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Arch Intern Med 167:1983-9. 2007
..In previous studies, the rates for Hispanics have not been reported separately from other racial or ethnic groups...
- The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence
Hashem B El-Serag
Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center at Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 4:369-80. 2006
..We conducted a systematic review and a meta-analysis to estimate the magnitude and determinants of association between diabetes and hepatocellular carcinoma (HCC)...
- Oral contraception and the risk of hepatocellular carcinoma
Shail Maheshwari
Sections of Gastroenterology and Health Services Research at the Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Hepatol 47:506-13. 2007
..We performed a meta-analysis of observational epidemiological studies to examine the association between oral contraceptives (OC) and hepatocellular carcinoma (HCC)...
- Diagnosis and treatment of hepatocellular carcinoma
Hashem B El-Serag
Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas 77030, USA
Gastroenterology 134:1752-63. 2008
..In this article, we present a summary of the most recent information on screening, diagnosis, staging, and different treatment modalities of HCC, as well as our recommended management approach...
- Epidemiology of non-erosive reflux disease
Hashem B El-Serag
Department of Medicine, Baylor College of Medicine and The Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, Houston, Tex 77030, USA
Digestion 78:6-10. 2008
..The temporal trends in NERD are unclear, and are probably increasing because GERD symptom prevalence has increased...
- Complications of pediatric EGD: a 4-year experience in PEDS-CORI
Kalpesh Thakkar
Section of Pediatric Gastroenterology, Department of Hepatology and Nutrition, Texas Children s Hospital and Baylor College of Medicine, Houston, Texas 77030, USA
Gastrointest Endosc 65:213-21. 2007
..Available estimates of the incidence and type of complications during pediatric EGD are inconsistent...
- Time trends of gastroesophageal reflux disease: a systematic review
Hashem B El-Serag
Gastroenterology and Health Services Research Sections, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:17-26. 2007
..If this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, such as esophageal adenocarcinoma, as well as costs to healthcare systems and employers...
- Human immunodeficiency virus-associated squamous cell cancer of the anus: epidemiology and outcomes in the highly active antiretroviral therapy era
Elizabeth Y Chiao
Department of Medicine, Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey Veterans Affairs Medical Center 152, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 26:474-9. 2008
....
- A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States
Katherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20854 7234, USA
Cancer Epidemiol Biomarkers Prev 15:1198-203. 2006
..In conclusion, the rates of HCC and ICC approximately doubled between 1976 and 2000. Trends by age, gender, ethnicity, and birth cohort suggest that heterogeneity exists in the factors influencing these rates...
- Screening for hepatocellular carcinoma among veterans with hepatitis C on disease stage, treatment received, and survival
Luci K Leykum
South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Clin Gastroenterol Hepatol 5:508-12. 2007
..The purpose of this study was to examine the determinants of screening, as well as the impact of screening on disease stage, treatment received, and survival in a US veteran population...
- Geographic variation within the United States in the incidence of hepatocellular carcinoma
Jessica A Davila
Health Services Research, The Houston Veterans Affairs Medical Center, 2002 Holcombe Blvd. (152, Houston, TX 77030, USA
J Clin Epidemiol 56:487-93. 2003
..Significant geographic variation in HCC incidence exist in the United States. These variations are only partly explained by differences in age, gender, race, and year of diagnosis...
- The risk of hepatocellular carcinoma in patients with previous malignancy
Abby B Siegel
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10033, USA
Cancer Invest 26:511-5. 2008
- Noncardia gastric adenocarcinoma remains an important and deadly cancer in the United States: secular trends in incidence and survival
Melvin Lau
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 101:2485-92. 2006
..Unfortunately, there has been no significant improvement in survival during the past 20 yr. Moreover, there remain considerable regional as well as racial variations in mortality...
- Interferon for postresection recurrence of hepatocellular carcinoma
Damien B Mallat
Division of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 97:3200-2. 2002
- Cholangiocarcinoma: the "other" liver cancer on the rise
Jessica A Davila
The Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas, USA
Am J Gastroenterol 97:3199-200. 2002
- Racial differences in survival of hepatocellular carcinoma in the United States: a population-based study
Jessica A Davila
Section of Health Services Research, The Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
Clin Gastroenterol Hepatol 4:104-10; quiz 4-5. 2006
..CONCLUSIONS: We observed significant racial variation in survival. These variations in survival are partly explained by a lower likelihood of receipt of therapy and more advanced HCC at diagnosis among blacks and Hispanics...
- Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study
Tania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Clin Gastroenterol Hepatol 5:1221-8. 2007
..Because the etiology of both tumors is poorly understood, a population-based case-control study was conducted to examine the association of ECC and ICC with preexisting medical conditions...
- Surveillance for hepatocellular carcinoma: does it work?
Damien B Mallat
Division of Gastroenterology, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 97:2676-7. 2002
- Rising prevalence of hepatitis C virus infection among patients recently diagnosed with hepatocellular carcinoma in the United States
Manal M Hassan
University of Texas, Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Gastroenterol 35:266-9. 2002
..03). CONCLUSION: hepatitis C infection is the major viral factor contributing to the increase in HCC incidence observed in this large-scale, single-center United States-based experience...
- Characteristics of children receiving proton pump inhibitors continuously for up to 11 years duration
Eric Hassall
Division of Gastroenterology, BC Children s Hospital University of British Columbia, Vancouver, BC, Canada
J Pediatr 150:262-7, 267.e1. 2007
..To characterize those pediatric patients who receive long-term proton pump inhibitors (PPIs) and to determine the safety of long-term use of PPIs in this population...
- Outcomes of colorectal cancer in the United States: no change in survival (1986-1997)
Linda Rabeneck
Department of Veterans Affairs (VA) Health Services Research and Development (HSR and D) Center of Excellence, Houston, Texas, USA
Am J Gastroenterol 98:471-7. 2003
..However, the lack of improvement in survival over time in whites and blacks indicates that despite advances in screening and treatment, to date, no survival benefit has occurred...
- Survival of colorectal cancer patients hospitalized in the Veterans Affairs Health Care System
Linda Rabeneck
Department of Veterans Affairs Health Services Research and Development Center of Excellence, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 98:1186-92. 2003
..These results suggest that the benefits of prevention and treatment advances may be more readily achieved in the VA's equal access, integrated health care system...
- Racial disparities in utilization of liver transplantation for hepatocellular carcinoma in the United States, 1998-2002
Abby B Siegel
Department of Medicine, Mailman School of Public Health, Columbia University, New York, New York, USA
Am J Gastroenterol 103:120-7. 2008
..We assessed recent predictors of use of liver transplantation and its effect on survival for those with nonmetastatic HCC...
- Hepatocellular carcinoma associated with autoimmune hepatitis
James T Hardee
J Clin Gastroenterol 37:271-2. 2003
- Temporal trends in new and recurrent esophageal strictures in Department of Veterans Affairs
Hashem B El-Serag
The Section of Gastroenterology at The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Am J Gastroenterol 101:1727-33. 2006
..The role of proton pump inhibitors needs to be examined...
- Surgical volume and long-term survival following surgery for colorectal cancer in the Veterans Affairs Health-Care System
Linda Rabeneck
Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Canada
Am J Gastroenterol 99:668-75. 2004
..Future studies are needed to discover what aspects of clinical management explain these differences...
