Karam El-Bayoumy

Summary

Publications

  1. ncbi request reprint The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene) selenocyanate
    K El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Cancer Lett 151:7-13. 2000
  2. ncbi request reprint Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
    Karam El-Bayoumy
    Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 27:1369-76. 2006
  3. ncbi request reprint Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation
    Karam El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:557-61. 2002
  4. ncbi request reprint Multiorgan sensitivity to anticarcinogenesis by the organoselenium 1,4-phenylenebis(methylene)selenocyanate
    K El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Nutr Cancer 40:18-27. 2001
  5. ncbi request reprint The protective role of selenium on genetic damage and on cancer
    K El-Bayoumy
    Division of Cancer Etiology and Prevention, American Health Foundation, 1 Dana Road, 10595, Valhalla, NY, USA
    Mutat Res 475:123-39. 2001
  6. doi request reprint Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis
    Andrea Manni
    Division of Endocrinology, H044, Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 39:1153-64. 2011
  7. ncbi request reprint Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Chem Biol Interact 146:179-90. 2003
  8. ncbi request reprint Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene
    Dhimant Desai
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:964-71. 2002
  9. ncbi request reprint Identification of tobacco-derived compounds in human pancreatic juice
    Bogdan Prokopczyk
    American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:677-85. 2002
  10. doi request reprint The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols
    Neil Trushin
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Langenbecks Arch Surg 393:571-9. 2008

Collaborators

Detail Information

Publications62

  1. ncbi request reprint The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene) selenocyanate
    K El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Cancer Lett 151:7-13. 2000
    ..Although the mechanisms remain to be determined, to our knowledge, this is the first report demonstrating that PhIP and DMBA are capable of enhancing 8-OHdG levels in the rat mammary tissue in vivo...
  2. ncbi request reprint Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
    Karam El-Bayoumy
    Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 27:1369-76. 2006
    ....
  3. ncbi request reprint Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation
    Karam El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:557-61. 2002
    ..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials...
  4. ncbi request reprint Multiorgan sensitivity to anticarcinogenesis by the organoselenium 1,4-phenylenebis(methylene)selenocyanate
    K El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Nutr Cancer 40:18-27. 2001
    ..In addition, we suggest that 1,4-phenylenebis(methylene)selenocyanate not only serves as a chemopreventive agent, but it may be valuable in preventing metastatic diseases in future studies in the clinic...
  5. ncbi request reprint The protective role of selenium on genetic damage and on cancer
    K El-Bayoumy
    Division of Cancer Etiology and Prevention, American Health Foundation, 1 Dana Road, 10595, Valhalla, NY, USA
    Mutat Res 475:123-39. 2001
    ....
  6. doi request reprint Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis
    Andrea Manni
    Division of Endocrinology, H044, Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 39:1153-64. 2011
    ..These results suggest that the protective effect of n:3 in this experimental system is not mediated by changes in the levels of oxidative stress but may result from suppression of arachidonic acid-specific pathways...
  7. ncbi request reprint Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Chem Biol Interact 146:179-90. 2003
    ..Collectively, our in vivo and in vitro results indicate that p-XSC and its conjugate are better candidates than TSC for future studies on mammary cancer chemoprevention...
  8. ncbi request reprint Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene
    Dhimant Desai
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:964-71. 2002
    ..This hypothesis is currently being tested in our laboratory...
  9. ncbi request reprint Identification of tobacco-derived compounds in human pancreatic juice
    Bogdan Prokopczyk
    American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:677-85. 2002
    ..This research presents preliminary data that supports the hypothesis that pancreatic tissue is exposed to TSNA and that they may be important contributors to pancreatic carcinogenesis in humans...
  10. doi request reprint The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols
    Neil Trushin
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Langenbecks Arch Surg 393:571-9. 2008
    ..The carcinogenicity of NNAL is related to its stereochemistry; (S)-NNAL is a more potent lung tumorigen in the A/J mouse than is (R)-NNAL. In this study, we determined the potential of the human pancreas to convert NNK into NNAL...
  11. pmc Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 383:151-5. 2009
    ..The results of this study are encouraging to further evaluate the chemopreventive efficacy of p-XSC initially against B[a]P-induced tongue tumors in mice and ultimately in the clinic...
  12. ncbi request reprint Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Carcinogenesis 24:1505-14. 2003
    ..To our knowledge, this is the first report that provides insights into the effects of p-XSC and p-XSeSG at the molecular level that may account for mammary cancer chemoprevention in vivo in the rat...
  13. pmc Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2
    Sans W Emmert
    Graduate Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, USA
    Free Radic Biol Med 52:2064-71. 2012
    ..05). These results indicate that p-XSC may act through the Nrf2 pathway in vivo and that p-XSeSG is the putative metabolite responsible for such activation, thus offering p-XSeSG as a less toxic, yet highly efficacious, inducer of GSH...
  14. doi request reprint The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice
    Andrea Manni
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Horm Cancer 2:249-59. 2011
    ....
  15. pmc Association of selenium status and blood glutathione concentrations in blacks and whites
    John P Richie
    Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nutr Cancer 63:367-75. 2011
    ..05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor...
  16. ncbi request reprint The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung
    John P Richie
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State University, Milton S Hershey Medical Center, PA 17033, USA
    Chem Biol Interact 161:93-103. 2006
    ....
  17. pmc Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell li
    Yuan Wan Sun
    Department of Biochemistry and Molecular Biology and Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Chem Res Toxicol 22:1992-7. 2009
    ..On the basis of the results of the present study, we hypothesize that [R,R]-1,2-DHD-6-NC is the proximate carcinogen of 6-NC in the rat mammary gland in vivo and will test this hypothesis in a future study...
  18. doi request reprint Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking
    James D Bortner
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Proteome Res 10:1151-9. 2011
    ..Proteins identified in this pilot study may serve as candidate biomarkers of diseases resulting from exposure to cigarette smoke in future molecular epidemiological studies...
  19. ncbi request reprint Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochrysene
    Karam El-Bayoumy
    Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Chem Res Toxicol 17:1591-9. 2004
    ..We also report here for the first time that among those adducts identified in vitro, only 5-(dG-N2-yl)-1,2-DHD-6-AC is the major DNA lesion detected in the mammary glands of rats treated with 6-NC...
  20. pmc Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, USA
    Int J Cancer 133:1300-9. 2013
    ..Taken together, we conclude that the formation of diol epoxides plays a major role among the mechanisms by which DB[a,l]P exerts its oral mutagenicity and tumorigenicity...
  21. pmc Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells
    Yuan Wan Sun
    Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Chem Biol Interact 170:31-9. 2007
    ..g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue...
  22. ncbi request reprint 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet
    Sung Il Chang
    Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 16:228-35. 2007
    ..Therefore, we propose that both proteins may serve as potential biomarkers in future molecular epidemiologic and clinical chemoprevention intervention studies...
  23. pmc Selenium-responsive proteins in the sera of selenium-enriched yeast-supplemented healthy African American and Caucasian men
    Raghu Sinha
    Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 19:2332-40. 2010
    ....
  24. ncbi request reprint Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene
    Telih Boyiri
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    Carcinogenesis 25:637-43. 2004
    ..This is the first report that defines the relationship between carcinogenesis and mutagenesis, as well as between structures of 6-NC-DNA adducts and mutation characteristics in the target organ in vivo...
  25. pmc Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis
    James D Bortner
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Proteome Res 8:4050-61. 2009
    ..Identification of these proteins in surrogate tissue in future studies would be highly useful in early detection of lung adenocarcinoma and clinical chemoprevention trials...
  26. pmc Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination
    Telih Boyiri
    Department of Biochemistry and Molecular Biology and Penn State Cancer Institute, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Int J Oncol 35:559-67. 2009
    ....
  27. pmc Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span
    Arunangshu Das
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Prostate 73:363-75. 2013
    ..Our objectives were to examine for such changes, by systematically determining the effects of growth and development and aging on proteomic profiles in different lobes of the rat prostate...
  28. pmc The effect of selenium enrichment on baker's yeast proteome
    Karam El-Bayoumy
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Proteomics 75:1018-30. 2012
    ....
  29. doi request reprint The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis
    Andrea Manni
    Division of Endocrinology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Cancer Prev Res (Phila) 3:322-30. 2010
    ..Because of its safety, this combination can quickly be translated to the clinic if its superiority can be supported by future studies...
  30. ncbi request reprint Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats
    Shantu Amin
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 16:227-31. 2003
    ..It further supports previous observations that fjord region diol epoxides are more carcinogenic than structurally related bay region diol epoxides...
  31. pmc 1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells
    Nicole D Facompre
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, 17033, USA
    Cancer Prev Res (Phila) 3:975-84. 2010
    ..Our data suggest that p-XSC inhibits multiple signaling pathways in prostate cancer, likely accounting for the downstream effects on proliferation and apoptosis...
  32. ncbi request reprint Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice
    Dhimant Desai
    Institute for Cancer Prevention, American Helath Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Anticancer Res 23:499-503. 2003
    ..The results of this model study indicate that SAHA holds promise as a potential chemopreventive agent against lung cancer...
  33. ncbi request reprint Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines
    Yuan Wan Sun
    Division of Cancer Etiology and Prevention, Institute for Cancer Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 17:1077-85. 2004
    ....
  34. ncbi request reprint Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse
    Arunangshu Das
    Institute for Cancer Prevention formerly American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Nutr Cancer 46:179-85. 2003
    ..The inhibition of DNA methylation and the significantly higher retention of selenium from p-XSC as compared with selenium-enriched yeast in the target organ may in part account for the inhibition of lung tumorigenesis...
  35. pmc The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer
    Arunangshu Das
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    Chem Biol Interact 180:158-64. 2009
    ....
  36. pmc Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells
    Nicole D Facompre
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, PA PA 17033, USA
    Int J Cancer 131:2134-42. 2012
    ..The combination of p-XSC and rapamycin more effectively inhibited viability and mTOR signaling in C4-2, LNCaP and DU145 cells than either agent individually...
  37. pmc Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States
    Chem Res Toxicol 25:374-80. 2012
    ..This animal model should assist to better understand the mechanisms, account for the induction of ovarian cancer by tobacco carcinogens, and facilitate the development of chemopreventive agents against ovarian cancer...
  38. pmc Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Bogdan Prokopczyk
    Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Chem Biol Interact 177:173-80. 2009
    ..The results support previous epidemiological observations that, in addition to HPV, tobacco smoking also plays an important role in the development of cervical cancer...
  39. doi request reprint Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells
    Raghu Sinha
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Nutr Cancer 60:267-75. 2008
    ..This is the first report showing that SM and p-XSC are capable of altering these proteins; their roles in prostate cancer prevention warrant further investigations...
  40. ncbi request reprint Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland
    Karam El-Bayoumy
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:972-8. 2002
    ..Collectively, these results suggest that metabolites derived from both ring-oxidation and nitroreduction contribute to the overall carcinogenicity of 6-NC in the rat mammary gland...
  41. ncbi request reprint Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Res 67:10475-83. 2007
    ..This study shows for the first time that BSC and p-XSC may exert their chemopreventive activity, at least in part, by inhibiting NF-kappaB through covalent modification of Cys(62) of the p50 subunit of NF-kappaB...
  42. ncbi request reprint Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E
    Emerich S Fiala
    Institute for Cancer Prevention, Valhalla, NY, USA
    Carcinogenesis 26:605-12. 2005
    ....
  43. doi request reprint Proteomic Changes Induced by Effective Chemopreventive Ratios of n-3:n-6 Fatty Acids and Tamoxifen against MNU-Induced Mammary Cancer in the Rat
    Christine G Skibinski
    Cancer Institute, Penn State University College of Medicine, 500 University Drive, PO Box, Hershey, PA 17033
    Cancer Prev Res (Phila) 6:979-88. 2013
    ..Such proteins may serve as biomarkers to monitor efficacy of n-3 and Tamoxifen in future clinical chemoprevention trials. Cancer Prev Res; 6(9); 979-88. ©2013 AACR. ..
  44. pmc Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene
    Jacek Krzeminski
    Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Chem Res Toxicol 24:65-72. 2011
    ....
  45. ncbi request reprint Mechanisms of mammary cancer chemoprevention by organoselenium compounds
    Karam El-Bayoumy
    Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 551:181-97. 2004
    ..Collectively, the results described here, suggest that the molecular targets modulated by organoselenium compounds are highly useful indicators of success in clinical cancer chemoprevention trials...
  46. doi request reprint Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations
    Carina Signori
    Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Cancer Res 71:6091-6. 2011
    ....
  47. ncbi request reprint 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue
    Bogdan Prokopczyk
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033 0805, USA
    Cancer Epidemiol Biomarkers Prev 14:540-1. 2005
  48. ncbi request reprint Molecular chemoprevention by selenium: a genomic approach
    Karam El-Bayoumy
    Department of Biochemistry and Molecular Biology, Pennsylvania State Cancer Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mutat Res 591:224-36. 2005
    ..The molecular (genetic) biomarkers presented in this review will provide the foundation for future studies of the chemopreventive properties of structurally varied selenium compounds...
  49. pmc Age related changes in selenium and glutathione levels in different lobes of the rat prostate
    John P Richie
    Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, 500 University Drive, P O Box 850, Hershey, Pennsylvania 17033, USA
    Exp Gerontol 47:223-8. 2012
    ..01). These findings of age-related changes in GSSP and selenium in the DL prostate are consistent with the sensitivity of this lobe to carcinogenesis and, thus, may be playing a mechanistic role...
  50. ncbi request reprint Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines
    Telih Boyiri
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Cancer 100:395-400. 2002
    ..This is the first report to demonstrate the ability of human breast cells, MCF-10A, and breast cancer cell lines to activate 6-NC to metabolites that can damage DNA...
  51. ncbi request reprint Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds
    Karam El-Bayoumy
    Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Nutr 136:864S-869S. 2006
    ....
  52. ncbi request reprint Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate
    Ock Soon Sohn
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Chem Biol Interact 151:193-202. 2005
    ..It may be that the conversion of p-XSeSG to TSC is too facile, or the mere conjugation of p-XSC with glutathione does not occur in rats and mice...
  53. pmc Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib
    Dhimant Desai
    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Chem Biol Interact 188:446-56. 2010
    ....
  54. pmc Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes
    Neil Trushin
    Department of Pharmacology, Penn State University, Hershey, PA 17033, USA
    J Carcinog 11:1. 2012
    ..We determined the metabolism and P450 expression of B[a]P-treated human keratinocytes infected with HPV-16 or -18...
  55. ncbi request reprint Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study
    Karam El-Bayoumy
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Epidemiol Biomarkers Prev 11:1459-65. 2002
    ..001), and this difference disappeared after 12 months. Future trials will test the above hypothesis in prostate cancer patients and in subjects at high risk for prostate cancer...
  56. pmc Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer
    Dhimant Desai
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Bioorg Med Chem Lett 20:2038-43. 2010
    ..Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents...
  57. pmc Potential stages for prostate cancer prevention with selenium: implications for cancer survivors
    Nicole Facompre
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, Pennsylvania 17033, USA
    Cancer Res 69:2699-703. 2009
    ..Clearly, there is sufficient scientific support for its entry into current clinical trials, the outcome of which will be highly valuable in assessing whether selenium can be recommended for cancer survivors...
  58. ncbi request reprint Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Chem Biol Interact 156:81-91. 2005
    ....
  59. ncbi request reprint Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells
    John T Pinto
    Laboratory of Molecular Neurobiology, Cornell Burke Medical Research Institute, White Plains, NY 10605, USA
    Int J Cancer 120:1410-7. 2007
    ....
  60. ncbi request reprint Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice
    Joseph B Guttenplan
    Division of Basic Sciences Biochemistry, New York University, Dental Center, New York, NY 10100, USA
    Mutat Res 559:199-210. 2004
    ....
  61. pmc Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide
    Joseph Guttenplan
    Department of Basic Sciences, College of Dentistry, School of Medicine, New York University, New York, NY 10010, USA
    Mutat Res 634:146-55. 2007
    ..However, the fact that p-XSC is also effective when administered after 4-NQO, suggests additional mechanisms of inhibition exist...
  62. ncbi request reprint Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue
    Joseph B Guttenplan
    Division of Basic Sciences Biochemistry, New York University, Dental Center, 345 E 24th St, New York, NY 10100, USA
    Mutat Res 518:85-93. 2002
    ....