The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene) selenocyanateK El-Bayoumy
American Health Foundation, Valhalla, NY 10595, USA
Cancer Lett 151:7-13. 2000
..Although the mechanisms remain to be determined, to our knowledge, this is the first report demonstrating that PhIP and DMBA are capable of enhancing 8-OHdG levels in the rat mammary tissue in vivo...
- The protective role of selenium on genetic damage and on cancer
K El-Bayoumy
Division of Cancer Etiology and Prevention, American Health Foundation, 1 Dana Road, 10595, Valhalla, NY, USA
Mutat Res 475:123-39. 2001
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- Multiorgan sensitivity to anticarcinogenesis by the organoselenium 1,4-phenylenebis(methylene)selenocyanate
K El-Bayoumy
American Health Foundation, Valhalla, NY 10595, USA
Nutr Cancer 40:18-27. 2001
..In addition, we suggest that 1,4-phenylenebis(methylene)selenocyanate not only serves as a chemopreventive agent, but it may be valuable in preventing metastatic diseases in future studies in the clinic...
- Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation
Karam El-Bayoumy
American Health Foundation, Valhalla, NY 10595, USA
Int J Oncol 20:557-61. 2002
..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials...
- Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
Karam El-Bayoumy
Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Carcinogenesis 27:1369-76. 2006
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Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesisAndrea Manni
Division of Endocrinology, H044, Hershey Medical Center, Hershey, PA 17033, USA
Int J Oncol 39:1153-64. 2011
..These results suggest that the protective effect of n:3 in this experimental system is not mediated by changes in the levels of oxidative stress but may result from suppression of arachidonic acid-specific pathways...
- Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
Karam El-Bayoumy
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
Chem Biol Interact 146:179-90. 2003
..Collectively, our in vivo and in vitro results indicate that p-XSC and its conjugate are better candidates than TSC for future studies on mammary cancer chemoprevention...
- Identification of tobacco-derived compounds in human pancreatic juice
Bogdan Prokopczyk
American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
Chem Res Toxicol 15:677-85. 2002
..This research presents preliminary data that supports the hypothesis that pancreatic tissue is exposed to TSNA and that they may be important contributors to pancreatic carcinogenesis in humans...
- Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene
Dhimant Desai
American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 15:964-71. 2002
..This hypothesis is currently being tested in our laboratory...
- The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols
Neil Trushin
Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033 0850, USA
Langenbecks Arch Surg 393:571-9. 2008
..The carcinogenicity of NNAL is related to its stereochemistry; (S)-NNAL is a more potent lung tumorigen in the A/J mouse than is (R)-NNAL. In this study, we determined the potential of the human pancreas to convert NNK into NNAL...
Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanateKun Ming Chen
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
Biochem Biophys Res Commun 383:151-5. 2009
..The results of this study are encouraging to further evaluate the chemopreventive efficacy of p-XSC initially against B[a]P-induced tongue tumors in mice and ultimately in the clinic...
- Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray
Karam El-Bayoumy
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
Carcinogenesis 24:1505-14. 2003
..To our knowledge, this is the first report that provides insights into the effects of p-XSC and p-XSeSG at the molecular level that may account for mammary cancer chemoprevention in vivo in the rat...
- Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2
Sans W Emmert
Graduate Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, USA
Free Radic Biol Med 52:2064-71. 2012
..05). These results indicate that p-XSC may act through the Nrf2 pathway in vivo and that p-XSeSG is the putative metabolite responsible for such activation, thus offering p-XSeSG as a less toxic, yet highly efficacious, inducer of GSH...
- The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung
John P Richie
Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State University, Milton S. Hershey Medical Center, PA 17033, USA
Chem Biol Interact 161:93-103. 2006
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- The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice
Andrea Manni
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA
Horm Cancer 2:249-59. 2011
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- Association of selenium status and blood glutathione concentrations in blacks and whites
John P Richie
Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
Nutr Cancer 63:367-75. 2011
..05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor...
- Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking
James D Bortner
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Proteome Res 10:1151-9. 2011
..Proteins identified in this pilot study may serve as candidate biomarkers of diseases resulting from exposure to cigarette smoke in future molecular epidemiological studies...
- Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochrysene
Karam El-Bayoumy
Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Chem Res Toxicol 17:1591-9. 2004
..We also report here for the first time that among those adducts identified in vitro, only 5-(dG-N2-yl)-1,2-DHD-6-AC is the major DNA lesion detected in the mammary glands of rats treated with 6-NC...
- Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell li
Yuan Wan Sun
Department of Biochemistry and Molecular Biology and Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
Chem Res Toxicol 22:1992-7. 2009
..On the basis of the results of the present study, we hypothesize that [R,R]-1,2-DHD-6-NC is the proximate carcinogen of 6-NC in the rat mammary gland in vivo and will test this hypothesis in a future study...
- Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis
James D Bortner
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Proteome Res 8:4050-61. 2009
..Identification of these proteins in surrogate tissue in future studies would be highly useful in early detection of lung adenocarcinoma and clinical chemoprevention trials...
- Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination
Telih Boyiri
Department of Biochemistry and Molecular Biology and Penn State Cancer Institute, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Int J Oncol 35:559-67. 2009
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- 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet
Sung Il Chang
Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Cancer Epidemiol Biomarkers Prev 16:228-35. 2007
..Therefore, we propose that both proteins may serve as potential biomarkers in future molecular epidemiologic and clinical chemoprevention intervention studies...
- Selenium-responsive proteins in the sera of selenium-enriched yeast-supplemented healthy African American and Caucasian men
Raghu Sinha
Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 19:2332-40. 2010
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- Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene
Telih Boyiri
American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
Carcinogenesis 25:637-43. 2004
..This is the first report that defines the relationship between carcinogenesis and mutagenesis, as well as between structures of 6-NC-DNA adducts and mutation characteristics in the target organ in vivo...
- Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells
Yuan Wan Sun
Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Chem Biol Interact 170:31-9. 2007
..g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue...
- The effect of selenium enrichment on baker's yeast proteome
Karam El-Bayoumy
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
J Proteomics 75:1018-30. 2012
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- Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines
Yuan-Wan Sun
Division of Cancer Etiology and Prevention, Institute for Cancer Prevention, Valhalla, New York 10595, USA
Chem Res Toxicol 17:1077-85. 2004
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- The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer
Arunangshu Das
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
Chem Biol Interact 180:158-64. 2009
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- The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis
Andrea Manni
Division of Endocrinology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Cancer Prev Res (Phila) 3:322-30. 2010
..Because of its safety, this combination can quickly be translated to the clinic if its superiority can be supported by future studies...
- 1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells
Nicole D Facompre
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, 17033, USA
Cancer Prev Res (Phila) 3:975-84. 2010
..Our data suggest that p-XSC inhibits multiple signaling pathways in prostate cancer, likely accounting for the downstream effects on proliferation and apoptosis...
- Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice
Dhimant Desai
Institute for Cancer Prevention, American Helath Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Anticancer Res 23:499-503. 2003
..The results of this model study indicate that SAHA holds promise as a potential chemopreventive agent against lung cancer...
- Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse
Arunangshu Das
Institute for Cancer Prevention (formerly American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
Nutr Cancer 46:179-85. 2003
..The inhibition of DNA methylation and the significantly higher retention of selenium from p-XSC as compared with selenium-enriched yeast in the target organ may in part account for the inhibition of lung tumorigenesis...
- Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats
Shantu Amin
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 16:227-31. 2003
..It further supports previous observations that fjord region diol epoxides are more carcinogenic than structurally related bay region diol epoxides...
- Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells
Nicole D Facompre
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, PA PA 17033, USA
Int J Cancer 131:2134-42. 2012
..The combination of p-XSC and rapamycin more effectively inhibited viability and mTOR signaling in C4-2, LNCaP and DU145 cells than either agent individually...
- Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse
Kun Ming Chen
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States
Chem Res Toxicol 25:374-80. 2012
..This animal model should assist to better understand the mechanisms, account for the induction of ovarian cancer by tobacco carcinogens, and facilitate the development of chemopreventive agents against ovarian cancer...
- Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells
Raghu Sinha
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Nutr Cancer 60:267-75. 2008
..This is the first report showing that SM and p-XSC are capable of altering these proteins; their roles in prostate cancer prevention warrant further investigations...
- Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Bogdan Prokopczyk
Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Chem Biol Interact 177:173-80. 2009
..The results support previous epidemiological observations that, in addition to HPV, tobacco smoking also plays an important role in the development of cervical cancer...
- Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E
Emerich S Fiala
Institute for Cancer Prevention, Valhalla, NY, USA
Carcinogenesis 26:605-12. 2005
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- Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland
Karam El-Bayoumy
American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 15:972-8. 2002
..Collectively, these results suggest that metabolites derived from both ring-oxidation and nitroreduction contribute to the overall carcinogenicity of 6-NC in the rat mammary gland...
- Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit
Kun Ming Chen
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
Cancer Res 67:10475-83. 2007
..This study shows for the first time that BSC and p-XSC may exert their chemopreventive activity, at least in part, by inhibiting NF-kappaB through covalent modification of Cys(62) of the p50 subunit of NF-kappaB...
- 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue
Bogdan Prokopczyk
Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0805, USA
Cancer Epidemiol Biomarkers Prev 14:540-1. 2005
- Mechanisms of mammary cancer chemoprevention by organoselenium compounds
Karam El-Bayoumy
Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Mutat Res 551:181-97. 2004
..Collectively, the results described here, suggest that the molecular targets modulated by organoselenium compounds are highly useful indicators of success in clinical cancer chemoprevention trials...
- Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene
Jacek Krzeminski
Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
Chem Res Toxicol 24:65-72. 2011
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- Molecular chemoprevention by selenium: a genomic approach
Karam El-Bayoumy
Department of Biochemistry and Molecular Biology, Pennsylvania State Cancer Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Mutat Res 591:224-36. 2005
..The molecular (genetic) biomarkers presented in this review will provide the foundation for future studies of the chemopreventive properties of structurally varied selenium compounds...
- Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations
Carina Signori
Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Cancer Res 71:6091-6. 2011
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- Age related changes in selenium and glutathione levels in different lobes of the rat prostate
John P Richie
Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, 500 University Drive, P O Box 850, Hershey, Pennsylvania 17033, USA
Exp Gerontol 47:223-8. 2012
..01). These findings of age-related changes in GSSP and selenium in the DL prostate are consistent with the sensitivity of this lobe to carcinogenesis and, thus, may be playing a mechanistic role...
- Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate
Ock Soon Sohn
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA
Chem Biol Interact 151:193-202. 2005
..It may be that the conversion of p-XSeSG to TSC is too facile, or the mere conjugation of p-XSC with glutathione does not occur in rats and mice...
- Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib
Dhimant Desai
Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
Chem Biol Interact 188:446-56. 2010
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- Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines
Telih Boyiri
American Health Foundation, Valhalla, NY 10595, USA
Int J Cancer 100:395-400. 2002
..This is the first report to demonstrate the ability of human breast cells, MCF-10A, and breast cancer cell lines to activate 6-NC to metabolites that can damage DNA...
- Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds
Karam El-Bayoumy
Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
J Nutr 136:864S-869S. 2006
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- Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes
Neil Trushin
Department of Pharmacology, Penn State University, Hershey, PA 17033, USA
J Carcinog 11:1. 2012
..We determined the metabolism and P450 expression of B[a]P-treated human keratinocytes infected with HPV-16 or -18...
- Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study
Karam El-Bayoumy
American Health Foundation, Valhalla, New York 10595, USA
Cancer Epidemiol Biomarkers Prev 11:1459-65. 2002
..001), and this difference disappeared after 12 months. Future trials will test the above hypothesis in prostate cancer patients and in subjects at high risk for prostate cancer...
- Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer
Dhimant Desai
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Bioorg Med Chem Lett 20:2038-43. 2010
..Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents...
- Potential stages for prostate cancer prevention with selenium: implications for cancer survivors
Nicole Facompre
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, Pennsylvania 17033, USA
Cancer Res 69:2699-703. 2009
..Clearly, there is sufficient scientific support for its entry into current clinical trials, the outcome of which will be highly valuable in assessing whether selenium can be recommended for cancer survivors...
- Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice
Kun-ming Chen
Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
Chem Biol Interact 156:81-91. 2005
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- Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells
John T Pinto
Laboratory of Molecular Neurobiology, Cornell Burke Medical Research Institute, White Plains, NY 10605, USA
Int J Cancer 120:1410-7. 2007
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- Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice
Joseph B Guttenplan
Division of Basic Sciences Biochemistry, New York University, Dental Center, New York, NY 10100, USA
Mutat Res 559:199-210. 2004
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- Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide
Joseph Guttenplan
Department of Basic Sciences, College of Dentistry, School of Medicine, New York University, New York, NY 10010, USA
Mutat Res 634:146-55. 2007
..However, the fact that p-XSC is also effective when administered after 4-NQO, suggests additional mechanisms of inhibition exist...
- Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue
Joseph B Guttenplan
Division of Basic Sciences Biochemistry, New York University, Dental Center, 345 E 24th St, New York, NY 10100, USA
Mutat Res 518:85-93. 2002
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