Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urineSanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Eur Urol 52:1388-96. 2007
..The aim of this study was to assess the usefulness of MMP-2 and MMP-9 in relation to their inhibitor (TIMP2) as noninvasive diagnostic tests for bilharzial bladder cancer...
- Real-time PCR hTERT mRNA pattern in tumor core, edge, resection margin, and lymph nodes in laryngeal tumors: relation to proliferative index and impact on prognosis
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt
Clin Biochem 38:873-8. 2005
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- The diagnostic efficacy of urinary TGF-beta1 and VEGF in bladder cancer: comparison with voided urine cytology
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Cancer Biomark 3:275-85. 2007
..Moreover, the combined sensitivity of voided urine cytology with TGF-beta1 and VEGF together was higher than sensitivity of voided urine cytology alone in detection of bladder cancer...
Comparison of CD44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cancerSanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, 11566 Abbassia, Cairo, Egypt
Clin Biochem 41:1335-41. 2008
..We evaluated the diagnostic efficacy of urinary CD44 and cytokeratin 20 (CK20) mRNA in comparison with voided urine cytology (VUC) for the detection of bladder cancer...
- HER2/neu expression in bladder cancer: relationship to cell cycle kinetics
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Clin Biochem 38:142-8. 2005
..This study was conducted to evaluate the quantitative assessment of HER2/neu expression by enzyme immunoassay (EIA) and its prognostic significance in differentiating between high and low proliferating tumors...
- Cell cycle regulators in bladder cancer: relationship to schistosomiasis
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Ain Shams Faculty of Medicine, Cairo, Egypt
IUBMB Life 56:557-64. 2004
..Cyclin D1 over-expression appears to be an early event in bladder cancer and might explain bilharzial associated bladder carcinogenesis...
- Comparison of cytokeratin 20 RNA and angiogenin in voided urine samples as diagnostic tools for bladder carcinoma
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt
Clin Biochem 37:803-10. 2004
..We evaluated the diagnostic efficacy of urinary angiogenin (ANG) and cytokeratin 20 (CK-20) mRNA in comparison with voided urine cytology in the detection of bladder cancer patients...
- Diagnostic value of urinary molecular markers in bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Eygpt
Anticancer Res 23:4347-55. 2003
..Their results were compared with both voided urine cytology (VUC) and bladder wash cytology (BWC) for the detection of bladder cancer cells...
- Comparison of telomerase activity and matrix metalloproteinase-9 in voided urine and bladder wash samples as a useful diagnostic tool for bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Eur Urol 44:687-94. 2003
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- Detection of bladder tumours: role of cytology, morphology-based assays, biochemical and molecular markers
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Ain Shams Faculty of Medicine, Cairo, Egypt
Curr Opin Obstet Gynecol 15:395-403. 2003
..In this subject review, a series of morphology-based, biochemical and molecular markers were compared with urine cytology for the detection of bladder cancer...
- The clinical relevance of urine-based markers for diagnosis of bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11566, Egypt
Med Oncol 28:513-8. 2011
..Accordingly, when the diagnostic efficacy was considered, CK20 mRNA had the highest sensitivity and specificity compared to all investigated markers...
- Deletion of p16 and p15 genes In schistosomiasis-associated bladder cancer (SABC)
S Eissa
Oncology Diagnostic Unit, Biochemistry Department, Ain Sharns Faculty of Medicine, Abbassia, Cairo, Egypt
Clin Chim Acta 300:159-69. 2000
..Alteration of the p16 and p15 genes appears to be an early event in bladder cancer which occurs more frequently in SABC and SCC, and may play an important role in the development of schistosomal bladder cancer...
- Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11566, Egypt
Med Oncol 27:1286-94. 2010
..Mutant p53 is associated with disease recurrence and hence it has a significant prognostic role in bladder cancer...
- Breast cancer in Egypt: a review of disease presentation and detection strategies
S Omar
National Cancer Institute, University of Cairo, Cairo, Egypt
East Mediterr Health J 9:448-63. 2003
..Disease presentations common to the region and early detection strategies are presented...
- Multivariate analysis of bcl-2, apoptosis, P53 and HER-2/neu in breast cancer: a short-term follow-up
O El-Ahmady
Biochemistry Department, Ain Shams Faculty of Pharmacy, Cairo, Egypt
Anticancer Res 22:2493-9. 2002
..To determine the importance of molecular-genetic factors relative to more traditional surgical-pathological prognostic factors, multivariate analysis was performed...
- Comparative evaluation of the nuclear matrix protein, fibronectin, urinary bladder cancer antigen and voided urine cytology in the detection of bladder tumors
Sanaa Eissa
Oncology Diagnostic Unit, Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Eygpt
J Urol 168:465-9. 2002
..3%. The higher sensitivities of markers in bilharzial than nonbilharzial bladder cancer highlight their clinical use in screening patients with urinary bilharziasis...
- Emerging role of p53, bcl-2 and telomerase activity in Egyptian breast cancer patients
Menha Swellam
Biochemistry Department, National Research Center, Dokki, Giza, Egypt
IUBMB Life 56:483-90. 2004
..Among a panel of molecular genetic factors investigated, mutant p53 and relative telomerase activity were strongly associated with disease recurrence; hence they exert a significant prognostic role in breast cancer...
- Characterization of Mycobacterium tuberculosis isolated from cancer patients with suspected tuberculosis infection in Egypt: identification, prevalence, risk factors and resistance pattern
A el-Sharif
Department of Microbiology and Immunology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
Clin Microbiol Infect 18:E438-45. 2012
..MGIT-rifampin resistance may be used as a reliable marker for detection of multidrug-resistant TB. Diagnosis and instituting treatment course for active or latent TB infection are crucial before starting anticancer therapy...
- Drug-resistant tuberculosis in Egyptian children using Etest
W Morcos
Child Health Department, National Research Centre, Cairo, Egypt
Minerva Pediatr 60:1385-92. 2008
..The aim of this study was to assess the prevalence of drug-resistant Mycobacterium TB (MT) in newly diagnosed tuberculous Egyptian children, and to determine the effectiveness of the Etest to detect drug-resistant MT...
- Correlation between EBV DNA and rearrangement and expression of Bcl-2 gene in aggressive non-Hodgkin's lymphoma
S Eissa
Biochemistry Department, Ain Shams Faculty of Medicine, Abbassia, Cairo, Egypt
IUBMB Life 48:231-6. 1999
..EBV-positive tumors showed higher bcl-2 expression than EBV-negative tumors did. Our results suggest a role of EBV infection in inducing bcl-2 expression as a survival factor for EBV-positive cells...
Comparison of flow cytometric DNA content analysis in fresh and paraffin-embedded ovarian neoplasms: a prospective studyS Eissa
Oncology Diagnostic Unit Biochemistry Department, Ain Shams Faculty of Medicine, Cairo, Egypt
Br J Cancer 77:421-5. 1998
..Our finding indicates that data generated by flow cytometry analysis of formalin-fixed tissue should be interpreted with caution before the data can be used to draw clinical inferences...
- Detection of telomerase in urine by 3 methods: evaluation of diagnostic accuracy for bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
J Urol 178:1068-72. 2007
..New, noninvasive methods are needed for the diagnosis, followup and screening of patients with bladder cancer. Three methods of detecting telomerase were evaluated in this aspect...
- Detection of bladder carcinoma by combined testing of urine for hyaluronidase and cytokeratin 20 RNAs
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Cancer 103:1356-62. 2005
..A new, sensitive, noninvasive method for the detection of urothelial carcinomas of the urinary bladder would open new possibilities in both the diagnosis and followup of patients...
- A panel of angiogenic factors for early bladder cancer detection: enzyme immunoassay and Western blot
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
J Urol 181:1353-60. 2009
..We adapted and evaluated the measurement of these factors using enzyme-linked immunosorbent assay and compared the results with Western blot and voided urine cytology...
- Diagnostic evaluation of apoptosis inhibitory gene and tissue inhibitor matrix metalloproteinase-2 in patients with bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
IUBMB Life 62:394-9. 2010
..On combining cytology with both urinary survivin and TIMP-2, the highest sensitivity was reached (98%). Survivin and TIMP-2 can be considered as potentially useful urine markers in early detection of bladder cancer...
- Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation
H K Awwad
Department of Radiotherapy, National Cancer Institute, University of Cairo, Fom El Khalig 11796, Cairo, Egypt
Br J Cancer 86:517-23. 2002
..To gain a full benefit from treatment acceleration, the surgery-radiotherapy gap and the overall treatment time should not exceed 6 and 10 weeks respectively...
- Expression of HYAL1 and survivin RNA as diagnostic molecular markers for bladder cancer
Sanaa Eissa
Oncology Diagnostic Unit, Medical Biochemistry Department, Ain Shams University, Cairo, Egypt
J Urol 183:493-8. 2010
..We assessed the diagnostic efficacy of hyaluronidase (HYAL1) and survivin for early bladder cancer detection...
- Tumor suppressor protein p53 and anti-p53 autoantibodies in pediatric rheumatological diseases
Zeinab Awad El-Sayed
Departments of Pediatrics, Clinical Pathology and Biochemistry, Ain Shams University, Cairo, Egypt
Pediatr Allergy Immunol 14:229-33. 2003
..The presence of anti-p53 antibodies might cause malfunctioning of p53 protein interfering with its regulatory functions...
- Variability in the performance of nuclear matrix protein 22 for the detection of bladder cancer
Shahrokh F Shariat
Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Urol 176:919-26; discussion 926. 2006
..We assessed variability in the diagnostic performance of NMP22 for detecting recurrence and progression in patients with Ta, T1, and/or CIS transitional cell carcinoma of the bladder in a large international cohort...
- Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma
Georg C Hutterer
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
BJU Int 101:561-5. 2008
..To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC)...
- Institutional variability in the accuracy of urinary cytology for predicting recurrence of transitional cell carcinoma of the bladder
Pierre I Karakiewicz
Department of Urology, University of Montreal, Montreal, Quebec, Canada
BJU Int 97:997-1001. 2006
..Stratifying by grade and stage only partly attenuated the discrepancies between centres. CONCLUSIONS: The variability of urinary cytology results was very appreciable among the 10 centres and ranged from poor (63%) to excellent (89%)...
- Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder
Shahrokh F Shariat
Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
J Urol 173:1518-25. 2005
..We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort...
