P Eikelenboom

Summary

Publications

  1. doi request reprint Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 7:38-41. 2010
  2. ncbi request reprint The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
    Curr Alzheimer Res 8:142-50. 2011
  3. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
  4. doi request reprint Innate immunity and the etiology of late-onset Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 10:271-3. 2012
  5. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
  6. ncbi request reprint Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease
    J J Hoozemans
    Department of Psychiatry, Research Institute Neurosciences Vrije Universiteit, Vrije Universiteit, Amsterdam, The Netherlands
    Exp Gerontol 36:559-70. 2001
  7. ncbi request reprint Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain
    J J Hoozemans
    Department of Pathology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Acta Neuropathol 101:2-8. 2001
  8. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
  9. ncbi request reprint Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
  10. doi request reprint Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer's disease in non-depressed subjects
    E Richard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 33:204-9. 2012

Collaborators

Detail Information

Publications36

  1. doi request reprint Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 7:38-41. 2010
    ..Objectives: To show that the interest in inflammation in Alzheimer's disease (AD) is not only an early event in the history of AD but that inflammation is also an early event in the pathogenesis of AD...
  2. ncbi request reprint The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
    Curr Alzheimer Res 8:142-50. 2011
    ....
  3. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
    ..The view that peripheral inflammation can increase the risk of dementia in older people provides scope for prevention...
  4. doi request reprint Innate immunity and the etiology of late-onset Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 10:271-3. 2012
    ..Neuropathological studies supported by experimental animal studies show that the constituents of the innate immunity are intimately involved in the early steps of the pathological cascade of Alzheimer's disease (AD)...
  5. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
    ..However, the age-dependent relationship between inflammation and clinical phenotype of AD has never been investigated...
  6. ncbi request reprint Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease
    J J Hoozemans
    Department of Psychiatry, Research Institute Neurosciences Vrije Universiteit, Vrije Universiteit, Amsterdam, The Netherlands
    Exp Gerontol 36:559-70. 2001
    ..Although the physiological role of neuronal COX-2 still remains unclear, we suggest an interplay between glial derived IL-1 and neuronal upregulation of COX-2 expression in chronic neurodegenerative diseases, such as AD...
  7. ncbi request reprint Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain
    J J Hoozemans
    Department of Pathology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Acta Neuropathol 101:2-8. 2001
    ..The different distribution patterns of COX-1 and COX-2 in AD could implicate that these enzymes are involved in different cellular processes in the pathogenesis of AD...
  8. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
    ..We also discuss the possibilities of inflammation-based therapeutic strategies in AD...
  9. ncbi request reprint Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
    ..Our data suggest that ER and post-ER protein quality control mechanisms are activated early in the pathology of AD...
  10. doi request reprint Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer's disease in non-depressed subjects
    E Richard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 33:204-9. 2012
    ..Apathy may be associated with an increased risk of cognitive decline. The objective of this study was to investigate if apathy predicts the progression from MCI to Alzheimer's disease (AD)...
  11. ncbi request reprint Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
    ....
  12. ncbi request reprint Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
    ..These data show that the UPR is activated in PD and that UPR activation is closely associated with the accumulation and aggregation of alpha-synuclein...
  13. ncbi request reprint Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease
    J J M Hoozemans
    Academic Medical Center, Neurogenetics Laboratory, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 13:2599-605. 2006
    ..Insight into the role of different Abeta species during AD pathogenesis is essential for the development of disease modifying drugs and therapeutical strategies...
  14. ncbi request reprint The importance of inflammatory mechanisms for the development of Alzheimer's disease
    P Eikelenboom
    Graduate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Valeriuskliniek, The Netherlands
    Exp Gerontol 34:453-61. 1999
    ..An inflammation-based approach could also provide a valuable theoretical framework to study the influence of extracerebral factors (such as acute phase reactants) on the clinical course of Alzheimer's disease...
  15. ncbi request reprint Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
    J J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, P O Box 22700, 110DE Amsterdam, The Netherlands
    Int J Dev Neurosci 24:157-65. 2006
    ..This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis...
  16. ncbi request reprint Serum inflammatory proteins and cognitive decline in older persons
    M G Dik
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 64:1371-7. 2005
    ..To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons...
  17. ncbi request reprint The unfolded protein response is activated in Alzheimer's disease
    J J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Acta Neuropathol 110:165-72. 2005
    ..Although the initial participation of the UPR in AD pathogenesis might be neuroprotective, sustained activation of the UPR in AD might initiate or mediate neurodegeneration...
  18. ncbi request reprint [Vaccinations in psychiatry]
    A Dols
    GGZ Buitenamstel, Amsterdam
    Tijdschr Psychiatr 51:751-9. 2009
    ..In psychiatry there are also situations where antigens that have been introduced from outside or that have developed during an illness constitute a threat to the patient's health...
  19. ncbi request reprint [Melancholia, psychomotor disturbance or depressed mood?]
    A Dols
    Polikliniek voor ouderen bij GGZ inGeest VU mc te Amsterdam
    Tijdschr Psychiatr 52:583-8. 2010
    ..On the basis of two case studies we show that psychomotor symptoms can be extremely important for an accurate clinical evaluation...
  20. doi request reprint Social functioning among older community-dwelling patients with schizophrenia: a review
    Paul D Meesters
    GGZ inGeest, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 18:862-78. 2010
    ..Social support, impact of gender, and specific characteristics of older-old patients figure among areas that should be given priority in future research of social functioning in late life schizophrenia...
  21. doi request reprint Symptomatic remission and associated factors in a catchment area based population of older patients with schizophrenia
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Schizophr Res 126:237-44. 2011
    ....
  22. ncbi request reprint [Increased activity of stress-regulating systems in Alzheimer disease]
    W J Hoogendijk
    vakgroep Psychiatrie, Vrije Universiteit Amsterdam/GGZ Buitenamstel, Valeriusplein 9, 1075 BG Amsterdam
    Tijdschr Gerontol Geriatr 32:17-23. 2001
    ..These results can be related to another stress related system, the hypothalamo-pituitary-adrenal-(HPA)axis. This means that further evaluation of both of these systems is necessary...
  23. ncbi request reprint Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease
    P Eikelenboom
    Graduate School Neuroscience, Amsterdam, The Netherlands
    J Psychiatr Res 36:269-80. 2002
    ....
  24. ncbi request reprint Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 111:281-94. 2004
    ..Here we review the evidence that inflammation related events could be a critical etiological factor in certain forms of the sporadic AD...
  25. doi request reprint Dyshoric capillary cerebral amyloid angiopathy mimicking Creutzfeldt-Jakob disease
    L S M Eurelings
    Academic Medical Center, University of Amsterdam, Dept of Neurology, H2 225, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Neurol Sci 295:131-4. 2010
    ..Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer's disease, and in rare cases this is particularly capillary CAA with dyshoric changes...
  26. ncbi request reprint The two faces of Alzheimer's disease
    W A van Gool
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neurol 247:500-5. 2000
    ..It may provide a more realistic perspective, and it holds promise for new opportunities for prevention and treatment...
  27. ncbi request reprint Immunological aspects of alzheimer's disease: therapeutic implications
    J J Hoozemans
    Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    BioDrugs 15:325-37. 2001
    ..This review outlines the pathological and genetic evidence that an inflammatory mechanism is involved in AD and the therapeutic approaches based on inhibition or mediation of inflammation...
  28. ncbi request reprint Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?
    W A van Gool
    Dept of Neurology, H2 222 2, Academic Medical Center, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    J Neurol 250:788-92. 2003
    ..We conclude that studies on primary prevention of AD are the logical next step in testing the inflammatory hypothesis of AD...
  29. ncbi request reprint Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor
    R Veerhuis
    Department of Psychiatry, Graduate School Neurosciences, Vrije Universiteit, Amsterdam, The Netherlands
    Exp Neurol 160:289-99. 1999
    ....
  30. doi request reprint Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
    Eric van Exel
    Department of Psychiatry, VU University Medical Center GGZ inGeest, Osdorpplein 880, 1068 TD, Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:1263-70. 2009
    ..Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally...
  31. ncbi request reprint Head trauma and Alzheimer's disease
    Rishi D S Nandoe
    Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 4:303-8. 2002
    ..Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient...
  32. ncbi request reprint The cholinergic deficiency syndrome and its therapeutic implications
    Afina W Lemstra
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Gerontology 49:55-60. 2003
    ..CDS is suggested to occur in various neurodegenerative diseases like Alzheimer's disease, Lewy body dementia and Parkinson's disease and to respond well to cholinesterase inhibitor therapy...
  33. ncbi request reprint Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Curr Drug Targets 4:461-8. 2003
    ..Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD...
  34. ncbi request reprint The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
    ..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD...
  35. ncbi request reprint The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: therapeutic implications
    Annemieke J M Rozemuller
    Dept Neuropathology, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:223-33. 2005
    ..The implications of the reviewed studies for an inflammation-based therapeutical approach in AD will be discussed...
  36. ncbi request reprint Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    Jeroen J M Hoozemans
    Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 15:492-9. 2004
    ..These results suggest that p38 MAPK does not mediate COX-2 expression and pRb inactivation, which are involved in cellular changes in pyramidal neurons early in AD pathogenesis...