Mahmoud Elhefnawi

Summary

Affiliation: The American University in Cairo
Country: Egypt

Publications

  1. pmc Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy
    Fatimah S Alhamlan
    Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center MBC 03, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    J Transl Med 12:91. 2014
  2. pmc Ensemble-based classification approach for micro-RNA mining applied on diverse metagenomic sequences
    Sherin M ElGokhy
    Department of Computer Science and Engineering, Egypt Japan University of Science and Technology E Just, 21934, New Borg EL Arab, Alexandria, Egypt
    BMC Res Notes 7:286. 2014
  3. ncbi Accurate classification and hemagglutinin amino acid signatures for influenza A virus host-origin association and subtyping
    Mahmoud Elhefnawi
    Informatics and Systems Department and Biomedical Informatics and Chemoinformatics Group, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt Electronic address
    Virology 449:328-38. 2014
  4. ncbi An integrative meta-analysis of microRNAs in hepatocellular carcinoma
    Mahmoud Elhefnawi
    Centre of Excellence for Advanced Sciences, Informatics and Systems Department, National Research Centre, Cairo 12622, Egypt Electronic address
    Genomics Proteomics Bioinformatics 11:354-67. 2013
  5. pmc Multiple virtual screening approaches for finding new hepatitis C virus RNA-dependent RNA polymerase inhibitors: structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors
    Mahmoud Elhefnawi
    Informatics and Systems Department, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    BMC Bioinformatics 13:S5. 2012
  6. ncbi Natural genetic engineering of hepatitis C virus NS5A for immune system counterattack
    Mahmoud M El Hefnawi
    Informatics and Systems Department, Division of Engineering Research Sciences, The National Research Centre, Egypt
    Ann N Y Acad Sci 1178:173-85. 2009
  7. ncbi The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus
    Mahmoud Elhefnawi
    Informatics and Systems Department, Division of Engineering Research, National Research Centre, Egypt
    Bioinformatics 27:3364-70. 2011
  8. pmc Prediction of prognostic biomarkers for interferon-based therapy to hepatitis C virus patients: a meta-analysis of the NS5A protein in subtypes 1a, 1b, and 3a
    Mahmoud M Elhefnawi
    Informatics and Systems Department, Division of Engineering Research, National Research Centre, Tahrir Street, Cairo, Egypt
    Virol J 7:130. 2010
  9. pmc Identification of novel conserved functional motifs across most Influenza A viral strains
    Mahmoud Elhefnawi
    Informatics and Systems Department and Biomedical Informatics and chemo informatics group, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    Virol J 8:44. 2011
  10. ncbi MysiRNA: improving siRNA efficacy prediction using a machine-learning model combining multi-tools and whole stacking energy (ΔG)
    Mohamed Mysara
    Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    J Biomed Inform 45:528-34. 2012

Collaborators

  • Rania Siam
  • Mohamed Mysara
  • Sherin M ElGokhy
  • Fatimah S Alhamlan
  • Ahmed Temirak
  • Jonathan M Garibaldi
  • Mahmoud M El Hefnawi
  • Amin Shoukry
  • Faisal M Sanai
  • Ayman A Abdo
  • Nisreen Z Khalaf
  • Amina Zaid
  • Ahmed A Al-Qahtani
  • Mohammed N Al-Ahdal
  • Hamad I Al-Ashgar
  • Mona Abdulla
  • Atek Z Ghalwash
  • Lamya A El Housseiny
  • Suher Zada
  • Aliaa A Youssif
  • Wessam H El Behaidy

Detail Information

Publications12

  1. pmc Genetic variability of the core protein in hepatitis C virus genotype 4 in Saudi Arabian patients and its implication on pegylated interferon and ribavirin therapy
    Fatimah S Alhamlan
    Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center MBC 03, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    J Transl Med 12:91. 2014
    ..Previous studies have reported that the substitution of amino acids in the HCV subgenotype 1b core protein in infected patients is associated with a poor response to pegylated interferon and ribavirin (PEG-IFN/RBV) combined therapy...
  2. pmc Ensemble-based classification approach for micro-RNA mining applied on diverse metagenomic sequences
    Sherin M ElGokhy
    Department of Computer Science and Engineering, Egypt Japan University of Science and Technology E Just, 21934, New Borg EL Arab, Alexandria, Egypt
    BMC Res Notes 7:286. 2014
    ..Different approaches for identification of miRNAs have been proposed based on homology, thermodynamic parameters, and cross-species comparisons...
  3. ncbi Accurate classification and hemagglutinin amino acid signatures for influenza A virus host-origin association and subtyping
    Mahmoud Elhefnawi
    Informatics and Systems Department and Biomedical Informatics and Chemoinformatics Group, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt Electronic address
    Virology 449:328-38. 2014
    ..This finding indicated the lower specificity of the swine host, perhaps pointing to its ability to mix different strains. ..
  4. ncbi An integrative meta-analysis of microRNAs in hepatocellular carcinoma
    Mahmoud Elhefnawi
    Centre of Excellence for Advanced Sciences, Informatics and Systems Department, National Research Centre, Cairo 12622, Egypt Electronic address
    Genomics Proteomics Bioinformatics 11:354-67. 2013
    ..Therefore some of these miRNAs may be addressed as therapeutic targets or used as therapeutic agents. Such dual roles thus expand the view of miRNAs as active maintainers of cellular homeostasis. ..
  5. pmc Multiple virtual screening approaches for finding new hepatitis C virus RNA-dependent RNA polymerase inhibitors: structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors
    Mahmoud Elhefnawi
    Informatics and Systems Department, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    BMC Bioinformatics 13:S5. 2012
    ..Eventually molecular dynamics simulations were carried out, confirming the binding hypothesis and resulting in 4 hits...
  6. ncbi Natural genetic engineering of hepatitis C virus NS5A for immune system counterattack
    Mahmoud M El Hefnawi
    Informatics and Systems Department, Division of Engineering Research Sciences, The National Research Centre, Egypt
    Ann N Y Acad Sci 1178:173-85. 2009
    ..The different mechanisms by which the NS5A protein leads to immune system signaling dysfunction points to the natural genetic engineering of this protein...
  7. ncbi The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus
    Mahmoud Elhefnawi
    Informatics and Systems Department, Division of Engineering Research, National Research Centre, Egypt
    Bioinformatics 27:3364-70. 2011
    ..There is an urgent need for new medications to combat influenza pandemics...
  8. pmc Prediction of prognostic biomarkers for interferon-based therapy to hepatitis C virus patients: a meta-analysis of the NS5A protein in subtypes 1a, 1b, and 3a
    Mahmoud M Elhefnawi
    Informatics and Systems Department, Division of Engineering Research, National Research Centre, Tahrir Street, Cairo, Egypt
    Virol J 7:130. 2010
    ....
  9. pmc Identification of novel conserved functional motifs across most Influenza A viral strains
    Mahmoud Elhefnawi
    Informatics and Systems Department and Biomedical Informatics and chemo informatics group, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    Virol J 8:44. 2011
    ....
  10. ncbi MysiRNA: improving siRNA efficacy prediction using a machine-learning model combining multi-tools and whole stacking energy (ΔG)
    Mohamed Mysara
    Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Tahrir Street, 12311 Cairo, Egypt
    J Biomed Inform 45:528-34. 2012
    ..This multiclassifier approach could help improve the performance of prediction in several bioinformatics areas. MysiRNA model, part of MysiRNA-Designer package [1], is expected to play a key role in siRNA selection and evaluation...
  11. ncbi Rational drug design for identifying novel multi-target inhibitors for hepatocellular carcinoma
    Ahmed Temirak
    Biomedical Informatics and Chemoinformatics Group, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt
    Anticancer Agents Med Chem 12:1088-97. 2012
    ..Finally 7 compounds were selected as they exhibited excellent binding interactions with the receptors in addition to their high safety profile that are recommended for further development...
  12. pmc MysiRNA-designer: a workflow for efficient siRNA design
    Mohamed Mysara
    Informatics and Systems Department and Biomedical Informatics and Chemoinformatics Group, Division of Engineering Research and Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt
    PLoS ONE 6:e25642. 2011
    ..We believe that MysiRNA-Designer has the potential to play an important role in this area...