M R Hussein

Summary

Affiliation: Assuit University
Country: Egypt

Publications

  1. pmc Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions
    M R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Egypt
    J Clin Pathol 59:316-24. 2006
  2. ncbi Dendritic cells and melanoma tumorigenesis: an insight
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cancer Biol Ther 4:501-5. 2005
  3. ncbi Role of fine needle aspirate mapping and touch imprint preparations in the evaluation of azoospermia
    Mahmoud R Hussein
    Department of Pathology, Obstetrics and Gynecology, and Urology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Anal Quant Cytol Histol 27:67-70. 2005
  4. ncbi Skin cancer in Egypt: a word in your ear
    Mahmoud R Hussein
    University of Wisconsin Medical School and William S Middleton Memorial Veteran Hospital, Madison, WI 53705 USA
    Cancer Biol Ther 4:593-5. 2005
  5. pmc Immunohistological analysis of immune cells in blistering skin lesions
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assiut University Hospitals, Assiut University, Assiut, Egypt
    J Clin Pathol 60:62-71. 2007
  6. pmc Analysis of Bcl-2 protein expression in choroidal melanomas
    M R Hussein
    Pathology Department, School of Medicine, Assuit University, Egypt
    J Clin Pathol 58:486-9. 2005
  7. pmc Melanocytic dysplastic naevi occupy the middle ground between benign melanocytic naevi and cutaneous malignant melanomas: emerging clues
    M R Hussein
    Department of Pathology, Assiut University Hospital, Egypt
    J Clin Pathol 58:453-6. 2005
  8. pmc The effects of glucocorticoid therapy on the inflammatory and dendritic cells in muscular dystrophies
    Mahmoud R Hussein
    Department of Pathology, Assiut University, Assiut, Egypt
    Int J Exp Pathol 87:451-61. 2006
  9. pmc Intake of melatonin is associated with amelioration of physiological changes, both metabolic and morphological pathologies associated with obesity: an animal model
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Int J Exp Pathol 88:19-29. 2007
  10. ncbi Transforming growth factor-beta and malignant melanoma: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, School of Medicine, Assuit University, Assuit, Egypt
    J Cutan Pathol 32:389-95. 2005

Collaborators

Detail Information

Publications76

  1. pmc Immunohistological characterisation of tumour infiltrating lymphocytes in melanocytic skin lesions
    M R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Egypt
    J Clin Pathol 59:316-24. 2006
    ..This study attempted to test this hypothesis and to characterise TIL in the melanocytic skin lesions...
  2. ncbi Dendritic cells and melanoma tumorigenesis: an insight
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cancer Biol Ther 4:501-5. 2005
    ..This review provides insights into DCs status in the skin, and their roles in melanoma. It also sheds light on the possible use of DCs in melanoma therapy...
  3. ncbi Role of fine needle aspirate mapping and touch imprint preparations in the evaluation of azoospermia
    Mahmoud R Hussein
    Department of Pathology, Obstetrics and Gynecology, and Urology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Anal Quant Cytol Histol 27:67-70. 2005
    ..To assess the utility of fine needle aspiration cytology (FNAC) and touch imprint cytology (TIC) in the evaluation of azoospermia...
  4. ncbi Skin cancer in Egypt: a word in your ear
    Mahmoud R Hussein
    University of Wisconsin Medical School and William S Middleton Memorial Veteran Hospital, Madison, WI 53705 USA
    Cancer Biol Ther 4:593-5. 2005
    ..In Egypt, the clinicopathologic features of skin cancer are still unknown...
  5. pmc Immunohistological analysis of immune cells in blistering skin lesions
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assiut University Hospitals, Assiut University, Assiut, Egypt
    J Clin Pathol 60:62-71. 2007
    ..Bullous skin lesions are characterised by the presence of intraepidermal or subepidermal bullae. Although inflammatory cell infiltrate is a constant feature in these lesions, their immunophenotypic characterisation is still incomplete...
  6. pmc Analysis of Bcl-2 protein expression in choroidal melanomas
    M R Hussein
    Pathology Department, School of Medicine, Assuit University, Egypt
    J Clin Pathol 58:486-9. 2005
    ..Bcl-2 protooncogene alterations are involved in tumorigenesis and may have prognostic ramifications...
  7. pmc Melanocytic dysplastic naevi occupy the middle ground between benign melanocytic naevi and cutaneous malignant melanomas: emerging clues
    M R Hussein
    Department of Pathology, Assiut University Hospital, Egypt
    J Clin Pathol 58:453-6. 2005
    ..Although this argument appears to be straightforward, it is still controversial. This review explores the components of this argument and provides supporting evidence for this hypothesis...
  8. pmc The effects of glucocorticoid therapy on the inflammatory and dendritic cells in muscular dystrophies
    Mahmoud R Hussein
    Department of Pathology, Assiut University, Assiut, Egypt
    Int J Exp Pathol 87:451-61. 2006
    ..In DMD/BMD, prednisone therapeutic effect was associated with reduced MICs and DCs numbers. Whether this therapeutic effect reflects targeting of the deleterious immune response produced by these cells mandates further investigations...
  9. pmc Intake of melatonin is associated with amelioration of physiological changes, both metabolic and morphological pathologies associated with obesity: an animal model
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Int J Exp Pathol 88:19-29. 2007
    ..Although the underlying mechanisms are unclear, they may include its antioxidant and receptor-mediated effects. The clinical ramifications of these effects await further investigations...
  10. ncbi Transforming growth factor-beta and malignant melanoma: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, School of Medicine, Assuit University, Assuit, Egypt
    J Cutan Pathol 32:389-95. 2005
    ..This review seeks to examine the present knowledge about TGF-beta receptor/SMAD signaling pathway and its related genes (SMADs, SKI, Filamin, endoglin, Follistatin, and other molecules) in melanomas...
  11. ncbi The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
    Cancer Biol Ther 5:1129-33. 2006
    ..Phytic acid is an anti-neoplastic agent. We hypothesize that during mammary tumorigenesis, the administration of phytic acid is associated with biochemical changes including enhancement of apoptosis and inhibition of oxidative stress...
  12. ncbi Analysis of fibronectin expression in the bilharzial granulomas and of laminin in the transformed urothelium in schistosoma haematobium infested patients
    M R Hussein
    Department of Pathology, Faculty of Medicine, Assiut University Hospitals, Assiut, Egypt
    Cancer Biol Ther 4:676-8. 2005
    ..In dysplastic urothelium (20 cases), it showed breaks in continuity. Conclusions: Alterations of FN and LN occur during the development of the bilharzial granuloma and urothelial transformation...
  13. pmc Tumour-associated macrophages and melanoma tumourigenesis: integrating the complexity
    Mahmoud R Hussein
    Department of Histopathology, Assuit University Hospitals, Faculty of Medicine, Assuit University, Assuit, Egypt
    Int J Exp Pathol 87:163-76. 2006
    ..To date, little is available in the literature about the interactions between TAMs and melanoma cells. This viewpoint not only tries to examine these interactions but also provides relevant speculations...
  14. ncbi Clinicopathological features of melanocytic skin lesions in Egypt
    Mahmoud R Hussein
    Department of Pathology, Assuit University Hospitals, Faculty of Medicine, Assuit University, Assuit, Egypt
    Eur J Cancer Prev 15:64-8. 2006
    ..Another key difference from the West is the 'sun-bed' culture of the West and the desire to have suntans. This is the first study that reports the clinicopathologic features of melanocytic skin lesions in Egypt...
  15. ncbi Melatonin and roentgen irradiation of the testis
    Mahmoud R Hussein
    Department of Histopathology, Assir Central Hospital King Khlid University Teaching Hospitals, Assir, Kingdom of Saudi Arabia
    Fertil Steril 86:750-2. 2006
    ..In roentgen-irradiated, melatonin-pretreated animals, these changes were markedly ameliorated. Thus administration of melatonin before irradiation can protect testis from some of the destructive effects of roentgen irradiation...
  16. pmc Alterations of p53, BCL-2, and hMSH2 protein expression in the normal brain tissues, gliosis, and gliomas
    Mahmoud R Hussein
    Faculty of Medicine, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Int J Exp Pathol 87:297-306. 2006
    ..07, P > 0.05) and between p53 and hMSH2 (r = -0.08, P > 0.05) protein expression. Alterations of the p53, BCL-2, and hMSH2 proteins occur during the development of these tumors...
  17. ncbi Analysis of the mononuclear inflammatory cell infiltrate in the non-tumorigenic, pre-tumorigenic and tumorigenic keratinocytic hyperproliferative lesions of the skin
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Egypt
    Cancer Biol Ther 4:819-21. 2005
    ..This study tries to test this hypothesis and to characterize MICs in these lesions...
  18. ncbi Analysis of the mononuclear inflammatory cell infiltrate in the cirrhotic, dysplastic nodules and hepatocellular carcinomas in patients with chronic hepatitis C infection
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut, Egypt
    Cancer Biol Ther 4:1075-8. 2005
    ..We hypothesized that hepatocarcinogeneis on top of chronic hepatitis C (CH-C) is associated with alterations in the mononuclear inflammatory cell infiltrate (MICs) in response to altered antigenicity of the damaged hepatocytes...
  19. pmc Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations
    M R Hussein
    Department of Histopathology, Assir Central Hospital, Abha, Kingdom of Saudi Arabia
    J Clin Pathol 59:972-7. 2006
    ..Mammary carcinogenesis is a multistep process entailing the transition from normal breast to benign proliferative breast disease (ductal hyperplasia) to ductal carcinoma in situ to infiltrating ductal carcinoma...
  20. ncbi Tumour-infiltrating lymphocytes and melanoma tumorigenesis: an insight
    M R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Br J Dermatol 153:18-21. 2005
    ..This review seeks to examine the characteristics, activation and role of TILs and their associated molecules in melanomas...
  21. pmc Genomic instability in radial growth phase melanoma cell lines after ultraviolet irradiation
    M R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    J Clin Pathol 58:389-96. 2005
    ....
  22. ncbi Rhinosporidiosis in Egypt: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Mycopathologia 159:205-7. 2005
    ..The clinicopathological and immunologic features were discussed and the literature was reviewed. To the best of our knowledge this is the first case of this disease to be reported in Egypt in the human literature...
  23. ncbi Expression of KIT receptor tyrosine kinase protein in normal human skin: preliminary observations
    Mahmoud R Hussein
    Pathology Department, School of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 31:748-51. 2007
    ..Thus, the expression of KIT protein in normal human skin suggests its possible role in regulation of cutaneous development and function...
  24. doi Extracutaneous malignant melanomas
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Cancer Invest 26:516-34. 2008
    ..Special staining and immunohistochemistry should be resorted to establish the diagnosis...
  25. doi Evaluation of Langerhans' cells in normal and eczematous dermatitis skin by CD1a protein immunohistochemistry: preliminary findings
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit University, Assuit, Egypt
    J Cutan Pathol 35:554-8. 2008
    ..Langerhans' cells (CD1a positive, bone marrow-derived cells), are the antigen presenting cells of the skin. Our knowledge about the status of these cells in eczematous dermatitis is incomplete...
  26. doi Cranial fasciitis of childhood: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    J Cutan Pathol 35:212-4. 2008
    ..It also emphasizes that the correct diagnosis of these lesions is needed to avoid unnecessary surgery and radiotherapy...
  27. ncbi Primary cutaneous meningioma of the scalp: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Egypt
    J Cutan Pathol 34:26-8. 2007
    ..Immunostains for cytokeratin, S-100 protein, vascular (CD34 and CD31) and muscle markers (Desmin and smooth muscle actin) were negative. The diagnosis of cutaneous meningioma was established. A review of literature was presented...
  28. pmc Central nervous system capillary haemangioblastoma: the pathologist's viewpoint
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit University Hospitals, Assuit, Egypt
    Int J Exp Pathol 88:311-24. 2007
    ..Moreover, 'stromal' cells represent the neoplastic cells of haemangioblastomas and are capable of forming blood islands with extramedullary haematopoiesis...
  29. ncbi Histological and ultrastructural features of gastrointestinal basidiobolomycosis
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
    Mycol Res 111:926-30. 2007
    ..This paper reviews the relevant literature regarding basidiomycosis, and discusses its diverse clinicopathological features, as well as distinguishing it from other diseases...
  30. doi Cutaneous and lymphadenopathic Kaposi's sarcoma: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit University, Egypt
    J Cutan Pathol 35:575-8. 2008
    ..The vascular nature of the lesion was supported by positive staining for CD31 and CD34. This study examines the clinicopathologic features of KS in children and summarizes the relevant literature...
  31. ncbi Alterations of p53 and Bcl-2 protein expression in the laryngeal intraepithelial neoplasia
    Mahmoud R Hussein
    University of Wisconsin Medical School and William S Middleton Memorial Veteran Hospital, Madison, Wisconsin 53705, USA
    Cancer Biol Ther 4:213-7. 2005
    ..I hypothesize that the development of laryngeal intraepithelial neoplasia (LIN) involves alterations of tumor suppressor genes (p53) and protooncogenes (Bcl-2)...
  32. ncbi Alterations of p53, Bcl-2, and hMSH2 protein expression in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas in the upper Egypt
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
    Cancer Biol Ther 3:983-8. 2004
    ..We hypothesized that mammary carcinogenesis involves interactions among p53, Bcl-2 and hMSh2 proteins. In the Upper Egypt, the clinicopathologic features and genetic changes during mammary carcinogenesis are unknown...
  33. ncbi Analysis of p53 and bcl-2 protein expression in the non-tumorigenic, pretumorigenic, and tumorigenic keratinocytic hyperproliferative lesions
    Mahmoud R Hussein
    Department of Pathology, Faculties of Medicine, Assuit and South Valley Universities, Assuit, Egypt
    J Cutan Pathol 31:643-51. 2004
    ..The aim of this work was to examine the expression patterns of apoptosis-linked molecules (bcl-2 and p53) in these lesions...
  34. ncbi Ultraviolet radiation and skin cancer: molecular mechanisms
    Mahmoud R Hussein
    Pathology Department, Assuit University Hospitals, Assuit University, Assuit, Egypt
    J Cutan Pathol 32:191-205. 2005
    ..This review presents background information about the skin optics, UV radiation, and molecular events involved in photocarcinogenesis...
  35. ncbi Evaluation of angiogenesis in normal and lichen planus skin by CD34 protein immunohistochemistry: preliminary findings
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals and Faculty of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 31:1292-5. 2007
    ..These results provide a morphological evidence of potent angiogenic activity in cutaneous lichen planus, indicating that the local microvasculature may undergo an intense process of inflammation-dependent angiogenesis...
  36. pmc Alterations of mononuclear inflammatory cells, CD4/CD8+ T cells, interleukin 1beta, and tumour necrosis factor alpha in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis
    M R Hussein
    Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
    J Clin Pathol 58:178-84. 2005
    ..Systemic sclerosis (SSc) is a multisystem disease with underlying immune mechanisms...
  37. pmc Ultrastructural evaluation of the radioprotective effects of melatonin against X-ray-induced skin damage in Albino rats
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Int J Exp Pathol 86:45-55. 2005
    ..The ability of melatonin to minimize the injurious effects of XRI suggests a radioprotective role. The clinical ramifications of these observations warrant further studies...
  38. ncbi The relationships between p53 protein expression and the clinicopathological features in the uveal melanomas
    Mahmoud R Hussein
    University of Wisconsin Medical School and William S Middleton Memorial Veteran Hospital, Madison 53705, USA
    Cancer Biol Ther 4:57-9. 2005
    ..p53 alterations are common events in cancer and may have some prognostic ramifications...
  39. ncbi Alterations of p53, Bcl-2, and hMSH2 protein expression in the cirrhotic, macroregenerative, dysplastic nodules and hepatocellular carcinomas in Upper Egypt
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
    Liver Int 24:552-60. 2004
    ..In Upper Egypt, the clinicopathologic and genetic changes during hepatocarcinogensis (cirrhotic nodules (CN); macroregenerative nodules (MRN) and dysplastic nodules (DN) are unknown...
  40. ncbi The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit City, Egypt
    Tumour Biol 25:200-7. 2004
    ....
  41. ncbi p53-related pathways and the molecular pathogenesis of melanoma
    M R Hussein
    Department of Pathology, Faculty of Medicine, Assuit Univeristy, Assuit, Egypt
    Eur J Cancer Prev 12:93-100. 2003
    ..To remedy this issue, this review seeks to provide a brief overview of p53 and discuss the genes targeted along its related pathways...
  42. pmc Genetic pathways to melanoma tumorigenesis
    M R Hussein
    Department of Pathology, Assiut University Hospitals, Egypt
    J Clin Pathol 57:797-801. 2004
    ..This review seeks to examine melanoma tumorigenesis based on these genetic changes...
  43. doi Decidual immune cell infiltrate in hydatidiform mole
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Cancer Invest 27:60-6. 2009
    ..quot;..
  44. ncbi hMLH1 and hMSH2 gene mutations are present in radial growth-phase cutaneous malignant melanoma cell lines and can be induced further by ultraviolet-B irradiation
    Mahmoud R Hussein
    Department of Dermatology, University of Wisconsin, William S Middleton Veteran Hospital, Madison, WI 53705, USA
    Exp Dermatol 12:872-5. 2003
    ..Further investigation will be needed to determine whether mutations such as these contribute to the development of microsatellite instability in melanoma...
  45. ncbi Analysis of the Bcl-2 and p53 protein expression in the lymphoproliferative lesions in the upper Egypt
    Mahmoud R Hussein
    Pathology Departments, School of Medicine and South Egypt Cancer Institute, Assuit University, Assuit, Egypt
    Cancer Biol Ther 4:324-8. 2005
    ..In the Upper Egypt, the clinicopathologic and genetic characteristics (p53 and Bcl-2) of the lymphoproliferative lesions (reactive hyperplasia, RH; Non-Hodgkin's lymphoma, NHL and Hodgkin's disease, HD) is unknown...
  46. ncbi Morphological changes and apoptosis in radial growth phase melanoma cell lines following ultraviolet-B irradiation
    Mahmoud R Hussein
    Department of Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, Wisconsin 537158, USA
    Am J Dermatopathol 25:466-72. 2003
    ..Knowledge about the morphologic changes following ultraviolet irradiation in the earliest stages of melanomas is still lacking...
  47. ncbi Age-associated decrease of CD1d protein production in normal human skin
    M A Adly
    Department of Zoology, Sohag Faculty of Science, South Valley University, Sohag, Egypt, and Department of Dermatology and Venereology, Faculty of Medicine, University Hospital of Hamburg Eppendorf, Germany
    Br J Dermatol 155:186-91. 2006
    ..CD1d belongs to a family of antigen-presenting molecules structurally related to the classical major histocompatibility complex class I proteins...
  48. pmc Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model
    T H El-Metwally
    Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
    J Clin Pathol 59:603-10. 2006
    ..The pancreatic ductal adenocarcinoma (HPAF) cells have a multipotent stem cell potential. It was hypothesised that all-trans-retinoic acid (atRA) can induce transdifferentiation of these cells into cells with an endocrine phenotype...
  49. pmc Glomerular expression and elevated serum Bcl-2 and Fas proteins in lupus nephritis: preliminary findings
    N A Fathi
    Department of Rheumatology and Rehabilitation, Faculty of Medicine and Assuit University Hospitals, Assuit, Egypt
    Clin Exp Immunol 146:339-43. 2006
    ..These findings suggest possible roles for Bcl-2 and Fas in glomerular injury during evolution of lupus nephritis. The diagnostic, prognostic and therapeutic ramifications of our findings are open to further investigation...
  50. pmc Morphological evaluation of the radioprotective effects of melatonin against X-ray-induced early and acute testis damage in Albino rats: an animal model
    Mahmoud R Hussein
    Department of Histopathology, Assuit University Hospitals, Faculty of Medicine, Assuit, Egypt
    Int J Exp Pathol 87:237-50. 2006
    ..The protective effects include amelioration of germ-cell depletion and apoptotic changes. The clinical ramifications of these observations mandate further studies...
  51. doi Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Exp Mol Pathol 87:63-9. 2009
    ..Epidermal growth factor receptor (EGF-R) is a transmembrane glycoprotein, which can bind and be activated by various ligands. It stimulates cell division and differentiation...
  52. ncbi Phenotypic characterization of the immune and mast cell infiltrates in the human testis shows normal and abnormal spermatogenesis
    Mahmoud R Hussein
    Department of Pathology, Faculties of Medicine, Assuit and South Valley Universities, Egypt
    Fertil Steril 83:1447-53. 2005
    ..To assess the types, distributions, and numbers of immune cell infiltrates in the testes of men with azoospermia...
  53. ncbi Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cell Biol Int 32:157-62. 2008
    ..However, these issues should be tested by further studies...
  54. ncbi Apoptosis and melanoma: molecular mechanisms
    Mahmoud R Hussein
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Pathol 199:275-88. 2003
    ..This review summarizes the state of current knowledge about the key molecular components and mechanisms of apoptosis in melanoma, discusses potential therapeutic ramifications, and provides directions for future research...
  55. ncbi Analysis of apoptotic cell death, Bcl-2, and p53 protein expression in freshly fixed and cryopreserved ovarian tissue after exposure to warm ischemia
    Mahmoud R Hussein
    Department of Pathology, Assiut University School of Medicine, Assiut, Egypt
    Fertil Steril 85:1082-92. 2006
    ..To evaluate the effect of ischemia time on the expression of Bcl-2 and p53 proteins on freshly fixed and cryopreserved-thawed ovarian tissue...
  56. doi Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 32:1353-61. 2008
    ..Although roentgen rays are widely used for both imaging and therapeutic purposes, our knowledge about the morphological changes associated with radiation enteritis is lacking...
  57. doi Mucocutaneous Splendore-Hoeppli phenomenon
    Mahmoud R Hussein
    Department of Pathology, Assir Central Hospital, King Khalid University, Abha, Kingdom of Saudi Arabia
    J Cutan Pathol 35:979-88. 2008
    ..To conclude, Splendore-Hoeppli reaction is a tell tale of a spectrum of infections and reactive conditions. The molecular pathways involved in the development of this reaction are open for future investigations...
  58. ncbi Microsatellite instability in human melanocytic skin tumors: an incidental finding or a pathogenetic mechanism?
    Mahmoud R Hussein
    The Department of Medicine Dermatology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Cutan Pathol 29:1-4. 2002
  59. ncbi Primary renal lymphoma
    Hyder A Omer
    Department of Medicine, College of Medicine, King Khalid University, Nephrology Section, Assir Central Hospital, Abha, Kingdom of Saudi Arabia
    Nephrology (Carlton) 12:314-5. 2007
  60. ncbi Apoptosis in the ovary: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Assiut, Egypt
    Hum Reprod Update 11:162-77. 2005
    ..It also presents the existing literature and assesses the gaps in our knowledge...
  61. ncbi Microsatellite instability and alterations of mismatch repair protein expression in choroidal melanomas
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit University Hospitals, Assuit, Egypt
    Arch Ophthalmol 123:1705-11. 2005
    ....
  62. ncbi Microsatellite instability and its relevance to cutaneous tumorigenesis
    Mahmoud R Hussein
    The Department of Medicine Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, WI 53705, USA
    J Cutan Pathol 29:257-67. 2002
    ..Thus far, MSI is considered to be a distinct tumorigenic pathway that reveals surprising versatility. The ramifications for cutaneous neoplasms warrant further investigation...
  63. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  64. ncbi Loss of heterozygosity, microsatellite instability, and mismatch repair protein alterations in the radial growth phase of cutaneous malignant melanomas
    Mahmoud R Hussein
    Department of Medicine Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, Wisconsin 53715, USA
    Mol Carcinog 34:35-44. 2002
    ..Further studies are necessary to support these finding and to determine their diagnostic and prognostic significance...
  65. doi Primary meningioma of the nasal septum: a case report and review of literature
    Ali Hassan Alzarae
    Department of Otorhinolaryngology Head and Neck Surgery, Asser Central Hospital, Abha, Kingdom of Saudi Arabia
    Appl Immunohistochem Mol Morphol 18:296-8. 2010
    ..The clinicopathologic features and pathogenesis of the primary nasal meningioma is briefly discussed...
  66. pmc Enhancement of the repair of meniscal wounds in the red-white zone (middle third) by the injection of bone marrow cells in canine animal model
    Mohammed Abdel-Hamid
    Department of Orthopedics, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Int J Exp Pathol 86:117-23. 2005
    ..Whether this improvement occurs through BMSC differentiation into cells operational in the repair process, the release of certain mediator or other unknown mechanisms mandates further investigations...
  67. ncbi Building bridges in cancer: mismatch repair and microsatellite instability
    Mahmoud R Hussein
    Department of Medicine Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, Wisconsin 53705, USA
    Am J Dermatopathol 24:76-81. 2002
    ....
  68. pmc The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model
    Mohamad A Abd el-Aziz
    Department of Biochemistry, Al Azhar University, Egypt
    Int J Exp Pathol 86:383-96. 2005
    ..To conclude, the administration of Mel, RA and NS reduced the carcinogenic effects of DMBA, suggesting a protective role. The possible underlying mechanisms of these effects await further investigations...
  69. ncbi Quantitative comparison of infected Schistosomiasis mansoni and Haematobium: animal model analysis of the granuloma cell population
    Mahmoud R Hussein
    Department of Pathology, Assuit University, Egypt
    J Egypt Soc Parasitol 35:467-76. 2005
    ..The differrence in the granuloma cell population between S. haematobium and S. mansoni may reflect different tissue reactions to the deposited ova...
  70. ncbi Cryopreservation of intact human ovary with its vascular pedicle
    Mohamed A Bedaiwy
    Department of Obstetrics and Gynecology, Minimally Invasive Surgery Center, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Hum Reprod 21:3258-69. 2006
    ..The aim of this study was to assess the immediate post-thawing injury to the human ovary that was cryopreserved either as a whole with its vascular pedicle or as ovarian cortical strips...
  71. ncbi Identification of novel deletion Loci at 1p36 and 9p22-21 in melanocytic dysplastic nevi and cutaneous malignant melanomas
    Mahmoud R Hussein
    Arch Dermatol 139:816-7. 2003
  72. ncbi High concentrations of retinoids induce differentiation and late apoptosis in pancreatic cancer cells in vitro
    Tarek H el-Metwally
    Department of Biomedical Sciences, Creighton University School of Medicine, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Biol Ther 4:602-11. 2005
    ..In this investigation, we hypothesize that high concentrations of retinoids can induce phenotypic changes (differentiation) and late apoptosis in pancreatic cancer cells in vitro...
  73. doi Alterations of estrogen receptors, progesterone receptors and c-erbB2 oncogene protein expression in ductal carcinomas of the breast
    Mahmoud R Hussein
    Department of Histopatholgy, Assir Central Hospital and King Khalid University College of Medicine, Abha, Saudi Arabia
    Cell Biol Int 32:698-707. 2008
    ..These findings substantiate the notion that breast cancer progression is often associated with alterations of ER, PgR and HER-2/neu expression. The underlying mechanisms of these alterations are open for further investigation...
  74. ncbi Analysis of the expression pattern of glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1 and GFRalpha-2, and a common signal transduction element c-Ret in the human scalp skin
    Mohamed A Adly
    Department of Zoology, Sohag Faculty of Science, South Valley University, Assir, KSA
    J Cutan Pathol 33:799-808. 2006
    ..To date, their expression in human scalp skin is still unknown...
  75. ncbi Restoration of ovarian function after autotransplantation of intact frozen-thawed sheep ovaries with microvascular anastomosis
    Mohamed A Bedaiwy
    Department of Obstetrics and Gynecology and Minimally Invasive Surgery Center, The Cleveland Clinic Foundation, Ohio 44195, USA
    Fertil Steril 79:594-602. 2003
    ..To test the feasibility of transplanting an intact frozen-thawed ovary with microvascular anastomosis of the ovarian vascular pedicle to the deep inferior epigastric vessels...
  76. ncbi Age-associated decrease of the nerve growth factor protein expression in the human skin: preliminary findings
    Mohamed A Adly
    J Dermatol Sci 42:268-71. 2006