Tarek Aboul-Fadl

Summary

Affiliation: Assiut University
Country: Egypt

Publications

  1. ncbi request reprint Selenium derivatives as cancer preventive agents
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Egypt
    Curr Med Chem Anticancer Agents 5:637-52. 2005
  2. doi request reprint Antisense oligonucleotide technologies in drug discovery
    Tarek Aboul-Fadl
    Professor of Pharmacuetical Medicinal Chemistry, Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Expert Opin Drug Discov 1:285-8. 2006
  3. ncbi request reprint Antisense oligonucleotides: the state of the art
    T aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Curr Med Chem 12:2193-214. 2005
  4. ncbi request reprint Synthesis, degradation kinetics and in vitro antimicrobial activity of tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives of some beta-amino acids
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Arzneimittelforschung 53:526-31. 2003
  5. ncbi request reprint Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH)
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm Res 26:778-84. 2003
  6. ncbi request reprint 1, 2-dihydroisoquinoline-N-acetic acid derivatives as new carriers for brain-specific delivery II: delivery of phenethylamine as model drug
    Sahar Mahmoud
    Medicinal Pharmaceutical Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm (Weinheim) 336:258-63. 2003
  7. doi request reprint Pharmacophoric model building for antitubercular activity of the individual Schiff bases of small combinatorial library
    Wesam S Abdel-Aal
    Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Eur J Med Chem 45:1098-106. 2010
  8. ncbi request reprint 1, 2-dihydroisoquinoline-N-acetic acid derivatives as new carriers for specific brain delivery I: synthesis and estimation of oxidation kinetics using multivariate calibration method
    Sahar Mahmoud
    Dept Pharm Med Chem, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm (Weinheim) 336:573-84. 2003
  9. pmc Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse
    Michael R Franklin
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Chem Biol Interact 168:211-20. 2007
  10. pmc Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds
    Wael M El-Sayed
    University of Utah, Department of Pharmacology and Toxicology, 30 South 2000 East, Room 201, Salt Lake City, UT 84112, USA
    Toxicol In Vitro 21:157-64. 2007

Collaborators

  • Mahmoud Sheha
  • ROBERT WALTER BUCKHEIT
  • Michael Franklin
  • Sahar Mahmoud
  • Wesam S Abdel-Aal
  • Hoda Y Hassan
  • Wael M El-Sayed
  • Safwat M Rabea
  • Hassan Farag
  • Stefan Löber
  • Adel F Youssef
  • John G Lamb
  • Jeanette C Roberts
  • Nawal A el-Koussi
  • Abdel Maaboud I Mouhamed
  • Harald Hubner
  • Peter Gmeiner

Detail Information

Publications14

  1. ncbi request reprint Selenium derivatives as cancer preventive agents
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Egypt
    Curr Med Chem Anticancer Agents 5:637-52. 2005
    ..The current review aims to outline recent developments in the application of selenium derivatives as cancer preventive agents...
  2. doi request reprint Antisense oligonucleotide technologies in drug discovery
    Tarek Aboul-Fadl
    Professor of Pharmacuetical Medicinal Chemistry, Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Expert Opin Drug Discov 1:285-8. 2006
    ..This editorial describes the established and emerging AS-OD technologies in drug discovery...
  3. ncbi request reprint Antisense oligonucleotides: the state of the art
    T aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Curr Med Chem 12:2193-214. 2005
    ..This review outlines the basic concept of the antisense technology, its development and recent potential therapeutic applications...
  4. ncbi request reprint Synthesis, degradation kinetics and in vitro antimicrobial activity of tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives of some beta-amino acids
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Arzneimittelforschung 53:526-31. 2003
    ....
  5. ncbi request reprint Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH)
    Tarek Aboul-Fadl
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm Res 26:778-84. 2003
    ..15 and 443.25 for 3f and 3d respectively as compared to INH. These results preliminary indicate the possible use of the prepared derivatives for treatment of tuberculosis infections in order to overcome the resistance developed with INH...
  6. ncbi request reprint 1, 2-dihydroisoquinoline-N-acetic acid derivatives as new carriers for brain-specific delivery II: delivery of phenethylamine as model drug
    Sahar Mahmoud
    Medicinal Pharmaceutical Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm (Weinheim) 336:258-63. 2003
    ..In vivo distribution of the ethyl ester derivative 7b studied in rats and showed that the concentration of the quaternary product is increasing in the brain and cleared from blood with time...
  7. doi request reprint Pharmacophoric model building for antitubercular activity of the individual Schiff bases of small combinatorial library
    Wesam S Abdel-Aal
    Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Eur J Med Chem 45:1098-106. 2010
    ..The distances bridging F1 to F2, F3 and F4 were essential for anti-TB activity in the developed pharmacophore model, as it was confirmed from model validation procedure...
  8. ncbi request reprint 1, 2-dihydroisoquinoline-N-acetic acid derivatives as new carriers for specific brain delivery I: synthesis and estimation of oxidation kinetics using multivariate calibration method
    Sahar Mahmoud
    Dept Pharm Med Chem, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm (Weinheim) 336:573-84. 2003
    ..Kinetic oxidation data of the tested compounds revealed that these new CDSs have a reasonable oxidation rate for efficient brain delivery...
  9. pmc Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse
    Michael R Franklin
    University of Utah, Department of Pharmacology and Toxicology, Salt Lake City, UT 84112, USA
    Chem Biol Interact 168:211-20. 2007
    ..Thus, several 2-aryl/alkyl selenazolidines possess chemopreventive activity against NNK-induced lung tumors, and variously demonstrate pre-initiation and post-initiation efficacy...
  10. pmc Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds
    Wael M El-Sayed
    University of Utah, Department of Pharmacology and Toxicology, 30 South 2000 East, Room 201, Salt Lake City, UT 84112, USA
    Toxicol In Vitro 21:157-64. 2007
    ..Thus, Hepa1c1c7 cells appear to provide a viable platform for the study of protective enzyme regulation by selenocompounds, and with the exception of Ugt1a6, the mRNA elevations from selenazolidines are transcriptionally dependent...
  11. ncbi request reprint Synthesis of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives of potential anti-inflammatory activity
    Safwat M Rabea
    Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
    Arch Pharm (Weinheim) 339:32-40. 2006
    ..Derivatives 4 and 8 showed promising results and were found to be equipotent or more potent than Indomethacin and Celecoxib as reference drugs at two dose levels, 5 and 10 mg/kg, and they have no ulcerogenic activity...
  12. ncbi request reprint New 2H-tetrahydro-1, 3, 5-thiadiazine-2-thiones incorporating glycine and glycinamide as potential antifungal agents
    Tarek Aboul-Fadl
    Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    Arch Pharm (Weinheim) 335:438-42. 2002
    ..These compounds exhibited varied inhibitory effects on growth or sporulation of some tested fungal species...
  13. ncbi request reprint An unusual "senseless" 2',5'-oligoribonucleotide with potent anti-HIV activity
    Tarek Aboul-Fadl
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Nucleosides Nucleotides Nucleic Acids 23:545-54. 2004
    ..The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase...
  14. ncbi request reprint Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy
    Stefan Löber
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052, Erlangen, Germany
    Bioorg Med Chem Lett 12:633-6. 2002
    ..The carbonitrile 11a (FAUC 327) showed excellent pharmacological properties combining high D4 affinity (K(i)=1.5 nM) and selectivity with significant intrinsic activity (31%) in low nanomolar concentrations (EC50=1.5 nM)...