Jean Marc Egly

Summary

Publications

  1. Coin F, Egly J. Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor. Mol Cell. 2015;59:513-4 pubmed publisher
    ..They unveiled an unexpected function of CDK7 in RNA polymerase II pausing and mRNA capping. ..
  2. Bidon B, Iltis I, Semer M, Nagy Z, Larnicol A, Cribier A, et al. XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1. Nat Commun. 2018;9:2610 pubmed publisher
    ..Our data reveal that the DNA repair factor XPC is also an RNA polymerase II cofactor recruiting the ATAC coactivator complex to promoters by interacting with the DNA binding transcription factor E2F1. ..
  3. Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, et al. Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochim Biophys Acta. 2016;1859:1440-1448 pubmed publisher
    ..Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. ..
  4. Egly J, Coin F. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst). 2011;10:714-21 pubmed publisher
    ..This review intends to give a non-exhaustive survey of the most prominent discoveries on the molecular functioning of TFIIH. ..
  5. Singh A, Compe E, Le May N, Egly J. TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription. Am J Hum Genet. 2015;96:194-207 pubmed publisher
    ..The subtle transcriptional differences found between various TFIIH variants thus participate in the phenotypic variability observed among XP, XP/CS, and TTD individuals. ..
  6. Epanchintsev A, Costanzo F, Rauschendorf M, Caputo M, Ye T, Donnio L, et al. Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation. Mol Cell. 2017;68:1054-1066.e6 pubmed publisher