Archimedes: a trial-validated model of diabetesDavid M Eddy
Kaiser Permanente Southern California, Pasadena, California, USA
Diabetes Care 26:3093-101. 2003
..To build a mathematical model of the anatomy, pathophysiology, tests, treatments, and outcomes pertaining to diabetes that could be applied to a wide variety of clinical and administrative problems and that could be validated...
- Clinical outcomes and cost-effectiveness of strategies for managing people at high risk for diabetes
David M Eddy
Archimedes Project, Kaiser Permanente, Oakland, California, USA
Ann Intern Med 143:251-64. 2005
..Lifestyle modification can forestall diabetes in high-risk people, but the long-term cost-effectiveness is uncertain...
- Archimedes: a new model for simulating health care systems--the mathematical formulation
Leonard Schlessinger
Department of Biomathematical Analysis, Care Management Institute, Kaiser Permanente Program Office, Pasadena, CA, USA
J Biomed Inform 35:37-50. 2002
..Although Archimedes was originally designed for health care applications, the formulation, and equations are general and can be applied to many natural systems...
- Evidence-based medicine: a unified approach
David M Eddy
Health Aff (Millwood) 24:9-17. 2005
..This paper describes the problem that we are asking "evidence" to solve and the different methods by which evidence can be used to help solve that problem, and recommends a unified approach...
- Linking electronic medical records to large-scale simulation models: can we put rapid learning on turbo?
David M Eddy
Archimedes Inc, San Francisco, CA, USA
Health Aff (Millwood) 26:w125-36. 2007
..Linking the models to EMR data also facilitates tailoring analyses to specific populations. The models' power and accuracy can be improved by linkage to comprehensive, person-specific, longitudinal data from EMRs...
The 'Global Outcomes Score': a quality measure, based on health outcomes, that compares current care to a target level of careDavid M Eddy
Archimedes, San Francisco, California, USA
Health Aff (Millwood) 31:2441-50. 2012
..The GO Score can be used to assess the potential effectiveness of different interventions such as prevention activities, tests, and treatments...
- A simulation shows limited savings from meeting quality targets under the Medicare Shared Savings Program
David M Eddy
Archimedes, San Francisco, California, USA
Health Aff (Millwood) 31:2554-62. 2012
..To achieve greater savings, accountable care organizations will have to lower costs by other means, such as through improved use of information technology and care coordination...
- Accuracy versus transparency in pharmacoeconomic modelling: finding the right balance
David M Eddy
Archimedes, Inc, San Francisco, California, USA
Pharmacoeconomics 24:837-44. 2006
..Rigorous simulations of clinical trials are a good place to start. This is the type of empirical validation we need to provide if the potential of mathematical models in pharmacoeconomics is to be fully achieved...
- Validation of the archimedes diabetes model
David M Eddy
Care Management Institute, Kaiser Permanente and Kaiser Permanente Southern California, Oakland, California, USA
Diabetes Care 26:3102-10. 2003
..To validate the Archimedes model of diabetes and its complications for a variety of populations, organ systems, treatments, and outcomes...
- Model transparency and validation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-7
David M Eddy
Archimedes, Inc, San Francisco, CA 94105, USA
Med Decis Making 32:733-43. 2012
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- The potential effects of HEDIS performance measures on the quality of care
David M Eddy
Archimedes Inc, San Francisco, California, USA
Health Aff (Millwood) 27:1429-41. 2008
..1 million cases of end-stage renal disease (17 percent). If performance had been 100 percent, 1.4 million more MIs would have been prevented. Control of blood pressure has the largest potential effect on quality at the national level...
- Individualized guidelines: the potential for increasing quality and reducing costs
David M Eddy
Archimedes, 201 Mission Street, San Francisco, CA 91405, USA
Ann Intern Med 154:627-34. 2011
..Current guidelines focus on a particular risk factor and specify criteria for categorizing persons into a small number of treatment groups...
- Diabetes Risk Calculator: a simple tool for detecting undiagnosed diabetes and pre-diabetes
Kenneth E Heikes
Archimedes, San Francisco, California, USA
Diabetes Care 31:1040-5. 2008
..The objective of this study was to develop a simple tool for the U.S. population to calculate the probability that an individual has either undiagnosed diabetes or pre-diabetes...
- Model transparency and validation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force--7
David M Eddy
Archimedes, Inc, San Francisco, CA, USA
Value Health 15:843-50. 2012
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- Effect of smoking cessation advice on cardiovascular disease
David M Eddy
Archimedes, Inc, San Francisco, California, USA
Am J Med Qual 24:241-9. 2009
..The 30-year cost/QALY is approximately $3000 less than the base-case assumptions and less than $10 000 under pessimistic assumptions...
