Michael J Eddins

Summary

Publications

  1. doi request reprint Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy
    Michael J Eddins
    Progenra, Inc, 277 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 60:113-8. 2011
  2. doi request reprint Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases
    Jeffrey G Marblestone
    Progenra, Inc, 277 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 67:161-7. 2013
  3. doi request reprint Novel approach for characterizing ubiquitin E3 ligase function
    Jeffrey G Marblestone
    Progenra, Inc, Malvern, Pennsylvania, USA
    J Biomol Screen 15:1220-8. 2010
  4. pmc Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases
    Steven J Orcutt
    LifeSensors, Inc, Malvern, PA 19355, USA
    Biochim Biophys Acta 1823:2079-86. 2012
  5. doi request reprint Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates
    Christian M Loch
    Division of Research and Development, LifeSensors, Inc, 271 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 60:127-35. 2011

Collaborators

Detail Information

Publications5

  1. doi request reprint Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy
    Michael J Eddins
    Progenra, Inc, 277 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 60:113-8. 2011
    ..Thus MuRF1 can be targeted in a specific manner and produce positive results in cellular atrophy models...
  2. doi request reprint Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases
    Jeffrey G Marblestone
    Progenra, Inc, 277 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 67:161-7. 2013
    ..Finally, substrate ubiquitylation was assayed for the E3 ligase MuRF1 using various E2/MuRF1 pairs. These studies demonstrate the utility of identifying the correct E2/E3 pair to monitor specific substrate ubiquitylation. ..
  3. doi request reprint Novel approach for characterizing ubiquitin E3 ligase function
    Jeffrey G Marblestone
    Progenra, Inc, Malvern, Pennsylvania, USA
    J Biomol Screen 15:1220-8. 2010
    ..As the number of E3 ligases associated with various disease states increases, the ability to quantitate the activity of these enzymes in an expeditious manner becomes imperative in drug discovery...
  4. pmc Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases
    Steven J Orcutt
    LifeSensors, Inc, Malvern, PA 19355, USA
    Biochim Biophys Acta 1823:2079-86. 2012
    ..67) yielding robust signal, and providing an alternative drug discovery platform for Ub/Ubl isopeptidases. This article is part of a Special Issue entitled: Ubiquitin Drug Discovery and Diagnostics...
  5. doi request reprint Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates
    Christian M Loch
    Division of Research and Development, LifeSensors, Inc, 271 Great Valley Parkway, Malvern, PA 19355, USA
    Cell Biochem Biophys 60:127-35. 2011
    ..Gene ontology clustering identified putative substrates consistent with information previously known about Praja1 function, and provides clues into novel aspects of this enzyme's function...