P J Cooper

Summary

Affiliation: Laboratorio de Investigaciones
Country: Ecuador

Publications

  1. pmc Interactions between helminth parasites and allergy
    Philip J Cooper
    Centre for Infection, St George s University of London, London, UK
    Curr Opin Allergy Clin Immunol 9:29-37. 2009
  2. pmc Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted helminth infections
    Ana Lucia Moncayo
    Instituto de Microbiologia, Universidad San Francisco de Quito, Diego Robles y Via Interoceanica S N, Cumbaya, Quito, Ecuador
    PLoS Negl Trop Dis 2:e293. 2008
  3. pmc Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response
    Rommy Teran
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Clin Immunol 138:299-310. 2011
  4. pmc Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study
    Rafael V Veiga
    Social Change, Asthma and Allergy in Latin America Research Program
    BMC Pulm Med 11:24. 2011
  5. pmc Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study)
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universiade Federal de Bahia, Salvador, Brazil
    BMC Pulm Med 6:15. 2006
  6. pmc Estimating adjusted prevalence ratio in clustered cross-sectional epidemiological data
    Carlos Antonio S T Santos
    State University of Feira de Santana, Feira de Santana, Brazil
    BMC Med Res Methodol 8:80. 2008
  7. pmc Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection
    Juan Carlos Vieira
    Programa Nacional de Eliminación de la Oncocercosis en el Ecuador, Servicio Nacional de Control de Enfermedades Transmitidas por Vectores Artrópodos, Ministry of Public Health, Guayaquil, Ecuador
    BMC Med 5:9. 2007
  8. pmc Leishmania isoenzyme polymorphisms in Ecuador: relationships with geographic distribution and clinical presentation
    Manuel Calvopina
    Department of Parasitology, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    BMC Infect Dis 6:139. 2006
  9. pmc A guide to modern statistical analysis of immunological data
    Bernd Genser
    BMC Immunol 8:27. 2007
  10. pmc Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics
    Philip J Cooper
    Centro de Investigaciones FEPIS, Quininde, Ecuador
    J Infect Dis 198:1237-42. 2008

Collaborators

Detail Information

Publications35

  1. pmc Interactions between helminth parasites and allergy
    Philip J Cooper
    Centre for Infection, St George s University of London, London, UK
    Curr Opin Allergy Clin Immunol 9:29-37. 2009
    ..To review the findings of recent human studies of the association between helminth parasite infections and allergy and discuss their potential relevance to public health...
  2. pmc Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted helminth infections
    Ana Lucia Moncayo
    Instituto de Microbiologia, Universidad San Francisco de Quito, Diego Robles y Via Interoceanica S N, Cumbaya, Quito, Ecuador
    PLoS Negl Trop Dis 2:e293. 2008
    ..The current study investigated the impact of 15 to 17 years of treatment with the broad-spectrum anthelmintic ivermectin, used for the control of onchocerciasis, on STH prevalence and intensity in school-age and pre-school children...
  3. pmc Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response
    Rommy Teran
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Clin Immunol 138:299-310. 2011
    ..Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology...
  4. pmc Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study
    Rafael V Veiga
    Social Change, Asthma and Allergy in Latin America Research Program
    BMC Pulm Med 11:24. 2011
    ..In this work we investigated the association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and asthma...
  5. pmc Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study)
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universiade Federal de Bahia, Salvador, Brazil
    BMC Pulm Med 6:15. 2006
    ....
  6. pmc Estimating adjusted prevalence ratio in clustered cross-sectional epidemiological data
    Carlos Antonio S T Santos
    State University of Feira de Santana, Feira de Santana, Brazil
    BMC Med Res Methodol 8:80. 2008
    ..This paper overviews the most commonly used procedures to obtain adjusted prevalence ratios and extends the discussion to the analysis of clustered cross-sectional studies...
  7. pmc Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection
    Juan Carlos Vieira
    Programa Nacional de Eliminación de la Oncocercosis en el Ecuador, Servicio Nacional de Control de Enfermedades Transmitidas por Vectores Artrópodos, Ministry of Public Health, Guayaquil, Ecuador
    BMC Med 5:9. 2007
    ..The long-term administration of ivermectin could eliminate Onchocerca volvulus infection from endemic areas in Latin America...
  8. pmc Leishmania isoenzyme polymorphisms in Ecuador: relationships with geographic distribution and clinical presentation
    Manuel Calvopina
    Department of Parasitology, Kochi Medical School, Kochi University, Kochi 783 8505, Japan
    BMC Infect Dis 6:139. 2006
    ..To examine the relationship between clinical presentation, species and isoenzyme polymorphisms, 56 Leishmania isolates from distinct presentations of American tegumentary leishmaniasis (ATL) from Ecuador were analyzed...
  9. pmc A guide to modern statistical analysis of immunological data
    Bernd Genser
    BMC Immunol 8:27. 2007
    ..Such approaches are used in many other scientific disciplines, but immunological studies on the whole still use simple statistical techniques for data analysis...
  10. pmc Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics
    Philip J Cooper
    Centro de Investigaciones FEPIS, Quininde, Ecuador
    J Infect Dis 198:1237-42. 2008
    ..The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity...
  11. pmc Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
    ..We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months...
  12. pmc Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Quito, Ecuador
    J Infect Dis 197:1333-40. 2008
    ..This study investigated whether IL-10 and populations of IL-10+ T cells may modulate atopy in children living in an area where intestinal helminth infections are endemic...
  13. ncbi request reprint Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations
    P J Cooper
    Centre for Infection, St George s University of London, London, UK
    Br Med Bull 79:203-18. 2006
    ....
  14. pmc Risk factors for asthma and allergy associated with urban migration: background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA Study)
    Philip J Cooper
    Instituto de Microbiologia, Universidad San Francisco de Quito, Quito, Ecuador
    BMC Pulm Med 6:24. 2006
    ..Understanding better why the prevalence of asthma is greater in urban migrant populations and the role of risk factors such as life style and environmental exposures, may be key to understand what is behind this trend...
  15. pmc Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study
    Philip J Cooper
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Infect Dis 11:184. 2011
    ....
  16. ncbi request reprint Risk factors for atopy among school children in a rural area of Latin America
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Clin Exp Allergy 34:845-52. 2004
    ..Few studies have investigated risk factors for atopy among children living in rural areas of Latin America...
  17. ncbi request reprint Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldoonado, Pichincha Provinece, Ecuador
    Am J Respir Crit Care Med 168:313-7. 2003
    ..The results suggest that geohelminth infections do not explain the low prevalence of allergic symptoms in the study population...
  18. ncbi request reprint Relationship between bacille Calmette-Guérin vaccination, Mantoux test positivity, and geohelminth infection
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Trans R Soc Trop Med Hyg 97:473-6. 2003
    ..The data provide little support for an important protective role of neonatal BCG vaccination or current mycobacterial sensitization against geohelminth infections...
  19. ncbi request reprint Geohelminth infections protect against severe inflammatory diarrhoea in children
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Trans R Soc Trop Med Hyg 97:519-21. 2003
    ..Our findings suggest that geohelminth infections have important protective effects against enteroinvasive infections in young children...
  20. ncbi request reprint Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to ascaris antigens in children exposed to ascariasis
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    J Infect Dis 190:1338-46. 2004
    ..Multivariate regression analyses showed significant effects for atopic status but not for infection status on Th2 cytokine expression and histamine release...
  21. ncbi request reprint Intestinal worms and human allergy
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Parasite Immunol 26:455-67. 2004
    ....
  22. ncbi request reprint Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Lancet 367:1598-603. 2006
    ..We investigated the effect of repeated anthelmintic treatments with albendazole over 12 months on the prevalence of atopy and clinical indices of allergy...
  23. ncbi request reprint The potential impact of early exposures to geohelminth infections on the development of atopy
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Clin Rev Allergy Immunol 26:5-14. 2004
    ....
  24. pmc Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity
    P Endara
    Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador
    Clin Exp Allergy 40:1669-77. 2010
    ..There is concern that treatment-based control programmes for these parasites may lead to an increase in the prevalence of allergic diseases...
  25. doi request reprint Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
    L C Rodrigues
    London School of Hygiene and Tropical Medicine, London, UK
    Clin Exp Allergy 38:1769-77. 2008
    ..Intestinal helminth parasites are prevalent in childhood in developing countries and are associated with a lower prevalence of allergen skin test reactivity and asthma...
  26. pmc Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
    A L Moncayo
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Clin Exp Allergy 43:60-72. 2013
    ..Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age...
  27. doi request reprint Geohelminth infections: a review of the role of IgE and assessment of potential risks of anti-IgE treatment
    P J Cooper
    Laboratorio de Investigaciones extensión Quinindé, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Allergy 63:409-17. 2008
    ....
  28. pmc Evidence for in utero sensitization to Ascaris lumbricoides in newborns of mothers with ascariasis
    Irene Guadalupe
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    J Infect Dis 199:1846-50. 2009
    ..Our data provide evidence of in utero sensitization to A. lumbricoides and raise the possibility that the immunological effects of infection start in the fetus...
  29. doi request reprint Asthma in Latin America: a public heath challenge and research opportunity
    P J Cooper
    Centro de Investigaciones FEPIS, Quininde, Esmeraldas Province Ecuador
    Allergy 64:5-17. 2009
    ..Asthma in Latin America poses enormous challenges for health policy makers, health services, and researchers to respond to and alleviate the growing burden of asthma disability, particularly among marginalized urban populations...
  30. pmc Can intestinal helminth infections (geohelminths) affect the development and expression of asthma and allergic disease?
    P J Cooper
    Department of Infectious Diseases, St George s Hospital Medical School, London, UK
    Clin Exp Immunol 128:398-404. 2002
  31. doi request reprint Mucosal immunology of geohelminth infections in humans
    P J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Mucosal Immunol 2:288-99. 2009
    ..Such studies are likely to provide important insights into the regulation of mucosal immunity and inflammation, and the development of more effective mucosal vaccines...
  32. doi request reprint High prevalence of bacterial vaginosis in adolescent girls in a tropical area of Ecuador
    M Vaca
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    BJOG 117:225-8. 2010
    ..06, 95% CI, 0.51-2.21, P = 0.88), although the power of this analysis was limited. The prevalence of BV was high among Ecuadorian adolescent girls, and did not appear to be associated with sexual activity...
  33. ncbi request reprint Comparison of two single-day regimens of triclabendazole for the treatment of human pulmonary paragonimiasis
    Manuel Calvopina
    Inmunología y Medicina Tropical, Centro de Biomedicina, Universidad Central, Quito, Ecuador
    Trans R Soc Trop Med Hyg 97:451-4. 2003
    ....
  34. ncbi request reprint Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 111:995-1000. 2003
    ..Childhood infections might protect against the expression of atopy. Geohelminths are among the most prevalent infections of childhood and might contribute to the low prevalence of allergic disease reported from rural areas of the tropics...
  35. ncbi request reprint Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 186:1307-13. 2002
    ..The data indicate that mast cells play a role in initiation of tissue inflammatory reactions after ivermectin treatment of onchocerciasis...