Dominic E Dwyer

Summary

Publications

  1. ncbi request reprint Pandemic clinical case definitions are non-specific: multiple respiratory viruses circulating in the early phases of the 2009 influenza pandemic in New South Wales, Australia
    Vigneswary Mala Ratnamohan
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Virol J 11:113. 2014
  2. pmc Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145, Australia
    Vaccine 29:B56-62. 2011
  3. pmc Molecular identification and analysis of nonserotypeable human enteroviruses
    Fei Zhou
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Darcy Road, Westmead, Sydney, New South Wales 2145, Australia
    J Clin Microbiol 48:1276-82. 2010
  4. doi request reprint Varicella zoster virus quantitation in blood from symptomatic and asymptomatic individuals
    Cheryl S Toi
    Clinical Virology, Centre for Infectious Diseases and Microbiology Public Health and Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia
    J Med Virol 85:1491-7. 2013
  5. doi request reprint Molecular characterization of enterovirus 71 and coxsackievirus A16 using the 5' untranslated region and VP1 region
    Fei Zhou
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Westmead, New South Wales, Australia
    J Med Microbiol 60:349-58. 2011
  6. pmc Viral pneumonitis is increased in obese patients during the first wave of pandemic A(H1N1) 2009 virus
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Sydney Institute for Emerging Infections and Biosecurity, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    PLoS ONE 8:e55631. 2013
  7. doi request reprint The impact of bacterial and viral co-infection in severe influenza
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Sydney, NSW, Australia
    Influenza Other Respir Viruses 7:168-76. 2013
  8. ncbi request reprint Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Antiviral Res 87:16-21. 2010
  9. pmc Treating and preventing influenza in aged care facilities: a cluster randomised controlled trial
    Robert Booy
    National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e46509. 2012
  10. doi request reprint Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    J Acquir Immune Defic Syndr 56:91-4. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Pandemic clinical case definitions are non-specific: multiple respiratory viruses circulating in the early phases of the 2009 influenza pandemic in New South Wales, Australia
    Vigneswary Mala Ratnamohan
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Virol J 11:113. 2014
    ..During the early phases of the 2009 pandemic, subjects with influenza-like illness only had laboratory testing specific for the new A(H1N1)pdm09 virus...
  2. pmc Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145, Australia
    Vaccine 29:B56-62. 2011
    ..These 'in progress' INSIGHT influenza observational studies may act as a model for obtaining epidemiological, clinical and laboratory information in future international disease outbreaks...
  3. pmc Molecular identification and analysis of nonserotypeable human enteroviruses
    Fei Zhou
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Darcy Road, Westmead, Sydney, New South Wales 2145, Australia
    J Clin Microbiol 48:1276-82. 2010
    ..Synchronous detection of the 5' UTR and VP1 region by RT-PCR-RLB will facilitate the identification of HEVs, especially nonserotypeable isolates...
  4. doi request reprint Varicella zoster virus quantitation in blood from symptomatic and asymptomatic individuals
    Cheryl S Toi
    Clinical Virology, Centre for Infectious Diseases and Microbiology Public Health and Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia
    J Med Virol 85:1491-7. 2013
    ..VZV DNA was detected but at low frequency and viral load in both immunocompetent and immunocompromised individuals asymptomatic for VZV infection, compared to individuals with active VZV infection...
  5. doi request reprint Molecular characterization of enterovirus 71 and coxsackievirus A16 using the 5' untranslated region and VP1 region
    Fei Zhou
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Westmead, New South Wales, Australia
    J Med Microbiol 60:349-58. 2011
    ..The combination of molecular typing and phylogenetic sequence analysis will be beneficial in both individual patient diagnosis and public health measures...
  6. pmc Viral pneumonitis is increased in obese patients during the first wave of pandemic A(H1N1) 2009 virus
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Sydney Institute for Emerging Infections and Biosecurity, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    PLoS ONE 8:e55631. 2013
    ..It is postulated that excess inflammation and cytokine production in obese patients following severe influenza infection leads to viral pneumonitis and/or acute respiratory distress syndrome...
  7. doi request reprint The impact of bacterial and viral co-infection in severe influenza
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Sydney, NSW, Australia
    Influenza Other Respir Viruses 7:168-76. 2013
    ..Many questions remain concerning the burden, risk factors and impact of bacterial and viral co-infection in patients with pandemic influenza admitted to the intensive care unit (ICU)...
  8. ncbi request reprint Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Antiviral Res 87:16-21. 2010
    ..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority...
  9. pmc Treating and preventing influenza in aged care facilities: a cluster randomised controlled trial
    Robert Booy
    National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e46509. 2012
    ..Our objective was to compare a policy of T versus T&P for influenza outbreaks in ACFs...
  10. doi request reprint Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    J Acquir Immune Defic Syndr 56:91-4. 2011
    ..Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave...
  11. ncbi request reprint Enhanced diagnosis of pandemic (H1N1) 2009 influenza infection using molecular and serological testing in intensive care unit patients with suspected influenza
    Jenna M Iwasenko
    Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Clin Infect Dis 51:70-2. 2010
    ..These results indicate that up to one-third of pH1N1 cases may not have laboratory confirmation of infection unless serological testing is included for suspected cases...
  12. pmc Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, New South Wales, Australia
    Virol J 8:405. 2011
    ..This work describes the development of a synthetic oligo-cassette for positive controls for accurate and highly sensitive diagnosis of several mutations relevant to influenza virus drug resistance...
  13. pmc Comparison of a rapid antigen test with nucleic acid testing during cocirculation of pandemic influenza A/H1N1 2009 and seasonal influenza A/H3N2
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Clin Microbiol 48:290-1. 2010
    ..4% versus 74.2%, P < 0.001). Nucleic acid tests should be used to detect pandemic influenza virus when rapid antigen tests are negative...
  14. pmc Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study
    C Raina MacIntyre
    School of Public Health and Community Medicine, UNSW Medicine, The University of New South Wales, Sydney, New South Wales, Australia
    Heart 99:1843-8. 2013
    ....
  15. pmc Rapid semi-automated quantitative multiplex tandem PCR (MT-PCR) assays for the differential diagnosis of influenza-like illness
    Elektra Szewczuk
    Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Westmead NSW 2145, Australia
    BMC Infect Dis 10:113. 2010
    ..Rapid and accurate detection is a key component of strategies to contain spread of infection, and the efficient diagnosis of influenza-like-illness is essential to protect health infrastructure in the event of a major influenza outbreak...
  16. pmc Influenza outbreaks during World Youth Day 2008 mass gathering
    Christopher C Blyth
    Westmead Hospital, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:809-15. 2010
    ..Greater flexibility by public health authorities and hospitals is required to appropriately manage and contain these outbreaks...
  17. pmc Influenza virus A (H10N7) in chickens and poultry abattoir workers, Australia
    George G Arzey
    Elizabeth Macarthur Agricultural Institute, Menangle, New South Wales, Australia
    Emerg Infect Dis 18:814-6. 2012
    ..After processing clinically normal birds from the farm, 7 abattoir workers reported conjunctivitis and minor upper respiratory tract symptoms. Influenza virus A subtype H10 infection was detected in 2 workers...
  18. doi request reprint Incompletely matched influenza vaccine still provides protection in frail elderly
    Anna S Dean
    National Centre for Immunisation Research and Surveillance for Vaccine Preventable Diseases, The Children s Hospital at Westmead, University of Sydney, NSW 2145, Australia
    Vaccine 28:864-7. 2010
    ..There is also reassurance that influenza vaccine can be effective against disease and severe outcomes, despite an incomplete vaccine match. This benefit is additional to protection from antivirals...
  19. doi request reprint Prevalence of varicella-zoster virus genotypes in Australia characterized by high-resolution melt analysis and ORF22 gene analyses
    Cheryl S Toi
    Clinical Virology, Centre for Infectious Diseases and Microbiology Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW 2145, Australia
    J Med Microbiol 59:935-40. 2010
    ..No significant association was shown between VZV genotype and region, age or gender. Although European strains were most common, the results suggest an increase in African/Asian, Japanese and clade VI genotypes circulating in Australia...
  20. doi request reprint Evaluation of twenty rapid antigen tests for the detection of human influenza A H5N1, H3N2, H1N1, and B viruses
    Janette Taylor
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Med Virol 81:1918-22. 2009
    ....
  21. pmc Linear normalised hash function for clustering gene sequences and identifying reference sequences from multiple sequence alignments
    Manal Helal
    Sydney Emerging Infections and Biosecurity Institute, Sydney Medical School Westmead, University of Sydney, Sydney, New South Wales, Australia
    Microb Inform Exp 2:2. 2012
    ..abstract:..
  22. pmc Identification of 20 common human enterovirus serotypes by use of a reverse transcription-PCR-based reverse line blot hybridization assay
    Fei Zhou
    Centre for Infectious Diseases and Microbiology CIDM, Institute of Clinical Pathology and Medical Research ICPMR, Westmead, New South Wales, Australia
    J Clin Microbiol 47:2737-43. 2009
    ..RT-PCR-RLB allows detection of specific enteroviral serotypes or genotypes associated with HEV outbreaks and significant disease...
  23. ncbi request reprint Current status of matrix-assisted laser desorption ionisation-time of flight mass spectrometry in the clinical microbiology laboratory
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia
    Pathology 45:4-17. 2013
    ..Novel applications include strain typing and the detection of antimicrobial resistance, but these are not widely used. This review discusses the technical aspects, current applications, and limitations of MALDI-TOF MS...
  24. pmc Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
    Retrovirology 8:18. 2011
    ..Therefore, this work aimed to define the genomic basis of HIV interactions with the cellular transcriptome of both CD4+ and CD8+ T cells...
  25. doi request reprint Point of care testing: diagnosis outside the virology laboratory
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Sydney, NSW, Australia
    Methods Mol Biol 665:415-33. 2011
    ..The sensitivity, specificity, and turn-around time of available POCTs are included for common conditions including respiratory viral infections (e.g. influenza, RSV) and blood-borne viral infections (e.g. HIV)...
  26. pmc Influenza A (H1N1) 2009 antibodies in residents of New South Wales, Australia, after the first pandemic wave in the 2009 southern hemisphere winter
    Gwendolyn L Gilbert
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 5:e12562. 2010
    ....
  27. doi request reprint Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
    Patricia E Ferguson
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
    J Clin Virol 56:255-9. 2013
    ..A previously unidentified species of human rhinovirus, HRV-C, was described in 2006 in association with lower respiratory tract infection (LRTI). Features of infection in immunosuppressed adults are poorly characterised...
  28. doi request reprint Hendra virus: a one health tale of flying foxes, horses and humans
    Briony Hazelton
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
    Future Microbiol 8:461-74. 2013
    ....
  29. pmc Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye
    Meav Lang J Lay
    Virology Department, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Institute Road, Westmead Hospital, Westmead 2145, New South Wales, Australia
    Virol J 7:252. 2010
    ..EBV DNA loads and viral capsid antigen (VCA) IgG antibody titres were also quantified on a population sample...
  30. pmc Face mask use and control of respiratory virus transmission in households
    C Raina MacIntyre
    niversity of New South Wales School of Public Health and Community Medicine, Sydney, New South Wales, Australia
    Emerg Infect Dis 15:233-41. 2009
    ..However, during a severe pandemic when use of face masks might be greater, pandemic transmission in households could be reduced...
  31. pmc Outbreaks of pandemic (H1N1) 2009 and seasonal influenza A (H3N2) on cruise ship
    Kate A Ward
    New South Wales Health, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:1731-7. 2010
    ..Among this population of generally healthy passengers, children seemed more susceptible to pandemic (H1N1) 2009 than to influenza (H3N2) viruses. Intensive disease control measures successfully contained these outbreaks...
  32. ncbi request reprint Advances in HIV laboratory testing
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital
    N S W Public Health Bull 21:86-8. 2010
    ..Quality assurance programs ensure high-level performance of HIV assays...
  33. ncbi request reprint Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients
    Nicholas B Cross
    Centre for Kidney Research, Children s Hospital at Westmead, Westmead, NSW 2145, Australia
    Nephrology (Carlton) 14:350-6. 2009
    ....
  34. pmc Mortality attributable to seasonal and pandemic influenza, Australia, 2003 to 2009, using a novel time series smoothing approach
    David J Muscatello
    School of Public Health and Community Medicine, University of New South Wales, Kensington, New South Wales, Australia
    PLoS ONE 8:e64734. 2013
    ..This approach assumes that the seasonal pattern of non-influenza mortality is the same each year, which may not always be accurate...
  35. pmc Bed bugs: clinical relevance and control options
    Stephen L Doggett
    Department of Medical Entomology, ICPMR, Westmead Hospital, Westmead, New South Wales, Australia
    Clin Microbiol Rev 25:164-92. 2012
    ..For accommodation providers, risk management procedures should be implemented to reduce the potential of bed bug infestations...
  36. pmc Influenza outbreak during Sydney World Youth Day 2008: the utility of laboratory testing and case definitions on mass gathering outbreak containment
    Sebastiaan J van Hal
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    PLoS ONE 4:e6620. 2009
    ..However, the utility of these clinical case definitions and laboratory testing in mass gathering outbreaks remains unknown...
  37. doi request reprint Influenza: One Health in action
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital
    N S W Public Health Bull 22:123-6. 2011
    ....
  38. doi request reprint Viral arthritides
    Alexander C Outhred
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
    Expert Rev Anti Infect Ther 9:545-54. 2011
    ..In general, viral arthritides are self-limiting and treatment is targeted at symptomatic relief. This article focuses on the causes, clinical features, diagnosis and treatment of viral arthritides...