Increased adiposity enhances intrafollicular estradiol levels in normoandrogenic ovulatory women receiving gonadotropin-releasing hormone analog/recombinant human follicle-stimulating hormone therapy for in vitro fertilizationDaniel A Dumesic
National Primate Research Center, University of Wisconsin, Madison 53715, USA
J Clin Endocrinol Metab 92:1438-41. 2007
..Body mass index (BMI) reflects the amount of insulin in the human follicle and may enhance insulin action as a cogonadotropin...
- Early origins of polycystic ovary syndrome
Daniel A Dumesic
Wisconsin National Primate Research Center, University of Wisconsin, Madison, 53715, USA
Reprod Fertil Dev 17:349-60. 2005
..By doing so, future studies promise to develop new clinical strategies that will lead to improved pregnancy outcome and reduced pregnancy loss in women with disorders of insulin action, including PCOS, obesity and diabetes mellitus...
Polycystic ovary syndrome and its developmental originsDaniel A Dumesic
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Rev Endocr Metab Disord 8:127-41. 2007
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- Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys
D A Dumesic
National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Hum Reprod 24:3188-95. 2009
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- Polycystic ovary syndrome and oocyte developmental competence
Daniel A Dumesic
Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA
Obstet Gynecol Surv 63:39-48. 2008
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- Implications of polycystic ovary syndrome on oocyte development
Daniel A Dumesic
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA
Semin Reprod Med 26:53-61. 2008
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- Intrafollicular antimüllerian hormone levels predict follicle responsiveness to follicle-stimulating hormone (FSH) in normoandrogenic ovulatory women undergoing gonadotropin releasing-hormone analog/recombinant human FSH therapy for in vitro fertilization
Daniel A Dumesic
Reproductive Medicine and Infertility Associates, 2101 Woodwinds Drive, Woodbury, MN 55125, USA
Fertil Steril 92:217-21. 2009
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- Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys
Rao Zhou
National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States
Reprod Toxicol 23:438-48. 2007
..To determine whether pioglitazone will improve menstrual cyclicity in a fetal programming model for polycystic ovary syndrome...
- Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood
D A Dumesic
Wisconsin Regional Primate Research Center, Madison, USA
Fertil Steril 67:155-63. 1997
..To determine whether prenatal androgenization of the developing primate hypothalamohypophyseal unit induces irreversible changes in LH secretion...
- Pituitary desensitization to gonadotropin-releasing hormone increases abdominal adiposity in hyperandrogenic anovulatory women
D A Dumesic
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA
Fertil Steril 70:94-101. 1998
..To determine whether hyperandrogenism in anovulatory women affects body fat distribution...
- Reduced intrafollicular androstenedione and estradiol levels in early-treated prenatally androgenized female rhesus monkeys receiving follicle-stimulating hormone therapy for in vitro fertilization
Daniel A Dumesic
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Biol Reprod 69:1213-9. 2003
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- Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization
Daniel A Dumesic
Wisconsin Regional Primate Research Center, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53715 1299, USA
J Clin Endocrinol Metab 87:1111-9. 2002
..Early prenatal androgenization in monkeys receiving gonadotropins impairs oocyte developmental competence and seems to induce premature follicle differentiation in the presence of LH hypersecretion and relative insulin excess...
- Developmental origin of polycystic ovary syndrome - a hypothesis
D H Abbott
Department of Obstetrics and Gynecology and Wisconsin Regional Primate Research Centre, University of Wisconsin, Madison 53715, USA
J Endocrinol 174:1-5. 2002
..This hypothesis therefore suggests a unifying, 'linear' model to explain the aetiology of the heterogeneous phenotype...
- Ovarian morphology and serum hormone markers as predictors of ovarian follicle recruitment by gonadotropins for in vitro fertilization
D A Dumesic
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 86:2538-43. 2001
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- Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
C M Bruns
Dean Clinic, Madison, WI, USA
Int J Obes (Lond) 31:1579-85. 2007
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- Follicle luteinization in hyperandrogenic follicles of polycystic ovary syndrome patients undergoing gonadotropin therapy for in vitro fertilization
Shu C Foong
Reproductive Medicine and Infertility Associates, 2101 Woodwinds Drive, Woodbury, Minnesota 55125, USA
J Clin Endocrinol Metab 91:2327-33. 2006
..CONCLUSION: Hyperandrogenic follicles with mature oocytes from PCOS women receiving GnRH analog/recombinant human FSH therapy for IVF show sufficient glucose utilization for normal luteinization...
- Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys
David H Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
Biol Reprod 79:154-63. 2008
..Thus, in this nonhuman primate model, differential programming of the fetal hypothalamo-pituitary unit with concomitant hyperandrogenism provides evidence to suggest developmental origins of LH and androgen excess in adulthood...
- Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome
David H Abbott
Department of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Endocr Dev 13:145-58. 2008
..As adult prenatally androgenized female rhesus monkeys closely emulate PCOS-like symptoms, excess fetal androgen programming may contribute to adult adrenal androgen excess in women with PCOS...
- Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring
David H Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, USA
Am J Physiol Endocrinol Metab 299:E741-51. 2010
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- Diminished intrafollicular estradiol levels in in vitro fertilization cycles from women with reduced ovarian response to recombinant human follicle-stimulating hormone
Shu C Foong
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 83:1377-83. 2005
..To correlate serum and intrafollicular E(2) levels in women receiving GnRH agonist and recombinant human (h)FSH for IVF...
- Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess
Joel R Eisner
Wisconsin Regional Primate Research Center, University of Wisconsin-Madison, 53715, USA
Fertil Steril 77:167-72. 2002
..CONCLUSION(S): Prenatal androgen excess in female rhesus monkeys causes perturbations in ovarian and adrenal steroidogenesis during adulthood, which may both contribute to hyperandrogenism...
- Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients
Jennifer L Phy
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Clin Endocrinol Metab 89:3561-6. 2004
..Granulosa cell IR heterogeneity, together with adiposity-dependent intrafollicular insulin availability, introduces a novel mechanism by which insulin may affect granulosa cell function within the follicle...
- Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome
Rao Zhou
National Primate Research Center, University of Wisconsin, Madison 53715, USA
J Clin Endocrinol Metab 90:6630-7. 2005
..Adrenal androgen excess is found in approximately 25-60% of women with polycystic ovary syndrome (PCOS), but the mechanisms underlying PCOS-related adrenal androgen excess are unclear...
- Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys
David H Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
Am J Primatol 71:776-84. 2009
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- Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation
Joel R Eisner
Wisconsin Primate Research Center, Department of Obstetrics and Gynecology, Endocrinology-Reproductive Physiology Program, University of Wisconsin, Madison, Wisconsin, USA
Obes Res 11:279-86. 2003
..This study establishes alterations in abdominal adiposity as another consequence of prenatal androgen excess in female rhesus monkeys that may contribute to the impaired insulin secretion observed in these animals during adulthood...
- Vitrification versus programmable rate freezing of late stage murine embryos: a randomized comparison prior to application in clinical IVF
David L Walker
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Reprod Biomed Online 8:558-68. 2004
..These data demonstrate that vitrification may be a better method for freezing murine blastocysts than PR, and may prove to be a superior method for freezing human blastocysts...
- Cumulative first live birth after elective cryopreservation of all embryos due to ovarian hyperresponsiveness
Ian S Tummon
Mayo Clinic, Rochester, Minnesota 55905, USA
Fertil Steril 81:309-14. 2004
..To estimate cumulative chance for first live birth after elective pronuclear stage cryopreservation of all embryos due to ovarian hyperresponsiveness...
- Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis
Jennifer R Wood
Department of Animal Science, University of Nebraska Lincoln, 3800 Fair Street, Lincoln, Nebraska 68583 0908, USA
J Clin Endocrinol Metab 92:705-13. 2007
..These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss...
- Regional uptake of meal fatty acids in humans
Michael D Jensen
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Am J Physiol Endocrinol Metab 285:E1282-8. 2003
..Using [3H]triolein, we were able to account for virtually 100% of meal fatty acids 24 h after meal ingestion. These results support the meal fatty acid tracer model as a way to study the metabolic fate of dietary fat...
- Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome
Rose C Christian
Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 88:2562-8. 2003
..CAC is more prevalent in PCOS women than in obese or nonobese women of similar age. PCOS women are at increased risk for atherosclerosis and should be targeted for primary prevention of CHD...
- Meal fatty acid uptake in visceral fat in women
Susanne B Votruba
Mayo Clinic, Endocrine Research Unit, 200 1st St SW, Rm 5 194 Joseph, Rochester, MN 55905, USA
Diabetes 56:2589-97. 2007
..Differential meal fat uptake into adipose tissue depots may be a determinant of body fat distribution...
- Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity
Zoi Michailidou
Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Obesity (Silver Spring) 15:1155-63. 2007
..Our objective was to determine the association between 11betaHSD1 and GRalpha mRNA levels in four distinct adipose depots and measures of obesity and the metabolic syndrome...
- Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound
Michael C Allemand
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Fertil Steril 85:214-9. 2006
..To study diagnostic thresholds for polycystic ovary (PCO)...
