Gina D'suze

Summary

Publications

  1. doi request reprint Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC Caracas, Venezuela
    Toxicon 56:1497-505. 2010
  2. doi request reprint Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes
    Patricia Diaz
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Toxicon 54:802-17. 2009
  3. doi request reprint Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicides
    Galax Joya
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
    J Agric Food Chem 59:6327-37. 2011
  4. doi request reprint Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
    Toxicon 60:1215-21. 2012
  5. doi request reprint Scorpion venom complexity fractal analysis. Its relevance for comparing venoms
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, IVIC CBB, Apartado 20632, Caracas 1020A, Venezuela
    J Theor Biol 267:405-16. 2010
  6. ncbi request reprint Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 50:1116-25. 2007
  7. ncbi request reprint Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans
    Gina D'suze
    Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Biochimie 91:1010-9. 2009
  8. ncbi request reprint Macrophage alteration induced by inflammatory toxins isolated from Tityus discrepans scorpion venom. The role of Na(+)/Ca(2+) exchangers
    Vanesa Ramírez-Bello
    Laboratory of Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 82:61-75. 2014

Collaborators

  • Carlos Sevcik
  • Jan Tytgat
  • Elisabeth F Schwartz
  • Vanesa Ramírez-Bello
  • Galax Joya
  • Victor Salazar
  • Patricia Diaz
  • Steve Peigneur
  • Arnaldo Rosales
  • Jonas Perales
  • André T S Ferreira
  • Gonzalo Visbal
  • John D Shannon
  • Nicholas E Sherman
  • Jay W Fox

Detail Information

Publications8

  1. doi request reprint Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC Caracas, Venezuela
    Toxicon 56:1497-505. 2010
    ..3 and 4.1% of SKBR3 apoptosis, respectively, in 5 h of exposure; the effect was larger with more prolonged exposures. Inmunohistochemistry showed that neopladines bind to SKBR3 cell surface inducing FasL and BcL-2 expression...
  2. doi request reprint Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes
    Patricia Diaz
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Toxicon 54:802-17. 2009
    ..We found no evidence of changes of K(+) or Ca(2+) concentrations neither inside nor outside the bacteria in experiments using the fluorescent dyes Fluo 4AM (10 microM) and PBFI (20 microM)...
  3. doi request reprint Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicides
    Galax Joya
    Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
    J Agric Food Chem 59:6327-37. 2011
    ..However, the antifungal effects at short times are indicative of a direct esterase inhibition, which, with the increased membrane leakiness to Na(+), makes the fungus inviable...
  4. doi request reprint Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness
    Carlos Sevcik
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
    Toxicon 60:1215-21. 2012
    ..Our results suggest that IgY may be a stronger activator of adaptive immunity than horse IgG in mammals. Adaptive immunity against IgY is detrimental to its IV therapeutic use in humans and other mammals...
  5. doi request reprint Scorpion venom complexity fractal analysis. Its relevance for comparing venoms
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, IVIC CBB, Apartado 20632, Caracas 1020A, Venezuela
    J Theor Biol 267:405-16. 2010
    ....
  6. ncbi request reprint Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom
    Gina D'suze
    Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 50:1116-25. 2007
    ..Blocking pro-inflammatory leukocyte metabolic pathways with BZ diminished FF, suggesting that neutrophil activation, inflammation and coagulation are correlated in the genesis of scorpionism acute lung injury...
  7. ncbi request reprint Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans
    Gina D'suze
    Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Biochimie 91:1010-9. 2009
    ..The N-terminal amino acid sequence of several peptides is reported here for the first time. A phylogenetic tree analysis is also reported, as well as three three-dimensional models of representative toxins...
  8. ncbi request reprint Macrophage alteration induced by inflammatory toxins isolated from Tityus discrepans scorpion venom. The role of Na(+)/Ca(2+) exchangers
    Vanesa Ramírez-Bello
    Laboratory of Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC, Apdo 20632, Caracas 1020 A, Venezuela
    Toxicon 82:61-75. 2014
    ..A rise of [Ca(2+)]i activates the synthesis and secretion of inflammatory molecules like TNF-α, which in turn, increases the gene transcription for inducible nitric oxide synthase, resulting on NO production. ..