Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell lineGina D'suze
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas IVIC Caracas, Venezuela
Toxicon 56:1497-505. 2010
..3 and 4.1% of SKBR3 apoptosis, respectively, in 5 h of exposure; the effect was larger with more prolonged exposures. Inmunohistochemistry showed that neopladines bind to SKBR3 cell surface inducing FasL and BcL-2 expression...
- Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes
Patricia Diaz
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Toxicon 54:802-17. 2009
..We found no evidence of changes of K(+) or Ca(2+) concentrations neither inside nor outside the bacteria in experiments using the fluorescent dyes Fluo 4AM (10 microM) and PBFI (20 microM)...
- Scorpion toxins modify phytopathogenic fungus physiology. A possible source of new fungicides
Galax Joya
Laboratory on Cellular Neuropharmacology, Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas, Venezuela
J Agric Food Chem 59:6327-37. 2011
..However, the antifungal effects at short times are indicative of a direct esterase inhibition, which, with the increased membrane leakiness to Na(+), makes the fungus inviable...
- Horse IgG- and ostrich IgY-F(ab')₂ groups have different affinities for mice erythrocytes and lymphocytes. Implications for avian immunoglobulin therapeutic usefulness
Carlos Sevcik
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
Toxicon 60:1215-21. 2012
..Our results suggest that IgY may be a stronger activator of adaptive immunity than horse IgG in mammals. Adaptive immunity against IgY is detrimental to its IV therapeutic use in humans and other mammals...
- Scorpion venom complexity fractal analysis. Its relevance for comparing venoms
Gina D'suze
Laboratory on Cellular Neuropharmacology, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, IVIC CBB, Apartado 20632, Caracas 1020A, Venezuela
J Theor Biol 267:405-16. 2010
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Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venomGina D'suze
Laboratory on Cellular Neuropharmacology, IVIC CBB, Apdo 20632, Caracas 1020 A, Venezuela
Toxicon 50:1116-25. 2007
..Blocking pro-inflammatory leukocyte metabolic pathways with BZ diminished FF, suggesting that neutrophil activation, inflammation and coagulation are correlated in the genesis of scorpionism acute lung injury...
- Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans
Gina D'suze
Biophysics and Biochemistry Center, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Biochimie 91:1010-9. 2009
..The N-terminal amino acid sequence of several peptides is reported here for the first time. A phylogenetic tree analysis is also reported, as well as three three-dimensional models of representative toxins...
