Malcolm J D'Souza

Summary

Publications

  1. pmc Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 11:2597-611. 2010
  2. pmc Use of empirical correlations to determine solvent effects in the solvolysis of S-methyl chlorothioformate
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 11:2253-66. 2010
  3. pmc Correlation of the Rates of Solvolysis of Two Arenesulfonyl Chlorides and of trans-beta-Styrenesulfonyl Chloride - Precursors in the Development of New Pharmaceuticals
    Zoon Ha Ryu
    Department of Chemistry, Dong Eui University, 24 Kaya dong, Busan Jin Gu, Busan 614 714, Korea
    Int J Mol Sci 9:2639-57. 2008
  4. pmc Extended Grunwald-Winstein Analysis - LFER Used to Gauge Solvent Effects in p-Nitrophenyl Chloroformate Solvolysis
    Kevin E Shuman
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875
    Int J Mol Sci 9:2231-42. 2008
  5. pmc Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 10:862-79. 2009
  6. pmc Kinetic Studies that Evaluate the Solvolytic Mechanisms of Allyl and Vinyl Chloroformate Esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 14:7286-301. 2013
  7. pmc Kinetic evaluation of the solvolysis of isobutyl chloro- and chlorothioformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Beilstein J Org Chem 7:543-52. 2011
  8. pmc Correlation of the rates of solvolysis of neopentyl chloroformate-a recommended protecting agent
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA
    Int J Mol Sci 12:1161-74. 2011
  9. pmc Use of Linear Free Energy Relationships (LFERs) to Elucidate the Mechanisms of Reaction of a γ-Methyl-β-alkynyl and an ortho-Substituted Aryl Chloroformate Ester
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA E Mails J A K G A F B
    Int J Mol Sci 13:665-82. 2012

Collaborators

  • Zoon Ha Ryu
  • Kevin E Shuman
  • Dennis N Kevill
  • Sang Wok Lee
  • Samantha E Feld
  • Shannon E Carter
  • Lamia Yaakoubd

Detail Information

Publications11

  1. pmc Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 11:2597-611. 2010
    ....
  2. pmc Use of empirical correlations to determine solvent effects in the solvolysis of S-methyl chlorothioformate
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 11:2253-66. 2010
    ....
  3. pmc Correlation of the Rates of Solvolysis of Two Arenesulfonyl Chlorides and of trans-beta-Styrenesulfonyl Chloride - Precursors in the Development of New Pharmaceuticals
    Zoon Ha Ryu
    Department of Chemistry, Dong Eui University, 24 Kaya dong, Busan Jin Gu, Busan 614 714, Korea
    Int J Mol Sci 9:2639-57. 2008
    ..For 3, kinetic solvent isotope effects of 1.46 for k(H(2)O)/k(D(2)O) and 1.76 for k(MeOH)/k(MeOD) were determined. These are also compared to literature values for other sulfonyl chlorides...
  4. pmc Extended Grunwald-Winstein Analysis - LFER Used to Gauge Solvent Effects in p-Nitrophenyl Chloroformate Solvolysis
    Kevin E Shuman
    Department of Chemistry, Wesley College, 120 N State Street, Dover, Delaware 19901 3875
    Int J Mol Sci 9:2231-42. 2008
    ..The l/m ratios obtained for 1, 2, and 3, are also compared to the previously published l/m ratios for benzyl chloroformate (4) and p-nitrobenzyl chloroformate (5)...
  5. pmc Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, Dover, Delaware 19901 3875, USA
    Int J Mol Sci 10:862-79. 2009
    ..Deficiencies in the acid production indicate 2-33% isopropyl chloride formation, with the higher values in less nucleophilic solvents...
  6. pmc Kinetic Studies that Evaluate the Solvolytic Mechanisms of Allyl and Vinyl Chloroformate Esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Int J Mol Sci 14:7286-301. 2013
    ..Both substrates were found to solvolyze by similar dual bimolecular carbonyl-addition and unimolecular ionization channels, each heavily dependent upon the solvents nucleophilicity and ionizing ability...
  7. pmc Kinetic evaluation of the solvolysis of isobutyl chloro- and chlorothioformate esters
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901 3875, USA
    Beilstein J Org Chem 7:543-52. 2011
    ....
  8. pmc Correlation of the rates of solvolysis of neopentyl chloroformate-a recommended protecting agent
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA
    Int J Mol Sci 12:1161-74. 2011
    ....
  9. pmc Use of Linear Free Energy Relationships (LFERs) to Elucidate the Mechanisms of Reaction of a γ-Methyl-β-alkynyl and an ortho-Substituted Aryl Chloroformate Ester
    Malcolm J D'Souza
    Department of Chemistry, Wesley College, 120 N State Street, Dover, DE 19901, USA E Mails J A K G A F B
    Int J Mol Sci 13:665-82. 2012
    ..For 2, the analyses indicate that the dominant mechanism is a bimolecular one where the formation of a tetrahedral intermediate is rate-determining...