Hans E Schoemaker

Summary

Affiliation: DSM Nutritional Products

Publications

  1. ncbi request reprint Dispelling the myths--biocatalysis in industrial synthesis
    Hans E Schoemaker
    DSM Research, Life Science Products, Post Office Box 18, 6160 MD Geleen, Netherlands
    Science 299:1694-7. 2003
  2. pmc L-selective amidase with extremely broad substrate specificity from Ochrobactrum anthropi NCIMB 40321
    Theo Sonke
    DSM Pharma Chemicals Advanced Synthesis, Catalysis and Development, P O Box 18, 6160 MD Geleen, The Netherlands
    Appl Environ Microbiol 71:7961-73. 2005
  3. ncbi request reprint Biocatalytic single-step alkene cleavage from aryl alkenes: an enzymatic equivalent to reductive ozonization
    Harald Mang
    Department of Chemistry, Organic and Bioorganic Chemistry, Research Centre Applied Biocatalysis, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    Angew Chem Int Ed Engl 45:5201-3. 2006
  4. ncbi request reprint Diastereoselective synthesis of (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives
    Peter N M Botman
    Chiralix B V, P O Box 31070, 6503 CB Nijmegen, The Netherlands
    Org Lett 6:4941-4. 2004
  5. ncbi request reprint Catalytic N-sulfonyliminium ion-mediated cyclizations to alpha-vinyl-substituted isoquinolines and beta-carbolines and applications in metathesis
    Sape S Kinderman
    J H van t Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, NL 1018 WS Amsterdam, The Netherlands
    J Org Chem 70:5519-27. 2005
  6. ncbi request reprint Total synthesis of (+)-epiquinamide
    Marloes A Wijdeven
    Chiralix B V, P O Box 31070, 6503 CB Nijmegen, The Netherlands, Radboud University Nijmegen, IMM, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Org Lett 7:4005-7. 2005
  7. ncbi request reprint Synthetic applications of aliphatic unsaturated alpha-H-alpha-amino acids
    Jasper Kaiser
    Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Org Biomol Chem 3:3435-67. 2005
  8. ncbi request reprint Biocatalytic reductions: from lab curiosity to "first choice"
    Stefaan M A de Wildeman
    DSM Pharmaceuticals Products, Advanced Synthesis, Catalysis and Development, PO Box 18, 6160 MD Geleen, The Netherlands
    Acc Chem Res 40:1260-6. 2007
  9. doi request reprint N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide
    Marloes A Wijdeven
    Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Org Lett 10:4001-3. 2008

Collaborators

  • Theo Sonke
  • Bernard Kaptein
  • J W Daly
  • Georg M Guebitz
  • Floris P J T Rutjes
  • Marloes A Wijdeven
  • Richard H Blaauw
  • Sape S Kinderman
  • Peter N M Botman
  • Stefaan M A de Wildeman
  • Roel Wijtmans
  • Floris L van Delft
  • Harald Mang
  • Jasper Kaiser
  • Thomas F Spande
  • Wim Noorduin
  • Rutger J F van den Berg
  • Richard W Fitch
  • Oliver May
  • Johannes Gross
  • Christian Goessler
  • Wolfgang Kroutil
  • Miguel Lara
  • Bart C J van Esseveldt
  • Jan H van Maarseveen
  • Henk Hiemstra
  • Monique M T Wekking
  • F Jan Dommerholt
  • Rene de Gelder
  • Quirinus B Broxterman

Detail Information

Publications9

  1. ncbi request reprint Dispelling the myths--biocatalysis in industrial synthesis
    Hans E Schoemaker
    DSM Research, Life Science Products, Post Office Box 18, 6160 MD Geleen, Netherlands
    Science 299:1694-7. 2003
    ..As a result, we expect many new industrial applications of biocatalysis to be realized, from single-step enzymatic conversions to customized multistep microbial synthesis by means of metabolic pathway engineering...
  2. pmc L-selective amidase with extremely broad substrate specificity from Ochrobactrum anthropi NCIMB 40321
    Theo Sonke
    DSM Pharma Chemicals Advanced Synthesis, Catalysis and Development, P O Box 18, 6160 MD Geleen, The Netherlands
    Appl Environ Microbiol 71:7961-73. 2005
    ..Subcloning of the gene in expression vector pTrc99A enabled efficient heterologous expression in Escherichia coli. Altogether, this amidase has a unique set of properties for application in the fine-chemicals industry...
  3. ncbi request reprint Biocatalytic single-step alkene cleavage from aryl alkenes: an enzymatic equivalent to reductive ozonization
    Harald Mang
    Department of Chemistry, Organic and Bioorganic Chemistry, Research Centre Applied Biocatalysis, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria
    Angew Chem Int Ed Engl 45:5201-3. 2006
  4. ncbi request reprint Diastereoselective synthesis of (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives
    Peter N M Botman
    Chiralix B V, P O Box 31070, 6503 CB Nijmegen, The Netherlands
    Org Lett 6:4941-4. 2004
    ..The key step in the synthetic sequence is a novel highly diastereoselective epoxidation reaction of an enantiomerically pure cyclic enamide intermediate...
  5. ncbi request reprint Catalytic N-sulfonyliminium ion-mediated cyclizations to alpha-vinyl-substituted isoquinolines and beta-carbolines and applications in metathesis
    Sape S Kinderman
    J H van t Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, NL 1018 WS Amsterdam, The Netherlands
    J Org Chem 70:5519-27. 2005
    ....
  6. ncbi request reprint Total synthesis of (+)-epiquinamide
    Marloes A Wijdeven
    Chiralix B V, P O Box 31070, 6503 CB Nijmegen, The Netherlands, Radboud University Nijmegen, IMM, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Org Lett 7:4005-7. 2005
    ..Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylation and a ring-closing metathesis reaction to provide the bicyclic skeleton. [reaction: see text]..
  7. ncbi request reprint Synthetic applications of aliphatic unsaturated alpha-H-alpha-amino acids
    Jasper Kaiser
    Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Org Biomol Chem 3:3435-67. 2005
    ..This article provides an overview of the literature concerning synthetic applications of unsaturated aliphatic amino acids in the period May 2000 to December 2004...
  8. ncbi request reprint Biocatalytic reductions: from lab curiosity to "first choice"
    Stefaan M A de Wildeman
    DSM Pharmaceuticals Products, Advanced Synthesis, Catalysis and Development, PO Box 18, 6160 MD Geleen, The Netherlands
    Acc Chem Res 40:1260-6. 2007
    ....
  9. doi request reprint N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide
    Marloes A Wijdeven
    Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Org Lett 10:4001-3. 2008
    ....