Alexander Drobyshevsky

Summary

Publications

  1. ncbi request reprint White matter injury correlates with hypertonia in an animal model of cerebral palsy
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Cereb Blood Flow Metab 27:270-81. 2007
  2. pmc Near-term fetal hypoxia-ischemia in rabbits: MRI can predict muscle tone abnormalities and deep brain injury
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University Health Systems, Evanston, IL 60202, USA
    Stroke 43:2757-63. 2012
  3. pmc Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University HealthSystem Research Institute, Evanston, IL, USA
    Exp Neurol 237:427-34. 2012
  4. pmc Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Neurosci 32:5500-9. 2012
  5. ncbi request reprint Fetal brain magnetic resonance imaging response acutely to hypoxia-ischemia predicts postnatal outcome
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, IL 60201, USA
    Ann Neurol 61:307-14. 2007
  6. pmc Involvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia
    Suma Rao
    Department of Pediatrics, Northwestern University, Chicago, IL, USA
    Dev Neurosci 33:288-98. 2011
  7. pmc Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test
    Matthew Derrick
    Department of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, United States
    Int J Dev Neurosci 27:549-57. 2009
  8. ncbi request reprint Sensory deficits and olfactory system injury detected by novel application of MEMRI in newborn rabbit after antenatal hypoxia-ischemia
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Northwestern University, 2650 Ridge Avenue, Evanston, IL 60201, USA
    Neuroimage 32:1106-12. 2006
  9. ncbi request reprint Intrauterine fetal demise can be remote from the inciting insult in an animal model of hypoxia-ischemia
    Matthew Derrick
    Department of Pediatrics, University of Chicago and Northshore University HealthSystem, Evanston, Illinois, USA
    Pediatr Res 72:154-60. 2012
  10. ncbi request reprint Serial diffusion tensor imaging detects white matter changes that correlate with motor outcome in premature infants
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare, Evanston, Ill 60201, USA
    Dev Neurosci 29:289-301. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint White matter injury correlates with hypertonia in an animal model of cerebral palsy
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Cereb Blood Flow Metab 27:270-81. 2007
    ..Furthermore, the dynamic response of FA may be a good indicator of the plasticity and repair of the postnatal developing brain...
  2. pmc Near-term fetal hypoxia-ischemia in rabbits: MRI can predict muscle tone abnormalities and deep brain injury
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University Health Systems, Evanston, IL 60202, USA
    Stroke 43:2757-63. 2012
    ....
  3. pmc Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University HealthSystem Research Institute, Evanston, IL, USA
    Exp Neurol 237:427-34. 2012
    ..Antenatal H-I injury remote from delivery may affect early functional development of the olfactory system by decreasing NO-dependent signal transduction...
  4. pmc Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants
    Alexander Drobyshevsky
    Department of Pediatrics, NorthShore University Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Neurosci 32:5500-9. 2012
    ..The etiological link between early injury and later motor deficits can thus be investigated by MRI, and allows us to distinguish between critical oxidative stress that causes motor deficits and noncritical oxidative stress that does not...
  5. ncbi request reprint Fetal brain magnetic resonance imaging response acutely to hypoxia-ischemia predicts postnatal outcome
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, IL 60201, USA
    Ann Neurol 61:307-14. 2007
    ..Our objective was to examine whether the immediate response of the fetus to an acute H-I event determined the motor deficits associated with cerebral palsy...
  6. pmc Involvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia
    Suma Rao
    Department of Pediatrics, Northwestern University, Chicago, IL, USA
    Dev Neurosci 33:288-98. 2011
    ..The subacute brain slice model could be a tool for studying the mechanisms involved in ongoing neuronal injury, and for rapidly assessing potential neuroprotectants...
  7. pmc Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test
    Matthew Derrick
    Department of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, United States
    Int J Dev Neurosci 27:549-57. 2009
    ..Identification and quantification of milder deficits allows mechanistic studies in the causation of H-I injury as well as estimation of recovery with therapeutic agents...
  8. ncbi request reprint Sensory deficits and olfactory system injury detected by novel application of MEMRI in newborn rabbit after antenatal hypoxia-ischemia
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare Research Institute and Northwestern University, 2650 Ridge Avenue, Evanston, IL 60201, USA
    Neuroimage 32:1106-12. 2006
    ..Antenatal hypoxia-ischemia causes long-lasting injury to neuronal tracts of the olfactory system including olfactory epithelium...
  9. ncbi request reprint Intrauterine fetal demise can be remote from the inciting insult in an animal model of hypoxia-ischemia
    Matthew Derrick
    Department of Pediatrics, University of Chicago and Northshore University HealthSystem, Evanston, Illinois, USA
    Pediatr Res 72:154-60. 2012
    ..We asked the question of whether the timing of fetal death was influenced by the age at which the insult occurred...
  10. ncbi request reprint Serial diffusion tensor imaging detects white matter changes that correlate with motor outcome in premature infants
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare, Evanston, Ill 60201, USA
    Dev Neurosci 29:289-301. 2007
    ..A low value of FA at 30 weeks and a higher change of FA predicted less favorable motor outcome at 2 years and suggests that early subtle white matter injury can be detected in premature infants even without obvious signs of injury...
  11. ncbi request reprint A model of cerebral palsy from fetal hypoxia-ischemia
    Matthew Derrick
    Department of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Stroke 38:731-5. 2007
    ..For the first time critical mechanistic pathways can be tested in a clinically relevant animal model of cerebral palsy...
  12. ncbi request reprint Model of cerebral palsy in the perinatal rabbit
    Sidhartha Tan
    Department of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    J Child Neurol 20:972-9. 2005
    ..This is the first animal model to mimic cerebral palsy. The findings also suggest a window of vulnerability during brain development when the injury results in hypertonia in newborn pups...
  13. ncbi request reprint Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential
    Alexander Drobyshevsky
    Departments of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Neurosci 25:5988-97. 2005
    ..These findings suggest that developmental expansion of immature oligodendrocytes during the premyelination period may be important in defining structural and functional maturation of the white matter...
  14. pmc A rapid fMRI task battery for mapping of visual, motor, cognitive, and emotional function
    Alexander Drobyshevsky
    Psychology Software Tools, Inc, Suite 200, 2050 Ardmore Blvd, Pittsburgh, PA 15221, USA
    Neuroimage 31:732-44. 2006
    ..The dataset can also serve as a reliability metric for new fMRI laboratories and novice investigators seeking to test their acquisition and analysis techniques with minimal time investment and expense...