William J Doyle

Summary

Publications

  1. pmc Sensitivity and specificity of eustachian tube function tests in adults
    William J Doyle
    Division of Pediatric Otolaryngology, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA Otolaryngol Head Neck Surg 139:719-27. 2013
  2. pmc Reproducibility of the forced response test in children with chronic otitis media with effusion
    William J Doyle
    Department of Otolaryngology, Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Otol Neurotol 34:16-21. 2013
  3. pmc The mastoid as a functional rate-limiter of middle ear pressure change
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
    Int J Pediatr Otorhinolaryngol 71:393-402. 2007
  4. ncbi request reprint The link between allergic rhinitis and otitis media
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Allergy Clin Immunol 2:21-5. 2002
  5. pmc Transmucosal O2 and CO2 exchange rates for the human middle ear
    William J Doyle
    Division of Pediatric Otolaryngology, Department of Otolaryngology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Auris Nasus Larynx 38:684-91. 2011
  6. pmc Eustachian tube-tensor veli palatini muscle-cranial base relationships in children and adults: an osteological study
    William J Doyle
    Dept of Otolaryngology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Int J Pediatr Otorhinolaryngol 74:986-90. 2010
  7. ncbi request reprint Rate of nitrous oxide exchange across the middle ear mucosa in monkeys before and after blockage of the mastoid antrum
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213 USA
    Otolaryngol Head Neck Surg 128:732-41. 2003
  8. pmc The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Infect Dis 201:199-206. 2010
  9. ncbi request reprint Middle ear pressure change during controlled breathing with gas mixtures containing nitrous oxide
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 94:199-204. 2003
  10. doi request reprint Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705, Fifth Avenue, DeSoto Street, Pittsburgh, PA 15213, USA
    Eur Arch Otorhinolaryngol 266:199-205. 2009

Detail Information

Publications75

  1. pmc Sensitivity and specificity of eustachian tube function tests in adults
    William J Doyle
    Division of Pediatric Otolaryngology, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA Otolaryngol Head Neck Surg 139:719-27. 2013
    ..The study demonstrates the utility of eustachian tube (ET) function (ETF) test results for accurately assigning ears to disease state...
  2. pmc Reproducibility of the forced response test in children with chronic otitis media with effusion
    William J Doyle
    Department of Otolaryngology, Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Otol Neurotol 34:16-21. 2013
    ..Eustachian tube function is stable over time in children with ventilation tubes for chronic otitis media with effusion...
  3. pmc The mastoid as a functional rate-limiter of middle ear pressure change
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
    Int J Pediatr Otorhinolaryngol 71:393-402. 2007
    ....
  4. ncbi request reprint The link between allergic rhinitis and otitis media
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Allergy Clin Immunol 2:21-5. 2002
    ..Interleukin-6 did not change the Eustachian tube or middle ear functions but did cause increased secretions in allergic patients...
  5. pmc Transmucosal O2 and CO2 exchange rates for the human middle ear
    William J Doyle
    Division of Pediatric Otolaryngology, Department of Otolaryngology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Auris Nasus Larynx 38:684-91. 2011
    ..Estimate the transmucosal CO(2) and O(2) rate-constants for adult middle ears (MEs)...
  6. pmc Eustachian tube-tensor veli palatini muscle-cranial base relationships in children and adults: an osteological study
    William J Doyle
    Dept of Otolaryngology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Int J Pediatr Otorhinolaryngol 74:986-90. 2010
    ..Here, those relationships were reconstructed from skulls and compared between children and adults...
  7. ncbi request reprint Rate of nitrous oxide exchange across the middle ear mucosa in monkeys before and after blockage of the mastoid antrum
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213 USA
    Otolaryngol Head Neck Surg 128:732-41. 2003
    ..We tested the hypothesis that mastoid volume buffers the rate of change in middle ear pressure caused by transmucosal, inert gas exchange...
  8. pmc The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Infect Dis 201:199-206. 2010
    ..Here, the effect of these polymorphisms on illness and seroconversion during infection with rhinovirus type 39 (RV39) was evaluated...
  9. ncbi request reprint Middle ear pressure change during controlled breathing with gas mixtures containing nitrous oxide
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 94:199-204. 2003
    ..003 to 0.008 min(-1) across animals but was not different for a given ear across sessions. These results show that breathing gas mixtures containing N(2)O causes predictable and quantifiable increases in middle ear pressure...
  10. doi request reprint Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705, Fifth Avenue, DeSoto Street, Pittsburgh, PA 15213, USA
    Eur Arch Otorhinolaryngol 266:199-205. 2009
    ..Cytokine polymorphisms may be one of an expectedly large number of genetic factors contributing to the known heritability of OM...
  11. pmc Eustachian tube function as a predictor of the recurrence of middle ear effusion in children
    Ellen M Mandel
    Department of Otolaryngology, Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U S A
    Laryngoscope 123:2285-90. 2013
    ....
  12. ncbi request reprint Mucosal expression of genes encoding possible upstream regulators of Na+ transport during pneumococcal otitis media
    Ha Sheng Li
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh Pennsylvania 15213, USA
    Acta Otolaryngol 123:575-82. 2003
    ....
  13. ncbi request reprint Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Hum Immunol 64:338-44. 2003
    ..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
  14. pmc Sleep habits and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Arch Intern Med 169:62-7. 2009
    ..This article examines whether sleep duration and efficiency in the weeks preceding viral exposure are associated with cold susceptibility...
  15. ncbi request reprint Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
    ..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
  16. pmc Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 109:5995-9. 2012
    ..Because inflammation plays an important role in the onset and progression of a wide range of diseases, this model may have broad implications for understanding the role of stress in health...
  17. ncbi request reprint Nasal prostaglandin challenge increases N2O exchange from blood to middle ear
    Sancak Yuksel
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh and Department of Otolaryngology, University of Pittsburgh School of Medicine, 3705 Fifth Ave at DeSoto Street, Pittsburgh, PA 15213, USA
    Auris Nasus Larynx 32:29-32. 2005
    ..ME to blood N2 transfer rate determines the physiological demand placed upon the ET for gas supply. That demand is increased by nasal exposure to certain inflammatory mediators...
  18. pmc Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    JAMA 309:699-705. 2013
    ..Although leukocyte telomere length is associated with mortality and many chronic diseases thought to be manifestations of age-related functional decline, it is not known whether it relates to acute disease in younger healthy populations...
  19. doi request reprint Objective and subjective socioeconomic status and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Department of Otolaryngology, Pittsburgh s Children s Hospital, Pittsburgh, PA 15213, USA
    Health Psychol 27:268-74. 2008
    ..We ask whether subjective socioeconomic status (SES) predicts who develops a common cold when exposed to a cold virus...
  20. pmc In vivo measurement of O(2) and CO(2) gas exchange across the human tympanic membrane
    Sancak Yuksel
    Department of Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Ave DeSoto St, Pittsburgh, PA 15213, USA
    Acta Otolaryngol 129:716-25. 2009
    ..The hypothesis that the human tympanic membrane (TM) is permeable to CO(2) and O(2) at physiologic pressure gradients is supported but additional experiments need to be done to validate this methodology...
  21. pmc Parenthood and host resistance to the common cold
    Rodlescia S Sneed
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychosom Med 74:567-73. 2012
    ..To determine whether parenthood predicts host resistance to the common cold among healthy volunteers experimentally exposed to a common cold virus...
  22. ncbi request reprint Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 20:175-81. 2006
    ..These results are consistent with the hypothesis that IL-6 acts as a biological mediator in linking positive emotional style to illness expression during rhinovirus infection...
  23. doi request reprint Daily tympanometry as a functional measure of middle ear status and Eustachian tube function
    William J Doyle
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Auris Nasus Larynx 36:20-5. 2009
    ....
  24. ncbi request reprint Accuracy of CO2 conductance predicted using a morphometric model of the middle ear mucosa
    S Chad Kanick
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Acta Otolaryngol 126:1252-9. 2006
    ..g. increased MEM thickness and capillary density)...
  25. ncbi request reprint Cytokine profiles in a rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection
    Patricia A Hebda
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pennsyvania 15213, USA
    Laryngoscope 112:1657-62. 2002
    ..Cytokine expression was studied in a rat model of otitis media with effusion...
  26. pmc The incidence, prevalence and burden of OM in unselected children aged 1-8 years followed by weekly otoscopy through the "common cold" season
    Ellen M Mandel
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Pediatr Otorhinolaryngol 72:491-9. 2008
    ..Often overlooked in past studies are the contributions of cold-like illnesses (CLIs) and sampling interval to those estimates...
  27. doi request reprint Upper respiratory virus detection without parent-reported illness in children is virus-specific
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705 Fifth Avenue DeSoto Street, Pittsburgh, PA 15213, United States
    J Clin Virol 43:120-2. 2008
    ..Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI)...
  28. doi request reprint Rate of concurrent otitis media in upper respiratory tract infections with specific viruses
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 135:17-21. 2009
    ..New OM episodes are usually coincident with a viral upper respiratory tract infection (vURTI), but there are conflicting data regarding the association between specific viruses and OM...
  29. doi request reprint Nasal secretion concentrations of IL-5, IL-6, and IL-10 in children with and without upper respiratory tract viruses
    Cuneyt M Alper
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, PA, USA
    Arch Otolaryngol Head Neck Surg 136:281-6. 2010
    ..To determine if levels of interleukin (IL) 5, IL-6, and IL-10 or their ratios in nasal secretion are diagnostic of viral upper respiratory tract infections (vURTIs) and coldlike illnesses (CLIs) in children...
  30. ncbi request reprint Cathepsin gene expression profile in rat acute pneumococcal otitis media
    Ha Sheng Li-Korotky
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 114:1032-6. 2004
    ..The objective was to identify candidate effector and signaling molecules involved in acute otitis media pathogenesis caused by S pneumoniae infection...
  31. ncbi request reprint Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Immunol 64:93-8. 2003
    ..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
  32. ncbi request reprint Gas diffusion across the tympanic membrane in chinchillas: effect of repeated perforations
    Ulrik N Felding
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Auris Nasus Larynx 31:353-9. 2004
    ..However, structural changes caused by repeated TM perforations could affect gas diffusion rates. This possibility was evaluated using a chinchilla model...
  33. pmc Role of the mastoid in middle ear pressure regulation
    Cuneyt M Alper
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Laryngoscope 121:404-8. 2011
    ..Determine the role of mastoid volume in middle ear pressure (MEP) regulation. The hypothesis was that inert gas exchange between blood and middle ear (ME) is slower for larger mastoid volumes...
  34. pmc Directional asymmetry in the measured nitrous oxide time constant for middle ear transmucosal gas exchange
    William J Doyle
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, and the Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Ann Otol Rhinol Laryngol 116:69-75. 2007
    ..Previous model applications assumed directional asymmetry for those parameters, which has not been experimentally validated...
  35. pmc Interaction of pneumococcal phase variation and middle ear pressure/gas composition: an in vitro model of simulated otitis media
    Ha Sheng Li-Korotky
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 8100 Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Microb Pathog 45:201-6. 2008
    ..Attachment of T variant to epithelial cells was documented by scanning electron microscopy. These results suggest that the T variant is more highly adapted to various ME environments than the O variants...
  36. pmc The Cephalic Index is not different among groups of children aged 36-48 months with chronic otitis media with effusion, recurrent acute otitis media and controls
    Margaretha L Casselbrant
    Department of Otolaryngology, Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Pediatr Otorhinolaryngol 77:334-7. 2013
    ....
  37. doi request reprint Panel 2: Eustachian tube, middle ear, and mastoid--anatomy, physiology, pathophysiology, and pathogenesis
    J Douglas Swarts
    Department of Otolaryngology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Otolaryngol Head Neck Surg 148:E26-36. 2013
    ....
  38. ncbi request reprint Middle ear gas exchange in the air phase
    Ulrik N Felding
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    Acta Otolaryngol 123:808-11. 2003
    ..The aim of this study was to determine the time required for the equilibration of tympanum and mastoid partial pressures for two inert gases, argon and helium, in cadaveric cynomolgus monkey middle ears...
  39. ncbi request reprint Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, Virginia, USA
    Pediatrics 119:1069-75. 2007
    ..We determined the incidence of otitis-media complications in young children when referenced to cold-like illnesses and to concurrent virus recovery from the nasopharynx...
  40. pmc A cross-sectional study of the change in mastoid geometry with age in children without a history of otitis media
    J Douglas Swarts
    Department of Otolaryngology, Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, USA
    Laryngoscope 122:649-53. 2012
    ..This study assessed the normal growth and development of mastoid air-cell system (MACS) geometry from infancy through adolescence...
  41. pmc Mastoid geometry in a cross-section of humans from infancy through early adulthood with a confirmed history of otitis media
    J Douglas Swarts
    Department of Otolaryngology, Children s Hospital of Pittsburgh and University of Pittsburgh, School of Medicine, USA
    Int J Pediatr Otorhinolaryngol 76:137-41. 2012
    ..This study describes the changes in mastoid air cell system (MACS) geometry with age in ears with a history of otitis media (OM), without (GR-I) or with (GR-II) middle ear fluid on the CT scan...
  42. pmc A pilot study of the ability of the forced response test to discriminate between 3-year-old children with chronic otitis media with effusion or with recurrent acute otitis media
    Margaretha L Casselbrant
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Acta Otolaryngol 131:1150-4. 2011
    ..While the sample size was small, the high variability in all test parameters suggests that the FRT alone is not capable of distinguishing between children with different expressions of otitis media...
  43. pmc Cynical hostility and stimulated Th1 and Th2 cytokine production
    Denise Janicki-Deverts
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Brain Behav Immun 24:58-63. 2010
    ..This effect on stimulated cytokine activity may have implications for a role of hostility in exacerbating immune-related disease...
  44. ncbi request reprint Childhood socioeconomic status and host resistance to infectious illness in adulthood
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychosom Med 66:553-8. 2004
    ....
  45. pmc Infection-induced proinflammatory cytokines are associated with decreases in positive affect, but not increases in negative affect
    Denise Janicki-Deverts
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA
    Brain Behav Immun 21:301-7. 2007
    ..There were no associations between cytokines and negative affect. Findings support a causal association between pathogen-induced local cytokine production and changes in positive affect over a 24-h timeline...
  46. ncbi request reprint Temporal relationships for cold-like illnesses and otitis media in sibling pairs
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 26:778-81. 2007
    ..Interference with intrafamily CLI transmission may present a strategy for OM prophylaxis in high risk children. This study estimated factors relevant to strategy efficiency...
  47. pmc Evaluation of microbial RNA extractions from Streptococcus pneumoniae
    Ha Sheng Li-Korotky
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA
    J Microbiol Methods 68:342-8. 2007
    ....
  48. pmc Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA Electronic address
    Brain Behav Immun 34:31-8. 2013
    ....
  49. ncbi request reprint A rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection: methods and disease course
    Otavio B Piltcher
    Department of Otolaryngology, Children s Hospital of Pittsburgh, PA 15213, USA
    Otolaryngol Head Neck Surg 126:490-8. 2002
    ..To describe the clinical and histopathologic progression of a rat model of otitis media with effusion caused by eustachian tube obstruction (ETO) with and without Streptococcus pneumoniae infection...
  50. doi request reprint Relationship between the electromyographic activity of the paratubal muscles and eustachian tube opening assessed by sonotubometry and videoendoscopy
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, One Children s Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    Arch Otolaryngol Head Neck Surg 138:741-6. 2012
    ..To determine the role played by the tensor veli palatini and levator veli palatini muscles (mTVP and mLVP, respectively) in eustachian tube (ET) opening...
  51. pmc Pre- and post-palatoplasty Eustachian tube function in infants with cleft palate
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh of UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, United States
    Int J Pediatr Otorhinolaryngol 76:388-91. 2012
    ..The present study was designed to determine the reproducibility of those results...
  52. pmc Surface area-volume relationships for the mastoid air cell system and tympanum in adult humans: Implications for mastoid function
    J Douglas Swarts
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh, PA, USA
    Acta Otolaryngol 130:1230-6. 2010
    ..The mastoid air-cell system (MACS) will not function as an ME gas reserve unless the blood perfusion/surface area is much greater for the tympanum than the MACS and decreases as MACS volume increases...
  53. ncbi request reprint Tympanometry accurately measures middle ear underpressures in monkeys
    Cuneyt M Alper
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ann Otol Rhinol Laryngol 112:877-84. 2003
    ..These results show that in monkeys, tympanometry provides an accurate, relatively unbiased estimate of ME underpressure and suggest that the measurement error for tympanometry can be predicted for MEs of other species...
  54. ncbi request reprint Sociability and susceptibility to the common cold
    Sheldon Cohen
    Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychol Sci 14:389-95. 2003
    ..The association between sociability and disease was also independent of baseline immunity (virus-specific antibody), demographics, emotional styles, stress hormones, and health practices...
  55. ncbi request reprint Viral and bacterial rhinitis
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Allergy Immunol 19:177-95. 2007
    ....
  56. ncbi request reprint Emotional style and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
    Psychosom Med 65:652-7. 2003
    ..We tested these hypotheses for host resistance to the common cold...
  57. doi request reprint Daily tympanometry for high-resolution measurement of the time between onset of cold-like illness and middle ear effusion
    William J Doyle
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 118:1066-71. 2008
    ..Tympanometry is a simple method to assess middle ear pressure (MEP) and the presence of middle ear effusion (MEE), a marker of otitis media (OM)...
  58. pmc Eustachian tube function in adults without middle ear disease
    J Douglas Swarts
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, USA
    Ann Otol Rhinol Laryngol 120:220-5. 2011
    ..We sought to develop normative values for 5 eustachian tube function (ETF) test protocols in adults without otitis media (OM)...
  59. ncbi request reprint Effect of tensor veli palatini muscle paralysis on eustachian tube mechanics
    Samir N Ghadiali
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Otol Rhinol Laryngol 112:704-11. 2003
    ..Knowledge of how these physical components affect the global mechanical environment may lead to improved treatments for ET dysfunction that target the underlying mechanical abnormality...
  60. ncbi request reprint Suppression of epithelial ion transport transcripts during pneumococcal acute otitis media in the rat
    Ha Sheng Li
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    Acta Otolaryngol 122:488-94. 2002
    ..Any or all of these changes may contribute to the initiation and persistence of middle ear mucosa inflammation and effusion during an episode of bacterial acute otitis media...
  61. ncbi request reprint State and trait affect as predictors of salivary cortisol in healthy adults
    Deborah E Polk
    Psychology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 30:261-72. 2005
    ..Differences in rhythmicity found here are noteworthy given the possible role of cortisol dysregulation in disease incidence, morbidity, mortality, and severity...
  62. ncbi request reprint On morphometric measurement of oxygen diffusing capacity in middle ear gas exchange
    Stephen Chad Kanick
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto St, Pittsburgh, PA 15213, USA
    J Appl Physiol (1985) 98:114-9. 2005
    ..The morphometric techniques underestimate diffusion length by failing to account for the curvilinear gas flow pathways predicted by the finite element model...
  63. ncbi request reprint Socioeconomic status is associated with stress hormones
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Psychosom Med 68:414-20. 2006
    ....
  64. ncbi request reprint Effect of 10 pharmacologic probes on mRNA levels of inducible nitric oxide synthetase and selected inflammatory cytokines in a rat model of acute otitis media
    Patricia A Hebda
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania 15213 2583, USA
    Acta Otolaryngol 122:255-61. 2002
    ..Tacrolimus and dexamethasone decreased IL-6, iNOS and MCP-1. These results show that pharmacological agents can modify the expression of inflammatory mediators in this model and may have clinically relevant effects...
  65. ncbi request reprint Nasal cytokines as mediators of illness during the common cold
    William J Doyle
    Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 5:173-81. 2005
    ..The available evidence for mediation of the common cold is the subject of this manuscript...
  66. ncbi request reprint Prevention of otitis media caused by viral upper respiratory tract infection: vaccines, antivirals, and other approaches
    William J Doyle
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    Curr Allergy Asthma Rep 3:326-34. 2003
    ..In this review, we discuss the hypothesized mechanisms by which a vURI is translated into an acute OM episode and describe different strategies for aborting that process. Limitations to deployment of each strategy are outlined...
  67. ncbi request reprint Use of diagnostic algorithms and new technologies to study the incidence and prevalence of viral upper respiratory tract infections and their complications in high risk populations
    William J Doyle
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Allergy Clin Immunol 7:11-6. 2007
    ..These factors bias estimates of the incidence and prevalence of viral upper respiratory tract infections and their complications. Here we review new methodologies that can be adapted for use in future studies to refine those estimates...
  68. doi request reprint Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis
    David P Skoner
    Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 101:431-6. 2008
    ..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
  69. ncbi request reprint Allergy skin test responses during experimental infection with respiratory syncytial virus
    David P Skoner
    Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 96:834-9. 2006
    ..False-positive allergen skin test results are known to occur; however, contributing factors are not well understood...
  70. ncbi request reprint Barotrauma during air travel: predictions of a mathematical model
    Stephen Chad Kanick
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Ave at DeSoto St, Pittsburgh, PA 15213, USA
    J Appl Physiol (1985) 98:1592-602. 2005
    ..These buffering systems can explain why some children and adults with poor eustachian tube function do not experience middle ear barotrauma...
  71. ncbi request reprint Measurement of the viscoelastic compliance of the eustachian tube using a modified forced-response test
    Samir N Ghadiali
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 Fifth Ave at DeSoto Street, Pittsburgh, PA 15213, USA
    Auris Nasus Larynx 29:1-5. 2002
    ..Here, we present a new method for measuring ETC that conforms more closely to the engineering definition of compliance...
  72. ncbi request reprint Comparison of subject-reported allergy versus skin test results in a common cold trial
    Jason S Krahnke
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Rhinol 17:159-62. 2003
    ..The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study...
  73. ncbi request reprint Nasal and otologic effects of experimental respiratory syncytial virus infection in adults
    Craig A Buchman
    Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Otolaryngol 23:70-5. 2002
    ..This study was conducted to more clearly define the extent and frequency of nasal and otologic effects of respiratory syncytial virus infection in healthy adult volunteers...
  74. ncbi request reprint Daily home tympanometry to study the pathogenesis of otitis media
    Stephanie Moody Antonio
    House Ear Clinic and Institute Los Angeles CA, USA
    Pediatr Infect Dis J 21:882-5. 2002
    ..A total of 136 patients identified colds, and 43 episodes of otitis media were recorded. New episodes of otitis media were observed in 22% of all colds, and 63% of all otitis media episodes occurred during a cold...
  75. ncbi request reprint A high prevalence of new onset otitis media during parent diagnosed common colds
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, United States
    Int J Pediatr Otorhinolaryngol 70:1725-30. 2006
    ..A prospective format was used to determine the coincidence of otitis media and parent diagnosed cold/flu episodes in young children followed over a typical cold/flu season...