Research Topics

Genomes and Genes


Robson Augusto Souza dos Santos



  1. de Souza Neto F, Silva M, Santuchi M, de Alcântara Leonídio T, Motta Santos D, Oliveira A, et al. Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice. Clin Sci (Lond). 2019;133:629-643 pubmed publisher
    ..Hence, this work opens new avenues for the use of this heptapeptide also as a therapeutic target for vascular disease. ..
  2. Passos Silva D, Brandan E, Santos R. Angiotensins as therapeutic targets beyond heart disease. Trends Pharmacol Sci. 2015;36:310-20 pubmed publisher
    ..In this article, we briefly review novel targets for angiotensins and its therapeutic implications in diverse areas, including cancer, inflammation, and glaucoma. ..
  3. Velloso E, Pimentel R, Braga J, Cabral A, Reis Z, Bader M, et al. Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients. Am J Hypertens. 2016;29:405-12 pubmed publisher
    ..We described, for the first time, the presence of endothelin-1 ETA receptor AABs in PE. Our results suggest that the presence of both agonistic AABs may be involved in the pathogenesis of severe PE. ..
  4. Fontes M, Martins Lima A, Santos R. Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress. Neuropeptides. 2016;56:9-17 pubmed publisher
    ..The present review focuses on angiotensin-(1-7)/Mas axis as a promising target to attenuate the physiological response to emotional stress reducing the risk of cardiovascular diseases. ..
  5. Felix Braga J, Ravizzoni Dartora D, Alenina N, Bader M, Santos R. Glucagon-producing cells are increased in Mas-deficient mice. Endocr Connect. 2017;6:27-32 pubmed publisher
    ..001; percentage per islet: 16?±?0.8 vs 10?±?0.5% in WT, P?<?0.0001). These results suggest that Mas has a previously unexpected role on the pancreatic glucagon production. ..
  6. Lautner R, Fraga Silva R, Ferreira A, Santos R. Vascular Reactivity of Isolated Aorta to Study the Angiotensin-(1-7) Actions. Methods Mol Biol. 2017;1527:369-379 pubmed publisher
    ..Here, we described the isolated aorta technique and pitfalls about the use of angiotensin-(1-7) peptide in this preparation. ..
  7. Rabello Casali K, Ravizzoni Dartora D, Moura M, Bertagnolli M, Bader M, Haibara A, et al. Increased vascular sympathetic modulation in mice with Mas receptor deficiency. J Renin Angiotensin Aldosterone Syst. 2016;17:1470320316643643 pubmed publisher
    ..Our results suggest that the Ang-(1-7)/Mas axis seems more important in autonomic modulation of arterial pressure than HR. ..
  8. Soares E, Barbosa C, Campagnole Santos M, Santos R, Alzamora A. Hypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin-(1-7), into caudal ventrolateral medulla of 2K1C hypertensive rats. Peptides. 2017;96:67-75 pubmed publisher
    ..These results provide new insights about the differential mechanisms participating in the central cardiovascular effects of alamandine and angiotensin-(1-7) in normotensive and 2K1C hypertensive rats. ..